Quantification of myocardial blood flow with 82Rb positron emission tomography: Clinical validation with 15O-water

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 39, Issue 6, 2012, Pages 1037-1047

  Prior, John O ^a   Allenbach, Gilles ^a   Valenta, Ines ^b   Kosinski, Marek ^a   Burger, Cyrill ^b   Verdun, Francis R ^a   Bischof Delaloye, Angelika ^a   Kaufmann, Philipp A ^b,c  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b Cardiac Imaging ^*  (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Coronary artery disease; Healthy subjects; Myocardial blood flow; Positron emission tomography; Rubidium 82

Indexed keywords

ADENOSINE; OXYGEN 15; OXYGEN 15 WATER; RUBIDIUM CHLORIDE RB 82; UNCLASSIFIED DRUG; WATER;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY DISEASE; DIAGNOSTIC ACCURACY; FEMALE; FLOW RATE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE BLOOD FLOW RESERVE; HEART MUSCLE PERFUSION; HUMAN; HYPEREMIA; MALE; POSITRON EMISSION TOMOGRAPHY; REST;

ADULT; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; CORONARY CIRCULATION; FEMALE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL PERFUSION IMAGING; OXYGEN RADIOISOTOPES; POSITRON-EMISSION TOMOGRAPHY; REPRODUCIBILITY OF RESULTS; RUBIDIUM RADIOISOTOPES; WATER;

EID: 84862686055     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-012-2082-3     Document Type: Article

References (62)

1. KL Gould RA Goldstein NA Mullani RL Kirkeeide WH Wong TJ Tewson, et al. 1986 Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac imaging without a cyclotron using generator-produced rubidium-82 J Am Coll Cardiol 7 775 789 3485669 10.1016/S0735-1097(86)80336-9 1:STN:280:DyaL287mvFaquw%3D%3D
2. J Machac 2005 Cardiac positron emission tomography imaging Semin Nucl Med 35 17 36 15645392 10.1053/j.semnuclmed.2004.09.002
3. HR Schelbert 2009 Quantification of myocardial blood flow: what is the clinical role? Cardiol Clin 27 277 289 19306770 10.1016/j.ccl.2008.12.009
4. TM Bateman GV Heller AI McGhie JD Friedman JA Case JR Bryngelson, et al. 2006 Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99m sestamibi SPECT J Nucl Cardiol 13 24 33 16464714 10.1016/j.nuclcard.2005.12.004
5. UK Sampson S Dorbala A Limaye R Kwong MF Di Carli 2007 Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease J Am Coll Cardiol 49 1052 1058 17349884 10.1016/j.jacc.2006.12.015 1:CAS:528:DC%2BD2sXivVams7o%3D
6. AM Groves ME Speechly-Dick JC Dickson I Kayani R Endozo P Blanchard, et al. 2007 Cardiac (82)rubidium PET/CT: initial European experience Eur J Nucl Med Mol Imaging 34 1965 1972 17768620 10.1007/s00259-007-0537-8
7. P Herrero J Markham ME Shelton CJ Weinheimer SR Bergmann 1990 Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model Circulation 82 1377 1386 2401071 10.1161/01.CIR.82.4.1377 1:STN:280:DyaK3czotFyqtA%3D%3D
8. K Yoshida N Mullani KL Gould 1996 Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia J Nucl Med 37 1701 1712 8862316 1:STN:280:DyaK2s%2FhsFKlug%3D%3D
9. SC Huang BA Williams J Krivokapich L Araujo ME Phelps HR Schelbert 1989 Rabbit myocardial 82Rb kinetics and a compartmental model for blood flow estimation Am J Physiol 256 H1156 H1164 2784945 1:STN:280:DyaL1M3gsFOksA%3D%3D
10. P Herrero J Markham ME Shelton SR Bergmann 1992 Implementation and evaluation of a two-compartment model for quantification of myocardial perfusion with rubidium-82 and positron emission tomography Circ Res 70 496 507 1537087 1:CAS:528:DyaK38XhvFSgsrY%3D
11. PG Coxson RH Huesman L Borland 1997 Consequences of using a simplified kinetic model for dynamic PET data J Nucl Med 38 660 667 9098221 1:STN:280:DyaK2s3lt1OlsQ%3D%3D
12. JW Lin RR Sciacca RL Chou AF Laine SR Bergmann 2001 Quantification of myocardial perfusion in human subjects using 82Rb and wavelet-based noise reduction J Nucl Med 42 201 208 11216517 1:STN:280:DC%2BD3M7kt1Crug%3D%3D
13. G El Fakhri A Sitek B Guerin MF Kijewski MF Di Carli SC Moore 2005 Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses J Nucl Med 46 1264 1271 16085581
14. M Lortie RS Beanlands K Yoshinaga R Klein JN Dasilva RA Dekemp 2007 Quantification of myocardial blood flow with (82)Rb dynamic PET imaging Eur J Nucl Med Mol Imaging 34 1765 1774 17619189 10.1007/s00259-007-0478-2
15. J Knuuti S Kajander M Maki H Ukkonen 2009 Quantification of myocardial blood flow will reform the detection of CAD J Nucl Cardiol 16 497 506 19495903 10.1007/s12350-009-9101-1
16. K Yoshinaga O Manabe C Katoh L Chen R Klein M Naya, et al. 2010 Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET Eur J Nucl Med Mol Imaging 37 2233 2241 20625721 10.1007/s00259-010-1541-y
17. K Yoshinaga O Manabe N Tamaki 2011 Assessment of coronary endothelial function using PET J Nucl Cardiol 18 486 500 21448758 10.1007/s12350-011-9370-3
18. RS Beanlands O Muzik P Melon R Sutor S Sawada D Muller, et al. 1995 Noninvasive quantification of regional myocardial flow reserve in patients with coronary atherosclerosis using nitrogen-13 ammonia positron emission tomography. Determination of extent of altered vascular reactivity J Am Coll Cardiol 26 1465 1475 7594072 10.1016/0735-1097(95)00359-2 1:STN:280:DyaK28%2FmtV2nsw%3D%3D
19. PG Camici F Crea 2007 Coronary microvascular dysfunction N Engl J Med 356 830 840 17314342 10.1056/NEJMra061889 1:CAS:528:DC%2BD2sXhvFKltLY%3D
20. MM Hajjiri MB Leavitt H Zheng AE Spooner AJ Fischman H Gewirtz 2009 Comparison of positron emission tomography measurement of adenosine-stimulated absolute myocardial blood flow versus relative myocardial tracer content for physiological assessment of coronary artery stenosis severity and location JACC Cardiovasc Imaging 2 751 758 19520347 10.1016/j.jcmg.2009.04.004
21. BA Herzog L Husmann I Valenta O Gaemperli PT Siegrist FM Tay, et al. 2009 Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve J Am Coll Cardiol 54 150 156 19573732 10.1016/j.jacc.2009.02.069
22. P Knaapen PG Camici KM Marques R Nijveldt JJ Bax N Westerhof, et al. 2009 Coronary microvascular resistance: methods for its quantification in humans Basic Res Cardiol 104 485 498 19468781 10.1007/s00395-009-0037-z
23. D Neglia A L'Abbate 2009 Myocardial perfusion reserve in ischemic heart disease J Nucl Med 50 175 177 19164216 10.2967/jnumed.108.056317
24. RA Tio A Dabeshlim HM Siebelink J de Sutter HL Hillege CJ Zeebregts, et al. 2009 Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease J Nucl Med 50 214 219 19164219 10.2967/jnumed.108.054395
25. K Fukushima MS Javadi T Higuchi R Lautamaki J Merrill SG Nekolla, et al. 2011 Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging J Nucl Med 52 726 732 21498538 10.2967/jnumed.110.081828
26. MC Ziadi RA Dekemp KA Williams A Guo BJ Chow JM Renaud, et al. 2011 Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia J Am Coll Cardiol 58 740 748 21816311 10.1016/j.jacc.2011.01.065
27. RS Beanlands MC Ziadi K Williams 2009 Quantification of myocardial flow reserve using positron emission imaging the journey to clinical use J Am Coll Cardiol 54 157 159 19573733 10.1016/j.jacc.2009.03.049
28. PG Camici OE Rimoldi 2009 The clinical value of myocardial blood flow measurement J Nucl Med 50 1076 1087 19525470 10.2967/jnumed.108.054478
29. R Lautamaki RT George K Kitagawa T Higuchi J Merrill C Voicu, et al. 2009 Rubidium-82 PET-CT for quantitative assessment of myocardial blood flow: validation in a canine model of coronary artery stenosis Eur J Nucl Med Mol Imaging 36 576 586 18985343 10.1007/s00259-008-0972-1
30. G El Fakhri A Kardan A Sitek S Dorbala N Abi-Hatem Y Lahoud, et al. 2009 Reproducibility and accuracy of quantitative myocardial blood flow assessment with 82Rb PET: comparison with 13N-ammonia PET J Nucl Med 50 1062 1071 19525467 10.2967/jnumed.104.007831
31. PG Camici 2009 Absolute figures are better than percentages JACC Cardiovasc Imaging 2 759 760 19520348 10.1016/j.jcmg.2009.04.005
32. SR Bergmann KA Fox AL Rand KD McElvany MJ Welch J Markham, et al. 1984 Quantification of regional myocardial blood flow in vivo with H215O Circulation 70 724 733 6332687 10.1161/01.CIR.70.4.724 1:STN:280:DyaL2M%2Fgt1agtw%3D%3D
33. A Bol JA Melin JL Vanoverschelde T Baudhuin D Vogelaers M De Pauw, et al. 1993 Direct comparison of [13N]ammonia and [15O]water estimates of perfusion with quantification of regional myocardial blood flow by microspheres Circulation 87 512 525 8425298 1:STN:280:DyaK3s7ksFCltg%3D%3D
34. GA Diamond JS Forrester 1979 Analysis of probability as an aid in the clinical diagnosis of coronary artery disease N Engl J Med 300 1350 1358 440357 10.1056/NEJM197906143002402 1:STN:280:DyaE1M7nvVCrtg%3D%3D
35. I Adachi O Gaemperli I Valenta T Schepis PT Siegrist V Treyer, et al. 2007 Assessment of myocardial perfusion by dynamic O-15-labeled water PET imaging: validation of a new fast factor analysis J Nucl Cardiol 14 698 705 17826323 10.1016/j.nuclcard.2007.05.012
36. S Senthamizhchelvan PE Bravo C Esaias MA Lodge J Merrill RF Hobbs, et al. 2010 Human biodistribution and radiation dosimetry of 82Rb J Nucl Med 51 1592 1599 20847168 10.2967/jnumed.110.077669
37. AJ Einstein KW Moser RC Thompson MD Cerqueira MJ Henzlova 2007 Radiation dose to patients from cardiac diagnostic imaging Circulation 116 1290 1305 17846343 10.1161/CIRCULATIONAHA.107.688101
38. K Yoshinaga BJ Chow K Williams L Chen RA de Kemp L Garrard, et al. 2006 What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? J Am Coll Cardiol 48 1029 1039 16949498 10.1016/j.jacc.2006.06.025
39. Schelbert HR. Positron emission tomography of the heart: methodology, findings in the normal and the diseased heart, and clinical applications. In: Phelps ME, editor. Molecular imaging and its biological applications. 1st ed. New York: Springer; 2004. p. 389-508.
40. P Royston 1992 sg1.2: nonlinear regression command Stata Tech Bull 7 11 18
41. LI Lin 1989 A concordance correlation coefficient to evaluate reproducibility Biometrics 45 255 268 2720055 10.2307/2532051 1:STN:280:DyaL1M3kslKrtg%3D%3D
42. LIK Lin 1992 Assay validation using the concordance correlation coefficient Biometrics 48 599 604 10.2307/2532314
43. Correction: A Note on the Concordance Correlation Coefficient. Biometrics 2000;56:324-5.
44. Glatting G, Bergmann KP, Stollfu JC, Weismüller P, Kochs M, Hombach V, et al. Myocardial Rb Extraction Fraction: Determination in Humans. Journal of the American College of Cardiology 1995;25:364A-5A.
45. HR Schelbert ME Phelps SC Huang NS MacDonald H Hansen C Selin, et al. 1981 N-13 ammonia as an indicator of myocardial blood flow Circulation 63 1259 1272 7226473 10.1161/01.CIR.63.6.1259 1:CAS:528:DyaL3MXkt1SmsLY%3D
46. PA Kaufmann T Gnecchi-Ruscone JT Yap O Rimoldi PG Camici 1999 Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET J Nucl Med 40 1848 1856 10565780 1:STN:280:DC%2BD3c%2FivFGisg%3D%3D
47. S Nagamachi J Czernin AS Kim KT Sun M Bottcher ME Phelps, et al. 1996 Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET J Nucl Med 37 1626 1631 8862296 1:STN:280:DyaK2s%2FhsFKnug%3D%3D
48. O Manabe K Yoshinaga C Katoh M Naya RA De Kemp N Tamaki 2009 Repeatability of rest and hyperemic myocardial blood flow measurements with 82Rb dynamic PET J Nucl Med 50 68 71 19091892 10.2967/jnumed.108.055673
49. S Sdringola NP Johnson RL Kirkeeide E Cid KL Gould 2011 Impact of unexpected factors on quantitative myocardial perfusion and coronary flow reserve in young, asymptomatic volunteers JACC Cardiovasc Imaging 4 402 412 21492816 10.1016/j.jcmg.2011.02.008
50. K Yoshinaga C Katoh K Noriyasu Y Iwado H Furuyama Y Ito, et al. 2003 Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: a study using oxygen 15-labeled water PET J Nucl Cardiol 10 275 283 12794626 10.1016/S1071-3581(02) 43243-6
51. NG Uren T Crake DC Lefroy R de Silva GJ Davies A Maseri 1994 Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction N Engl J Med 331 222 227 7832835 10.1056/ NEJM199407283310402 1:STN:280:DyaK2c3osF2lsQ%3D%3D
52. KL Gould 2007 Positron emission tomography in coronary artery disease Curr Opin Cardiol 22 422 428 17762543 10.1097/HCO.0b013e3281fc9835
53. S Sdringola C Loghin F Boccalandro KL Gould 2006 Mechanisms of progression and regression of coronary artery disease by PET related to treatment intensity and clinical events at long-term follow-up J Nucl Med 47 59 67 16391188
54. FM Bengel 2011 Leaving relativity behind: quantitative clinical perfusion imaging J Am Coll Cardiol 58 749 751 21816312 10.1016/j.jacc.2011.02.068
55. AR Schleipman FP Castronovo Jr MF Di Carli S Dorbala 2006 Occupational radiation dose associated with Rb-82 myocardial perfusion positron emission tomography imaging J Nucl Cardiol 13 378 384 16750783 10.1016/j.nuclcard.2006. 03.001
56. PT Siegrist L Husmann M Knabenhans O Gaemperli I Valenta T Hoefflinghaus, et al. 2008 (13)N-ammonia myocardial perfusion imaging with a PET/CT scanner: impact on clinical decision making and cost-effectiveness Eur J Nucl Med Mol Imaging 35 889 895 18057933 10.1007/s00259-007-0647-3
57. PA Kaufmann 2007 82-Rubidium - the dawn of cardiac PET in Europe? Eur J Nucl Med Mol Imaging 34 1963 1964 18034240 10.1007/s00259-007-0632-x
58. KL Gould T Pan C Loghin NP Johnson A Guha S Sdringola 2007 Frequent diagnostic errors in cardiac PET/CT due to misregistration of CT attenuation and emission PET images: a definitive analysis of causes, consequences, and corrections J Nucl Med 48 1112 1121 17574974 10.2967/jnumed.107.039792
59. PMOD Technologies. User's guide: PMOD Cardiac Modeling (PCARD). http://www.pmod.ch/technologies/pdf/doc/PCARD.pdf. Accessed 10 Feb 2012.
60. R Klein JM Renaud MC Ziadi SL Thorn A Adler RS Beanlands, et al. 2010 Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program J Nucl Cardiol 17 600 616 20387135 10.1007/s12350-010-9225-3
61. EU Nitzsche Y Choi J Czernin CK Hoh SC Huang HR Schelbert 1996 Noninvasive quantification of myocardial blood flow in humans. A direct comparison of the [13N]ammonia and the [15O]water techniques Circulation 93 2000 2006 8640974 1:STN:280:DyaK283ktVCltQ%3D%3D
62. BL Gerber W Wijns JL Vanoverschelde GR Heyndrickx B De Bruyne J Bartunek, et al. 1999 Myocardial perfusion and oxygen consumption in reperfused noninfarcted dysfunctional myocardium after unstable angina: direct evidence for myocardial stunning in humans J Am Coll Cardiol 34 1939 1946 10588207 10.1016/S0735-1097(99)00451-9 1:STN:280:DC%2BD3c%2FltlChug%3D%3D