A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5- benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice

Psychopharmacology

Volumn 221, Issue 3, 2012, Pages 469-478

  Kulikov, Alexander V ^a   Tikhonova, Maria A ^a   Kulikova, Elizabeth A ^c   Volcho, Konstantin P ^b   Khomenko, Tatyana M ^b   Salakhutdinov, Nariman F ^b   Popova, Nina K ^a  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

^b N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^c NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

Author keywords

Bdnf; Benzopenthatiepin; Catalepsy; Creb; Il6st; Mice; mRNA; Open field test

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 8 (TRIFLUOROMETHYL) 1,2,3,4,5 BENZOPENTATHIEPIN 6 AMINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOPROTEIN GP 130; MESSENGER RNA; PSYCHOTROPIC AGENT; TC 2153; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BDNF GENE; CATALEPSY; CONTROLLED STUDY; CREB1 GENE; DRUG DOSE COMPARISON; DRUG STRUCTURE; FRONTAL CORTEX; GENE; GENE EXPRESSION; GROOMING; HIPPOCAMPUS; IL6ST GENE; LOCOMOTION; MALE; MESENCEPHALON; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL;

ANIMALS; BEHAVIOR, ANIMAL; BENZOTHIEPINS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATALEPSY; CYTOKINE RECEPTOR GP130; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GROOMING; HIPPOCAMPUS; MALE; MICE; MOTOR ACTIVITY; PSYCHOTROPIC DRUGS; RNA, MESSENGER;

EID: 84862683721     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2594-8     Document Type: Article

References (86)

1. Ahlenius S, Hillegaart V (1986) Involvement of extrapyramidal motor mechanisms in the suppression of locomotor activity by antipsychotic drugs: a comparison between the effects produced by preand postsynaptic inhibition of dopaminergic neurotransmission. Pharmacol Biochem Behav 24:1409-1415 (Pubitemid 16067429)
2. Amir S, Brown ZW, Amir Z, Ornstein K (1981) Body-pinches induced long lasting cataleptic-like immobility in mice: behavioral characterization and the effects of naloxone. Life Sci 10:1189-1194 (Pubitemid 11100489)
3. Bai O, Chlan-Fourney J, Bowen R, Keegan D, Li XM (2003) Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J Neurosci Res 71:127-131 (Pubitemid 36008409)
4. Ballard ME, Basso AM, Gallagher KB, Browman KE, Fox GB, Drescher KU, Gross G, Decker MW, Rueter LE, Zhang M (2007) The drug-induced helplessness test: an animal assay for assessing behavioral despair in response to neuroleptic treatment. Psychopharmacology (Berl) 190:1-11 (Pubitemid 44885338)
5. Balsara JJ, Jadhav SA, Gaonkar RK, Gaikwad RV, Jadhav JH (2005) Effects of antidepressant trazadone, a 5-HT2A/2C receptor antagonist, on dopamine-dependent behaviors in rats. Psychopharmacology (Berl) 179:597-605 (Pubitemid 40674760)
6. Balu DT, Hoshaw BA, Malberg JE, Rosenzweig-Lipson S, Schechter LE, Lucki I (2008) Differential regulation of central BDNF protein levels by antidepressants and non-antidepressant drug treatments. Brain Res 1211:37-43
7. Bazovkina DV, Kulikov AV, Kondaurova EM, Popova NK (2005) Selection for predisposition to catalepsy enhances depressive-like traits in mice. Russ J Genet 41:1222-1228 (Pubitemid 44392095)
8. Bazovkina DV, Terenina EE, Kulikov AV (2010) Effect of selective agonist of 5-HT1A receptors on defensive behavior of mice with different predisposition to catalepsy. Bull Exp Biol Med 150:225-228
9. Bazovkina DV, Tibeikina MA, Kulikov AV, Popova NK (2011) Effects of lipopolysaccharide and interleukin-6 on cataleptic immobility and locomotor activity in mice. Neurosci Lett 487:302-304
10. Berendsen HHG, Broekkamp CLE, Pinder RM (1998) Mitrazapine enhances the effect of haloperidol on apomorphine-induced climbing behaviour in mice and attenuates haloperidol-induced catalepsy in rats. Psychopharmacology (Berl) 135:284-289 (Pubitemid 28055464)
11. Bluthe R-M, Michaud B, Poli V, Dantzer R (2000) Role of IL-6 in cytokine induced sickness behavior: a study with IL-6 deficient mice. Physiol Behav 70:367-373
12. Calabrese EJ (2008) An assessment of anxiolytic drug screening tests: hormetic dose responses predominate. Crit Rev Toxicol 38:489-542
13. Calabrese F, Molteni R, Gabriel C, Mocaer E, Racagni G, Riva MA (2011) Modulation of neuroplastic molecules in selected brain regions after chronic administration of the novel antidepressant agomelatine. Psychopharmacology (Berl) 251:267-275
14. Caroff SN, Mann SC, Keck PE Jr, Francis A (2000) Residual catatonic state following neuroleptic malignant syndrome. J Clin Psychopharmacol 20:257-259 (Pubitemid 30202371)
15. Castagne V, Moser PC, Porsolt RD (2009) Preclinical behavioral models for predicting antipsychotic activity. Adv Pharmacol 57:381-418
16. Castren E (2004) Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol 4:58-64
17. Chatterji T, Gates KS (1998) DNA cleavage by 7- methylbenzopentathiepin: a simple analog of the antitumor antibiotic varacin. Bioorg Med Chem Lett 8:535-538 (Pubitemid 28092389)
18. Chesnokova V, Melmed S (2002) Minireview: Neuro-immunoendocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology 143:1571-1574 (Pubitemid 34415869)
19. Chlan-Fourney J, Ashe P, Nylen K, Juorio AV, Li XM (2002) Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain Res 954:11-20 (Pubitemid 35223437)
20. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by guanidinium thiocyanate-phenole-chloroform extraction. Anal Biochem 162:156-159 (Pubitemid 17064313)
21. Daniels J (2009) Catatonia: clinical aspects and neurobiological correlates. J Neuropsychiatry Clin Neurosci 21:371-380
22. Davidson BS, Molinski TF, Barrows LR, Ireland CM (1991) Varacin: a novel benzopentathiepin from Lissoclinum vareau that is cytotoxic towards human colon turmor. J Am Chem Soc 113:4709-4710
23. Desino KE, Pignatello R, Guccione S, Basile L, Ansar S, Michaelis ML, Ramsay RR, Audus KL (2009) TCP-FA4: a derivative of tranylcypromine showing improved blood-brain permeability. Biochem Pharmacol 78:1412-1417
24. Duman RS (2002) Synaptic plasticity and mood disorders. Mol Psychiatry 7:S29-S34
25. Duman RS, Heninger GR, Nestler EJ (1997) A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597-606 (Pubitemid 27306570)
26. Duman RS, Malberg J, Makagawa S (2001) Regulation of adult neurogenesis by psychotropic drugs and stress. J Pharmacol Exp Ther 299:401-407 (Pubitemid 32979649)
27. Emsley R (2009) Drugs in development for the treatment of schizophrenia. Expert Opin Investig Drugs 18:1103-1118
28. Fasnacht N, Muller W (2008) Conditional gp130 different mouse mutants. Semin Cell Dev Biol 19:379-384
29. Fava M (2003) Diagnosis and definition of treatment-resistant depression. Biol Psychiatry 53:649-659
30. Gyárfás T, Knuuttila J, Lindholm P, Rantamäki T, Castrén E (2010) Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo. Cell Mol Neurobiol 30:361-368
31. Haddad PM, Dursun SM (2008) Neurological complications of psychiatric drugs: clinical features and management. Hum Psychopharmacol Clin Exp 23:15-26 (Pubitemid 351166609)
32. Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 64:341-357
33. Hayley S, Poulter MO, Merali Z, Anisman H (2005) The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity. Neuroscience 135:659-678 (Pubitemid 41407732)
34. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F (2003) Principles of interleukin (IL)-6-type cytokine signaling and regulation. Biochem J 374:1-20 (Pubitemid 37046923)
35. Khomenko TM, Tolstikova TG, Bolkunov AV, Dolgikh MP, Pavlova AV, Korchagina DV, Volcho KP, Salakhutdinov NF (2009) 8- (Trifluoromethyl)-1,2,3,4, 5-benzopentathiepin-6-amine: novel aminobenzopentathiepine having in vivo anticonvulsant and anxiolytic activities. Lett Drug Des Discov 6:464-467
36. Khomenko TM,KorchaginaDV, Komarova NI,VolchoKP, Salakhutdinov NF (2011) Synthesis of 6-amino-benzopentathiepines by reactions of 4-nitro-benzyldithiol- 2-ones with NaHS. Lett Org Chem 8:193-197
37. Klemm WR (1989) Drug effects on active immobility responses: what they tell us about neurotransmitter systems and motor functions. Prog Neurobiol 32:403-422
38. Kliethermes CL (2005) Anxiety-like behaviors following chronic ethanol exposure. Neurosci Biobehav Rev 28:837-850
39. Kondaurova EM, Bazovkina DV, Kulikov AV, Popova NK (2006) Selective breeding for catalepsy changes the distribution of microsatellite D13Mit76 alleles linked to the 5-HT1A serotonin receptor gene in mice. Genes Brain Behav 5:596-601 (Pubitemid 44665357)
40. Kulikov AV, Popova NK (2008) Genetic control of catalepsy in mice. In: Torres S, Martin M (eds) Genetic Predisposition to Disease. Nova Publishers, New York, pp 215-236
41. Kulikov AV, Kozlachkova EY, Maslova GB, Popova NK (1993) Inheritance of predisposition to catalepsy in mice. Behav Genet 23:379-384 (Pubitemid 23263863)
42. 2 antagonists on inherited catalepsy in rats. Psychopharmacology (Berl) 114:172-174
43. 2A serotonin receptor mRNAs using genomic DNA as a standard. J Neurosci Methods 141:97-101
44. Kulikov AV, Bazovkina DV, Kondaurova EM, Popova NK (2008a) Genetic structure of hereditary catalepsy in mice. Genes Brain Behav 7:506-512 (Pubitemid 351590938)
45. Kulikov AV, Tikhonova MA, Kulikov VA (2008b) Automated measurement of special preference in the open field test with transmitted lighting. J Neurosci Methods 170:345-351
46. Kulikov AV, Sinyakova NA, Naumenko VS, Bazovkina DV, Popova NK (2010) Association of glycoprotein gp130 with hereditary catalepsy in mice. Genes Brain Behav 9:997-1003
47. Kulikov AV, Tikhonova MA, Kulikova EA, Khomenko TM, Korchagina DV, Volcho KP, Salakhutdinov NF, Popova NK (2011) Effect of a new potential psychotropic drug, 8-(trifluoromethyl)- 1,2,3,4,5-benzopentathiepin-6-amine hydrochloride, on the expression of serotonin-related genes in the mouse brain. Mol Biol (Mosk) 45:251-257
48. Lee JW (2007) Catatonic variants, hyperthermic extrapyramidal reactions, and subtypes of neuroleptic malignant syndrome. Ann Clin Psychiatry 19:9-16
49. Lee SH (2009) Disulfide and multisulfide antitumor agents and their modes of action. Arch Pharm Res 32:299-315
50. Lee JW (2010) Neuroleptic-induced catatonia: clinical presentation, response to benzodiazepines, and relationship to neuroleptic malignant syndrome. J Clin Psychopharmacol 30:3-10
51. Lee AHF, Chen J, Liu D, Leung TYC, Chan ASC, Li T (2002) Acid-promoted DNA-cleaving activities and total synthesis of varacin C. J Am Chem Soc 124:13972-13973 (Pubitemid 35386831)
52. Lipska BK, Khaing ZZ, Weickert CS, Weinberger DR (2001) BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs. Eur J Neurosci 14:135-144 (Pubitemid 32738482)
53. Litaudon M, Trigalo F, Martin M-T, Frappier F, Guyot M (1994) Lissoclinotoxins: antibiotic polysulfur derivatives from the tunicate Lissoclinum perforatum. Revised structure of lissoclinotoxin A. Tetrahedron 50:5323-5334 (Pubitemid 24152214)
54. Mizuta I, Ohta M, Ohta K, Nishimura M, Mizuta E, Hayashi K, Kuno S (2000) Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes. Biochem Biophys Res Commun 279:751-755 (Pubitemid 32042852)
55. Montgomery SA (2005) Antidepressants and seizures: emphasis on newer agents and clinical implications. Int J Clin Pract 59:1435-1440
56. Naka T, Nishimoto N, Kishimoto T (2002) The paradigm of IL-6: from basic science to medicine. Arthritis Res 4:S233-S242
57. Naoi M, Maruyama W (2009) Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease. Expert Rev Neurother 9:1233-1250
58. Naumemko VS, Osipova DV, Kostina EV, Kulikov AV (2008) Utilization of a two-standard system in real-time PCR for quantification of gene expression in the brain. J Neurosci Methods 170:197-203
59. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34:13-25 (Pubitemid 34270695)
60. Nibuya M, Morinobu A, Duman RS (1995) Regulation of BDNF and TrkB m RNA in rat brain by chronic elecroconvulsive seizure and antidepressant drug treatment. J Neurosci 15:7539-7547
61. Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 16:2365-2372 (Pubitemid 26154346)
62. Oda T, Kamoshita K, Maruyama S, Masuda K, Nishimoto M, Xu J, Ukai K, Mangindaan REP, Namikoshi M (2007) Cytotoxicity of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, against human solid-tumor-derived cell lines. Biol Pharm Bull 30:385-387
63. Ornstein K, Amir S (1981) Pinch-induced catalepsy in mice. J Comp Physiol Psychol 95:827-835
64. Paparrigopoulos T, Tzavellas E, Ferentinos P, Mourikis I, Liappas J (2009) Catatonia as a risk factor for the development of neuroleptic malignant syndrome: report of a case following treatment with clozapine. World J Biol Psychiatry 10:70-73
65. Parikh V, Khan MM, Mahadik SP (2004) Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol. Neurosci Lett 356:135-139 (Pubitemid 38121487)
66. Pillai A, Terry AV Jr, Mahadik SP (2006) Differential effects of longterm treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus. Schizophr Res 82:95-106 (Pubitemid 43202652)
67. Pillai A, Dhandapani KM, Pillai BA, Terry AV Jr, Mahadik SP (2008) Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF. Neuropsychopharmacology 33:1942-1951 (Pubitemid 351832588)
68. Pires JG, Bonikovski V, Futuro-Neto HA (2005) Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice. Braz J Med Biol Res 38:1867-1872 (Pubitemid 43078616)
69. Porsolt RD, Moser PC, Castagne V (2010) Behavioral indices in antipsychotic drug discovery. J Pharmacol Exp Ther 333:632-638
70. Prut L, Belzung C (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463:3-33 (Pubitemid 36205070)
71. Remick RA (2002) Diagnosis and management of depression in primary care: a clinical update and review. CMAJ 167:1253-1260
72. Sanberg PR, Bunsey MD, Giordano M, Norman AB (1988) The catalepsy test: its ups and downs. Behav Neurosci 102:748-759
73. Sato R, Ohyama T, Ogawa S (1995) Efficient synthesis and biological properties of new benzopentathiepins. Heterocycles 41:893
74. Serretti A, De Ronchi D, Lorenzi C, Berardi D (2004) New antipsychotics and schizophrenia: a review on efficacy and side effects. Curr Med Chem 11:343-358 (Pubitemid 38240211)
75. Singerman B, Raheja R (1994) Malignant catatonia - a continuing reality. Ann Clin Psychiatry 6:259-266
76. Thome J, Sakai N, Shin K-H, Steffen C, Zhang Y-J, Impey S, Storm D, Duman RS (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 20:4030-4036 (Pubitemid 30365673)
77. Tikhonova MA, Lebedeva VV, Kulikov AV, Bazovkina DV, Popova NK (2006) Effect of imipramine on the behavior and cerebral 5- HT1A serotonin receptors in mice genetically predisposed to catalepsy. Bull Exp Biol Med 141:48-50 (Pubitemid 43880505)
78. Tikhonova MA, Alperina EL, Tolstikova TG, Bazovkina DV, Di VY, Idova GV, Kulikov AV, Popova NK (2010) Effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1A and 2A serotonin receptors and the tph2 and SERT genes. Neurosci Behav Physiol 40:521-527
79. Ukai W, Ozawa H, Tateno M, Hashimoto E, Saito T (2004) Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol. J Neural Transm 111:667-681 (Pubitemid 38716547)
80. 2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. J Neurosci 17:2785-2795
81. Wadenberg ML (1996) Serotonergic mechanisms of neuroleptic-induced catalepsy in rats. Neurosci Biobehav Rev 20:325-339
82. Walsh MT, Dinan TG (2001) Selective serotonin reuptake inhibitor and violence: a review of the available evidence. Acta Psychiatr Scand 104:84-91
83. Weder ND, Muralee S, Penland H, Tampi RR (2008) Catatonia: a review. Ann Clin Psychiatry 20:97-107 (Pubitemid 351892650)
84. Willner P (1990) Animal models of depression: an overview. Pharmacol Ther 45:425-455
85. Worms P, Kan JP, Wermuth CG, Roncucci R, Bizière K (1987) SR 95191, a selective inhibitor of type A monoamine oxidase with dopaminergic properties. I. Psychopharmacological profile in rodents. J Pharmacol Exp Ther 240:241-250 (Pubitemid 17235444)
86. Zienowicz M, Wisiowska-Stanek A, Lrhner M, Taracha E, Maciejak P, Sobolewska A, Szyndler J, Turzynsks D, Walkowiak J, Plaznik A (2006) Fluoxetine-induced anxiety and nervousness. Pharmacol Rep 58:115-119