Detection of β-catenin, gastrokine-2 and embryonic stem cell expressed ras in gastric cancers

International Journal of Clinical and Experimental Pathology

Volumn 3, Issue 8, 2010, Pages 782-791

  Zhang, Fan ^a   Tang, Jian Min ^b   Wang, Li ^a   Shen, Jing Ying ^b   Zheng, Lin ^a   Wu, Ping Ping ^a   Zhang, Mei ^a   Yan, Zhao Wen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Beta catenin; Eras; Gastric mucosa; Gastrokine 2; Stomach neoplasm

Indexed keywords

BETA CATENIN; CARRIER PROTEIN; CTNNB1 PROTEIN, HUMAN; ERAS PROTEIN, HUMAN; GKN2 PROTEIN, HUMAN; PROTEIN P21; TUMOR MARKER;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CELL NUCLEUS; EMBRYONIC STEM CELL; FEMALE; HUMAN; LYMPH NODE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH MUCOSA; STOMACH TUMOR; TISSUE MICROARRAY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CARRIER PROTEINS; CELL NUCLEUS; EMBRYONIC STEM CELLS; FEMALE; GASTRIC MUCOSA; HUMANS; LYMPH NODES; MALE; MIDDLE AGED; ONCOGENE PROTEIN P21(RAS); STOMACH NEOPLASMS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 79953138858     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Yamamoto T, Nagahama R, Nakashima H, Suyama M, Yoshida M, Ohkura Y, Watanabe N, Hirashima H, Miyamoto A. Basis of the diagnosis and feature of scirrhous gastric cancer. Stomach and Intestine (Tokyo) 2010; 45: 428-444.
2. Nabais S, Machado JC, Lopes C, Seruca R, Carneiro F, Sobrinho-Simoes M. Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis. Int J Surg Pathol 2003; 11: 1-9.
3. Utsunomiya T, Doki Y, Takemoto H, Shiozaki H, Yano M, Sekimoto M, Tamura S, Yasuda T, Fujiwara Y, Monden M. Correlation of beta-catenin and cyclin D1 expression in colon cancer. Oncology 2001; 61: 226-233.
4. Brabletz T, Herrmann K, Jung A, Faller G, Kirchner T. Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am J Pathol 2000; 156: 865-870.
5. Grabsch H, Takeno S, Noguchi T, Hommel G, Gabbert HE, Mueller W. Different patterns of beta-catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome. Histopathology 2001; 39: 141-149.
6. Hung KH, Wu JJ, Yang HB, Su LJ, Sheu BS. Host Wnt/beta-catenin pathway triggered by Helicobacter pylori correlates with regression of gastric intestinal metaplasia after H. pylori eradication. J Med Microbiol 2009; 58: 567-576.
7. Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Gaus K, O'Brien DP, Romero-Gallo J, Peek RM Jr. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A 2005; 102:10646-10651.
8. Barth AI, Näthke IS, Nelson WJ. Caderins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol 1997; 9: 683-690.
9. Wang L, Zhang F, Wu PP, Jiang XC, Zheng L, Yu YY. Disordered beta-catenin expression and Ecadherin/ CDH1 promoter methylation in gastric carcinoma. World J Gastroenterol 2006; 12: 4228-4231.
10. Wang JY, Hsieh JS, Chen CC, Tzou WS, Cheng TL, Chen FM, Huang TJ, Huang YS, Huang SY, Yang T, Lin SR. Alterations of APC, c-met, and p53 genes in tumor tissue and serum of patients with gastric cancers. J Surg Res 2004; 120: 242-248.
11. Tsukamoto T, Yamamoto M, Ogasawara N, Ushijima T, Nomoto T, Fujita H, Matsushima T, Nozaki K, Cao X, Tatematsu M. Beta-catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer Sci 2003; 94: 1046-1051.
12. Sasaki Y, Morimoto I, Kusano M, Hosokawa M, Itoh F, Yanagihara K, Imai K, Tokino T. Mutational analysis of the beta-catenin gene in gastric carcinoma. Tumour Biol 2001; 22: 123-130.
13. Otto WR, Patel K, McKinnell I, Evans MD, Lee CY, Frith D, Hanrahan S, Blight K, Blin N, Kayademir T, Poulsom R, Jeffery R, Hunt T, Wright NA, McGregor F, Oien KA. Identification of blottin: a novel gastric trefoil factor family-2 binding protein. Proteomics 2006; 6:4235-4245.
14. Moss SF, Lee JW, Sabo E, Rubin AK, Rommel J, Westley BR, May FE, Gao J, Meitner PA, Tavares R, Resnick MB. Decreased expression of gastrokine1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. Clin Cancer Res 2008; 14: 4161-4167.
15. May FE, Griffin SM, Westley BR. The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosael cells but the co-expression of these proteins is deregulated in gastric cancer. Int J Biochem Cell Biol 2009; 41: 632-640.
16. Resnick MB, Sabo E, Meitner PA, Kim SS, Cho Y, Kim HK, Tavares R, Moss SF. Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo. Gut 2006; 55: 1717-1724.
17. Du JJ, Dou KF, Peng SY, Wang WZ, Wang ZH, Xiao HS, Guan WX, Liu YB, Gao ZQ. Downregulated full-length novel gene GDDR and its effect on gastric cancer. Zhonghua Yi Xue Za Zhi 2003; 83: 1166-1168.
18. Baus-Loncar M, Lubka M, Pusch CM, Otto WR, Poulsom R, Blin N. Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells. Cell Physiol Biochem 2007; 20: 193-204.
19. Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM, Oshima M. Activated macrophages promote Wnt signaling through tumour necrosis factoralpha in gastric tumor cells. EMBO J 2008; 27:1671-1681.
20. Kristensen DM, Kalisz M, Nielsen JH. Cytokine signaling in embryonic stem cells. APMIS 2005; 113: 756-772.
21. Takahashi K, Mitsui K, Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 2003; 423: 541-545.
22. Yasuda K, Yashiro M, Sawada T, Ohira M, Hirakawa K. Clinical significance of ERas oncogene on cancer. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition): J Clin Oncol 2007; 25 Suppl 18: S15083.
23. Kaizaki R, Yashiro M, Shinto O, Yasuda K, Matsuzaki T, Sawada T, Hirakawa K. Expression of ERas oncogene in gastric carcinoma. Anticancer Res 2009; 29: 2189-2193.
24. Everly DN Jr, Kusano S, Raab-Traub N. Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells. J Virol 2004; 78: 11648-11655.
25. Rugge M, Correa P, Dixon MF, Hattori T, Leandro G, Lewin K, Riddell RH, Sipponen P, Watanabe H. Gastric dysplasia: the Padova international classification. Am J Surg Pathol 2000; 24: 167-176.
26. Tsukashita S, Kushima R, Bamba M, Nakamura E, Mukaisho K, Sugihara H, Hattori T. Betacatenin expression in intramucosael neoplastic lesions of the stomach. Oncology 2003; 64: 251-258.
27. D'Odorico A, Cassaro M, Grillo S, Lazzari R, Buda A, Cardellini P, Sturniolo Giacomo C, Rugge M. Trefoil peptides, E-cadherin, and betacatenin expression in sporadic fundic gland polyps: further evidence toward the benign nature of these lesions. Appl Immunohistochem Mol Morphol 2009; 17:431-437.
28. Ishida K, Ito S, Wada N, Deguchi H, Hata T, Hosoda M, Nohno T. Nuclear localization of betacatenin involved in precancerous changes in oral leukoplakia. Mol Cancer 2007; 6: 62.
29. Miyazawa K, Iwaya K, Kuroda M, Harada M, Serizawa H, Koyanagi Y, Sato Y, Mizokami Y, Matsuoka T, Mukai K. Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion. Virchows Arch 2000; 437: 508-513.
30. Yashiro M, Yasuda K, Nishii T, Kaizaki R, Sawada T, Ohira M, Hirakawa K. Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells. Int J Oncol 2009; 35: 997-1003.
31. Kameda T, Thomson JA. Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript. Stem Cells 2005; 23: 1535-1540.
32. Calvanese V, Lara E, Kahn A, Fraga MF. The role of epigenetics in aging and age-related diseases. Ageing Res Rev 2009; 8: 268-276.
33. Nakayama M, Hisatsune J, Yamasaki E, Isomoto H, Kurazono H, Hatakeyama M, Azuma T, Yamaoka Y, Yahiro K, Moss J, Hirayama T. Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. J Biol Chem 2009; 284: 1612-1619.