Chemopreventive effects of elm tree bark extract on Helicobacter pylori-associated mouse gastric carcinogenesis

Basic and Applied Pathology

Volumn 5, Issue 2, 2012, Pages 31-38

  Kim, Tae Wang ^a   Youm, So Young ^a   Shin, Sang Kyung ^a   Kim, Dae Joong ^a   Hong, Jin Tae ^b   Kim, Youngsoo ^b   Nam, Sang Yoon ^a   Ahn, Byeongwoo ^a  

^a College of Veterinary Medicine ^*  (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

catenin; Chronic gastritis; Intestinal metaplasia; Stomach neoplasms; Ulmus davidiana japonica.

Indexed keywords

EID: 84862732927     PISSN: None     EISSN: 17559294     Source Type: Journal    
DOI: 10.1111/j.1755-9294.2012.01125.x     Document Type: Article

References (50)

1. Brenner H, Rothenbacher D, Arndt V. Epidemiology of stomach cancer. Methods Mol Biol 2009; 472: 467-77.
2. Tsukamoto T, Mizoshita T, Tatematsu M. Animal models of stomach carcinogenesis. Toxicol Pathol 2007; 35: 636-48.
3. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992; 52: 6735-40.
4. Goldenring JR, Nomura S. Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Am J Physiol Gastrointest Liver Physiol 2006; 291: G999-1004.
5. Correa P. A human model of gastric carcinogenesis. Cancer Res 1988; 48: 3554-60.
6. Reis CA, David L, Correa P et al Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer Res 1999; 59: 1003-7.
7. Kaneko Y, Yanagihara K, Miyazaki Y et al Overproduction of MUC5AC core protein in patients with diffuse panbronchiolitis. Respiration 2003; 70: 475-8.
8. Hoffmann W, Hauser F. The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia Trends Biochem Sci 1993; 18: 239-43.
9. Wong WM, Poulsom R, Wright NA. Trefoil peptides. Gut 1999; 44: 890-5.
10. Taupin D, Pedersen J, Familari M, Cook G, Yeomans N, Giraud AS. Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium. Lab Invest 2001; 81: 397-408.
11. Haruma K, Komoto K, Kamada T et al Helicobacter pylori infection is a major risk factor for gastric carcinoma in young patients. Scand J Gastroenterol 2000; 35: 255-9.
12. Blaser MJ, Chyou PH, Nomura A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res 1995; 55: 562-5.
13. Maeda S, Yoshida H, Ogura K et al H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells. Gastroenterology 2000; 119: 97-108.
14. Penta R, De Falco M, Iaquinto G, De Luca A. Helicobacter pylori and gastric epithelial cells: from gastritis to cancer. J Exp Clin Cancer Res 2005; 24: 337-45.
15. Yamaoka Y, Ojo O, Fujimoto S et al Helicobacter pylori outer membrane proteins and gastroduodenal disease. Gut 2006; 55: 775-81.
16. Nakayama M, Hisatsune J, Yamasaki E et al Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. J Biol Chem 2009; 284: 1612-9.
17. Sokolova O, Bozko PM, Naumann M. Helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity. J Biol Chem 2008; 283: 29367-74.
18. Chen XY, Wang ZC, Li H et al Nuclear translocations of beta-catenin and TCF4 in gastric cancers correlate with lymph node metastasis but probably not with CD44 expression. Hum Pathol 2005; 36: 1294-301.
19. Takasu S, Tsukamoto T, Ushijima T et al Cyclin D1 overexpression in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas. Exp Toxicol Pathol 2007; 59: 171-5.
20. Lynch HT, Grady W, Suriano G, Huntsman D. Gastric cancer: new genetic developments. J Surg Oncol 2005; 90: 114-33.
21. Nabais S, Machado JC, Lopes C, Seruca R, Carneiro F, Sobrinho-Simões M. Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis. Int J Surg Pathol 2003; 11: 1-9.
22. Utsunomiya T, Doki Y, Takemoto H et al Correlation of beta-catenin and cyclin D1 expression in colon cancers. Oncology 2001; 61: 226-33.
23. Lee KH, Lee HE, Cho SJ et al Immunohistochemical analysis of cell cycle-related molecules in gastric carcinoma: prognostic significance, correlation with clinicopathological parameters, proliferation and apoptosis. Pathobiology 2008; 75: 364-72.
24. Gao P, Zhou GY, Liu Y, Li JS, Zhen JH, Yuan YP. Alteration of cyclin D1 in gastric carcinoma and its clinicopathologic significance. World J Gastroenterol 2004; 10: 2936-9.
25. Lee SJ. Korean Folk Medicine, Monographs Series No. 3. Seoul: Seoul National University Press, 1966.
26. Kim HK, Lim YM, Kim DK, Nho YC. Effect of natural extracts mixture from Houttuynia cordata and Ulmus davidiana var. japonica in mast cell-induced allergic inflammatory response. Lab Anim Res 2008; 24: 1-7.
27. Lee JC, Lim KT. Inhibitory effects of the ethanol extract of Ulmus davidiana on apoptosis induced by glucose-glucose oxidase and cytokine production in cultured mouse primary immune cells. J Biochem Mol Biol 2001; 34: 463-71.
28. Son YO, Lee KY, Choi KC et al Inhibitory effects of glycoprotein-120 (G-120) from Ulmus davidiana Nakai on cell growth and activation of matrix metalloproteinases. Mol Cells 2004; 18: 163-70.
29. Jung HJ, Jeon HJ, Lim EJ et al Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica. J Ethnopharmacol 2007; 112: 406-9.
30. Yun JH, Lee JH, Kim TH, Lyu YS, Kang HW. Study on antigastritic and anti Helicobacter pylori effects from water extract of Ulmus davidiana var. japonica Nakai. Korean J Orient Physiol Pathol 2008; 22: 108-14.
31. Kwon HJ, Kim TM, Ryu JM et al Chemopreventive effects of elm tree root extract on colonic aberrant crypt foci induced by 1, 2-dimethylhydrazine in F344 rats. J Food Sci Nutr 2008; 13: 157-65.
32. Nam KT, Hahm KB, Oh SY et al The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model. Clin Cancer Res 2004; 10: 8105-13.
33. Lauren P. The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
34. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996; 20: 1161-81.
35. Tatematsu M, Tsukamoto T, Yamamoto M. Preneoplastic changes of stomach cancer: mice, rats and Mongolian gervils. J Toxicol Pathol 2002; 15: 133-6.
36. Zhang F, Tang JM, Wang L et al Detection of beta-catenin, gastrokine-2 and embryonic stem cell expressed ras in gastric cancers. Int J Clin Exp Pathol 2010; 3: 782-91.
37. Park WS, Oh RR, Park JY et al Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Cancer Res 1999; 59: 4257-60.
38. Tsukamoto T, Yamamoto M, Ogasawara N et al Beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer Sci 2003; 94: 1046-51.
39. Shtutman M, Zhurinsky J, Simcha I et al The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A 1999; 96: 5522-7.
40. Guilford P, Hopkins J, Harraway J et al E-cadherin germline mutations in familial gastric cancer. Nature 1998; 392: 402-5.
41. Shimoyama Y, Hirohashi S. Expression of E- and P-cadherin in gastric carcinomas. Cancer Res 1991; 51: 2185-92.
42. Suzuki M, Mimuro H, Suzuki T, Park M, Yamamoto T, Sasakawa C. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med 2005; 202: 1235-47.
43. Murata-Kamiya N, Kurashima Y, Teishikata Y et al Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene 2007; 26: 4617-26.
44. Brambilla E, Moro D, Gazzeri S, Brambilla C. Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance. J Pathol 1999; 188: 351-60.
45. Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouysségur J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 1996; 271: 20608-16.
46. Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 1999; 19: 2690-8.
47. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398: 422-6.
48. Arber N, Hibshoosh H, Moss SF et al Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology 1996; 110: 669-74.
49. Buckley MF, Sweeney KJ, Hamilton JA et al. Expression and amplification of cyclin genes in human breast cancer. Oncogene 1993; 8: 2127-33.
50. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 2003; 1653: 1-24.