Altered expression of CD46 and CD59 on leukocytes in neovascular age-related macular degeneration

American Journal of Ophthalmology

Volumn 154, Issue 1, 2012, Pages 193-199.e2

  Singh, Amardeep ^a,b   Faber, Carsten ^b   Falk, Mads ^a,b   Nissen, Mogens H ^b   Hviid, Thomas V F ^a,b   Sørensen, Torben L ^a,b  

^a Mental Health Services CPH   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; DECAY ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BODY MASS; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; EPIRETINAL MEMBRANE; FEMALE; GRANULOCYTE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LEUKOCYTE; MALE; MONOCYTE; NEOVASCULAR AGE RELATED MACULAR DEGENERATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEOVASCULARIZATION; SMOKING;

EID: 84862754558     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2012.01.036     Document Type: Article

References (43)

1. Klein R, Chou CF, Klein BE, Zhang X, Meuer SM, Saaddine JB. Prevalence of age-related macular degeneration in the US population. Arch Ophthalmol 2011;129(1):75-80.
2. Owen CG, Fletcher AE, Donoghue M, Rudnicka AR. How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom? Br J Ophthalmol 2003;87(3):312-317. (Pubitemid 36307906)
3. Woo JH, Sanjay S, Au Eong KG. The epidemiology of age-related macular degeneration in the Indian subcontinent. Acta Ophthalmol 2009;87(3):262-269.
4. Kawasaki R, Yasuda M, Song SJ, et al. The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology 2010;117(5):921-927.
5. Chakravarthy U, Wong TY, Fletcher A, et al. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol 2010;10:31.
6. Charbel IP, Chong NV, Scholl HP. The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application. Graefes Arch Clin Exp Ophthalmol 2011;249(2):163-174.
7. Markiewski MM, Lambris JD. The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol 2007;171(3):715-727. (Pubitemid 47440971)
8. Yang P, Tyrrell J, Han I, Jaffe GJ. Expression and modulation of RPE cell membrane complement regulatory proteins. Invest Ophthalmol Vis Sci 2009;50(7):3473-3481.
9. Bora NS, Gobleman CL, Atkinson JP, Pepose JS, Kaplan HJ. Differential expression of the complement regulatory proteins in the human eye. Invest Ophthalmol Vis Sci 1993;34(13):3579-3584. (Pubitemid 24011995)
10. Johnson LV, Leitner WP, Staples MK, Anderson DH. Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Exp Eye Res 2001;73(6):887-896. (Pubitemid 34112114)
11. Seddon JM, Sharma S, Adelman RA. Evaluation of the clinical age-related maculopathy staging system. Ophthalmology 2006;113(2):260-266. (Pubitemid 43170775)
12. Kaiser PK. Prospective evaluation of visual acuity assessment: a comparison of Snellen versus ETDRS charts in clinical practice (An AOS Thesis). Trans Am Ophthalmol Soc 2009;107:311-324.
13. Freedman ND, Leitzmann MF, Hollenbeck AR, Schatzkin A, Abnet CC. Cigarette smoking and subsequent risk of lung cancer in men and women: analysis of a prospective cohort study. Lancet Oncol 2008;9(7):649-656.
14. Burgisser P, Vaudaux J, Bart PA. Severe interference between retinal angiography and automated four-color flow cytometry analysis of blood mononuclear cells. Cytometry A 2007;71(8):632-636. (Pubitemid 47221726)
15. Johnson PT, Betts KE, Radeke MJ, Hageman GS, Anderson DH, Johnson LV. Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. Proc Natl Acad Sci U S A 2006;103(46):17456-17461. (Pubitemid 44788990)
16. Loeffler KU, Mangini NJ. Immunolocalization of ubiquitin and related enzymes in human retina and retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol 1997;235(4):248-254. (Pubitemid 27326095)
17. Zhou J, Jang YP, Kim SR, Sparrow JR. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A 2006;103(44):16182-16187. (Pubitemid 44715171)
18. Scholl HP, Charbel IP, Walier M, et al. Systemic complement activation in age-related macular degeneration. PLoS One 2008;3(7):e2593.
19. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005;308(5720):385-389. (Pubitemid 40530070)
20. Edwards AO, Ritter R III, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and age-related macular degeneration. Science 2005;308(5720):421-424. (Pubitemid 40530082)
21. Hageman GS, Anderson DH, Johnson LV, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A 2005;102(20):7227- 7232. (Pubitemid 40696361)
22. Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 2005;308(5720):419-421. (Pubitemid 40530081)
23. Gold B, Merriam JE, Zernant J, et al. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet 2006;38(4):458-462.
24. Fagerness JA, Maller JB, Neale BM, Reynolds RC, Daly MJ, Seddon JM. Variation near complement factor I is associated with risk of advanced AMD. Eur J Hum Genet 2009;17(1):100-104.
25. Rohrer B, Coughlin B, Kunchithapautham K, et al. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Mol Immunol 2011;48(6 -7):e1-e8.
26. Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP. CD46: expanding beyond complement regulation. Trends Immunol 2004;25(9):496-503. (Pubitemid 39490257)
27. Giddings KS, Zhao J, Sims PJ, Tweten RK. Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol 2004;11(12):1173-1178.
28. Haas P, Aggermann T, Nagl M, Steindl-Kuscher K, Krugluger W, Binder S. Implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration. Am J Ophthalmol 2011;152(3):396-399.
29. Harkness KA, Sussman JD, Davies-Jones GA, Greenwood J, Woodroofe MN. Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells. J Neuroimmunol 2003;142(1-2):1-9. (Pubitemid 38368583)
30. Chen M, Forrester JV, Xu H. Dysregulation in retinal para-inflammation and age-related macular degeneration in CCL2 or CCR2 deficient mice. PLoS One 2011;6(8):e22818.
31. Ambati J, Anand A, Fernandez S, et al. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med 2003;9(11):1390-1397. (Pubitemid 37466188)
32. Koch N, Jung M, Sabat R, et al. IL-10 protects monocytes and macrophages from complement-mediated lysis. J Leukoc Biol 2009;86(1):155-166.
33. Bora NS, Kaliappan S, Jha P, et al. CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration. J Immunol 2007;178(3):1783-1790. (Pubitemid 46154650)
34. Bora NS, Jha P, Lyzogubov VV, et al. Recombinant membrane- targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice. J Biol Chem 2010;285(44):33826-33833.
35. Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z. Cell signals transduced by complement. Mol Immunol 2004;41(6-7):583-597. (Pubitemid 38824616)
36. Kunchithapautham K, Rohrer B. Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem 2011;286(27):23717-23724.
37. Vogt SD, Curcio CA, Wang L, et al. Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. Exp Eye Res 2011;93(4):413-423.
38. Thornton J, Edwards R, Mitchell P, Harrison RA, Buchan I, Kelly SP. Smoking and age-related macular degeneration: a review of association. Eye (Lond) 2005;19(9):935-944. (Pubitemid 43114972)
39. Robbins RA, Nelson KJ, Gossman GL, Koyama S, Rennard SI. Complement activation by cigarette smoke. Am J Physiol 1991;260(4 Pt 1):L254-L259.
40. Kew RR, Ghebrehiwet B, Janoff A. Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement. J Clin Invest 1985;75(3):1000-1007. (Pubitemid 15115269)
41. Palestine AG, Nussenblatt RB, Chan CC, Hooks JJ, Friedman L, Kuwabara T. Histopathology of the subretinal fibrosis and uveitis syndrome. Ophthalmology 1985;92(6):838-844. (Pubitemid 15060017)
42. Lim WK, Chee SP, Sng I, Nussenblatt RB, Chan CC. Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. Am J Ophthalmol 2004;138(3):475-477. (Pubitemid 39208579)
43. Iyer A, Woodruff TM, Wu MC, et al. Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. J Cardiovasc Pharmacol 2011;58(5):479-486.