Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China

Human Genetics

Volumn 131, Issue 7, 2012, Pages 1251-1260

  Wang, Dong ^a,e   Feng, Jia Qi ^a,d   Li, Yu Ye ^b   Zhang, Deng Feng ^a,e   Li, Xiao An ^c   Li, Qing Wei ^d   Yao, Yong Gang ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

^c Yuxi City Center for Disease Control and Prevention   (China)

^d LIAONING NORMAL UNIVERSITY   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MRC1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BRAZIL; CHINESE; CONTROLLED STUDY; EXON; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MULTIBACILLARY LEPROSY; PAUCIBACILLARY LEPROSY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VIET NAM;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CHINA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; INTERFERON-GAMMA; LEPROSY, MULTIBACILLARY; LEPROSY, PAUCIBACILLARY; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, IMMUNOLOGIC; SEQUENCE ANALYSIS, DNA;

EID: 84862766895     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-012-1153-7     Document Type: Article

References (40)

1. A Alcaïs M Mira JL Casanova E Schurr L Abel 2005 Genetic dissection of immunity in leprosy Curr Opin Immunol 17 44 48 15653309 10.1016/j.coi.2004. 11.006
2. S Al-Muhsen JL Casanova 2008 The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases J Allergy Clin Immunol 122 1043 1051 19084105 10.1016/j.jaci.2008.10.037 1:CAS:528:DC%2BD1cXhsV2lsbfE
3. A Alter L de Léséleuc N Van Thuc VH Thai NT Huong NN Ba CC Cardoso AV Grant L Abel MO Moraes A Alcaïs E Schurr 2010 Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility Hum Genet 127 337 348 20035344 10.1007/s00439-009-0775-x 1:CAS:528:DC%2BC3cXhvFektLo%3D
4. A Alter A Grant L Abel A Alcaïs E Schurr 2011 Leprosy as a genetic disease Mamm Genome 22 19 31 20936290 10.1007/s00335-010-9287-1 1:CAS:528:DC%2BC3MXht1Whsbs%3D
5. M Awad V Pravica C Perrey A El Gamel N Yonan PJ Sinnott IV Hutchinson 1999 CA repeat allele polymorphism in the first intron of the human interferon-gamma gene is associated with lung allograft fibrosis Hum Immunol 60 343 346 10363726 10.1016/S0198-8859(98)00133-5 1:STN:280:DyaK1M3ptVeqtg%3D%3D
6. JC Barrett B Fry J Maller MJ Daly 2005 Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 263 265 15297300 10.1093/bioinformatics/bth457 1:CAS:528:DC%2BD2MXkt1WitQ%3D%3D
7. WR Berrington M Macdonald S Khadge BR Sapkota M Janer DA Hagge G Kaplan TR Hawn 2010 Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states J Infect Dis 201 1422 1435 20350193 10.1086/651559 1:CAS:528:DC%2BC3cXmtlSmtLs%3D
8. PY Bochud TR Hawn MR Siddiqui P Saunderson S Britton I Abraham AT Argaw M Janer LP Zhao G Kaplan A Aderem 2008 Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy J Infect Dis 197 253 261 18177245 10.1086/524688 1:CAS:528:DC%2BD1cXitlaksLY%3D
9. WJ Britton DN Lockwood 2004 Leprosy Lancet 363 1209 1219 15081655 10.1016/S0140-6736(04)15952-7
10. CC Cardoso AC Pereira VN Brito-de-Souza IM Dias-Baptista VC Maniero J Venturini FR Vilani-Moreno FC de Souza M Ribeiro-Alves EN Sarno AG Pacheco MO Moraes 2010 IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians Hum Genet 128 481 490 20714752 10.1007/s00439-010-0872- x 1:CAS:528:DC%2BC3cXhtlSjsLzI
11. CC Cardoso AC Pereira C de Sales Marques MO Moraes 2011 Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome Future Microbiol 6 533 549 21585261 10.2217/fmb.11.39 1:CAS:528:DC%2BC3MXmt1yltrs%3D
12. ST Cole K Eiglmeier J Parkhill KD James NR Thomson PR Wheeler N Honoré T Garnier C Churcher D Harris K Mungall D Basham D Brown T Chillingworth R Connor RM Davies K Devlin S Duthoy T Feltwell A Fraser N Hamlin S Holroyd T Hornsby K Jagels C Lacroix J Maclean S Moule L Murphy K Oliver MA Quail MA Rajandream KM Rutherford S Rutter K Seeger S Simon M Simmonds J Skelton R Squares S Squares K Stevens K Taylor S Whitehead JR Woodward BG Barrell 2001 Massive gene decay in the leprosy bacillus Nature 409 1007 1011 11234002 10.1038/35059006 1:CAS:528:DC%2BD3MXhs1Cqtr8%3D
13. L East CM Isacke 2002 The mannose receptor family Biochim Biophys Acta 1572 364 386 12223280 10.1016/S0304-4165(02)00319-7 1:CAS:528: DC%2BD38XmvVagsbc%3D
14. WJ Gauderman 2002 Sample size requirements for matched case-control studies of gene-environment interaction Stat Med 21 35 50 11782049 10.1002/sim.973
15. T Hattori S Konno A Takahashi A Isada K Shimizu N Taniguchi P Gao E Yamaguchi N Hizawa SK Huang M Nishimura 2010 Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis BMC Med Genet 11 151 21029423 10.1186/1471-2350-11-151 1:CAS:528:DC%2BC3cXhsVaiu7fO
16. MM Holland W Parson 2011 GeneMarker® HID: A reliable software tool for the analysis of forensic STR data J Forensic Sci 56 29 35 20887353 10.1111/j.1556-4029.2010.01565.x
17. A Khani-Hanjani D Lacaille D Hoar A Chalmers D Horsman M Anderson R Balshaw PA Keown 2000 Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis Lancet 356 820 825 11022930 10.1016/S0140-6736(00)02657-X 1:CAS:528:DC%2BD3cXmtlOgu78%3D
18. Y-Y Li X-A Li L He D Wang W-Y Chen L Chen J-B Lu Y-G Yao 2011 Trends in new leprosy case detection over 57 years (1952-2008) in Yuxi, Yunnan Province of Southwest China Lepr Rev 82 6 16 21644467
19. D Malhotra K Darvishi S Sood S Sharma C Grover V Relhan BS Reddy RN Bamezai 2005 IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy Hum Genet 118 295 300 16163478 10.1007/s00439-005-0042-8 1:CAS:528:DC%2BD2MXht1aitLzL
20. EN Miller SE Jamieson C Joberty M Fakiola D Hudson CS Peacock HJ Cordell MA Shaw Z Lins-Lainson JJ Shaw F Ramos F Silveira JM Blackwell 2004 Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians Genes Immun 5 63 67 14735151 10.1038/sj.gene.6364031 1:CAS:528:DC%2BD2cXltFamtA%3D%3D
21. MT Mira 2006 Genetic host resistance and susceptibility to leprosy Microbes Infect 8 1124 1131 16513393 10.1016/j.micinf.2005.10.024 1:CAS:528:DC%2BD28XktVGgt78%3D
22. MT Mira A Alcaïs N Van Thuc VH Thai NT Huong NN Ba A Verner TJ Hudson L Abel E Schurr 2003 Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population Nat Genet 33 412 415 12577057 10.1038/ng1096 1:CAS:528:DC%2BD3sXhsV2kurw%3D
23. EA Misch WR Berrington JC Vary Jr TR Hawn 2010 Leprosy and the human genome Microbiol Mol Biol Rev 74 589 620 21119019 10.1128/MMBR.00025-10 1:CAS:528:DC%2BC3MXhsFKmtbk%3D
24. RL Modlin 2010 The innate immune response in leprosy Curr Opin Immunol 22 48 54 20060279 10.1016/j.coi.2009.12.001 1:CAS:528:DC%2BC3cXis1Shs7o%3D
25. M Monot N Honoré T Garnier N Zidane D Sherafi A Paniz-Mondolfi M Matsuoka GM Taylor HD Donoghue A Bouwman S Mays C Watson D Lockwood A Khamesipour Y Dowlati S Jianping TH Rea L Vera-Cabrera MM Stefani S Banu M Macdonald BR Sapkota JS Spencer J Thomas K Harshman P Singh P Busso A Gattiker J Rougemont PJ Brennan ST Cole 2009 Comparative genomic and phylogeographic analysis of Mycobacterium leprae Nat Genet 41 1282 1289 19881526 10.1038/ng.477 1:CAS:528:DC%2BD1MXhtlers7bO
26. D Montoya RL Modlin 2010 Learning from leprosy: insight into the human innate immune response Adv Immunol 105 1 24 20510728 10.1016/S0065-2776(10) 05001-7 1:CAS:528:DC%2BC3cXhtFSnurbF
27. AG Pacheco CC Cardoso MO Moraes 2008 IFNG+874T/A, IL10-1082G/A and TNF-308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study Hum Genet 123 477 484 18414898 10.1007/s00439-008-0497-5 1:CAS:528:DC%2BD1cXmtVaisrs%3D
28. V Pravica A Asderakis C Perrey A Hajeer PJ Sinnott IV Hutchinson 1999 In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene Eur J Immunogenet 26 1 3 10068907 10.1046/j.1365-2370.1999. 00122.x 1:CAS:528:DyaK1MXhvVOkt74%3D
29. V Pravica C Perrey A Stevens JH Lee IV Hutchinson 2000 A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production Hum Immunol 61 863 866 11053629 10.1016/S0198-8859(00) 00167-1 1:CAS:528:DC%2BD3cXosVWlu7s%3D
30. M Rossouw HJ Nel GS Cooke PD van Helden EG Hoal 2003 Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene Lancet 361 1871 1872 12788577 10.1016/S0140-6736(03)13491-5 1:CAS:528:DC%2BD3sXkt1artrw%3D
31. BR Sapkota M Macdonald WR Berrington EA Misch C Ranjit MR Siddiqui G Kaplan TR Hawn 2010 Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes Hum Immunol 71 992 998 20650301 10.1016/j.humimm.2010.07.001 1:CAS:528:DC%2BC3cXhtFOrtL7F
32. MR Siddiqui S Meisner K Tosh K Balakrishnan S Ghei SE Fisher M Golding NP Shanker Narayan T Sitaraman U Sengupta R Pitchappan AV Hill 2001 A major susceptibility locus for leprosy in India maps to chromosome 10p13 Nat Genet 27 439 441 11279529 10.1038/86958 1:CAS:528:DC%2BD3MXjtFShsLk%3D
33. M Stephens NJ Smith P Donnelly 2001 A new statistical method for haplotype reconstruction from population data Am J Hum Genet 68 978 989 11254454 10.1086/319501 1:STN:280:DC%2BD3M3kslWgsA%3D%3D
34. K Tosh S Meisner MR Siddiqui K Balakrishnan S Ghei M Golding U Sengupta RM Pitchappan AV Hill 2002 A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population J Infect Dis 186 1190 1193 12355375 10.1086/343806 1:CAS:528:DC%2BD38Xos1eksL4%3D
35. C Wallace J Fitness B Hennig L Sichali L Mwaungulu JM Pönnighaus DK Warndorff D Clayton PE Fine AV Hill 2004 Linkage analysis of susceptibility to leprosy type using an IBD regression method Genes Immun 5 221 225 15014432 10.1038/sj.gene.6364062 1:CAS:528:DC%2BD2cXjt1CmurY%3D
36. WHO 2010 Global leprosy situation, 2010 Wkly Epidemiol Rec 85 337 348
37. SH Wong S Gochhait D Malhotra FH Pettersson YY Teo CC Khor A Rautanen SJ Chapman TC Mills A Srivastava A Rudko MB Freidin VP Puzyrev S Ali S Aggarwal R Chopra BS Reddy VK Garg S Roy S Meisner SK Hazra B Saha S Floyd BJ Keating C Kim BP Fairfax JC Knight PC Hill RA Adegbola H Hakonarson PE Fine RM Pitchappan RN Bamezai AV Hill FO Vannberg 2010 Leprosy and the adaptation of human toll-like receptor 1 PLoS Pathog 6 e1000979 20617178 10.1371/journal.ppat.1000979
38. SH Wong AV Hill FO Vannberg 2010 Genomewide association study of leprosy N Engl J Med 362 1446 1447 20393182 10.1056/NEJMc1001451 1:CAS:528: DC%2BC3cXkslahtr4%3D
39. FR Zhang W Huang SM Chen LD Sun H Liu Y Li Y Cui XX Yan HT Yang RD Yang TS Chu C Zhang L Zhang JW Han GQ Yu C Quan YX Yu Z Zhang BQ Shi LH Zhang H Cheng CY Wang Y Lin HF Zheng XA Fu XB Zuo Q Wang H Long YP Sun YL Cheng HQ Tian FS Zhou HX Liu WS Lu SM He WL Du M Shen QY Jin Y Wang HQ Low T Erwin NH Yang JY Li X Zhao YL Jiao LG Mao G Yin ZX Jiang XD Wang JP Yu ZH Hu CH Gong YQ Liu RY Liu DM Wang D Wei JX Liu WK Cao HZ Cao YP Li WG Yan SY Wei KJ Wang ML Hibberd S Yang XJ Zhang JJ Liu 2009 Genomewide association study of leprosy N Engl J Med 361 2609 2618 20018961 10.1056/NEJMoa0903753 1:CAS:528:DC%2BC3cXjsFSmtg%3D%3D
40. F Zhang H Liu S Chen H Low L Sun Y Cui T Chu Y Li X Fu Y Yu G Yu B Shi H Tian D Liu X Yu J Li N Lu F Bao C Yuan J Liu L Zhang Y Sun M Chen Q Yang H Yang R Yang Q Wang F Zuo H Zhang CC Khor ML Hibberd S Yang X Zhang 2011 Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy Nat Genet 43 1247 1251 22019778 10.1038/ng.973 1:CAS:528: DC%2BC3MXhtlGksL7E