Evaluation of an oral carrier system in rats: Bioavailability and gastrointestinal absorption properties of curcumin encapsulated PBCA nanoparticles

Journal of Nanoparticle Research

Volumn 14, Issue 2, 2012, Pages

  Sun, Min ^a,b   Zhao, Lixia ^a,c   Guo, Chenyu ^a   Cao, Fengliang ^a   Chen, Huanlei ^a   Zhao, Liyan ^a   Tan, Qi ^a   Zhu, Xiuqing ^a   Zhu, Fanping ^a   Ding, Tingting ^a   Zhai, Yingjie ^a   Zhai, Guangxi ^a  

^a SHANDONG UNIVERSITY   (China)

^b Central Hospital of Zibo   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Bioavailability; Curcumin; In situ absorption; Nanomedicine; Nanoparticle; Polybutylcyanoacrylate

Indexed keywords

BIOAVAILABILITY; CURCUMIN; IN-SITU ABSORPTION; NANOMEDICINES; POLYBUTYLCYANOACRYLATE;

MEDICAL NANOTECHNOLOGY; MICROCRYSTALS; NANOPARTICLES; OPTIMIZATION; RATS; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

BIOCHEMISTRY;

CURCUMIN; ENBUCRILATE; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON ABSORPTION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; ENCAPSULATION; EXPERIMENT; GASTROINTESTINAL ABSORPTION; NONHUMAN; ORTHOGONAL ROTATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

EID: 84862783036     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-011-0705-4     Document Type: Article

References (54)

1. Alyautdin RN, Petrov VE, Langer K, Berthold A, Kharkevich DA, Kreuter J (1997) Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm Res 14:325-328. doi:10.1023/A:1012098005098 (Pubitemid 27160944)
2. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807-818. doi:10.1021/mp700113r
3. Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB (2010) Design of curcuminloaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol 79: 330-338. doi:10.1016/j.bcp.2009.09.003
4. Behan N, Birkinshaw C (2000) Mechanism of polymerization of butylcyanoacrylate in aqueous dispersions. Macromol Rapid Commun 21:884-886. doi:10.1002/1521-3927 (20000801
5. Behan N, Birkinshaw C, Clarke N (2001) Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation. Biomaterials 22:1335-1344. doi:10.1016/S0142-9612(00)00286-6 (Pubitemid 32409955)
6. Chen RD, Ren F, Li GF, Liu SJ (2010) Preparation of paclitaxelloaded polybutylanaocrylate nanoparticle. J South Med Univ 30:763-766
7. Cirri M, Muraa P, Corvi MP(2007) Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems. Int J Pharm 340:84-91. doi:10.1016/j.ijpharm. 2007.03.021 (Pubitemid 47049783)
8. Cui J, Yu B, Zhao Y, Zhu WW, Li HL, Lou HX, Zhai GX (2009) Enhancement of oral absorption of curcumin by selfmicroemulsifying drug delivery systems. Int J Pharm 371:148-155. doi:10.1016/j.ijpharm.2008.12.009
9. David W, Fryb J, White C, Goldman ID (1978) Rapid separation of low molecular weight solutes from liposomes without dilution. Anal Biochem 90:809-815. doi:10.1016/0003- 2697(78)90172-0 (Pubitemid 9087732)
10. Dembri A, Montisci MJ, Gantier JC, Chacun H, Ponchel G (2001) Targeting of 30-Azido 30-deoxythymidine (AZT)- loaded poly(isohexylcyanoacrylate) nanospheres to the gastrointestinal mucosa and associated lymphoid tissues. Pharm Res 18:467-474. doi:10.1023/A:1011050209986 (Pubitemid 32592578)
11. Douglas SJ, Illum L, Davisand SS, Kreuter J (1984) Particle size and size distribution of poly(butyl-2-cyanoacrylate) nanoparticles. II. Influence of physicochemical factors. J Colloid Interface Sci 101:149-157. doi:10.1016/0021-9797 (84)90015-8
12. Duchêne D, Ponchel G (1997) Bioadhesion of solid oral dosage forms, why and how? Eur J Pharm Biopharm 44:15-23. doi:10.1016/S0939-6411(97)00097-0 (Pubitemid 28298771)
13. Duro R, Alvarez C, Martýonez-Pacheco R, Goomez-Amoza JL, Concheiro A, Souto C (1998) The adsorption of cellulose ethers in aqueous suspensions of pyrantel pamoate: effects on zeta potential and stability. Eur J Pharm Biopharm 45:181-188. doi:10.1016/S0939-6411(97)00103-3 (Pubitemid 28167745)
14. Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glockner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ (2004) Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science 304:600-602. doi:10.1126/ science.1093941 (Pubitemid 38541921)
15. Eldridge JH (1990) Controlled release in the gut-associated lymphoid tissues. 1. Orally administered biodegradable microspheres target the Peyer's patches. J Control Release 11:205-214. doi:10.1016/0168-3659(90)90133-E (Pubitemid 20070098)
16. Fawaz F, Guyot M, Lagueny AM, Devissaguet JP (1997) Ciprofloxacin- loaded poly (isobutylcyanoacrylate) nanoparticles: preparation and characterization. Int J Pharm 154: 191-203
17. Gao XF, Deng YJ, Cao JN, Wang XM (2009a) Minicolumn centrifugation-HPLC determination of entrapment efficiency for liposomal formulation of altretamine. Chin J Pharm Anal 29:247-250
18. Gao Y, Wang YQ, Ma YK, Yu AH, Cai FQ, Shao W, Zhai GX (2009b) Formulation optimization and in situ absorption in rat intestinal tract of quercetin-loaded microemulsion. Colloids Surf B 71:306-314. doi:10.1016/j.colsurfb.2009. 03.005
19. Gulyaev AE, Gelperina SE, Skidan IN, Antropov AS, Kivman GY, Kreuter J (1999) Significant transport of doxorubicin into the brain with polysorbate 80 coated nanoparticles. Pharm Res 16:1564-1570. doi:10.1023/A:1018983904537 (Pubitemid 29510553)
20. He WL, Jiang XH, Zhang ZR (2008) Preparation and evaluation of poly-butylcyanoacrylate nanoparticles for oral delivery of thymopentin. J Pharm Sci 97:2250-2259. doi:10.1002/ jps.21148
21. Hu YQ, Zheng LY, Qian CQ, Yu WH (1996) Absorption of phenol red from rat intestine. J Chin Pharm Univ 27: 355-359
22. Huang CY, Lee YD (2006) Core-shell type of nanoparticles composed of poly [(n-butyl cyanoacrylate)-co-(2-octylcyanoacrylate)] copolymers for drug delivery application: synthesis, characterization and in vitro degradation. Int J Pharm 325:132-139. doi:10.1016/j.ijpharm.2006.06.008 (Pubitemid 44573685)
23. Huang CY, Chen CM, Lee YD (2007) Synthesis of high loading and encapsulation efficient paclitaxel-loaded poly (n-butyl cyanoacrylate) nanoparticles via miniemulsion. Int J Pharm 338:267-275. doi:10.1016/j.ijpharm. 2007.01.052 (Pubitemid 46777229)
24. Huo DJ, Deng SH, Li LB, Ji JB (2005) Studies on the poly (lactic-co-glycolic) acid microspheres of cisplatin for lungtargeting. Int J Pharm 289:63-67. doi:10.1016/j.ijpharm. 2004.10.017
25. Hussain N, Jaitley V, Florence AT (2001) Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv Drug Deliv Rev 50: 107-142. doi:10.1016/S0169-409X(01)00152-1 (Pubitemid 32727279)
26. Johnson JJ, Mukhtar H (2007) Curcumin for chemoprevention of colon cancer. Cancer Lett 255:170-181. doi:10.1016/ j.canlet.2007.03.005 (Pubitemid 47268637)
27. Kakkar V, Singh S, Singla D, Kaur IP (2010) Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol Nutr Food Res 54:1-9. doi:10.1002/ mnfr.201000310
28. Lao C, Ruffin M, Normolle D, Heath D, Murray S, Bailey J (2006) Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 6:10-15. doi:10.1186/1472- 6882-6-10
29. Liu J, Zhu J, Du Z, Qin B (2005) Preparation and pharmacokinetic evaluation of Tashinone IIA solid lipid nanoparticles. Drug Dev Ind Pharm 31:551-556. doi:10.1080/03639040 500214761 (Pubitemid 41285733)
30. Lv QZ, Yu AH, Xi YW, Li HL, Song ZM, Cui J, Cao FL, Zhai GX (2009) Development and evaluation of penciclovirloaded solid lipid nanoparticles for topical delivery. Int J Pharm 372:191-198. doi:10.1016/j.ijpharm.2009.01.014
31. Masaoka Y, Tanaka Y, Kataoka M, Sakuma S, Yamashita S (2006) Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract. Eur J Pharm Sci 29:240-250. doi:10.1016/j.ejps.2006.06.004 (Pubitemid 44602413)
32. Mulik R, Mahadika K, Paradkarb A (2009) Development of curcuminoids loaded poly (butyl) cyanoacrylate nanoparticles: physicochemical characterization and stability study. Eur Pharm Sci 37:395-404. doi:10.1016/j.ejps.2009. 03.009
33. Müller RH, Mäder K, Gohla S (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery-are view of the state of the art. Eur J Pharm Biopharm 50:161-177. doi:10.1016/ S0939-6411(00)00087-4 (Pubitemid 30326695)
34. Murthy RSR, Reddy LH (2007) Poly (alkyl cyanocrylate) nanoparticles for delivery of anti-cancer drugs. Nanotechnology 251-288. doi:10.1201/ 9781420006636.ch15
35. Onoue S, Takahashi H, Kawabata Y, Seto Y, Hatanaka J, Timmermann B, Yamada S (2009) Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J Pharm Sci 99:1871-1881. doi:10.1002/jps.21964
36. Pan MH, Huang TM, Lin JK (1999) Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos 27:486-494. doi:0090-9556/99/2701- 0486-494
37. Pappo J, Ermak TH (1989) Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for Mcell uptake. Clin Exp Immunol 76:144-148 (Pubitemid 19125528)
38. Shaikha J, Ankolab DD, Beniwal V, Singha D, RaviKumar MNV (2009) Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 37:223-230. doi:10.1016/ j.ejps.2009.02.019
39. Shankar T, Shantha N, Ramesh H, Murthy I, Murthy V (1980) Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guinea pigs and monkeys. Indian J Exp Biol 18:73-75 (Pubitemid 10143537)
40. Shantha KTR, Chawla S, Nachaegari SK, Singh SK, Srinivas NR (2005) Validated HPLC analytical method with programmed wavelength UV detection for simultaneous determination of DRF-4367 and Phenol red in rat in situ intestinal perfusion study. J Pharm Biomed Anal 38: 173-179. doi:10.1016/j.jpba.2004.11.063 (Pubitemid 40725105)
41. Sharma RA, Steward WP, Gescher AJ (2007) Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol 595:453-470. doi:10.1007/978-0- 387-46401-5-20
42. Simeonova M, Ivanova G, Enchev V, Markova N, Kamburov M, Petkov C, Devery A, Connor R, Brougham D (2009) Physicochemical characterization and in vitro behavior of daunorubicin-loaded poly(butylcyanoacrylate) nanoparticles. Acta Biomater 5:2109-2121
43. Singh B, Mehta G, Kumar R, Bhatia A, Ahuja N, Katare OP (2005) Design, development and optimization of nimesulide- loaded liposomal systems for topical application. Curr Drug Deliv 2:143-153 (Pubitemid 40488624)
44. Sun M, Gao Y, Guo CY, Cao FL, Song ZM, Xi YW, Yu AH, LiAG,ZhaiGX(2010) Enhancement of transport of curcumin to brain in mice by poly(n- butylcyanoacrylate) nanoparticle. J Nanopart Res 12:3111-3122. doi:10.1007/s11051-010- 9907-4
45. Takahashi M, Uechi S, Takara K, Asikin Y, Wada K (2009) Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric Food Chem 57:9141-9146. doi:10.1021/ jf9013923
46. Tonnesen HH, Masson M, Loftsson T (2002) Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int J Pharm 244:127-135. doi:10.1016/S0378-5173(02) 00323-X (Pubitemid 35245453)
47. Venkatesan N, Uchino K, Amagase K, Ito Y, Shibata N, Takada K (2006) Gastrointestinal patch system for the delivery of erythropoietin. J Control Release 111:19-26. doi:10.1016/ j.jconrel.2005.11.009 (Pubitemid 43289990)
48. Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, Lin JK (1997) Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed 15:1867-1876. doi:10.1016/S0731-7085(96) 02024-9 (Pubitemid 27341993)
49. Yang XX, Chen JH, Guo D (2005) Study of biocompatible of polybutylcyanoacrylate nanoparticles. J First Mil Med Univ 25:1261-1263. doi:http://www.j-smu.com/pdf2/ 200510/2005101261.pdf
50. Yang KY, Lin LC, Tseng TY, Wang SC, Tsai TH (2007) Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr B Anal Technol Biomed Life Sci 853:183-189. doi:10.1016/ j.jchromb.2007.03.010
51. Ye JS, Wang Q, Zhou XF, Zhang Na (2008) Injectable actaritloaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis. Int J Pharm 319: 162-168. doi:10.1016/j.ijpharm.2007.10.014 (Pubitemid 351273921)
52. Yuan H, Chen J, Du YZ, Hu FQ, Zeng S, Zhao HL (2007) Studies on oral absorption of stearic acid SLN by a novel fluorometricmethod. Colloids Surf B Biointerfaces 58: 157-164. doi:10.1016/j.colsurfb.2007.03.002 (Pubitemid 46921452)
53. Zakeri-Milania P, Valizadeha H, Tajerzadehc H, Azarmia Y, Islambolchilara Z, Barzegara S, Barzegar-Jalalia M (2007) Predicting human intestinal permeability using single-pass intestinal perfusion in rat. J Pharm Pharm Sci 10:368-379
54. Zhu WW, Yu AH, Wang WH, Dong RQ, Wu J, Zhai GX (2008) Formulation design of microemulsion for dermal delivery of penciclovir. Int J Pharm 360:184-190. doi:10.1016/ j.ijpharm.2008.04.008