Salicylic acid induces apoptosis in colon carcinoma cells grown in-vitro: Influence of oxygen and salicylic acid concentration

Experimental Cell Research

Volumn 318, Issue 7, 2012, Pages 828-834

  Zitta, Karina ^a   Meybohm, Patrick ^a   Bein, Berthold ^a   Huang, Ying ^a   Heinrich, Christin ^a   Scholz, Jens ^a   Steinfath, Markus ^a   Albrecht, Martin ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Aspirin; Colon carcinoma; Hypoxia; Salicylic acid

Indexed keywords

CASPASE 3; CASPASE 7; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SALICYLIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER GROWTH; CARCINOMA CELL; CELL ASSAY; CELL HYPOXIA; CELL PROLIFERATION; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 84862778488     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.02.002     Document Type: Article

References (45)

1. Bardia A., Olson J.E., Vachon C.M., Lazovich D., Vierkant R.A., Wang A.H., Limburg P.J., Anderson K.E., Cerhan J.R. Effect of aspirin and other NSAIDs on postmenopausal breast cancer incidence by hormone receptor status: results from a prospective cohort study. Breast Cancer Res. Treat. 2011, 126:149-155.
2. Coleman E.A. Taking aspirin daily for at least 4 years reduces long-term risk of cancer death. Evid. Based Nurs. 2011, 14:71.
3. Cuzick J., Otto F., Baron J.A., Brown P.H., Burn J., Greenwald P., Jankowski J., La Vecchia C., Meyskens F., Senn H.J., Thun M. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol. 2009, 10:501-507.
4. Holmes M.D., Chen W.Y., Li L., Hertzmark E., Spiegelman D., Hankinson S.E. Aspirin intake and survival after breast cancer. J. Clin. Oncol. 2010, 28:1467-1472.
5. Tan X.L., Reid-Lombardo K.M., Bamlet W.R., Oberg A.L., Robinson D.P., Anderson K.E., Petersen G.M. Aspirin, nonsteroidal anti-inflammatory drugs (NSAID), acetaminophen, and pancreatic cancer risk: a clinic-based case-control study. Cancer Prev. Res. (Phila.) 2011, 4(11):1835-1841. (Electronic publication ahead of print 2011 Jul 29).
6. Wilson J.C., Anderson L.A., Murray L.J., Hughes C.M. Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer: a systematic review. Cancer Causes Control 2011, 22:803-810.
7. Benamouzig R., Uzzan B. Aspirin to prevent colorectal cancer: time to act?. Lancet 2010, 376:1713-1714.
8. Benamouzig R., Uzzan B., Deyra J., Martin A., Girard B., Little J., Chaussade S. Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial. Gut 2012, 61(2):255-261. Association pour la Prévention par l'Aspirine du Cancer Colorectal Study Group (APACC), (Electronic publication ahead of print 2011 Sep 2).
9. Chan A.T., Giovannucci E.L., Meyerhardt J.A., Schernhammer E.S., Curhan G.C., Fuchs C.S. Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA 2005, 294:914-923.
10. Courtney E.D., Melville D.M., Leicester R.J. Review article: chemoprevention of colorectal cancer. Aliment. Pharmacol. Ther. 2004, 19:1-24.
11. Rothwell P.M., Wilson M., Elwin C.E., Norrving B., Algra A., Warlow C.P., Meade T.W. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 2010, 376:1741-1750.
12. Squires H., Tappenden P., Cooper K., Carroll C., Logan R., Hind D. Cost-effectiveness of aspirin, celecoxib, and calcium chemoprevention for colorectal cancer. Clin. Ther. 2011, 33(9):1289-1305. (Electronic publication ahead of print 2011 Aug 12).
13. Zhang X., Smith-Warner S.A., Chan A.T., Wu K., Spiegelman D., Fuchs C.S., Willett W.C., Giovannucci E.L. Aspirin use, body mass index, physical activity, plasma c-peptide, and colon cancer risk in US health professionals. Am. J. Epidemiol. 2011, 174:459-467.
14. Zubiaurre L., Bujanda Fernandez de Pierola L. Aspirin in the prevention of colorectal cancer. Gastroenterol. Hepatol. 2011, 34:337-345.
15. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J. Clin. 2008, 61:69-90.
16. Brown J.M. Tumor hypoxia in cancer therapy. Methods Enzymol. 2007, 435:297-321.
17. Vaupel P., Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007, 26:225-239.
18. Vaupel P. Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist 2008, 13(Suppl. 3):21-26.
19. Goethals L., Debucquoy A., Perneel C., Geboes K., Ectors N., De Schutter H., Penninckx F., McBride W.H., Begg A.C., Haustermans K.M. Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers. Int. J. Radiat. Oncol. Biol. Phys. 2006, 65:246-254.
20. De Jaeger K., Kavanagh M.C., Hill R.P. Relationship of hypoxia to metastatic ability in rodent tumours. Br. J. Cancer 2001, 84:1280-1285.
21. Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., Giaccia A.J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996, 379:88-91.
22. Drew J.E., Arthur J.R., Farquharson A.J., Russell W.R., Morrice P.C., Duthie G.G. Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colon. Biochem. Pharmacol. 2005, 70:888-893.
23. Zitta K., Meybohm P., Bein B., Rodde C., Steinfath M., Scholz J., Albrecht M. Hypoxia-induced cell damage is reduced by mild hypothermia and postconditioning with catalase in-vitro: application of an enzyme based oxygen deficiency system. Eur. J. Pharmacol. 2009, 628:11-18.
24. Zitta K., Meybohm P., Bein B., Ohnesorge H., Steinfath M., Scholz J., Albrecht M. Cytoprotective effects of the volatile anesthetic sevoflurane are highly dependent on timing and duration of sevoflurane conditioning: findings from a human, in-vitro hypoxia model. Eur. J. Pharmacol. 2010, 645:39-46.
25. Saito Y., Nishio K., Ogawa Y., Kimata J., Kinumi T., Yoshida Y., Noguchi N., Niki E. Turning point in apoptosis/necrosis induced by hydrogen peroxide. Free Radic. Res. 2006, 40:619-630.
26. Gough D.R., Cotter T.G. Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell Death Dis. 2011, 2:e213.
27. Veal E., Day A. Hydrogen peroxide as a signaling molecule. Antioxid. Redox Signal. 2011, 15:147-151.
28. Hausenloy D.J., Yellon D.M. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc. Res. 2004, 61:448-460.
29. Paterson J.R., Lawrence J.R. Salicylic acid: a link between aspirin, diet and the prevention of colorectal cancer. QJM 2001, 94:445-448.
30. Paterson J.R., Baxter G., Dreyer J.S., Halket J.M., Flynn R., Lawrence J.R. Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid. J. Agric. Food Chem. 2008, 56:11648-11652.
31. Hammond E.M., Giaccia A.J. The role of p53 in hypoxia-induced apoptosis. Biochem. Biophys. Res. Commun. 2005, 331:718-725.
32. Zitta K., Meybohm P., Bein B., Rodde C., Steinfath M., Scholz J., Albrecht M. Hypoxia-induced cell damage is reduced by mild hypothermia and postconditioning with catalase in-vitro: application of an enzyme based oxygen deficiency system. Eur. J. Pharmacol. 2010, 628:11-18.
33. Honma H., Gross L., Windebank A.J. Hypoxia-induced apoptosis of dorsal root ganglion neurons is associated with DNA damage recognition and cell cycle disruption in rats. Neurosci. Lett. 2004, 354:95-98.
34. Oberringer M., Meins C., Bubel M., Pohlemann T. In vitro wounding: effects of hypoxia and transforming growth factor beta1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model. J. Mol. Histol. 2008, 39:37-47.
35. Rojkind M., Dominguez-Rosales J.A., Nieto N., Greenwel P. Role of hydrogen peroxide and oxidative stress in healing responses. Cell. Mol. Life Sci. 2002, 59:1872-1891.
36. Stone J.R., Yang S. Hydrogen peroxide: a signaling messenger. Antioxid. Redox Signal. 2006, 8:243-270.
37. Durner J., Klessig D.F. Salicylic acid is a modulator of tobacco and mammalian catalases. J. Biol. Chem. 1996, 271:28492-28501.
38. McCubrey J.A., Steelman L.S., Abrams S.L., Bertrand F.E., Ludwig D.E., Basecke J., Libra M., Stivala F., Milella M., Tafuri A., Lunghi P., Bonati A., Martelli A.M. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. Leukemia 2008, 22:708-722.
39. Pillinger M.H., Capodici C., Rosenthal P., Kheterpal N., Hanft S., Philips M.R., Weissmann G. Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:14540-14545.
40. Park I.S., Jo J.R., Hong H., Nam K.Y., Kim J.B., Hwang S.H., Choi M.S., Ryu N.H., Jang H.J., Lee S.H., Kim C.S., Kwon T.G., Park G.Y., Park J.W., Jang B.C. Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT. Toxicol. In Vitro 2010, 24:713-720.
41. Tuvdendorj D., Oketani M., Ikeda R., Kohara K., Komorizono Y., Ishibashi K., Munkhtuvshin N., Arima T. Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway. Hepatol Res 2003, 26:47-54.
42. Redlak M.J., Power J.J., Miller T.A. Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J. Surg. Res. 2008, 145:66-73.
43. Kim S.R., Bae M.K., Kim J.Y., Wee H.J., Yoo M.A., Bae S.K. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochem. Biophys. Res. Commun. 2009, 387:342-347.
44. Stark L.A., Reid K., Sansom O.J., Din F.V., Guichard S., Mayer I., Jodrell D.I., Clarke A.R., Dunlop M.G. Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 2007, 28:968-976.
45. Khaidakov M., Szwedo J., Mitra S., Mehta J.L. Angiostatic effects of aspirin in hypoxia-reoxygenation are linked to modulation of TGFbeta1 signaling. J. Cardiovasc. Pharmacol. Ther. 2011, 16:105-110.