Guanine-nucleotide exchange factor H1 mediates lipopolysaccharide-induced interleukin 6 and tumor necrosis factor α expression in endothelial cells via activation of nuclear factor κb

Shock

Volumn 37, Issue 5, 2012, Pages 531-538

  Guo, Feng ^a   Xing, Ying ^b,c   Zhou, Zengding ^a   Dou, Yi ^a   Tang, Jiajun ^a   Gao, Chengjin ^d   Huan, Jingning ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b 98th Hospital of Nanjing Military Command   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

Author keywords

Extracellular signalYregulated kinase 1 2; Guanine nucleotide exchange factor; Interleukin 6; Lipopolysaccharide; Nuclear factor B; P38; Tumor necrosis factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR H1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RHO KINASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CLOSTRIDIUM DIFFICILE; CYTOKINE RELEASE; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

AMIDES; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMIDAZOLES; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; PYRIDINES; RNA, MESSENGER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862781786     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31824caa96     Document Type: Article

References (35)

1. Tsujimoto H, Ono S, Efron PA, Scumpia PO, Moldawer LL, Mochizuki H: Role of Toll-like receptors in the development of sepsis. Shock 29(3):315-321, 2008. (Pubitemid 351271701)
2. Maniatis NA, Orfanos SE: The endothelium in acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care 14(1):22-30, 2008.
3. Hochdö rfer T, Kuhny M, Zorn CN, Hendriks RW, Vanhaesebroeck B, Bohnacker T, Krystal G, Huber M: Activation of the PI3K pathway increases TLR-induced TNF-! and IL-6 but reduces IL-1" production in mast cells. Cell Signal 23(5):866-875, 2011.
4. Reinhart K, Bayer O, Brunkhorst F, Meisner M: Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med 30(suppl 5):S302-S312, 2002. (Pubitemid 34508007)
5. Schmidt C, Kurt B, Höcherl K, Bucher M: Inhibition of NF-kappaB activity prevents downregulation of alpha1-adrenergic receptors and circulatory failure during CLP-induced sepsis. Shock 32(3):239-246, 2009.
6. Zeuke S, Ulmer AJ, Kusumoto S, Katus HA, Heine H: TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS. Cardiovasc Res 56(1):126-134, 2002. (Pubitemid 35247809)
7. Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, et al.: Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med 39(6):1407-1413, 2011.
8. Parameswaran N, Patial S: Tumor necrosis factor-! signaling in macrophages. Crit Rev Eukaryot Gene Expr 20(2):87-103, 2010.
9. Kibe S, Adams K, Barlow G: Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother 66(suppl 2):ii33-ii40, 2011.
10. Haasper C, Kalmbach M, Dikos GD, Meller R, Mü ller C, Krettek C, Hildebrand F, Frink M: Prognostic value of procalcitonin (PCT) and/or interleukin-6 (IL-6) plasma levels after multiple trauma for the development of multi organ dysfunction syndrome (MODS) or sepsis. Technol Health Care 18(2):89-100, 2010.
11. Cohen J, Carlet J: INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 24(9):1431-1440, 1996. (Pubitemid 26313741)
12. Horton JW, Maass DL, Ballard-Croft C: Rho-associated kinase modulates myocardial inflammatory cytokine responses. Shock 24(1):53-58, 2005. (Pubitemid 40946595)
13. Sakoda K, Yamamoto M, Negishi Y, Liao JK, Node K, Izumi Y: Simvastatin decreases IL-6 and IL-8 production in epithelial cells. J Dent Res 85(6): 520-523, 2006. (Pubitemid 43945489)
14. Just I, Hofmann F, Aktories K: Molecular mode of action of the large clostridial cytotoxins. Curr Top Microbiol Curr Top Microbiol Immunol 250:55-83, 2000. (Pubitemid 30463102)
15. Hippenstiel S, Soeth S, Kellas B, Fuhrmann O, Seybold J, Krüll M, Eichel-Streiber C, Goebeler M, Ludwig S, Suttorp N: Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells. Blood 95(10):3044-3051, 2000. (Pubitemid 30321152)
16. Perona R, Montaner S, Saniger L, Sánchez-Pérez I, Bravo R, Lacal JC: Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev 11(4):463-475, 1997. (Pubitemid 27097645)
17. Zheng Y: Dbl family guanine nucleotide exchange factors. Trends Biochem Sci 26(12):724-732, 2001. (Pubitemid 34014839)
18. Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM: GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell 12(5):699-712, 2007. (Pubitemid 46671149)
19. Shibolet O, Giallourakis C, Rosenberg I, Mueller T, Xavier RJ, Podolsky DK: AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. J Biol Chem 282(48):35308-35317, 2007. (Pubitemid 350232485)
20. YoonWJ, Moon JY, Kang JY, KimGO, Lee NH, Hyun CG: Neolitsea sericea essential oil attenuates LPS-induced inflammation in RAW 264.7 macrophages by suppressing NF-kappaB and MAPK activation. Nat Prod Commun 5(8):1311-1316, 2010.
21. Bhatia M, He M, Zhang H, Moochhala S: Sepsis as a model of SIRS. Front Biosci 14:4703-4711, 2009.
22. Perrier C, Rutgeerts P: Cytokine blockade in inflammatory bowel diseases. Immunotherapy 3(11):1341-1352, 2011.
23. Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H, Köhler G: Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368(6469):339-342, 1994. (Pubitemid 24104268)
24. Mira JP, Cariou A, Grall F, Delclaux C, Losser MR, Heshmati F, Cheval C, Monchi M, Teboul JL, Riché F, et al.: Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. JAMA 282(6):561-568, 1999. (Pubitemid 29380293)
25. Libermann TA, Baltimore D: Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 10(5):2327-2334, 1990.
26. Shimada H, Rajagopalan LE: Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acidYmediated expression of cell adhesion molecules via NF-kappaB p65. J Biol Chem 285(17):12536-12542, 2010.
27. Ruse M, Knaus UG: New players in TLR-mediated innate immunity: PI3K and small Rho GTPases. Immunol Res 34(1):33-48, 2006. (Pubitemid 43780375)
28. Bos JL, Rehmann H, Wittinghofer A: GEFs and GAPs: critical elements in the control of small G proteins. Cell 129(5):865-877, 2007. (Pubitemid 46802708)
29. Krendel M, Zenke FT, Bokoch GM: Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol 4(4):294-301, 2002. (Pubitemid 34308855)
30. Isowa N, Keshavjee SH, Liu M: Role of microtubules in LPS-induced macrophage inflammatory protein-2 production from rat pneumocytes. Am J Physiol Lung Cell Mol Physiol 279(6):L1075-L1082, 2000. (Pubitemid 32009493)
31. Fukazawa A, Alonso C, Kurachi K, Gupta S, Lesser CF, McCormick BA, Reinecker HC: GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. PLoS Pathog 4(11):e1000228, 2008.
32. Chen LY, Zuraw BL, Liu FT, Huang S, Pan ZK: IL-1 receptorYassociated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription. J Immunol 169(7):3934-3939, 2002.
33. Schmandke A, Schmandke A, Strittmatter SM: ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist 13(5):454-469, 2007. (Pubitemid 47437930)
34. Campos SB, Ashworth SL, Wean S, Hosford M, Sandoval RM, Hallett MA, Atkinson SJ, Molitoris BA: Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation. Am J Physiol Renal Physiol 296(3): F487-F495, 2009.
35. Kakiashvili E, Speight P, Waheed F, Seth R, Lodyga M, Tanimura S, Kohno M, Rotstein OD, Kapus A, Szászi K: GEF-H1 mediates tumor necrosis factoralphaYinduced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability. J Biol Chem 284(17):11454-11466, 2009.