Micronutrients and pregnancy outcome: A review of the literature

Nutrition Research

Volumn 19, Issue 1, 1999, Pages 103-159

  Ramakrishnan, Usha ^a   Manjrekar, Renu ^a   Rivera, Juan ^b   Gonzáles Cossío, Teresa ^b   Martorell, Reynaldo ^a  

^a EMORY UNIVERSITY   (United States)

^b INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

Author keywords

Folic Acid; Low birth weight; Micronutrients; Pregnancy; Vitamin B Complex

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CALCIUM; COPPER; FOLIC ACID; IODINE; IRON; MAGNESIUM; RETINOL; SELENIUM; TRACE ELEMENT; VITAMIN B COMPLEX; VITAMIN D; ZINC;

CLINICAL TRIAL; DIET SUPPLEMENTATION; DIETARY INTAKE; FEMALE; HUMAN; LOW BIRTH WEIGHT; NUTRIENT; NUTRITIONAL DEFICIENCY; PREGNANCY COMPLICATION; PREMATURITY; PRIORITY JOURNAL; REVIEW;

EID: 0032961857     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0271-5317(98)00178-X     Document Type: Review

References (241)

1. World Health Organization (WHO) and United Nations Children's Fund. Revised 1990 estimates of maternal mortality: A new approach by WHO and UNICEF. (Geneva), WHO, Apr. 1996, 20 p.
2. United Nations Children's Fund. The State of the World's Children 1997. Oxford: Oxford University Press. 1997.
3. Villar J, Belizan JM. The relative contribution of prematurity and fetal growth retardation to the incidence of low birth weight in developed and developing societies. Am J Obstet Gynecol 1982; 143:793-798.
4. Martorell R. Undernutrition during pregnancy and early childhood: Consequences for cognitive and behavioral development. IN: Early Childhood Development: Investing in Our Children's Future, Ed. ME Young. Elsevier Science B.V.,1997, pp.39-83.
5. Koblinsky, MA. Beyond maternal mortality - Magnitude, interrelationship, and consequences of women's health, pregnancy-related complications and nutritional status on pregnancy outcomes. Int J Gyn Obstet 1995;48:S21-S32.
6. Gulmezoglu M., De Onis M., Villar J. Effectiveness of interventions to prevent or treat impaired fetal growth. Obstet. Gynecol. Sur. 1997;52(2):139-49.
7. Kramer MS. Determinants of low birth weight: Methodological assessment and meta analysis. Bull of the Wrld Hlth Org 1987; 65(5): 633-737.
8. Lechtig A, Habicht JP, Delgado H, Klein RE, Yarbrough C, Martorell R. Effect of food supplementation during pregnancy on birth weight. Pediatrics 1975;6(4):508-520.
9. Martorell R, González-Cossío T. Maternal nutrition and birth weight. Yearbook of Physical Anthropology. 1987;30:195-220.
10. ACC/SCN. Women and nutrition. ACC/SCN Symposium Report Nutrition Policy Discussion Paper No.6. ACC/SCN, 1990.
11. ACC/SCN (1992) Second Report on the World Nutrition Situation: Volume I: Global and Regional Results, ACC/SCN Geneva
12. Katz J, Khatry SK, West KP, Humphrey JH, Leclerq SC, Kimbrough E, Pohkrey PR, Sommer A. Night blindness is prevalent during pregnancy and lactation in rural Nepal. J Nutr 1995;125(8):2122.
13. Bloem MW, Huq N, Gorstein J, Burger S, Kahn T, Islam N, Baker S, Davidson F. Does the production of dark green leafy vegetables and fruits play a role in the etiology of maternal night blindness, diarrhea and malnutrition in Bangladesh? Report of the XVIIIVACG Meeting.
14. Hetzel BS. An overview of the prevention and control of iodine deficiency disorders. In: Hetzel BS, Dunn JT, Stanbury JB, eds. The Prevention and Control of Iodine Deficiency Disorders, Elsevier, Amsterdam 1987;7:31-4.
15. Murphy SP, Beaton GH, Calloway DH. Estimated mineral intakes of toddlers: Predicted prevalence of inadequacy in village populations in Egypt, Kenya and Mexico. Am J Clin Nutr 1992;56:562-72.
16. Allen LH, Backstrand JR, Chavez A, Pelto GH. People cannot live by tortillas alone. The Results of the Mexico Nutrition CRSP. Department of Nutritional Sciences, University of Connecticut, Storrs, CT, 1992.
17. Allen LH. The nutrition CRSP: What is marginal malnutrition, and does it affect human function? Nutr Rev 1993;51(9):255-267.
18. Rosado JL, López P, Morales M, Munoz E, Allen, LH. Bioavailability of energy, nitrogen, fat, zinc, iron and calcium from rural and urban Mexican diets. Br J Nutr 1992; 68:45-58.
19. Schroeder DG, Ramakrishnan U, Martorell R. Nutritional determinants of growth and development. IN "Child Nutrition: An International Perspective" Ed. Solomons NW, Brown KH, Caballero B. (In press).
20. Czeizel AE. Controlled studies of multivitamin supplementation on pregnancy outcomes. Ann NY Acad Sci 1993;687:266-275.
21. MRC vitamin study research group. Prevention of neural tube defects: Results of the medical research council vitamin study. Lancet 1991;338(8760):131-137.
22. Czeizel AE, Tóth M, Rockenbauer M. Population-based case control study of folic acid supplementation during pregnancy. Teratology 1996;53:345-51.
23. Kleinbaum DG, Kupper LL, Morgenstern H. Epidemiologic Research. Van Nostrand Reinhold Company: New York, 1982.
24. Cohen, J. Statistical Power Analysis for the Behavioral Sciences, Revised Edition. Academic Press, Inc. New York, 1977.
25. Wallingford JC, Underwood BA. 1986. Vitamin A deficiency in pregnancy, lactation and the nursing child, in: Vitamin A Deficiency and Its Control. (Bauernfield CJ, ed). Academic Press, Inc., New York.
26. Ross AC, Gardner EM. The function of vitamin A in cellular growth and differentiation and its role during pregnancy and lactation. In: Nutrient Regulation during Pregnancy, Lactation and Infant Growth. ED Allen L King and Lonnerdal B. Plenum Press, NY 1994; ch15: pp 187-200.
27. Ghebremeskal K, Burns L, Burden TJ, Harbige L, Costeloe K, Powell JJ, Crawford M. Vitamin A and related essential nutrient in cord blood: Relationships with anthropometric measurements at birth. Early Hum Dev 1994;39:177-188.
28. Neel NR, Alvarez JO. Chronic fetal malnutrition and vitamin A in cord serum. Eur J Clin Nutr 1990;44(3):207-212.
29. Shah R, Rajalakshmi R. Vitamin A status of newborn in relation to gestational age, body weight and maternal nutritional status. Am J Clin Nutr 1984;40:794-800.
30. Shenai JP, Chytil F, Jhaveri A, Stahlman MT. Plasma vitamin A and retinol-binding protein in premature and term neonates. J Pediatr 1981;99:302-305.
31. Brandt RB, Mueller DG, Schroeder JR, Guyer KG, Kirkpatrick BV, Hutcher NE, Ehrlich FE. Serum vitamin A in premature and term neonates. Pediatrics 1978;92:101-104.
32. Navarro J, Causse MB, Desquilbet N, Herve F, Lallemand D. The vitamin status of low birth weight infants and their mothers. J Pediatr Gastroent Nutr 1984;3:744-748.
33. Butte NF, Calloway DH. Proteins, vitamin A, carotene, folacin, ferritin and zinc in navajo maternal and cord blood. Biol Neonate 1982;41(5-6):273-278.
34. Shah R, Rajalakshmi R, Bhatt RV, Hazra MN, Patel BC, Swamy NB. Liver stores of vitamin A in human fetuses in relation to gestational age, fetal size and maternal nutritional status. Br J Nutr 1987;58:181-189.
35. Hubal CA, Roberts JM, Taylor RN, et al. Lipid peroxidation in pregnancy: New perspectives on preeclampsia. Am J Obstet Gynecol 1989;161:1025-1034.
36. Davidge ST, Hubal CA, Brayden RO, Capeless EC, McLaughlin MK. Sera antioxidant activity in uncomplicated and complicated pregnancies. Obstet Gynecol 1992;79:897-901.
37. Mikhail MS, Anyaegnunam A, Garfinkel D, Palan PR, Basu J, Romney SL. Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, alpha-tocopherol, and beta-carotene in women with preeclampsia. Am J Obstet Gynecol 1994;171:150-157.
38. Ziari SA, Mireles VL, Cantu CG, Cervantes M, Idrisa A, Bobsom D, Tsin ATC, Glew RH. Serum vitamin A, vitamin E and beta carotene levels in pre-eclamptic women in northern Nigeria. Am J Perinatol 1996;13(5):287-291.
39. Semba RD, Miotti PG, Chiphangwi JD, Saah AJ, Canner JK, Dallabetta GA, Hoover DR. Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. Lancet 1994;343:1593-1596.
40. Suharno D, West CE, Muhilal, Karyadi D, Hautvast JGAJ. Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in west Java, Indonesia. Lancet 1993;1 342:1325-1328.
41. Crosby WM, Metcoff J, Costiloe JP, Mameesh M, Sandstead HH, Jacob RA, et al. Fetal malnutrition: An appraisal of correlated factors. Am J Obstet Gynecol 1977;128:22-31.
42. Metcoff J, Costiloe JP, Crosby W, Bentle L, Seshachalam D, Sandstead HH, et al. Maternal nutrition and fetal outcome. Amer J Clin Nutr 1981;34:708-721.
43. Jaya Rao KS, Shatrugna V. Effect of vitamin A supplementation on plasma progesterone levels in pregnancy. Ind J Med Res 1976;64:1261-1266.
44. Howell DW, Haste F, Rosenburg D, Brown IRF, Brooke OG. Investigation of vitamin A nutrition in pregnant British Asians and their infants. Hum Nutr Clin Nutr 1986;40C:43-50.
45. Panth M, Raman L, Ravinder P, Sivakumar B. Effect of vitamin A supplementation on plasma progesterone and estradiol levels during pregnancy. Inter J Vit Nutr 1991; 61:17-19.
46. West K Jr. Impact of weekly supplementation of women with vitamin A or β-carotene on foetal, infant and maternal mortlality in nepal. Sight and Sound Newsletter 1997;4.
47. ACOG. Vitamin A supplementation during pregnancy. Inter J Gyn Obstet 1995;51:286-287.
48. Martha M, Werler EJ, Rosenberg L, Mitchell AA. Maternal vitamin A supplementation in relation to selected birth defects. Teratology 1990;42:497-503.
49. Rothman K, Moore LL, Singer MR, Nguyen U-SDT, Mannino S, Milunsky A. Teratogenicity of high vitamin A intake. New Eng J Med 1995;333(21):1369-1373.
50. Buss NE, Tembe EA, Prendergast BD, Renwick AG, George CF. The teratogenic metabolites of vitamin A in women following supplements and liver. Human & Expt Toxicol 1994;13:33-43.
51. Mills JL, Simpson JL, Cunningham GC, Conley MR, Rhoads GG. Vitamin A and birth defects. Am J Obstet Gynecol 1997;177(1):31-6.
52. Bamji MS. Enzyme evaluation of thiamin, riboflavin and pyridoxine status of parturient women and their new born infants. Br J Nutr 1976;35:259-265.
53. Chong YH, Ho GS. Erythrocyte transketolase activity. Am J Clin Nutr 1970;23:261-266.
54. Butterworth RF. Maternal thiamine deficiency. Ann. NY. Acad Sci 1993:678;325-329.
55. Institute of Medicine. Nutrition During Pregnancy. Part II - Nutrient Supplements Washington DC: National Academy Press. 1990.
56. Roecklein B, Sondra BS, Levin W, Comly M, Mukherjee AB. Intrauterine growth retardation induced by thiamine deficiency and pyrithiamine during pregnancy in the rat. Am J Obs Gyn, 1985;151(4):455-460.
57. Fournier H, Butterworth RF. Effects of thiamine deficiency on thiamine-dependent enzymes in regions of the brain of pregnant rats and their offspring. Metab Brain Dis 1990:5;77-84.
58. Butterworth RF. 1990. Vitamin deficiencies and brain development. In (Mal)nutrition and the Infant Brain. N.M. Van Gelder, R.F. Butterworth & B. Drujan, Eds: 207-224. Wiley-Liss Inc. New York.
59. Heinze T, Weber W. Determination of thiamine in maternal blood during normal pregnancies and pregnancies with IUGR. Zeitschrift fur Ernahrungswissenschaft, 1990;29(1):39-46.
60. Kirksey A, Wasynczuk AZ. Morphological, biochemical, and functional consequences of vitamin B6 deficits during central nervous system development. Annals of the New York Academy of Sciences. 678:62-80. 1993.
61. Alton-Mackey MG, Walker BL. Graded levels of pyridoxine in the rat diet during gestation and the physical and neuromotor development of offspring. Am J Clin Nutr 1973;26:420-8.
62. Alton-Mackey MG, Walker BL. The physical and neuromotor development of progeny of female rats for graded levels of pyridoxine during lactation. Am J Clin Nutr 1978;31:76-81.
63. Driskell JA, Kirksey A. The cellular approach to the determination of pyridoxine requirements in pregnant and nonpregnant rats. J Nutr 1971;101:661-667.
64. Aycock JE, Kirksey A. Influence of different levels of dietary pyridoxine on certain parameters of developing and mature brains in rats. J Nutr 1976;106:680-688.
65. 6 deficiency on the developing central nervous system of the rat. Ross measurements and cytoarchitectural alterations. J Nutr 1978;108:1250-1259.
66. 12 supplementation during pregnancy: A prospective study. Amer J Clin Nutr 1976;29:1376-1383.
67. Baker H, Thind IS, Frank O, DeAngelis B, Caterini H, Louria DB. Vitamin levels in low-birth-weight newborn infants and their mothers. Am J Obstet Gynecol 1977;129(5):521-524.
68. 6 intake, levels of the vitamin in biological fluids, and condition of the infant at birth. Am J Clin Nutr 1979:32:2249-56.
69. Schuster K, Bailey LB, Mahan CS. Vitamin B-6 status of low-income adolescent and adult pregnant women and the condition of their infants at birth. Am J Clin Nutr 1981;34:1731-1735.
70. Kaminetzky HA, Langer A, Baker H, Frank O, Thomson AD, Munves ED, et al. The effect of nutrition in teenage gravidas on pregnancy and the status of the neonate. Am J Obstet Gynecol 1973;115:639-646.
71. Schuster K, Bailey LB, Mahan CS. Effect of maternal pyridoxine HCL supplementation on the vitamin B-6 status of mother and infant and on pregnancy outcome. J Nutr 1984;114:977-988.
72. 12 and folate deficiency. Blood 1966;27:800-15.
73. Sutherland GR, Ledbetter DH. Report of the committee on cytogenic markers. Cytogenet Cell Genet 1989;51:452-458.
74. Rondo PHC, Abort R, Rodrigues Lc and Tomkins AM. Vitamin A, folate, iron and iron concentrations in cord and maternal blood of intrauterine growth retarded and appropriate birth weight babies. Eur J Clin Nutr 1995;49:391-399.
75. Ek J. Plasma and red cell folate in mothers and infants in normal pregnancies: Relation to birth weight. Acta Obstet Gynecol Scand 1982;61:17-20.
76. Mukherjee MD, Sandstead HH, Ratnaparkhi MV, Johnson LK, Milne DB, Stelling HP. Maternal zinc, iron, folic acid and protein nutriture and outcome of human pregnancy. Am J Clin Nutr 1984;40:496-507.
77. Laurence KM, James N, Miller MH, Tennant GB, Campbell H. Increased risk of recurrence of pregnancies complicated by fetal neural tube defects in mothers receiving poor diets, and possible benefit of dietary counseling. Br Med J 1980;281:1592-94.
78. Mulinare J, Cordero JF, Eriksen D, Berry RJ. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988;260:3141-45.
79. Bower C, Stanley FJ. Dietary folate as a risk factor for neural tube defects: Evidence from a case-control study in Western Australia. Med J Aust 1989; 150:613-18.
80. Pietrzik K, Prinz R, Reusch K, Bung P, Mallmann P, Chronides A. Folate status and pregnancy outcome. Ann NY Acad Sci 1993; 669:371-373.
81. Neiger R, Wise C, Contag SA, Tumber MB, Canick JA. First trimester bleeding and pregnancy outcome in gravidas with normal and low folate levels. Am J Perinatol 1993;10(6):460-462.
82. Goldenberg RL, Tamura T, Cliver SP, Cutter GR, Hoffman HJ, Copper RL. Serum folate and fetal growth retardation: A matter of compliance. Obs Gyn 1992; 79 (5):719-722.
83. Tamura T, Goldenberg RL, Freeberg LE, Cliver SP, Cutter GR, Hoffman HJ. Maternal serum folate and zinc concentrations and their relationships to pregnancy outcome. Am J Clin Nutr 1992;56:365-370.
84. Neggers YH, Goldenbert RL, Tsunenobu T, Cliver SP, Hoffman HJ. The relationship between maternal dietary intake and infant birthweight. Acta Obstet Gynecol Scand 1997;76:71-75
85. Frelut ML, Courcy P, Christides J-P, Blot P, Navarro J. Relationship between maternal serum folate and foetal hypotrophy in a population with a good socioeconomical level. Int J Vit Nutr Res 1994;65:267-271.
86. Scholl TO, Hediger ML, Scholl JI, Khoo C-S, Fischer RL. Dietary and serum folate: Their influence on the outcome of pregnancy. Am J Clin Nutr 1996: 63: 520-525.
87. Rasmussen KM, Thenen SW, Hayes KC. Effect of folic acid supplementation on pregnancy in the squirrel monkey. J Med Primatol 1980;9:169-184.
88. Iyengar L, Rajalakshmi K. Effect of folic acid supplementation on birth weights of infants. Am J Obs Gyn 1975;122(3):332-336.
89. Baumslag N, Edelstein T, Metz J. Reduction of incidence of prematurity by folic acid supplementation in pregnancy. Br Med J 1970; 1:16-17.
90. Rolschau J, Date J, Kristoffersen K. Folic acid supplement and intrauterine growth. Acta Obst Gyn Scand 1979;58:343-346.
91. Tchernia G, Blot I, Rey A. Maternal folate status, birth weight and gestational age. Dev Pharmacol Ther 1982;4(suppl 1):58-65.
92. Blot I, Papiernik E, Kalwasser JP, Werner E, Tchernia G. Influence of routine administration of folic acid and iron during pregnancy. Gyn Obs Invest 1981;12(6):294-304.
93. Giles PFH, Harcourt AG, Whiteside MG. The effect of prescribing folic acid during pregnancy on birth weight and duration of pregnancy: A double-blind trial. Med J Austr 1971;2:17-21.
94. Fletcher J, Gull A, Fellingham FR, Pranherd TAJ, Brant HA, Menzies DN. The value of folic acid supplements in pregnancy. J Obstet Gynaecol Br Comm 1971;78:781.
95. Trigg KH, Rendell EJ, Johnson A, Fellingham FR, Prankerd TA. Folate supplements during pregnancy. J Roy Coll Gen Practit 1976; 26:228-230.
96. Chanarin I. Folate and cobalamin. Clin Haematol 1985;14:629-641.
97. Thompson WG, Freedman ML. Vitamin B12 and geriatrics: Unanswered questions. Acta. Haematol. 1989;82:169-74.
98. Allen LH. Vitamin B-12 metabolism and status during pregnancy, lactation and infancy. In: Nutrient Regulation during Pregnancy, Lactation and Infant Growth. Eds Allen LH, King J, Lonnerdal B. Plenum Press, New York, 1994, ch 14:pp 173-186.
99. Shojania AM. Folic acid and vitamin B12 deficiency in pregnancy and in the neonatal period. Clin. Perinatol 1984;11:433-459.
100. Temperly IJ, Meehan MJM, Gatenby PBB. Serum folic acid levels in pregnancy and their relationship to megaloblastic marrow change. Br J Haemat 1968;14:13.
101. Frery N, Huel G, Leroy M, Moreau T, Savard R, Blot P, Lellouch J. Vitamin B12 among parturients and their newborns and its relationship with birth weight. Eur J Obs Gyn Repr Biol 1992;45:155-163.
102. Wayne MA, Bishop DT, Stringham JD, Ford MH, West DW. Relationship between body mass index, cigarette smoking, and plasma sex steroids in normal male twins. Genet Epidemiol 1989;6:399-412.
103. Wendy CY, Polamaki GE, Haddow JE. Cigarette smoking and serum lipid and lipoprotein concentrations: An analysis of published data. Br Med J 1989;298(6676):784-788.
104. Myllala R, Kuitti-Savolainen ER, Kivirikko K. The role of ascorbate in the prolyl hydroxylase reaction. Biochem. Biophys Res Commun 1978; 83:441-448.
105. Sbarra AJ, Selvaraj RJ, Cetrolo CL. Infection and phagocytosis as possible mechanisms of rupture in premature rupture of the membrane. Obstet Gynecol 1985;153:38-43.
106. Vadillo OF, González AG, Karchmer S, Meraz CN, Ayala RA, Selman LM. Collaagen metabolism in premature rupture of amniotic membranes. Obstet Gynecol 1990;75(1)84-88.
107. Pfeffer F, Casanueva E, Vadillo-Ortega F. "Vitamin C Effect on Matrix Metalloproteinases Expression in Cultured Human Anmion-derived Cells. A Model of Diet-induced Biochemical Changes in Fetal Membranes." International Congress of Nutrition. Montreal, Canada. July 27-August 1 1997.
108. Wideman GL, Baird GH, Bolding OT. Ascorbic acid deficiency and premature rupture of fetal membranes. Am J Obs Gyn 1964;88 (5)592-595.
109. Casanueva E, Magana L, Pfeffer F, Baez A. Incidence of premature rupture of membranes in pregnant women with low leucocyte level of vitamin C. Eur J Clin Nutr 1991;45:401-405.
110. Barrett BM, Sowell A, Gunter E, Wang M. Potential role of ascorbic acid and beta carotene in the prevention of preterm rupture of fetal membranes. Int J Vit Nutr Res 1994;64:192-197.
111. Marya RK, Rathee S, Lata V, Mudgil S. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 1981;12:155-161.
112. Brooke G, Brown IRF, Bone CDM, Carter AND, Cleeve HJW, Maxwell, Probinson VP, Winder SM.. Vitamin D supplements in pregnant asian women: Effects on calcium status and fetal growth. BMJ 1990;1:751-754.
113. Gairdner D, Pearson J. A growth chart for premature and other infants. Arch Dis Child 1971;46:783-87.
114. Mallet E, Gugi B, Brunelle A, Basuyau JP, Lemeur H. Vitmin D supplementation in pregnancy: A controlled trial of two methods. Obstet Gynecol 1986;68(3):300-304.
115. Brunvand L, Quigstad D, Urdal P, Haug E. Vitamin D deficiency and fetal growth. Early Hum Dev 1996;45:27-33.
116. Martin MM, Hurley LS. Effects of large amounts of vitamin E during pregnancy and lactation. Am J Clin Nutr 1977;30:1629.
117. th Ed. Washington DC: ILSI, 1990:117-21.
118. Jagadeesan V, Prema K. Plasma tochopherol and lipid levels in mothers and umbilical cord; influence on birth weight. Br J Obstet Gynaecol 1980;87:908-10.
119. Von Mandach U, Huch R, Huch A. Maternal and cord serum vitamin E levels in normal and abnormal pregnancy. Int J Vitam Nutr Res 1993;63:26-32.
120. Ibeziako PA, Ette SI. Vitamin E levels in pregnant Nigerian women and newborn. J Trop Med Hyg 1982; 85: 265-268.
121. Uotila JT, Tuimala RJ, Aarnio TM, Pyykkö K, Ahotupa M.O. Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. Br J Obstet Gynaecol 1993;100:270-6.
122. Villar J, Repke J, Belizan JM, Pareja G. Calcium supplementation reduces blood pressure during pregnancy: Results of a randomized controlled clinical trial. Obs Gyn 1987; 70 (part 1):317-322.
123. Bucher HC, Guyatt GH, Cook RJ, Hatala R, Cook DJ, Lang JD, Hunt D. Effect of Calcium supplementation on pregnancy-induced hypertension and preeclampsia. JAMA 1996;275(14):1113-1117.
124. Levine RJ, Hauth JC, Curet LB, et al. Trial of calcium to prevent preeclampsia. N Engl J Med 1997;337:69-76.
125. Villar J, Repke JT. Calcium supplementation during pregnancy may reduce preterm delivery in high risk populations. Am J Obs Gyn 1990:163(4):1124-31.
126. Belizan JM, Villar J, Gonzalez L, Campodonico L, Bergel E. Calcium supplementation to prevent hypertensive disorders of pregnancy. New Eng J Med 1991;325(20): 1399-1405.
127. Sanchez-Ramos L, del Valle GO, Briones D, Walker C, Delke I, Gaudier F. Prevention of pre-eclampsia by calcium supplementation in angiotensin-sensitive patients. Am J Obstet Gynecol 1994; 170:48.
128. Lopez-Jarmillo JP, Narvaez WM, Weigel RM, Yepez R. Calcium supplementation reduces the risk of pregnancy-induced hypertension in an Andes population. Br J Obstet Gynecol 1989;96:649-55.
129. Lopez-Jarmillo P, Narvaez M, Felix C, Lopez A. Dietary calcium supplementation and prevention of pregnancy hypertension. Lancet 1990;335:293.
130. Belizan JM, Villar J. The relationship between calcium intake and edema, proteinuria-and hypertension-gestosis:a hypothesis. Am J Clin Nutr 1980;33:2202-10.
131. Purwar M, Kulkaarni H, Motghare V, Dhole S. Calcium supplementation and prevention of pregnancy induced hypertension. J. Obstet Gynaecol Res 1996;22(5):425-30.
132. Dunn JT. Iodine supplementation and the prevention of cretinism. Ann. N.Y. Acad. Sci. 1993;678:158-68.
133. Delange F. Administration of iodized oil during pregnancy: A summary of the published evidence. Bull WHO 1996;74:101-108.
134. Pharoah POD, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency through pregnancy. Lancet 1971;1:308-10.
135. Pharoah POD, Connolly K. A controlled trial of iodinated oil for the prevention of endemic cretinism: A long-term follow-up. Int J Epid 1987;16:68-73.
136. Pretell EA, Palacies P, Tello L, Wan M, Litiger RD, Stanbury JB. Iodine deficiency and the maternal-fetal relationship. In: Dunn JT, Medeiros-Neto GA, eds. Endemic Goitre and Cretinism: Continuing Threats to World Health. Washington. Pan American Health Organization. 1974:143-155. (PAHO Scientific Publ. No. 292).
137. Thilly CH, Delange F. Lagasse R, Bourdoux P, Ramidul L, Berguist H et al. Fetal hypothyrodism and maternal thyroid status in severe endemic goitre. J Clin Endocrin Metab 1978;47:354-360.
138. Thilly CH, et al. Fetal hypothyroidism in endemic goitre: The probable pathogenic mechanism of endemic cretinism. In: Dunn JT, Medeiros-Neto GA, eds. Endemic Goitre and Cretinism: Continuing Threats to World Health. Washington. Pan American Health Organization. 1974;121-128 (PAHO Scientific Publ. No. 292).
139. Thilly CH, et al. Maternal, fetal, and juvenile hypothyroidism, birthweight, and infant mortality in the etiopathogenesis of the IDD spectrum in zaire and malawi. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. New York. Cognizant Communication. 1994:241-250.
140. Vanderpas J, Thilly CH. Endemic neonatal infantile and juvenile hypothyroidism in Ubangi, Northern Zaire: Clinical consequences and prevention. In: Stanbury JB, ed. The Damaged Brain of Iodine Deficiency. New York. Cognizant Communication 1984:209-224.
141. Chaouki ML, Benmiloud M. Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. Europ J Endocrin 1994;130:547-551.
142. Kochupillai N, et al., Environmental iodine deficiency, neonatal chemical hypothyroidism (NCH) and iodized oil prophylaxis. In:Kochupillai N, Karmakar MG, Ramalingaswami V, eds. Iodine Nutrition, Thyroxine and Brain Development. New Dehli, Tata McGraw-Hill. 1986;87-93.
143. Kochupillai N. Prevention and control of goitre. Demerits of iodized oil injections. Bull Nutr Found. India. 1991;12:1-5.
144. Scholl TO, Hediger ML. Anemia and iron deficiency anemia: Compilation of data on pregnancy outcome. Am J Clin Nutr 1994;59(suppl):492S-501S.
145. Goldenberg RL, Yip R. Routine iron supplementation during pregnancy. Abs Clin Care Guidelines 1994; (Feb)15-18.
146. Svanberg B, Arvidsson B, Bjorn-Rasmussen L, Hallberg L, Rossander L, Swolin B. Dietary iron absorption in pregnancy - A longitudinal study with repeated measurements of non-heme iron absorption from whole diet. Acta Obstet Gynecol Scand Suppl 1976; 48:43-68.
147. Milman N, Agger AO, Nielsen OJ. Iron status markers and serum erythropoietin in 120 mothers and newborn infants: Effect of iron supplementation in normal pregnancy. Acta Obs Gyn Scan 1994;73:200-204.
148. Allen LH. Nutritional supplementation for the pregnant woman. Clin Obstet Gynecol 1994;37(3):587-595.
149. Allen LH. Pregnancy and iron deficiency: Unresolved issues. Nutr Rev 1997;55(4):91-101.
150. US Preventive Services Task Force: Routine iron supplementation during pregnancy. Policy statement. JAMA 1993;270(23):2846-2848.
151. Hemminki E, Starfield B. Routine administration of iron and vitamins during pregnancy: Review of controlled clinical trials. Br J Obstet Gynecol 1978; 85:404-410.
152. Bhargava M, Kumar R, Iyer PU, Ramji S, Kapani V, Bhargava SK. Effect of maternal anemia and iron depletion on foetal iron stores, birth weight and gestation. Acta Ped Scand 1989; 78:321-322.
153. Agarwal RMD, Tripathi AM, Agarwal KN. Cord blood hemoglobin, iron and ferritin status in maternal anaemia. Acta Ped Scand 1983; 72:545-548.
154. Milman N, Ibsen KK, Christiansen JJ. Serum ferritin and iron status in mothers and new born infants. Acta Obstet Gynecol Scand 1987;66:205-211
155. Klebanoff MA, Shiono PH, Berendes HW, Rhoads GG. Facts and artifacts about anemia and preterm delivery. J Am Med Assoc 1990;262:511-515.
156. Centers for Disease Control. CDC criteria for anemia in children and child bearing-aged women. Mort Morb Week Rep 1989;38:400-404.
157. Khan MU. Influence of mother's hemoglobin level and weight on newborn's hemoglobin level and weight. Nutr Rep Int 1985;32(5): 1081-1087.
158. Hasin A, Begum R, Khan MR, Ahmed F. Relationship between birth weight and biochemical measures of maternal nutritional status at delivery in Bangladeshi urban poor. Int J Food Sci Nutr 1996;47:273-279.
159. Kuizon MD, Cheong LR, Ancheta LP, Desnacido JA, Macapinlac MP, Baens JS. Effect of anaemia and other maternal characteristics on birth weight. Hum Nutr:Clin Nutr 1985;39 C: 419-426.
160. Garn SM, Ridella SA, Petzold S, Falkner F. Maternal Hb levels and pregnancy outcomes. Sem Perinat 1981;5(2):155-162.
161. Murphy JF, O'Riordan J, Newcombe RG, Coles EC, Pearson JF. Relation of Hb levels in first and second trimesters to outcome of pregnancy. Lancet 1986;1:992-994.
162. Swain S, Singh S, Bhatia BD, Pandy S, Krishna M. Maternal hemoglobin and serum albumin and fetal growth. Ind Pediatr 1994;31(7):777-82.
163. Brabin BJ, Ginny M, Sapau J, Gaslme K, Paino J. Consequences of maternal anaemia on outcome of pregnancy in a malaria endemic area in Papua New Guinea. Ann Trop Med Parasitol 1990;84(1):11-24.
164. Lu ZM, Goldenberg RL, Cliver S, Cutter G, Blankson M. The relationship between maternal hematocrit and pregnancy outcome. Obstet Gyn 1991;77(2):191-194.
165. Higgins AC, Pencharz PB, Strawbridge JE, Maughan GB, Moxley JE. Maternal hemoglobin changes and their relationship to infant birth weight in mothers receiving a program of nutritional assessment and rehabilitation. Nutr Res 1982;2:641-649.
166. Galloway R, McGuire J. Determinants of compliance with iron supplementation: Supplies, side effects, or psychology? Soc Sci Med 1994;39:381-90.
167. Dreyfuss ML, Stolzfus RJ, Shrestha JB, Khatry SK, Shrethsa SR, Pradhan EK, West KP Jr. "Pregnancy Anemia and Neonatal Weight in Rural Nepal." International Congress of Nutrition. Montreal, Canada. July 27-August 1, 1997.
168. Scholl TO, Hediger ML, Fischer RL, Shearer JW. Anemia vs iron deficiency: Increased risk of pre term delivery in a prospective study. Am J Clin Nut 1992;55:985-988.
169. Gaspar MJ, Ortega RM, Moreiras O. Relationship between iron status in pregnant women and their new born babies. Acta Obs Gyn Scand 1993;72:534-537.
170. Turkay S, Tanzer F, Gultekin A, Bakici Z. The influence of maternal iron deficiency anemia on the hemoglobin concentration of the infant. J Trop Med 1995;41:369-371.
171. Achadi EL, Hansell MJ, Sloan NL, Anderson MA. Women's nutritional status, iron consumption and weight gain during pregnancy in relation tp neonatal weight and length in West Java, Indonesia. Int J Gyn Obs 1995;48 suppl:S103-S119.
172. Perry GS, Yip R, Zyrkowski C. Nutritional risk factors among low income pregnant US women: The centers for disease control and prevention pregnancy, nutrition surveillance system, 1979 through 1993. Sem Perinat 1995; 19(3):211-221.
173. Scanlon, personal communication 1997
174. Goldenberg RL, Tamura T, Dubard M, Johnston KE, Copper RL, Neggers Y. Plasma ferritin and pregnancy outcome. Am J Obs Gyn 1996;175:1356-1359.
175. Tamura T, Goldenburg RL, Johnston KE, Cliver SP, Hickey C. Serum ferritin: A predictor of early spontaneous preterm delivery. Obstet Gynecol 1996;87:360-5.
176. Raman L, Pawashe AB, Yasodhara P. Hyperferritinemia in pregnancy induced hypertension and eclampsia. J Postgrad Med 1992;38:65-67.
177. Menendez C, Todd J, Alonso PL, Francis N, Lulat S, Ceesay S, Boge BM. The effects of iron supplementation during pregnancy, given by traditional birth attendants, on the prevalence of anaemia and malaria. Tran Royal Soc Trop Med Hyg 1994;88:590-593.
178. Preziosi P, Prual A, Galan P, Daouda H, Boureima H, Hercberg S. Effect of iron supplementation on the iron status of pregnant women: Consequences for newborns. Am J Clin Nutr 1997;66:1178-82.
179. Hemminki E, Rimpela U. A randomized comparison of routine versus selective iron supplementation during pregnancy. Am Coll Nutr 1991;10(1):3-10.
180. Chien PFW, Khan KS, Arnott N. Magnesium sulphate in the treatment of eclampsia and pre-eclampsia: An overview of the evidence from randomized trials. Br J Obstet Gynecol 1996;103:1085-1091.
181. Conradt A, Weidinger H, Algayer H. Magnesium therapy decreased the rate of intrauterine fetal retardation, premature rupture of membranes and premature delivery in risk pregnancies treated with betamimetics. Magnesium 4(1):20-28,1985.
182. Kurzel RB. Is low serum magnesium associated with premature labor? Ann NY Acad Sci 1993;678:350-352.
183. Neito-Diaz A, Villar J, Matorras R, Valenzuela-Ruiz P. Intrauterine growth retardation at term association between anthropometric and endocrine parameters. Acta Obstet Gynecol Scand 1996;75:127-131.
184. Kovacs L, Molnar E, Huhn E, Bodis L. Magnesium substitution in der scwanggerschaft. Geburtsch Frauenheilk 1988;48:595-600.
185. Spatling L, Spatling G. Magnesium supplementation in pregnancy: A double blind study. Br J Obs Gyn 1988;95:120-125.
186. Sibai BM, Villar L, Bray E. Magnesium supplementation during pregnancy: A double-blind randomized controlled clinical trial. Am J Obstet Gynecol 1989;115-9.
187. Swanson CA, King JC. Zinc and pregnancy outcome. Am J Clin Nutr 1987;46:763-771.
188. Jameson S. Zinc status in pregnancy: The effect of zinc therapy on perinatal mortality, prematurity and placental ablation. Ann NY Acad Sci 1993 ;678:178-192.
189. Tamura T, Goldenberg RL. Zinc nutriture and pregnancy outcome. Nut Res 1996;16(1):139-181.
190. Hambidge KM, Casey CE, Krebs NF. Zinc. In: Mertz W, ed. Trace Elements in Human and Animal Nutrition. Vol 2, 5th Ed. Orlando: Academic Press, 1986:1-137.
191. Scholl TO, Hediger ML, Scoll JI, Fischer RL, Khoo C-S. Low zinc intake during pregnancy: Its association with preterm and very preterm delivery. Am J Epid 1993;137:115-124.
192. Hunt IF, Murphy NJ, Cleaver AE, Faraji B, Swendseid ME, Coulson AH, Clark VA, Bowdy BL, Cabalum MT, Smith JC. Zinc supplementation during pregnancy: Effects on selected blood constituents and progress and outcome of pregnancy in low-income women of mexican descent. Am J Clin Nutr 1984;40:508-521.
193. Hunt IF, Murphy NJ, Cleaver AE, Faraji B, Swendseid ME, Coulson AH, Clark VA, Bowdy BL, Cabalum MT, Smith JC. Zinc supplementation in low income teenagers of Mexican descent:effects on selected blood constituents and on progress of pregnancy. Am J Clin Nutr 1985;42:815-828.
194. Wolfe SA, Gibson RS, Gadowsky SL, O'Connor. Zinc status of a group of pregnant adolescents at 36 weeks gestation living in southern Ontario. J Am Col Nutr 1994;13:154-164.
195. Jameson S. Zinc and copper in pregnancy. Correlations to fetal and maternal complications. Acta Med Scand 1976;593:5-20.
196. Meadows NJ, Ruse W, Smith MF, Day J, Keeling PWN, Scopes JW. Zinc and small babies. Lancet 1981;2(8256):1135-1137.
197. Meadows N, Ruse W, Keeling PWN, Scopes JW, Thompson RPH. Peripheral blood leucocyte zinc depletion in babies with intrauterine growth retardation. Arch Dis Child 1983;58:807-809.
198. Patrick J, Dervish C, Gillieson M. Zinc and small babies. Lancet 1982; 1:169-170.
199. Simmer K, Thompson RPH. Maternal zinc and intrauterine growth retardation. Clin Sci 1985;68:395-399.
200. Wells JL, James DK, Luxton R, Pennock CA. Maternal leucocyte zinc deficiency at start of third trimester as a predictor of fetal growth retardation. Br Med J 1987;294:1054-1056.
201. Ghosh A, Fong LYY, Wan CW, Liang ST, Wo JSK, Wong V. Zinc defeiciency is not a cause for abortion, congenital abnormality and small for gestational age infant in Chinese women. Br J Obs Gyn 1985;92:886-891.
202. Neggers YH, Cutter GR, Alvarez JO, Goldenburg RL, Acton R, Go RCP, Roseman JM. The relationship between maternal serum zinc levels during pregnancy and birthweight. Early Hum. Develop 1991;25:75-85.
203. Spiech M, Bousquet B, Auget J-L, Gelot S, Laborde O. Association between magnesium, calcium, phosphorus, copper, and zinc in umbilical cord plasma and erythrocytes and the gestational age and growth variables of full term newborns. Clin Chem 1992;38(1):141-143.
204. Neumann CG, Harrison GG. Onset and evolution of stunting in infants and children. Examples from the human nutrition collaborative research support program. Kenya and Egypt Studies. Eur J Clin Nutr 1994; 48;Supp 1 :S90-S102.
205. Kirksey A, Wachs TD, Yunis F, Srinath U, Rahmanifar A, McCabe GP, Galal OM, Harrison GG, Jerome NW. Relation of maternal zinc nutriture to pregnancy outcome and infant development in an Egyptian village. Am J Clin Nutr 1994;60:782-792.
206. Goldenberg RL, Tamura T, Neggers Y, Copper RL, Johnston K, Dubard MB, Hauth JC. The effect of zinc supplementation on pregnancy outcome. J Am Med Assoc 1995;274:463-468.
207. Cherry FF, Sandstead HH, Rojas P, Johnson LK, Batson HK, Wang XB. Adolescent pregnancy: Associations among body weight, zinc nutriture, and pregnancy outcome. Am J Clin Nutr. 1989; 50:945-54.
208. Simmer K, Lort-Phillips L, James C, Thompson RP. A double-blind trial of zinc supplementation in pregnancy. Eur J Clin Nutr 1991; 45:139-44.
209. Kynast G, Saling E. Effect of oral zinc application during pregnancy. Gyn Obs Invest 1986; 21:117-123.
210. Mahomed K, James DK, Goldling J, McCabe R. Zinc supplementation during pregnancy: A double blinded randomized controlled trial. BMJ 1989;299(6703):826-830.
211. Jameson S. Zinc status and pregnancy outcome in humans. In: Prasad AS, Dreosti IE, Hetzel BS, eds. Clinical Applications of Recent Advances in Zinc Metabolism, New York: Alan R. Liss, 1982:39-52.
212. Ross SM, Nel E, Naeye RL. Differing effects of low and high bulk maternal dietary supplements during pregnancy. Early Hum Dev 1985;10:295-302.
213. Garg HK, Singhal KC, Arshad Z. A study of the effects of oral zinc supplementation during pregnancy outcome. Indian J Physiol Pharmacol 1993;37(4):276-284.
214. Jonsson B, Hauge B, Larsen MF, Hald F. Zinc supplementation during pregnancy: A double blind randomized controlled trial. Act Obs Gyn Scand 1996;75:725-729.
215. Kiilholma P, Gronroos M, Rkkola R, Pakarinen P, Nanto V. The role of calcium, copper, iron, and zinc in preterm delivery and premature rupture of fetal membranes. Gyn Obs Invest 1984;17:194-201.
216. Arnaud J, Preziosi L, Mashako L, Galan P, Favier A, Kapongo C, Hercberg S. Serum trace elements in Zairian mothers and their newborns. Eur J Clin Nutr 1994;48:341-348.
217. Wasowicz W, Wolkanin P, Bednarski M, Gromadzinska J, Sklodowska M, Grzybowska K. Plasma trace element (Se, Zn, Cu) concentrations on maternal and umbilical cord blood in Poland: Relation with birth weight, gestation age, parity. Biol Trace Element Res 1993;38:205-215.
218. Cherry FF, Sandstead HH, Wickeremasinghe AR. Adolescent pregnancy: Zinc supplementation and iron effects. Ann NY Acad Sci 1993;678:330-333.
219. Hodges RE, Sauberlich HE, Canham JE, Wallace DL, Rucker RB, Mejia LA, Mohanram M. Hematopoietic studies in vitamin A deficiency. Am J Clin Nutr 1978;31:876-885.
220. Mejia LA, Arroyave G. The effect of vitamin A fortification of sugar on iron metabolism in preschool children in Guatemala. Am J Clin Nutr 1982;36:87-93.
221. Skikne B, Baynes RD. Iron absorption. In Brock JH, Halliday JW, Pippard MJ, Powell LW (eds), Iron Metabolism in Health and Disease. WB Saunders, London 1994;151-187.
222. Shingwekar AG, Mohanram M. Reddy V. Effect of zinc supplementation on plasma levels of vitamin A and retinol-binding protein in malnourished children. Clinica Chimica Acta 1979; 93:97-100.
223. Marinho HA, Shrimpton R, Giugliano R, Burini RC. Influence of enteral parasites on the blood vitamin A levels in preschool children orally supplemented with retinol and/or zinc. Eur J Clin Nutr 1991;45:539-544.
224. Udomkesmalee E, Dhanamitta S, Yhoung-Aree J, Rojroongwasinkul N, Smith JC Jr. Biochemical evidence suggestive of suboptimal zinc and vitamin A status in school children in Northeastern Thailand. Am J Clin Nutr 1990;52:564-7.
225. Udomkesmalee E, Dhanamitta S, Sirisinha S, Charoenkiatkul S, Tuntipopipat S, Banj́ong O, Rojroongwasinkul N, Kramer TR, Smith JC Jr. Effect of vitamin A and zinc supplementation on the nutriture of children in northeast Thailand. Am J Clin Nutr 1992;56:50-57.
226. Milne DB, Canfield WK, Mahalko JR, Sandstead HH. Effect of oral folic acid supplements on zinc, copper, and iron absorption and excretion. Am J Clin Nutr 1984;39:535-9
227. Keen CL, Zidenberg-Cherr S. Should vitamin-mineral supplements be recommended for all women with childbearing potential? Am J Clin Nutr 1994:59(suppl)532S-539S.
228. Ackurt F, Weitherilt H, Loker M, Hacibekiroglu M. Biochemical assessment of nutritional status in pre and post-natal Turkish women and outcome of pregnancy. Eur J Clin Nutr 1995;49:613-622.
229. Pfeffer F, Valdes-Ramos R, Avila-Rosas H, Meza C, Casanueva E. Iron, zinc and vitamin C nutritional status is not related to weight gain in pregnant women. Nutr Res 1996;16:555-64.
230. Kullander S, Kallen B. A prospective study of drugs and pregnancy. Acta Obstet Gynecol Scand 1976;55:287.
231. Medieros DM, Bock MA, Raab C, Schutz HG, Sheehan ET, Williams DK. Vitamin and mineral supplementation practices of adults in seven western states. J Am Diet Assoc 1989;89:383-6.
232. Dickinson VA, Block G, Russek-Cohen E. Supplement use, other dietary and demographic variables, and serum vitamin C in NHANES II. J Am Coll Nutr 1994;13:22-32.
233. Subar AF, Block G. Use of vitamin and mineral supplements: Demographics and amounts of nutrients consumed: The 1987 health interview survey. Am J Epi 1990;132:1091-1101.
234. Kurinij N. Dietary supplement and food intake in women of childbearing age. Research 1986;86:1536-1540.
235. Doyle W, Crawford MA, Wynn MA, Wynn SW. The association between diet and birth dimensions. J Nutr Med 1990;1:9-17.
236. Haste FM, Brooke OG, Anderson HR, Bland JM. The effect of nutritional intake on outcome of pregnancy in smokers and non smokers. Br J Nutr 1991;65:347-354.
237. Weigel MM, Narvaez WM, Lopez A, Felix C, Lopez P. Prenatal diet, nutrient intake and pregnancy outcome in urban Eucadorian preimiparas. Arch Lat Am Nutr 1991;XLI(1):21-37.
238. Johnson AA, Knight EM Edwards CH, Oyeamde UJ, Cole OJ, Westney OE, Westney LS, Larayea H and Jones S. Dietary intakes, anthropometric measurements and pregnancy outcomes. J Nutr 1994;124:936S-942S.
239. Ceesay SM, Prentice AM, Cole TJ, Foord F, Weaver LT, Poskitt EME, Whitehead RG. Effects on birth weight and perinatal mortality of maternal dietary supplements in rural Gambia: 5 year randomised controlled trial. BMJ 1997;315:786-90.
240. Yip R. Iron supplementation during pregnancy: Is it effective? Am J Clin Nutr 1996;63:853-5.
241. Huffman SL, Baker J, Shumann J, Zehner ER. The Case for Promoting Multiple Vitamin/mineral Supplements for Women in Developing Countries. Working documents (Linkages, Academy for Educational Development and Population Services International, Washington DC)