Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems

International Journal of Pharmaceutics

Volumn 371, Issue 1-2, 2009, Pages 148-155

  Cui, Jing ^a,b   Yu, Bo ^c   Zhao, Yu ^a   Zhu, Weiwei ^a   Li, Houli ^a   Lou, Hongxiang ^a   Zhai, Guangxi ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c Ohio State University   (United States)

Author keywords

Curcumin; Microemulsion; Self microemulsifying drug delivery system (SMEDDS); Simplex lattice experiment design

Indexed keywords

COSURFACTANT; CURCUMIN; MACROGOL 400; OLEIC ACID ETHYL ESTER; POLOXAMER; SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; EMULSION; EXCIPIENT COMPATIBILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SELF MICROEMULSIFYING DRUG DELIVERY SYTEM;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMIN; DRUG DELIVERY SYSTEMS; ELECTRIC CONDUCTIVITY; EMULSIONS; INTESTINAL ABSORPTION; MALE; MICE; MOUTH MUCOSA; PARTICLE SIZE; PHASE TRANSITION; RATS; RATS, WISTAR; SOLUBILITY;

EID: 62749095208     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.12.009     Document Type: Article

References (37)

1. Anand P., Kunnumakkara A.B., Newman R.A., and Aggarwal B.B. Bioavailability of curcumin: problems and promises. Mol. Pharm. 4 (2007) 807-818
2. Araujo C.C., and Leon L.L. Biological activities of Curcuma longa L. Mem. Inst. Oswaldo Cruz. 96 (2001) 723-728
3. Borhade V., Nair H., and Hegde D. Design and evaluation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus. AAPS PharmSciTech 9 (2008) 13-21
4. Casanova R., Srikanth R., Baer A., Laurienti P.J., Burdette J.H., Hayasaka S., Flowers L., Wood F., and Maldjian J.A. Biological parametric mapping: a statistical toolbox for multimodality brain image analysis. Neuroimage 34 (2007) 137-143
5. Chen Y., Li G., Wu X.G., Chen Z.Y., Hang G.J., Qin B., Chen S., and Wang R.H. Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment. Biol. Pharm. Bull. 31 (2008) 118-125
6. Cirri M., Muraa P., and Corvi Morab P. Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems. Int. J. Pharm. 340 (2007) 84-91
7. Holder G.M., Plummer J.L., and Ryan A.J. The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat. Xenobiotica 8 (1978) 761-768
8. Holm R., Jensen I.H.M., and Sonnergaard J. Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function. Drug Dev. Ind. Pharm. 32 (2006) 1025-1032
9. Hsu C.H., and Cheng A.L. Clinical studies with curcumin. Adv. Exp. Med. Biol. 595 (2007) 471-480
10. Hu Y.Q., Zheng L.Y., Qian C.Q., and Yu W.H. Absorption of phenol red from rat intestine. J. Chin. Pharm. Univ. 27 (1996) 355-359
11. Johnson J.J., and Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 255 (2007) 170-181
12. Kale N.J., and Allen L.V.J.R. Studies on microemulsions using Brij 96 as surfactant and glycerine, ethylene glycol and propylene glycol as cosurfactant. Int. J. Pharm. 57 (1989) 87-93
13. Kawakami K., Yoshikawa T., Moroto Y., Kanaoka E., Takahashi K., Nishihara Y., and Masuda K. Microemulsion formulation for enhanced absorption of poorly soluble drugs. I. Prescription design. J. Control. Release 81 (2002) 65-74
14. Kompany-zareh M., and Khoshkam M. Application of chemometrics methods with kinetic constraints for estimation of rate constants of second order consecutive reactions. Anal. Sci. 24 (2008) 635-637
15. Liao Z.G., Ping Q.N., Xiao W., and Liang X.L. The study in situ on rat intestinal absorption of the active components in GuizhiFuling capsule. Chin. J. Nat. Med. 3 (2005) 303-307
16. Mao S.S., Zhou J.X., and Chen Y. Design of Experiment (2004), China Statistics Press, Beijing
17. Marczylo T.H., Verschoyle R.D., Cooke D.N., Morazzoni P., Steward W.P., and Gescher A.J. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother. Pharmacol. 60 (2007) 171-177
18. Narang A.S., Delmarre D., and Gao D. Stable drug encapsulation in micelles and microemulsions. Int. J. Pharm. 345 (2007) 9-25
19. Pan M.H., Huang T.M., and Lin J.K. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab. Dispos. 27 (1999) 486-494
20. Paradkar A., Ambike A.A., Jadhav B.K., and Mahadik K.R. Characterization of curcumin-PVP solid dispersion obtained by spray drying. Int. J. Pharm. 271 (2004) 281-286
21. Patel A.R., and Vavia P.R. Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J. 9 (2007) 344-352
22. Patel D., and Sawant K.K. Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery systems (SMEDDS). Drug Dev. Ind. Pharm. 33 (2007) 1318-1326
23. Patel D.M., Patel N.M., Pandya N.N., and Jogani P.D. Gastroretentive drug delivery system of carbamazepine: formulation optimization using simplex lattice design: a technical note. AAPS PharmSciTech 8 (2007) 11-15
24. Ritesh J., Sridhar D., Viral K., Nanda K.M., and Ashim K.M. Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats. Int. J. Pharm. 336 (2007) 233-240
25. Sharma R.A., Euden S.A., Platton S.L., Cooke D.N., Shafayat A., Hewitt H.R., Marczylo T.H., Morgan B., Hemingway D., Plummer S.M., Pirmohamed M., Gescher A.J., and Steward W.P. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin. Cancer Res. 10 (2004) 6847-6854
26. Shen H., and Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J. Pharm. Pharmacol. 58 (2006) 1183-1191
27. Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., and Srinivas P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 64 (1998) 353-356
28. Song N.N., Li Q.S., and Liu C.X. Intestinal permeability of metformin using single-pass intestinal perfusion in rats. World J. Gastroenterol. 12 (2006) 4064-4070
29. Subramanian N., Ray S., Ghosal S.K., Bhadra R., and Moulik S.P. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. Biol. Pharm. Bull. 27 (2004) 1993-1999
30. Tonnesen H.H., Masson M., and Loftsson T. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int. J. Pharm. 244 (2002) 127-135
31. Wang D.K., Shi Z.H., Liu L., Wang X.Y., Zhang C.X., and Zhao P. Development of self-microemulsifying drug delivery systems for oral bioavailability enhancement of alpha-Asarone in beagle dogs. PDA J. Pharm. Sci. Technol. 60 (2006) 343-349
32. Wahlstrom B., and Blennow G. A study on the fate of curcum in the rat [J]. Acta Pharm. Acol. Toxicol. 43 (1978) 862-921
33. Yang K.Y., Lin L.C., Tseng T.Y., Wang S.C., and Tsai T.H. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 853 (2007) 183-189
34. Zakeri-Milania P., Valizadeha H., Tajerzadehc H., Azarmia Y., Islambolchilara Z., Barzegara S., and Barzegar-Jalalia M. Predicting human intestinal permeability using single-pass intestinal perfusion in rat. J. Pharm. Pharm. Sci. 10 (2007) 368-379
35. Zeng Y., Qiu F., Liu Y., Qu G., and Yao X. Isolation and identification of phase 1 metabolites of demethoxycurcumin in rats. Drug Metab. Dispos. 35 (2007) 1564-1573
36. Zhang P., Liu Y., Feng N., and Xu J. Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int. J. Pharm. 355 (2008) 269-276
37. Zhou P., Li L.P., Luo S.Q., Jiang H.D., and Zeng S. Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin. J. Agric. Food Chem. 56 (2008) 296-300