Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library

Journal of the American Chemical Society

Volumn 128, Issue 7, 2006, Pages 2182-2183

  Zhang, Qiong ^a   Liu, Yi ^a   Gao, Feng ^a   Ding, Qiang ^a   Cho, Charles ^b   Hur, Wooyoung ^b   Jin, Yunho ^a   Uno, Tetsuo ^a   Joazeiro, Claudio A P ^a   Gray, Nathanael ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIANILINOPYRIMIDINE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERLOTINIB; METHIONINE; PYRIMIDINE DERIVATIVE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; COMBINATORIAL LIBRARY; CRYSTALLOGRAPHY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; IC 50; REPORTER GENE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; HYDROPHOBICITY; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644542081     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0567485     Document Type: Article

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