Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan- 1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 12, 2006, Pages 3219-3223

  Ablordeppey, Seth Y ^a   Lyles Eggleston, Margaret ^a   Bricker, Barbara ^a   Zhang, Wang ^a   Zhu, Xue ^a   Goodman, Carl ^a   Roth, Bryan L ^b  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b NIMH Psychoactive Drug Screening Program   (United States)

Author keywords

Analog; Antipsychotic; Chiral separation; Dopamine receptor Ligand; Enantiomer; Eutomer; Haloperidol

Indexed keywords

4 [3 (4 CHLOROPHENYL) 3 HYDROXYPYRROLIDIN 1 YL] 1 (4 FLUOROPHENYL)BUTAN 1 ONE; CLOZAPINE; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR; HALOPERIDOL; NEUROLEPTIC AGENT; PYRROLIDINE DERIVATIVE; SEROTONIN RECEPTOR; SYA 09; UNCLASSIFIED DRUG; 4 (3 (4 CHLOROPHENYL) 3 HYDROXYPYRROLIDIN 1 YL) 1 (4 FLUOROPHENYL)BUTAN 1 ONE; 4-(3-(4-CHLOROPHENYL)-3-HYDROXYPYRROLIDIN-1-YL)-1-(4-FLUOROPHENYL)BUTAN-1-ONE; ALKANONE; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; ENANTIOMER; MALE; MOUSE; NONHUMAN; PSYCHOSIS; SEPARATION TECHNIQUE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; ISOMERISM; RAT; SYNTHESIS;

ANIMALIA;

ANIMALS; BUTANONES; CLOZAPINE; HALOPERIDOL; HUMANS; ISOMERISM; MICE; MOLECULAR STRUCTURE; PYRROLIDINES; RATS;

EID: 33747134457     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.057     Document Type: Article

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