miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure

Apoptosis

Volumn 17, Issue 7, 2012, Pages 702-716

  An, Fangmei ^a   Gong, Bangdong ^a   Wang, Hui ^a   Yu, Dongshan ^a   Zhao, Gangde ^a   Lin, Lanyi ^a   Tang, Weiliang ^a   Yu, Hong ^a   Bao, Shisan ^b   Xie, Qing ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Acute liver failure; Apoptosis; BCL2; miR 15b; miR 16; miRNAs

Indexed keywords

MICRORNA 15B; MICRORNA 16; PROTEIN BCL 2; TUMOR NECROSIS FACTOR;

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CELL; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; APOPTOSIS; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; DOWN-REGULATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; LIVER; LIVER FAILURE, ACUTE; MALE; MICE; MICE, INBRED BALB C; MICRORNAS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

MURINAE;

EID: 84862779470     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0704-7     Document Type: Article

References (46)

1. Bernal W, Auzinger G, Dhawan A, Wendon J (2010) Acute liver failure. Lancet 376(9736):190-201
2. Rahman T, Hodgson H (2001) Clinical management of acute hepatic failure. Intensive Care Med 27(3):467-476 (Pubitemid 32250075)
3. Wu Z, Han M, Chen T, Yan W, Ning Q (2010) Acute liver failure: mechanisms of immune-mediated liver injury. Liver Int 30(6):782-794
4. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281-297
5. Beitzinger M, Meister G (2010) Preview. MicroRNAs: from decay to decoy. Cell 140(5):612-614
6. Hand NJ, Master ZR, Le Lay J, Friedman JR (2009) Hepatic function is preserved in the absence of mature microRNAs. Hepatology 49(2):618-626
7. Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H (2010) MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology 51(5):1735-1743
8. Chen X, Murad M, Cui YY, Yao LJ, Venugopal SK, Dawson K, Wu J (2011) miRNA regulation of liver growth after 50% partial hepatectomy and small size grafts in rats. Transplantation 91(3):293-299
9. Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P (2005) Modulation of hepatitis C virus RNA abundance by a liverspecific MicroRNA. Science 309(5740):1577-1581 (Pubitemid 41266486)
10. Cheung O, Puri P, Eicken C, Contos MJ, Mirshahi F, Maher JW, Kellum JM, Min H, Luketic VA, Sanyal AJ (2008) Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. Hepatology 48(6):1810-1820
11. Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K, Jacob ST (2009) Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology 50(4):1152-1161
12. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G (2000) Gene ontology: tool for the unification of biology. The gene ontology consortium. Nat Genet 25(1):25-29 (Pubitemid 30257031)
13. Shen E, Diao X, Wei C, Wu Z, Zhang L, Hu B (2010) MicroRNAs target gene and signaling pathway by bioinformatics analysis in the cardiac hypertrophy. Biochem Biophys Res Commun 397(3):380-385
14. Guo CJ, Pan Q, Cheng T, Jiang B, Chen GY, Li DG (2009) Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J 276(18): 5163-5176
15. Morikawa A, Sugiyama T, Kato Y, Koide N, Jiang GZ, Takahashi K, Tamada Y, Yokochi T (1996) Apoptotic cell death in the response of D-galactosamine- sensitized mice to lipopolysaccharide as an experimental endotoxic shock model. Infect Immunity 64(3):734-738 (Pubitemid 26065541)
16. Zhang X, Bao S, Lai D, Rapkins RW, Gillies MC (2008) Intravitreal triamcinolone acetonide inhibits breakdown of the bloodretinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes 57(4):1026-1033
17. Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6(2):99-104 (Pubitemid 29082297)
18. Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S (2008) The current state of serum biomarkers of hepatotoxicity. Toxicology 245(3):194-205
19. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402-408 (Pubitemid 34164012)
20. Cai Z, Mao X, Li S, Wei L (2006) Genome comparison using Gene Ontology (GO) with statistical testing. BMC Bioinform 7:374
21. Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M (2004) The KEGG resource for deciphering the genome. Nucleic Acids Res 32(Database issue):D277-D280 (Pubitemid 38081656)
22. Joung JG, Hwang KB, Nam JW, Kim SJ, Zhang BT (2007) Discovery of microRNA-mRNA modules via population-based probabilistic learning. Bioinformatics 23(9):1141-1147
23. Reddy MA, Shukla SD (2000) Nuclear activation and translocation of mitogen-activated protein kinases modulated by ethanol in embryonic liver cells. Biochim Biophys Acta 1497(2):271-278 (Pubitemid 30618839)
24. Zhao X, Tang Y, Qu B, Cui H, Wang S, Wang L, Luo X, Huang X, Li J, Chen S, Shen N (2010) MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum 62(11):3425-3435
25. Antoniades CG, Berry PA, Wendon JA, Vergani D (2008) The importance of immune dysfunction in determining outcome in acute liver failure. J Hepatol 49(5):845-861
26. Sonkoly E, Stahle M, Pivarcsi A (2008) MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18(2):131-140
27. Imose M, Nagaki M, Naiki T, Osawa Y, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H (2003) Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int 23(5):386-396 (Pubitemid 37259210)
28. Rutherford A, Chung RT (2008) Acute liver failure: mechanisms of hepatocyte injury and regeneration. Semin Liver Dis 28(2):167-174 (Pubitemid 351632956)
29. Kerr TA, Korenblat KM, Davidson NO (2011) MicroRNAs and liver disease. Transl Res 157(4):241-252
30. Garofalo M, Condorelli GL, Croce CM, Condorelli G (2010) MicroRNAs as regulators of death receptors signaling. Cell Death Differ 17(2):200-208
31. Nowak M, Gaines GC, Rosenberg J, Minter R, Bahjat FR, Rectenwald J, MacKay SL, Edwards CK III, Moldawer LL (2000) LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol 278(5):R1202-R1209 (Pubitemid 30366448)
32. Liu G, Ding M, Chen J, Huang J, Wang H, Jing Q, Shen B (2010) Computational analysis of microRNA function in heart development. Acta Biochim Biophys Sin 42(9):662-670
33. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM (2005) miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102(39):13944-13949 (Pubitemid 41377683)
34. Xia L, Zhang D, Du R, Pan Y, Zhao L, Sun S, Hong L, Liu J, Fan D (2008) miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int J Cancer 123(2):372-379 (Pubitemid 351842022)
35. Guo CJ, Pan Q, Li DG, Sun H, Liu BW (2009) miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis. J Hepatol 50(4):766-778
36. Huntzinger E, Izaurralde E (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12(2):99-110
37. Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A (1996) Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med 2(1):80-86 (Pubitemid 26028076)
38. Willimott S, Wagner SD (2010) Post-transcriptional and post-translational regulation of Bcl2. Biochem Soc Trans 38(6): 1571-1575
39. Singhal S, Jain S, Kohaar I, Singla M, Gondal R, Kar P (2009) Apoptotic mechanisms in fulminant hepatic failure: potential therapeutic target. Appl Immunohistochem Mol Morphol 17(4):282-285
40. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, Brenner D, Manns M, Trautwein C (2000) Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology 119(2):446-460 (Pubitemid 30621995)
41. Gonzalez-Amaro R, Garcia-Monzon C, Garcia-Buey L, Moreno-Otero R, Alonso JL, Yague E, Pivel JP, Lopez-Cabrera M, Fernandez-Ruiz E, Sanchez-Madrid F (1994) Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis. J Exp Med 179(3):841-848 (Pubitemid 24065641)
42. Kanzler S, Galle PR (2000) Apoptosis and the liver. Semin Cancer Biol 10(3):173-184 (Pubitemid 30611679)
43. Neuman MG (2001) Apoptosis in diseases of the liver. Crit Rev Clin Lab Sci 38(2):109-166
44. Rentsch M, Kienle K, Mueller T, Vogel M, Jauch KW, Pullmann K, Obed A, Schlitt HJ, Beham A (2005) Adenoviral bcl-2 transfer improves survival and early graft function after ischemia and reperfusion in rat liver transplantation. Transplantation 80(10): 1461-1467 (Pubitemid 41805072)
45. Faubel S, Edelstein CL (2005) Caspases as drug targets in ischemic organ injury. Curr Drug Targets Immune Endocr Metabol Disord 5(3):269-287 (Pubitemid 41131706)
46. An FM, Yu DS, Xie Q, Gong BD, Wang H, Guo Q, Yu H (2010) The role of miRNA-122 expression during the acute liver failure in mice induced by D-GalN/LPS. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chin J Hepatol 18(7): 527-532