Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor

Microbial Pathogenesis

Volumn 53, Issue 2, 2012, Pages 109-112

  Park, Hae Chul ^a   Sung, So Ra ^a   Lim, Su Min ^a   Lee, Jong Sun ^b   Kim, Sung Kun ^b   Yoon, Moon Young ^a  

^a Hanyang University   (South Korea)

^b BAYLOR UNIVERSITY   (United States)

Author keywords

Anthrax lethal factor; Inhibitor screening; Naturally extracted chemicals; Proteolytic assay

Indexed keywords

5 [4 [2 (3' (3,5 DIHYDROXYPHENYL) 6' HYDROXY 2,2' BIS(4 HYDROXYPHENYL) 2,2',3,3' TETRAHYDRO 3,4' BIBENZOFURAN 5 YL) 6 HYDROXY 2, (4 HYDROXYPHENYL) 2,3 DIHYDROBENZOFURAN 3 YL]BENZENE 1,3 DIOL]; ANTHRAX TOXIN; ANTITOXIN; BACTERIAL PROTEIN; LETHAL FACTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG BINDING; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; LETHAL GENE; MACROPHAGE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BINDING SITES; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MACROPHAGES; MICE; MOLECULAR STRUCTURE; PROTEOLYSIS; SMALL MOLECULE LIBRARIES;

EID: 84862765248     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2012.04.004     Document Type: Article

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