Hypoxia-induced apoptosis of dorsal root ganglion neurons is associated with DNA damage recognition and cell cycle disruption in rats

Neuroscience Letters

Volumn 354, Issue 2, 2004, Pages 95-98

  Honma, Hiroyuki ^a   Gross, LouAnn ^a   Windebank, Anthony J ^a  

^a Mayo Clinic   (United States)

Author keywords

Apoptosis; Cyclin D1; Diabetic neuropathy; Dorsal root ganglion neurons; Hypoxia; Nerve growth factor; p53

Indexed keywords

CASPASE; CASPASE 3; CYCLIN D1; DNA; GLUCOSE; MARKER; OXYGEN; PROTEIN P53;

AMBIENT AIR; ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DIABETIC NEUROPATHY; DNA DAMAGE; EMBRYO; ENZYME ACTIVATION; FETUS; HYPOXIA; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INCUBATION TIME; METABOLISM; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; OXYGEN TENSION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; SPINAL GANGLION; UPREGULATION; WESTERN BLOTTING;

EID: 0348048797     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.08.084     Document Type: Article

References (17)

1. Anand P., Terenghi G., Warner G., Kopelman P., Williams-Chestnut R.E., Sinicropi D.V. The role of endogenous nerve growth factor in human diabetic neuropathy. Nat. Med. 2:1996;703-707.
2. Clarke A.R., Purdie C.A., Harrison D.J., Morris R.G., Bird C.C., Hooper M.L., Wyllie A.H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
3. Dyck P.J., Kratz K.M., Karnes J.L., Litchy W.J., Klein R., Pach J.M., Wilson D.M., O'Brien P.C., Melton L.J. III, Service F.J. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology. 43:1993;817-824.
4. Enokido Y., Araki T., Tanaka K., Aizawa S., Hatanaka H. Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons. Eur. J. Neurosci. 8:1996;1812-1821.
5. Fischer S.J., McDonald E.S., Gross L., Windebank A.J. Alterations in cell cycle regulation underlie cisplatin induced apoptosis of dorsal root ganglion neurons in vivo. Neurobiol. Dis. 8:2001;1027-1035.
6. Gill J.S., Windebank A.J. Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle. J. Clin. Invest. 101:1998;2842-2850.
7. Hellweg R., Hartung H.D. Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: a possible role for NGF in the pathogenesis of diabetic neuropathy. J. Neurosci. Res. 26:1990;258-267.
8. Low P.A., Nickander K.K., Scionti L. Role of hypoxia, oxidative stress, and excitatory neurotoxins in diabetic neuropathy. Dyck P.J., Thomas P.K. Diabetic Neuropathy. 2nd Edition :1999;317-329 W.B. Saunders Company, Philadelphia.
9. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:1993;847-849.
10. Miyashita T., Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene. Cell. 80:1995;293-299.
11. Park D.S., Farinelli S.E., Greene L.A. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J. Biol. Chem. 271:1996;8161-8169.
12. Shaulsky G., Goldfinger N., Tosky M.S., Levine A.J., Rotter V. Nuclear localization is essential for the activity of p53 protein. Oncogene. 6:1991;2055-2065.
13. Will O., Gocke E., Eckert I., Schulz I., Pflaum M., Mahler H.C., Epe B. Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022. Mutat. Res. 435:1999;89-101.
14. Wilson D.M. III, Thompson L.H. Life without DNA repair. Proc. Natl. Acad. Sci. USA. 94:1997;12754-12757.
15. Wood K.A., Youle R.J. The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci. 15:1995;5851-5857.
16. Xiang H., Kinoshita Y., Knudson C.M., Korsmeyer S.J., Schwartzkroin P.A., Morrison R.S. Bax involvement in p53-mediated neuronal cell death. J. Neurosci. 18:1998;1363-1373.
17. Ziegler A., Jonason A.S., Leffell D.J., Simon J.A., Sharma H.W., Kimmelman J., Remington L., Jacks T., Brash D.E. Sunburn and p53 in the onset of skin cancer. Nature. 372:1994;773-776.