Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 5, 2012, Pages 1671-1678

  Peprah, Kwakye ^a   Zhu, Xue Y ^a   Eyunni, Suresh V K ^a   Etukala, Jagan R ^a   Setola, Vincent ^b   Roth, Bryan L ^b   Ablordeppey, Seth Y ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Antipsychotics; Atypical antipsychotics; Benzothiazole; Haloperidol analogs; Homopiperazine; Structure activity relationship studies

Indexed keywords

1 (4 CHLOROPHENYL) 4 [3 (4 FLUOROPHENOXY)PROPYL] 1,4 DIAZEPANE; 1 (4 CHLOROPHENYL) 4 [3 [(4 FLUOROPHENYL)THIO]PROPYL] 1,4 DIAZEPANE; 1 (4 CHLOROPHENYL) 4 [4 (4 FLUOROPHENYL)BUTYL] 1,4 DIAZEPANE; 1 (BENZO[D]THIAZOL 2 YL) 4 [4 (4 CHLOROPHENYL) 1,4 DIAZEPAN 1 YL]BUTAN 1 ONE; 1 (BENZO[D]THIAZOL 2 YL) 4 IODOBUTAN 1 ONE; 1 (BENZO[D]THIAZOL 2 YL) 5 [3 (4 CHLOROPHENYL) 3 HYDROXY 8 AZABICYCLO[3.2.1]OCTAN 8 YL]PENTAN 1 ONE; 1 (BENZO[D]THIAZOL 2 YL) 5 [4 (4 CHLOROPHENYL) 1,4 DIAZEPAN 1 YL]PENTAN 1 ONE; 1 (BENZO[D]THIAZOL 2 YL) 5 IODOPENTAN 1 ONE; 2 (3 CHLOROPROPYL)BENZO[D]THIAZOLE; 2 (4 CHLOROBUTYL)BENZO[D]THIAZOLE; 2 (CHLOROMETHYL)BENZO[D]THIAZOLE; 2 [2 [4 (4 CHLOROPHENYL) 1,4 DIAZEPAM 1 YL]ETHYL] 5 FLUORO 2,3 DIHYDRO 1H INDEN 1 ONE; 2 [3 [4 (4 CHLOROPHENYL) 1,4 DIAZEPAN 1 YL]PROPYL]BENZO[D]THIAZOLE; 2 [4 [4 (4 CHLOROPHENYL) 1,4 DIAZEPAN 1 YL]BUTYL]BENZO[D]THIAZOLE; 2 [[4 (4 CHLOROPHENYL) 1,4 DIAZEPAN 1 YL]METHYL]BENZO[D]THIAZOLE; 2' (2 CHLOROETHYL) 5' FLUORO 2',3' DIHYDROSPIRO([1,3]DIOXOLANE 2,1' INDENE); 3 (4 CHLOROPHENYL) 8 [3 (4 FLUOROPHENOXY)PROPYL] 8 AZABICYCLO[3.2.1]OCTAN 3 OL; 3 (4 CHLOROPHENYL) 8 [4 (4 FLUOROPHENYL)BUTYL] 8 AZABICYCLO[3.2.1]OCTAN 3 OL; 3 (4 FLUOROPHENYLTHIO)PROPAN 1 OL; 3 [(4 FLUOROPHENYL)THIO]PROPYL METHANESULFONATE; 4 [4 (4 CHLOROPHENYL) 1,4 DIAZEPAN 1 YL] 1 (4 FLUOROPHENYL)BUTAN 1 ONE; 8 [4 (BENZO[D]THIAZOL 2 YL)BUTYL] 3 (4 CHLOROPHENYL) 8 AZABICYCLO[3.2.1]OCTAN 3 OL; CLOZAPINE; DOPAMINE RECEPTOR; HALOPERIDOL; NEUROLEPTIC AGENT; SEROTONIN RECEPTOR; SYA 013; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; CATALEPSY; COLUMN CHROMATOGRAPHY; CYCLIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG PURIFICATION; DRUG SYNTHESIS; NONHUMAN; PARKINSON DISEASE; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION;

ANTIPSYCHOTIC AGENTS; AZEPINES; HALOPERIDOL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862778007     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.022     Document Type: Article

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