Knockdown of glucose-6-phosphate dehydrogenase (G6PD) following cerebral ischemic reperfusion: The pros and cons

Neurochemistry International

Volumn 61, Issue 2, 2012, Pages 146-155

  Zhao, Gang ^a   Zhao, Yanxin ^b   Wang, Xingyu ^c   Xu, Ying ^c  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Department of Yinluan Engineering   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Antisense oligodeoxynucleotides; Cerebral ischemia; G6PD; NADPH oxidase; Oxidative damage

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA DAMAGE; HIPPOCAMPAL CA1 REGION; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ANIMALS; BLOTTING, WESTERN; CA1 REGION, HIPPOCAMPAL; CELL DEATH; CEREBROVASCULAR DISORDERS; DNA DAMAGE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE; HEART ARREST; IMMUNOHISTOCHEMISTRY; MALE; NADP; NADPH OXIDASE; NERVE TISSUE PROTEINS; NEURONS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SUPEROXIDES;

RATTUS;

EID: 84862775013     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.05.003     Document Type: Article

References (44)

1. K. Abe, M. Aoki, J. Kawagoe, T. Yoshida, A. Hattori, K. Kogure, and Y. Itoyama Ischemic delayed neuronal death. A mitochondrial hypothesis Stroke 26 1995 1478 1489
2. A.Y. Abramov, A. Scorziello, and M.R. Duchen Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation J. Neurosci. 27 2007 1129 1138
3. I.B. Afanas'ev Signaling functions of free radicals superoxide & nitric oxide under physiological & pathological conditions Mol. Biotechnol. 37 2007 2 4
4. M. Arundine, and M. Tymianski Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury Cell Mol. Life Sci. 61 2004 657 668
5. F. Atif, S. Yousuf, and S.K. Agrawal S-allyl l-cysteine diminishes cerebral ischemia-induced mitochondrial dysfunctions in hippocampus Brain Res. 1265 2009 128 137
6. E. Candelario-Jalil, N.H. Mhadu, S.M. Al-Dalain, G. Martinez, and O.S. Leon Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils Neurosci. Res. 41 2001 233 241
7. P.H. Chan Reactive oxygen radicals in signaling and damage in the ischemic brain J. Cereb. Blood Flow Metab. 21 2001 2 14
8. H. Chen, Y.S. Song, and P.H. Chan Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion J. Cereb. Blood Flow Metab. 29 2009 1262 1272
9. S. Chrissobolis, A.A. Miller, G.R. Drummond, B.K. Kemp-Harper, and C.G. Sobey Oxidative stress and endothelial dysfunction in cerebrovascular disease Front Biosci. 16 2011 1733 1745
10. R.S. Gupte, B.C. Floyd, M. Kozicky, S. George, Z.I. Ungvari, V. Neito, M.S. Wolin, and S.A. Gupte Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver Free Radic. Biol. Med. 47 2009 219 228
11. R.S. Gupte, D.K. Rawat, S. Chettimada, D.L. Cioffi, M.S. Wolin, W.T. Gerthoffer, I.F. McMurtry, and S.A. Gupte Activation of glucose-6-phosphate dehydrogenase promotes acute hypoxic pulmonary artery contraction J. Biol. Chem. 285 2010 19561 19571
12. S.A. Gupte, P.M. Kaminski, B. Floyd, R. Agarwal, N. Ali, M. Ahmad, J. Edwards, and M.S. Wolin Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries Am. J. Physiol. Heart Circ. Physiol. 288 2005 H13 H21
13. S.A. Gupte, R.J. Levine, R.S. Gupte, M.E. Young, V. Lionetti, V. Labinskyy, B.C. Floyd, C. Ojaimi, M. Bellomo, M.S. Wolin, and F.A. Recchia Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart J. Mol. Cell Cardiol. 41 2006 340 349
14. T. Hayashi, A. Saito, S. Okuno, M. Ferrand-Drake, R.L. Dodd, T. Nishi, C.M. Maier, H. Kinouchi, and P.H. Chan Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death J. Cereb. Blood Flow Metab. 23 2003 1117 1128
15. H. Hong, J.S. Zeng, D.L. Kreulen, D.I. Kaufman, and A.F. Chen Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke Am. J. Physiol. Heart Circ. Physiol. 291 2006 H2210 H2215
16. M. Horn, and W. Schlote Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia Acta Neuropathol. 85 1992 79 87
17. J.E. Jung, G.S. Kim, H. Chen, C.M. Maier, P. Narasimhan, Y.S. Song, K. Niizuma, M. Katsu, N. Okami, H. Yoshioka, H. Sakata, C.E. Goeders, and P.H. Chan Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection Mol. Neurobiol. 41 2010 172 179
18. T. Kirino, and K. Sano Selective vulnerability in the gerbil hippocampus following transient ischemia Acta Neuropathol. 62 1984 201 208
19. R.F. Kletzien, P.K. Harris, and L.A. Foellmi Glucose-6-phosphate dehydrogenase: a "housekeeping" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress FASEB J. 8 1994 174 181
20. R.M. Leach, H.S. Hill, V.A. Snetkov, and J.P. Ward Hypoxia, energy state and pulmonary vasomotor tone Respir. Physiol. Neurobiol. 132 2002 55 67
21. R.M. Leach, H.M. Hill, V.A. Snetkov, T.P. Robertson, and J.P. Ward Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor J. Physiol. 536 2001 211 224
22. S. Love Oxidative stress in brain ischemia Brain Pathol. 9 1999 119 131
23. C.M. Maier, and P.H. Chan Role of superoxide dismutases in oxidative damage and neurodegenerative disorders Neuroscientist 8 2002 323 334
24. R. Matsui, S. Xu, K.A. Maitland, A. Hayes, J.A. Leopold, D.E. Handy, J. Loscalzo, and R.A. Cohen Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II Circulation 112 2005 257 263
25. M. Nishimura, T. Sugino, K. Nozaki, Y. Takagi, I. Hattori, J. Hayashi, N. Hashimoto, T. Moriguchi, and E. Nishida Activation of p38 kinase in the gerbil hippocampus showing ischemic tolerance J. Cereb. Blood Flow Metab. 23 2003 1052 1059
26. P.P. Pandolfi, F. Sonati, R. Rivi, P. Mason, F. Grosveld, and L. Luzzatto Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress EMBO J. 14 1995 5209 5215
27. G.L. Peterson A simplification of the protein assay method of Lowry et al. which is more generally applicable Anal. Biochem. 83 1977 346 356
28. F. Plum, R.P. Kraig, and W.A. Pulsinelli Compartmentation of acid-base balance in brain during complete ischemia Neurochem. Pathol. 9 1988 139 144
29. W.A. Pulsinelli, and J.B. Brierley A new model of bilateral hemispheric ischemia in the unanesthetized rat Stroke 10 1979 267 272
30. W.A. Pulsinelli, J.B. Brierley, and F. Plum Temporal profile of neuronal damage in a model of transient forebrain ischemia Ann. Neurol. 11 1982 491 498
31. M. Rajesh, P. Mukhopadhyay, S. Batkai, G. Hasko, L. Liaudet, V.R. Drel, I.G. Obrosova, and P. Pacher Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption Am. J. Physiol. Heart Circ. Physiol. 293 2007 H610 H619
32. F. Salvemini, A. Franze, A. Iervolino, S. Filosa, S. Salzano, and M.V. Ursini Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression J. Biol. Chem. 274 1999 2750 2757
33. S. Serpillon, B.C. Floyd, R.S. Gupte, S. George, M. Kozicky, V. Neito, F. Recchia, W. Stanley, M.S. Wolin, and S.A. Gupte Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH Am. J. Physiol. Heart Circ. Physiol. 297 2009 H153 H162
34. G. Stoll, S. Jander, and M. Schroeter Inflammation and glial responses in ischemic brain lesions Prog. Neurobiol. 56 1998 149 171
35. Sugawara T., Fujimura M., Morita-Fujimura Y., Kawase M., Chan P.H., 1999. Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J. Neurosci. 19: RC39.
36. S.W. Suh, B.S. Shin, H. Ma, M. Van Hoecke, A.M. Brennan, M.A. Yenari, and R.A. Swanson Glucose and NADPH oxidase drive neuronal superoxide formation in stroke Ann. Neurol. 64 2008 654 663
37. L.L. Tang, K. Ye, X.F. Yang, and J.S. Zheng Apocynin attenuates cerebral infarction after transient focal ischaemia in rats J. Int. Med. Res. 35 2007 517 522
38. W.N. Tian, L.D. Braunstein, K. Apse, J. Pang, M. Rose, X. Tian, and R.C. Stanton Importance of glucose-6-phosphate dehydrogenase activity in cell death Am. J. Physiol. 276 1999 C1121 C1131
39. S. Vemula, K.E. Roder, T. Yang, G.J. Bhat, T.J. Thekkumkara, and T.J. Abbruscato A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation J. Pharmacol. Exp. Ther. 328 2009 487 495
40. Q. Wang, K.D. Tompkins, A. Simonyi, R.J. Korthuis, A.Y. Sun, and G.Y. Sun Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus Brain Res. 1090 2006 182 189
41. W. Ying, and Z.G. Xiong Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives Curr. Med. Chem. 17 2010 2152 2158
42. H. Yoshioka, K. Niizuma, M. Katsu, N. Okami, H. Sakata, G.S. Kim, P. Narasimhan, and P.H. Chan NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia J. Cereb. Blood Flow Metab. 31 2011 868 880
43. Q.G. Zhang, L. Raz, R. Wang, D. Han, L. De Sevilla, F. Yang, R.K. Vadlamudi, and D.W. Brann Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation J. Neurosci. 29 2009 13823 13836
44. C.J. Zuurbier, O. Eerbeek, P.T. Goedhart, E.A. Struys, N.M. Verhoeven, C. Jakobs, and C. Ince Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heart Cardiovasc. Res. 62 2004 145 153