Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose

Molecular Endocrinology

Volumn 23, Issue 1, 2009, Pages 113-123

  Shen, Joseph J ^a   Huang, Lihua ^b   Li, Liunan ^c   Jorgez, Carolina ^b   Matzuk, Martin M ^b   Brown, Chester W ^b  

^a CHILDREN S HOSPITAL CENTRAL CALIFORNIA   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL METABOLIC RATE; BODY WEIGHT; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; LIPID DIET; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE ADIPOSE TISSUE; WILD TYPE;

3T3-L1 CELLS; ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; BASAL METABOLISM; DIETARY FATS; ENERGY METABOLISM; FEMALE; GENE EXPRESSION; GROWTH DIFFERENTIATION FACTOR 3; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; RNA, MESSENGER;

MUS;

EID: 58149214269     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2007-0322     Document Type: Article

References (45)

1. Altmann CR, Chang C, Munoz-Sanjuan I, Bell E, Heke M, Rifkin DB, Brivanlou AH 2002 The latent-TGFβ-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Dev Biol 248:118-127
2. Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN, McPherron AC, Wolfman NM, Lee SJ 2002 Induction of cachexia in mice by systemically administered myostatin. Science 296:1486-1488
3. Carlson CJ, Booth FW, Gordon SE 1999 Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading. Am J Physiol 277:R601-R606
4. Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM 2000 Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet 25:453-457
5. Brown CW, Li L, Houston-Hawkins DE, Matzuk MM 2003 Activins are critical modulators of growth and survival. Mol Endocrinol 17:2404-2417
6. Shah SB, Skromne I, Hume CR, Kessler DS, Lee KJ, Stern CD, Dodd J 1997 Misexpression of chick Vg1 in the marginal zone induces primitive streak formation. Development 124:5127-5138
7. Skromne I, Stern CD 2002 A hierarchy of gene expression accompanying induction of the primitive streak by Vg1 in the chick embryo. Mech Dev 114:115-118
8. Skromne I, Stern CD 2001 Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo. Development 128:2915-2927
9. Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW 2006 The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development 133:319-329
10. Levine AJ, Brivanlou AH 2006 GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos. Development 133:209-216
11. Andersson O, Bertolino P, Ibanez CF 2007 Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol 311:500-511
12. Caricasole AA, van Schaik RH, Zeinstra LM, Wierikx CD, van Gurp RJ, van den Pol M, Looijenga LH, Oosterhuis JW, Pera MF, Ward A, de Bruijn D, Kramer P, de Jong FH, van den Eijnden-van Raaij AJ 1998 Human growth- differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours. Oncogene 16:95-103
13. Jones CM, Simon-Chazottes D, Guenet JL, Hogan BL 1992 Isolation of Vgr-2, a novel member of the transforming growth factor-β-related gene family. Mol Endocrinol 6:1961-1968
14. Korkola JE, Houldsworth J, Chadalavada RS, Olshen AB, Dobrzynski D, Reuter VE, Bosl GJ, Chaganti RS 2006 Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res 66:820-827
15. Ezeh UI, Turek PJ, Reijo RA, Clark AT 2005 Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 104:2255-2265
16. Sottile V, Seuwen K 2000 Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone). FEBS Lett 475:201-204
17. Ji X, Chen D, Xu C, Harris SE, Mundy GR, Yoneda T 2000 Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A. J Bone Miner Metab 18:132-139
18. Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L 2003 Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis. Mol Cell Biol 23:7230-7242
19. Feldman BJ, Streeper RS, Farese Jr RV, Yamamoto KR 2006 Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci USA 103:15675-15680
20. Clouthier DE, Comerford SA, Hammer RE 1997 Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-β1 transgenic mice. J Clin Invest 100:2697-2713
21. Choy L, Derynck R 2003 Transforming growth factor-β inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem 278:9609-9619
22. Choy L, Skillington J, Derynck R 2000 Roles of autocrine TGF-β receptor and Smad signaling in adipocyte differentiation. J Cell Biol 149:667-682
23. McPherron AC, Lee S-J 1993 GDF-3 and GDF-9: two new members of the transforming growth factor-β superfamily containing a novel pattern of cysteines. J Biol Chem 268:3444-3449
24. Witthuhn BA, Bernlohr DA 2001 Upregulation of bone morphogenetic protein GDF-3/Vgr-2 expression in adipose tissue of FABP4/aP2 null mice. Cytokine 14:129-135
25. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr AW 2003 Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
26. Wang W, Yang Y, Meng Y, Shi Y 2004 GDF-3 is an adipogenic cytokine under high fat dietary condition. Biochem Biophys Res Commun 321:1024-1031
27. Andersson O, Korach-Andre M, Reissmann E, Ibanez CF, Bertolino P 2008 Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc Natl Acad Sci USA 105:7252-7256
28. Fried SK, Leibel RL, Edens NK, Kral JG 1993 Lipolysis in intraabdominal adipose tissues of obese women and men. Obes Res 1:443-448
29. Lefebvre AM, Laville M, Vega N, Riou JP, van Gaal L, Auwerx J, Vidal H 1998 Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 47:98-103
30. Montague CT, Prins JB, Sanders L, Zhang J, Sewter CP, Digby J, Byrne CD, O'Rahilly S 1998 Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes 47:1384-1391
31. Montague CT 2002 Adipose depot-specific effects of PPAR γ agonists: a consequence of differential expression of PPAR γ in adipose tissue depots? Diabetes Obes Metab 4:356-361
32. Moller DE, Kaufman KD 2005 Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 56:45-62
33. Schier AF 2003 Nodal signaling in vertebrate development. Annu Rev Cell Dev Biol 19:589-621
34. Schier AF, Shen MM 2000 Nodal signalling in vertebrate development. Nature 403:385-389
35. Whitman M, Mercola M 2001 TGF-β superfamily signaling and left-right asymmetry. Sci STKE 2001:RE1
36. De Taeye B, Smith LH, Vaughan DE 2005 Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease. Curr Opin Pharmacol 5:149-154
37. Gregoire FM, Smas CM, Sul HS 1998 Understanding adipocyte differentiation. Physiol Rev 78:783-809
38. Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras A-C, Katsume A, Elchebly M, Spiegelman BM, Harper M-E, Tremblay ML, Sonenberg N 2001 Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med 7:1128-1132
39. Cederberg A, Gronning LM, Ahren B, Tasken K, Carlsson P, Enerback S 2001 FOXC2 is a winged helix gene that counteracts obesity, hypertriglyderidemia, and diet-induced insulin resistance. Cell 106:563-573
40. Soloveva V, Graves RA, Rasenick MM, Spiegelman BM, Ross SR 1997 Transgenic mice overexpressing the β1-adrenergic receptor in adipose tissue are resistant to obesity. Mol Endocrinol 11:27-38
41. Hansen JB, Jorgensen C, Petersen RK, Hallenborg P, De Matteis R, Boye HA, Petrovic N, Enerback S, Nedergaard J, Cinti S, te Riele H, Kristiansen K 2004 Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci USA 101:4112-4117
42. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D, Langin D 2003 Acquirement of brown fat cell features by human white adipocytes. J Biol Chem 278:33370-33376
43. Bradley A 1987 Production and analysis of chimaeric mice. In: Robertson EJ, ed. Teratocarcinomas and embryonic stem cells: a practical approach. Oxford, UK: IRL; 131-151
44. Matzuk MM, Finegold MJ, Su J-GJ, Hsueh AJW, Bradley A 1992 α-Inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360:313-319
45. Guo KY, Halo P, Leibel RL, Zhang Y 2004 Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am J Physiol Regul Integr Comp Physiol 287:R112-R119