C-Met, epidermal growth factor receptor, and insulin-like growth factor-1 receptor are important for growth in uveal melanoma and independently contribute to migration and metastatic potential

Melanoma Research

Volumn 22, Issue 2, 2012, Pages 123-132

  Wu, Xinqi ^a,b   Zhou, Jun ^a,b   Rogers, Andrew M ^a   Jänne, Pasi A ^a,c   Benedettini, Elisa ^d   Loda, Massimo ^a,b   Hodi, F Stephen ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

C Met; Epidermal growth factor receptor; Insulin like growth factor 1R; Tumor migration; Uveal melanoma

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; TYROSINE KINASE RECEPTOR;

ARTICLE; CANCER GROWTH; CELL HOMING; CELL PROLIFERATION; CELL SURVIVAL; COMPARATIVE GENOMIC HYBRIDIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LIVER CELL; MELANOMA CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UVEA MELANOMA;

APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; COMPARATIVE GENOMIC HYBRIDIZATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INSULIN-LIKE GROWTH FACTOR I; LIVER NEOPLASMS; MELANOMA; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-MET; RECEPTOR, EPIDERMAL GROWTH FACTOR; UVEAL NEOPLASMS;

EID: 84862777227     PISSN: 09608931     EISSN: 14735636     Source Type: Journal    
DOI: 10.1097/CMR.0b013e3283507ffd     Document Type: Article

References (43)

1. Singh A, Bergman L, Seregard S. Uveal melanoma: epidemiologic aspects. Ophthalmol Clin North Am 2005; 18:75-84. (Pubitemid 40348812)
2. Grover A, Alexander HR Jr. The past decade of experience with isolated hepatic perfusion. Oncologist 2004; 9:653-664. (Pubitemid 39546406)
3. Feldman ED, Pingpank JF, Alexander HR Jr. Regional treatment options for patients with ocular melanoma metastatic to the liver. Ann Surg Oncol 2004; 11:290-297. (Pubitemid 40486769)
4. Sattler M, Salgia R. c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy. Curr Oncol Rep 2007; 9:102-108. (Pubitemid 46332381)
5. Puri N, Ahmed S, Janamanchi V, Tretiakova M, Zumba O, Krausz T, et al. c- Met is a potentially new therapeutic target for treatment of human melanoma. Clin Cancer Res 2007; 13:2246-2253. (Pubitemid 46649894)
6. Natali PG, Nicotra MR, Di Renzo MF, Prat M, Bigotti A, Cavaliere R, et al. Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br J Cancer 1993; 68:746-750. (Pubitemid 23301281)
7. Halaban R, Rubin JS, Funasaka Y, Cobb M, Boulton T, Faletto D, et al. Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells. Oncogene 1992; 7:2195-2206.
8. Cruz J, Reis-Filho JS, Silva P, Lopes JM. Expression of c-met tyrosine kinase receptor is biologically and prognostically relevant for primary cutaneous malignant melanomas. Oncology 2003; 65:72-82. (Pubitemid 36829093)
9. Otsuka T, Takayama H, Sharp R, Celli G, LaRochelle WJ, Bottaro DP, et al. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res 1998; 58:5157-5167. (Pubitemid 28521177)
10. Mallikarjuna K, Pushparaj V, Biswas J, Krishnakumar S. Expression of epidermal growth factor receptor, ezrin, hepatocyte growth factor, and c-Met in uveal melanoma: an immunohistochemical study. Curr Eye Res 2007; 32:281-290. (Pubitemid 46439685)
11. Di Cesare S, Marshall JC, Logan P, Antecka E, Faingold D, Maloney SC, et al. Expression and migratory analysis of 5 human uveal melanoma cell lines for CXCL12, CXCL8, CXCL1, and HGF. J Carcinog 2007; 6:2.
12. Hendrix MJ, Seftor EA, Seftor RE, Kirschmann DA, Gardner LM, Boldt HC, et al. Regulation of uveal melanoma interconverted phenotype by hepatocyte growth factor/scatter factor (HGF/SF). Am J Pathol 1998; 152:855-863. (Pubitemid 28173345)
13. Rusciano D, Lorenzoni P, Burger MM. Expression of constitutively activated hepatocyte growth factor/scatter factor receptor (c-met) in B16 melanoma cells selected for enhanced liver colonization. Oncogene 1995; 11:1979-1987.
14. Lin S, Rusciano D, Lorenzoni P, Hartmann G, Birchmeier W, Giordano S, et al. C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells. Clin Exp Metastasis 1998; 16:253-265. (Pubitemid 28201993)
15. Economou MA, All-Ericsson C, Bykov V, Girnita L, Bartolazzi A, Larsson O, et al. Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications. Acta Ophthalmol 2008; 86 (Thesis 4):20-25.
16. All-Ericsson C, Girnita L, Seregard S, Bartolazzi A, Jager MJ, Larsson O. Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target. Invest Ophthalmol Vis Sci 2002; 43:1-8. (Pubitemid 34032432)
17. Ma D, Niederkorn JY. Role of epidermal growth factor receptor in the metastasis of intraocular melanomas. Invest Ophthalmol Vis Sci 1998; 39:1067-1075. (Pubitemid 28247340)
18. Hurks HM, Metzelaar-Blok JA, Barthen ER, Zwinderman AH, De Wolff- Rouendaal D, Keunen JE, et al. Expression of epidermal growth factor receptor: risk factor in uveal melanoma. Invest Ophthalmol Vis Sci 2000; 41:2023-2027. (Pubitemid 30450966)
19. Duh FM, Scherer SW, Tsui LC, Lerman MI, Zbar B, Schmidt L. Gene structure of the human MET proto-oncogene. Oncogene 1997; 15:1583-1586. (Pubitemid 27464651)
20. Folberg R, Kadrol SS, Frankel S, Valyi-Nagy K, Jager MJ, Péer J, et al. Authenticating cell lines in ophthalmic research laboratories. Invest Ophthalmol Vis Sci 2008; 49:4697-4701.
21. Calipel A, Lefevre G, Pouponnot C, Mouriaux F, Eychene A, Mascarelli F. Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway. J Biol Chem 2003; 278:42409-42418. (Pubitemid 37310512)
22. Kiliç E,Brüggenwirth HT, Verbiest MM, Zwarthoff EC, Mooy NM, Luyten GP, et al. The RAS-BRAF kinase pathway is not involved in uveal melanoma. Melanoma Res 2004; 14:203-205. (Pubitemid 38879582)
23. Abdel-Rahman MH, Boru G, Massengill J, Salem MM, Davidorf FH. MET oncogene inhibition as a potential target of therapy for uveal melanomas. Invest Ophthalmol Vis Sci 2010; 51:3333-3339.
24. Lawrence RE, Salgia R. MET molecular mechanisms and therapies in lung cancer. Cell Adhes Migr 2010; 4:146-152.
25. Girnita A, All-Ericsson C, Economou MA, Astrom K, Axelson M, Seregard S, et al. The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells. Acta Ophthalmol 2008; 86 (Thesis 4):26-34.
26. Zhang Q, Liu Y, Gao F, Ding Q, Cho C, Hur W, et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J Am Chem Soc 2006; 128:2182-2183.
27. Pai R, Nakamura T, Moon WS, Tarnawski AS. Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. FASEB J 2003; 17:1640-1647. (Pubitemid 37100065)
28. Jo M, Stolz DB, Esplen JE, Dorko K, Michalopoulos GK, Strom SC. Crosstalk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J Biol Chem 2000; 275:8806-8811. (Pubitemid 30180235)
29. Yan D, Zhou X, Chen X, Hu DN, Dong XD, Wang J, et al. MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Invest Ophthalmol Vis Sci 2009; 50:1559-1565.
30. Foveau B, Leroy C, Ancot F, Deheuninck J, Ji Z, Fafeur V, et al. Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor. Cell Death Differ 2007; 14:752-764. (Pubitemid 46444513)
31. Tulasne D, Deheuninck J, Lourenco FC, Lamballe F, Ji Z, Leroy C, et al. Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage. Mol Cell Biol 2004; 24:10328-10339. (Pubitemid 39507870)
32. Tulasne D, Foveau B. The shadow of death on the MET tyrosine kinase receptor. Cell Death Differ 2008; 15:427-434. (Pubitemid 351267293)
33. Ye M, Hu D, Tu L, Zhou X, Lu F, Wen B, et al. Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells. Invest Ophthalmol Vis Sci 2008; 49:497-504.
34. Bonine-Summers AR, Aakre ME, Brown KA, Arteaga CL, Pietenpol JA, Moses HL, et al. Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells. Cancer Biol Ther 2007; 6:561-570. (Pubitemid 47328331)
35. Bergstrom JD,Westermark B, Heldin NE. Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells. Exp Cell Res 2000; 259:293-299.
36. Bauer TW, Somcio RJ, Fan F, LiuW, Johnson M, Lesslie DP, et al. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Mol Cancer Ther 2006; 5:1676-1682. (Pubitemid 44323235)
37. Bauer TW, Fan F, Liu W, Johnson M, Parikh NU, Parry GC, et al. Insulin like growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. Ann Surg 2005; 241:748-756.
38. Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, Péer J, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol 1999; 155:739-752. (Pubitemid 29426820)
39. Hendrix MJ, Seftor EA, Meltzer PS, Gardner LM, Hess AR, Kirschmann DA, et al. Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry. Proc Natl Acad Sci USA 2001; 98:8018-8023. (Pubitemid 32642679)
40. Seftor EA, Meltzer PS, Kirschmann DA, Péer J, Maniotis AJ, Trent JM, et al. Molecular determinants of human uveal melanoma invasion and metastasis. Clin Exp Metastasis 2002; 19:233-246. (Pubitemid 34553524)
41. Folberg R, Leach L, Valyi-Nagy K, Lin AY, Apushkin MA, Ai Z, et al. Modeling the behavior of uveal melanoma in the liver. Invest Ophthalmol Vis Sci 2007; 48:2967-2974. (Pubitemid 351261136)
42. Valyi-Nagy K, Dosa S, Kovacs SK, Bacsa S, Voros A, Shukla D, et al. Identification of virus resistant tumor cell subpopulations in three-dimensional uveal melanoma cultures. Cancer Gene Ther 2010; 17:223-234.
43. Marshall JC, Caissie AL, Callejo SA, Antecka E, Burnier MN Jr. Cell proliferation profile of five human uveal melanoma cell lines of different metastatic potential. Pathobiology 2004; 71:241-245. (Pubitemid 39370358)