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Volumn 12, Issue 3, 2012, Pages 388-396

Sarcopenia in the elderly: Basic and clinical issues

Author keywords

Geriatrics; Muscle; Sarcopenia

Indexed keywords

GHRELIN; GROWTH HORMONE; LEPTIN; MYOSTATIN; TESTOSTERONE; TIBOLONE; VITAMIN D;

EID: 84862677592     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2012.00851.x     Document Type: Review
Times cited : (125)

References (90)
  • 1
    • 19544381765 scopus 로고    scopus 로고
    • Trends in aging - United States and worldwide
    • Centers for Disease Control and Prevention (CDC). 106.
    • Centers for Disease Control and Prevention (CDC). Trends in aging - United States and worldwide. MMWR Morb Mortal Wkly Rep 2003; 52: 101-104, 106.
    • (2003) MMWR Morb Mortal Wkly Rep , vol.52 , pp. 101-104
  • 2
    • 49349093686 scopus 로고    scopus 로고
    • The trend toward geriatric nephrology
    • vii.
    • Tedla FM, Friedman EA. The trend toward geriatric nephrology. Prim Care 2008; 35: 515-530, vii.
    • (2008) Prim Care , vol.35 , pp. 515-530
    • Tedla, F.M.1    Friedman, E.A.2
  • 3
    • 79961071833 scopus 로고    scopus 로고
    • The epidemiology of sarcopenia
    • Janssen I. The epidemiology of sarcopenia. Clin Geriatr Med 2011; 27: 355-363.
    • (2011) Clin Geriatr Med , vol.27 , pp. 355-363
    • Janssen, I.1
  • 4
    • 0033649132 scopus 로고    scopus 로고
    • Age-related changes in muscle
    • Nair KS. Age-related changes in muscle. Mayo Clin Proc 2000; 75 (Suppl): S14-S18.
    • (2000) Mayo Clin Proc , vol.75 , Issue.SUPPL.
    • Nair, K.S.1
  • 5
    • 79955142004 scopus 로고    scopus 로고
    • Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia
    • Fielding RA, Vellas B, Evans WJ etal. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 2011; 12: 249-256.
    • (2011) J Am Med Dir Assoc , vol.12 , pp. 249-256
    • Fielding, R.A.1    Vellas, B.2    Evans, W.J.3
  • 6
    • 79958047615 scopus 로고    scopus 로고
    • The neurology of old age
    • Stanton BR. The neurology of old age. Clin Med 2011; 11: 54-56.
    • (2011) Clin Med , vol.11 , pp. 54-56
    • Stanton, B.R.1
  • 7
    • 0020509969 scopus 로고
    • Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections
    • Lexell J, Henriksson-Larsen K, Winblad B, Sjostrom M. Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve 1983; 6: 588-595.
    • (1983) Muscle Nerve , vol.6 , pp. 588-595
    • Lexell, J.1    Henriksson-Larsen, K.2    Winblad, B.3    Sjostrom, M.4
  • 8
    • 0030880633 scopus 로고    scopus 로고
    • Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women's Health and Aging Study
    • Ferrucci L, Guralnik JM, Buchner D etal. Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci 1997; 52: M275-M285.
    • (1997) J Gerontol A Biol Sci Med Sci , vol.52
    • Ferrucci, L.1    Guralnik, J.M.2    Buchner, D.3
  • 9
    • 0019299245 scopus 로고
    • Compartmental body composition based on total-body nitrogen, potassium, and calcium
    • Cohn SH, Vartsky D, Yasumura S etal. Compartmental body composition based on total-body nitrogen, potassium, and calcium. Am J Physiol 1980; 239: E524-E530.
    • (1980) Am J Physiol , vol.239
    • Cohn, S.H.1    Vartsky, D.2    Yasumura, S.3
  • 10
    • 0023856536 scopus 로고
    • What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men
    • Lexell J, Taylor CC, Sjostrom M. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci 1988; 84: 275-294.
    • (1988) J Neurol Sci , vol.84 , pp. 275-294
    • Lexell, J.1    Taylor, C.C.2    Sjostrom, M.3
  • 11
    • 34548473612 scopus 로고    scopus 로고
    • Factors contributing to neuromuscular impairment and sarcopenia during aging
    • Edstrom E, Altun M, Bergman E etal. Factors contributing to neuromuscular impairment and sarcopenia during aging. Physiol Behav 2007; 92: 129-135.
    • (2007) Physiol Behav , vol.92 , pp. 129-135
    • Edstrom, E.1    Altun, M.2    Bergman, E.3
  • 12
    • 50049120029 scopus 로고    scopus 로고
    • Sarcopenia: diagnosis and treatment
    • Morley JE. Sarcopenia: diagnosis and treatment. J Nutr Health Aging 2008; 12: 452-456.
    • (2008) J Nutr Health Aging , vol.12 , pp. 452-456
    • Morley, J.E.1
  • 13
    • 77953870112 scopus 로고    scopus 로고
    • Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People
    • Cruz-Jentoft AJ, Baeyens JP, Bauer JM etal. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412-423.
    • (2010) Age Ageing , vol.39 , pp. 412-423
    • Cruz-Jentoft, A.J.1    Baeyens, J.P.2    Bauer, J.M.3
  • 14
    • 0021928693 scopus 로고
    • The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals
    • Zadik Z, Chalew SA, McCarter RJ, Jr, Meistas M, Kowarski AA. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab 1985; 60: 513-516.
    • (1985) J Clin Endocrinol Metab , vol.60 , pp. 513-516
    • Zadik, Z.1    Chalew, S.A.2    McCarter Jr, R.J.3    Meistas, M.4    Kowarski, A.A.5
  • 15
    • 0029993686 scopus 로고    scopus 로고
    • Growth hormone replacement in healthy older men improves body composition but not functional ability
    • Papadakis MA, Grady D, Black D etal. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996; 124: 708-716.
    • (1996) Ann Intern Med , vol.124 , pp. 708-716
    • Papadakis, M.A.1    Grady, D.2    Black, D.3
  • 16
    • 9444290436 scopus 로고    scopus 로고
    • Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans
    • Guillet C, Prod'homme M, Balage M etal. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J 2004; 18: 1586-1587.
    • (2004) FASEB J , vol.18 , pp. 1586-1587
    • Guillet, C.1    Prod'homme, M.2    Balage, M.3
  • 18
    • 0036159506 scopus 로고    scopus 로고
    • The role of cytokines in regulating protein metabolism and muscle function
    • Zoico E, Roubenoff R. The role of cytokines in regulating protein metabolism and muscle function. Nutr Rev 2002; 60: 39-51.
    • (2002) Nutr Rev , vol.60 , pp. 39-51
    • Zoico, E.1    Roubenoff, R.2
  • 19
    • 0028837394 scopus 로고
    • Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle
    • Biolo G, Declan Fleming RY, Wolfe RR. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J Clin Invest 1995; 95: 811-819.
    • (1995) J Clin Invest , vol.95 , pp. 811-819
    • Biolo, G.1    Declan Fleming, R.Y.2    Wolfe, R.R.3
  • 23
    • 0025090868 scopus 로고
    • Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds
    • Klitgaard H, Mantoni M, Schiaffino S etal. Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds. Acta Physiol Scand 1990; 140: 41-54.
    • (1990) Acta Physiol Scand , vol.140 , pp. 41-54
    • Klitgaard, H.1    Mantoni, M.2    Schiaffino, S.3
  • 24
    • 34247568590 scopus 로고    scopus 로고
    • Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women
    • Delmonico MJ, Harris TB, Lee JS etal. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc 2007; 55: 769-774.
    • (2007) J Am Geriatr Soc , vol.55 , pp. 769-774
    • Delmonico, M.J.1    Harris, T.B.2    Lee, J.S.3
  • 25
    • 33750927350 scopus 로고    scopus 로고
    • The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study
    • Goodpaster BH, Park SW, Harris TB etal. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 2006; 61: 1059-1064.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 1059-1064
    • Goodpaster, B.H.1    Park, S.W.2    Harris, T.B.3
  • 26
    • 1042265092 scopus 로고    scopus 로고
    • Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women
    • Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004; 159: 413-421.
    • (2004) Am J Epidemiol , vol.159 , pp. 413-421
    • Janssen, I.1    Baumgartner, R.N.2    Ross, R.3    Rosenberg, I.H.4    Roubenoff, R.5
  • 27
    • 42449130997 scopus 로고    scopus 로고
    • Functional outcomes for clinical trials in frail older persons: time to be moving
    • Working Group on Functional Outcome Measures for Clinical Trials.
    • Working Group on Functional Outcome Measures for Clinical Trials. Functional outcomes for clinical trials in frail older persons: time to be moving. J Gerontol A Biol Sci Med Sci 2008; 63: 160-164.
    • (2008) J Gerontol A Biol Sci Med Sci , vol.63 , pp. 160-164
  • 28
    • 0032522560 scopus 로고    scopus 로고
    • Epidemiology of sarcopenia among the elderly in New Mexico
    • Baumgartner RN, Koehler KM, Gallagher D etal. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147: 755-763.
    • (1998) Am J Epidemiol , vol.147 , pp. 755-763
    • Baumgartner, R.N.1    Koehler, K.M.2    Gallagher, D.3
  • 29
    • 1242284372 scopus 로고    scopus 로고
    • Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women
    • Zoico E, Di Francesco V, Guralnik JM etal. Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women. Int J Obes Relat Metab Disord 2004; 28: 234-241.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 234-241
    • Zoico, E.1    Di Francesco, V.2    Guralnik, J.M.3
  • 31
    • 67650647165 scopus 로고    scopus 로고
    • Simultaneously significant hepatic and mild splenic uptake of Tc-99m MDP resulting from Waldenstrom macroglobulinemia
    • Yang JG, Yin CH, Li CL, Zou LF. Simultaneously significant hepatic and mild splenic uptake of Tc-99m MDP resulting from Waldenstrom macroglobulinemia. Clin Nucl Med 2009; 34: 441-442.
    • (2009) Clin Nucl Med , vol.34 , pp. 441-442
    • Yang, J.G.1    Yin, C.H.2    Li, C.L.3    Zou, L.F.4
  • 32
    • 0036246979 scopus 로고    scopus 로고
    • Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    • Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002; 50: 889-896.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 889-896
    • Janssen, I.1    Heymsfield, S.B.2    Ross, R.3
  • 33
    • 59349101544 scopus 로고    scopus 로고
    • Bioimpedance vector analysis as a measure of muscle function
    • Norman K, Pirlich M, Sorensen J etal. Bioimpedance vector analysis as a measure of muscle function. Clin Nutr 2009; 28: 78-82.
    • (2009) Clin Nutr , vol.28 , pp. 78-82
    • Norman, K.1    Pirlich, M.2    Sorensen, J.3
  • 34
    • 10744227011 scopus 로고    scopus 로고
    • Sarcopenia: alternative definitions and associations with lower extremity function
    • Newman AB, Kupelian V, Visser M etal. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc 2003; 51: 1602-1609.
    • (2003) J Am Geriatr Soc , vol.51 , pp. 1602-1609
    • Newman, A.B.1    Kupelian, V.2    Visser, M.3
  • 35
    • 17644378354 scopus 로고    scopus 로고
    • Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men - the MINOS study
    • Szulc P, Beck TJ, Marchand F, Delmas PD. Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men - the MINOS study. J Bone Miner Res 2005; 20: 721-729.
    • (2005) J Bone Miner Res , vol.20 , pp. 721-729
    • Szulc, P.1    Beck, T.J.2    Marchand, F.3    Delmas, P.D.4
  • 36
    • 0036066183 scopus 로고    scopus 로고
    • Corrected arm muscle area: an independent predictor of long-term mortality in community-dwelling older adults?
    • Miller MD, Crotty M, Giles LC etal. Corrected arm muscle area: an independent predictor of long-term mortality in community-dwelling older adults? J Am Geriatr Soc 2002; 50: 1272-1277.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 1272-1277
    • Miller, M.D.1    Crotty, M.2    Giles, L.C.3
  • 37
    • 34248640885 scopus 로고    scopus 로고
    • [Anthropometric measurements as a predictor of mortality of community-dwelling Japanese elderly: the Nagoya Longitudinal Study of Frail Elderly (NLS-FE)]
    • Enoki H, Kuzuya M, Masuda Y etal. [Anthropometric measurements as a predictor of mortality of community-dwelling Japanese elderly: the Nagoya Longitudinal Study of Frail Elderly (NLS-FE)]. Nihon Ronen Igakkai Zasshi 2007; 44: 212-218.
    • (2007) Nihon Ronen Igakkai Zasshi , vol.44 , pp. 212-218
    • Enoki, H.1    Kuzuya, M.2    Masuda, Y.3
  • 38
    • 36248991951 scopus 로고    scopus 로고
    • Decreased muscle mass and increased central adiposity are independently related to mortality in older men
    • Wannamethee SG, Shaper AG, Lennon L, Whincup PH. Decreased muscle mass and increased central adiposity are independently related to mortality in older men. Am J Clin Nutr 2007; 86: 1339-1346.
    • (2007) Am J Clin Nutr , vol.86 , pp. 1339-1346
    • Wannamethee, S.G.1    Shaper, A.G.2    Lennon, L.3    Whincup, P.H.4
  • 39
    • 0033982689 scopus 로고    scopus 로고
    • Mortality associated with body fat, fat-free mass and body mass index among 60-year-old swedish men-a 22-year follow-up. The study of men born in 1913
    • Heitmann BL, Erikson H, Ellsinger BM, Mikkelsen KL, Larsson B. Mortality associated with body fat, fat-free mass and body mass index among 60-year-old swedish men-a 22-year follow-up. The study of men born in 1913. Int J Obes Relat Metab Disord 2000; 24: 33-37.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 33-37
    • Heitmann, B.L.1    Erikson, H.2    Ellsinger, B.M.3    Mikkelsen, K.L.4    Larsson, B.5
  • 40
    • 77954581146 scopus 로고    scopus 로고
    • Nutritional recommendations for the management of sarcopenia
    • Morley JE, Argiles JM, Evans WJ etal. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 2010; 11: 391-396.
    • (2010) J Am Med Dir Assoc , vol.11 , pp. 391-396
    • Morley, J.E.1    Argiles, J.M.2    Evans, W.J.3
  • 41
    • 0033883578 scopus 로고    scopus 로고
    • Testosterone and leptin in older African-American men: relationship to age, strength, function, and season
    • Perry HM, 3rd, Miller DK, Patrick P, Morley JE. Testosterone and leptin in older African-American men: relationship to age, strength, function, and season. Metabolism 2000; 49: 1085-1091.
    • (2000) Metabolism , vol.49 , pp. 1085-1091
    • Perry III, H.M.1    Miller, D.K.2    Patrick, P.3    Morley, J.E.4
  • 42
    • 0034847204 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency
    • Ly LP, Jimenez M, Zhuang TN, Celermajer DS, Conway AJ, Handelsman DJ. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency. J Clin Endocrinol Metab 2001; 86: 4078-4088.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4078-4088
    • Ly, L.P.1    Jimenez, M.2    Zhuang, T.N.3    Celermajer, D.S.4    Conway, A.J.5    Handelsman, D.J.6
  • 43
    • 78049497960 scopus 로고    scopus 로고
    • Adverse events associated with testosterone administration
    • author reply 66-67.
    • Weikert C, Pischon T, Weikert S. Adverse events associated with testosterone administration. N Engl J Med 2010; 363: 1865; author reply 66-67.
    • (2010) N Engl J Med , vol.363 , pp. 1865
    • Weikert, C.1    Pischon, T.2    Weikert, S.3
  • 44
    • 0019423888 scopus 로고
    • Impaired growth hormone secretion in the adult population: relation to age and adiposity
    • Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest 1981; 67: 1361-1369.
    • (1981) J Clin Invest , vol.67 , pp. 1361-1369
    • Rudman, D.1    Kutner, M.H.2    Rogers, C.M.3    Lubin, M.F.4    Fleming, G.A.5    Bain, R.P.6
  • 45
    • 0028116813 scopus 로고
    • Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men
    • Taaffe DR, Pruitt L, Reim J etal. Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab 1994; 79: 1361-1366.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1361-1366
    • Taaffe, D.R.1    Pruitt, L.2    Reim, J.3
  • 46
    • 0031782336 scopus 로고    scopus 로고
    • Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women
    • Thompson JL, Butterfield GE, Gylfadottir UK etal. Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. J Clin Endocrinol Metab 1998; 83: 1477-1484.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1477-1484
    • Thompson, J.L.1    Butterfield, G.E.2    Gylfadottir, U.K.3
  • 47
    • 0035908954 scopus 로고    scopus 로고
    • Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    • Nagaya N, Uematsu M, Kojima M etal. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001; 104: 1430-1435.
    • (2001) Circulation , vol.104 , pp. 1430-1435
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3
  • 48
    • 35549012275 scopus 로고    scopus 로고
    • Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers
    • Garcia JM, Polvino WJ. Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers. Oncologist 2007; 12: 594-600.
    • (2007) Oncologist , vol.12 , pp. 594-600
    • Garcia, J.M.1    Polvino, W.J.2
  • 49
    • 77953845379 scopus 로고    scopus 로고
    • Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure
    • Scarlett JM, Bowe DD, Zhu X, Batra AK, Grant WF, Marks DL. Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure. J Endocrinol 2010; 206: 121-130.
    • (2010) J Endocrinol , vol.206 , pp. 121-130
    • Scarlett, J.M.1    Bowe, D.D.2    Zhu, X.3    Batra, A.K.4    Grant, W.F.5    Marks, D.L.6
  • 50
    • 77957886583 scopus 로고    scopus 로고
    • Advances in understanding and treating cardiac cachexia: highlights from the 5th Cachexia Conference
    • von Haehling S, Stepney R, Anker SD. Advances in understanding and treating cardiac cachexia: highlights from the 5th Cachexia Conference. Int J Cardiol 2010; 144: 347-349.
    • (2010) Int J Cardiol , vol.144 , pp. 347-349
    • von Haehling, S.1    Stepney, R.2    Anker, S.D.3
  • 51
    • 34547950312 scopus 로고    scopus 로고
    • Postmenopausal HRT and tibolone in relation to muscle strength and body composition
    • Jacobsen DE, Samson MM, Kezic S, Verhaar HJ. Postmenopausal HRT and tibolone in relation to muscle strength and body composition. Maturitas 2007; 58: 7-18.
    • (2007) Maturitas , vol.58 , pp. 7-18
    • Jacobsen, D.E.1    Samson, M.M.2    Kezic, S.3    Verhaar, H.J.4
  • 52
    • 70350519373 scopus 로고    scopus 로고
    • Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia
    • Onder G, Della Vedova C, Landi F. Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia. J Nutr Health Aging 2009; 13: 746-756.
    • (2009) J Nutr Health Aging , vol.13 , pp. 746-756
    • Onder, G.1    Della Vedova, C.2    Landi, F.3
  • 53
    • 0034751804 scopus 로고    scopus 로고
    • The effect of tibolone on fat mass, fat-free mass, and total body water in postmenopausal women
    • Meeuwsen IB, Samson MM, Duursma SA, Verhaar HJ. The effect of tibolone on fat mass, fat-free mass, and total body water in postmenopausal women. Endocrinology 2001; 142: 4813-4817.
    • (2001) Endocrinology , vol.142 , pp. 4813-4817
    • Meeuwsen, I.B.1    Samson, M.M.2    Duursma, S.A.3    Verhaar, H.J.4
  • 54
    • 2542487416 scopus 로고    scopus 로고
    • Minireview: a hypothalamic role in energy balance with special emphasis on leptin
    • Sahu A. Minireview: a hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 2004; 145: 2613-2620.
    • (2004) Endocrinology , vol.145 , pp. 2613-2620
    • Sahu, A.1
  • 55
    • 70149104583 scopus 로고    scopus 로고
    • Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice
    • Sainz N, Rodriguez A, Catalan V etal. Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS ONE 2009; 4: e6808.
    • (2009) PLoS ONE , vol.4
    • Sainz, N.1    Rodriguez, A.2    Catalan, V.3
  • 56
    • 56149109009 scopus 로고    scopus 로고
    • The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action
    • Holick MF. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med 2008; 29: 361-368.
    • (2008) Mol Aspects Med , vol.29 , pp. 361-368
    • Holick, M.F.1
  • 57
    • 70350359680 scopus 로고    scopus 로고
    • Vitamin d deficiency/insufficiency practice patterns in a veterans health administration long-term care population: a retrospective analysis
    • Braddy KK, Imam SN, Palla KR, Lee TA. Vitamin d deficiency/insufficiency practice patterns in a veterans health administration long-term care population: a retrospective analysis. J Am Med Dir Assoc 2009; 10: 653-657.
    • (2009) J Am Med Dir Assoc , vol.10 , pp. 653-657
    • Braddy, K.K.1    Imam, S.N.2    Palla, K.R.3    Lee, T.A.4
  • 58
    • 23044501742 scopus 로고    scopus 로고
    • Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    • Artaza JN, Bhasin S, Magee TR etal. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 2005; 146: 3547-3557.
    • (2005) Endocrinology , vol.146 , pp. 3547-3557
    • Artaza, J.N.1    Bhasin, S.2    Magee, T.R.3
  • 60
    • 73549088713 scopus 로고    scopus 로고
    • mTOR function in skeletal muscle: a focal point for overnutrition and exercise
    • Rivas DA, Lessard SJ, Coffey VG. mTOR function in skeletal muscle: a focal point for overnutrition and exercise. Appl Physiol Nutr Metab 2009; 34: 807-816.
    • (2009) Appl Physiol Nutr Metab , vol.34 , pp. 807-816
    • Rivas, D.A.1    Lessard, S.J.2    Coffey, V.G.3
  • 61
    • 66349104285 scopus 로고    scopus 로고
    • Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men
    • Hulmi JJ, Tannerstedt J, Selanne H, Kainulainen H, Kovanen V, Mero AA. Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J Appl Physiol 2009; 106: 1720-1729.
    • (2009) J Appl Physiol , vol.106 , pp. 1720-1729
    • Hulmi, J.J.1    Tannerstedt, J.2    Selanne, H.3    Kainulainen, H.4    Kovanen, V.5    Mero, A.A.6
  • 62
    • 58149307453 scopus 로고    scopus 로고
    • Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men
    • Kumar V, Selby A, Rankin D etal. Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 2009; 587: 211-217.
    • (2009) J Physiol , vol.587 , pp. 211-217
    • Kumar, V.1    Selby, A.2    Rankin, D.3
  • 63
    • 0014198263 scopus 로고
    • Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle
    • Holloszy JO. Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem 1967; 242: 2278-2282.
    • (1967) J Biol Chem , vol.242 , pp. 2278-2282
    • Holloszy, J.O.1
  • 64
    • 33847766208 scopus 로고    scopus 로고
    • Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function
    • Chow LS, Greenlund LJ, Asmann YW etal. Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function. J Appl Physiol 2007; 102: 1078-1089.
    • (2007) J Appl Physiol , vol.102 , pp. 1078-1089
    • Chow, L.S.1    Greenlund, L.J.2    Asmann, Y.W.3
  • 65
    • 0028832714 scopus 로고
    • The application of blood flow measurements to the study of aging muscle
    • Spec No.
    • McCully KK, Posner JD. The application of blood flow measurements to the study of aging muscle. J Gerontol A Biol Sci Med Sci 1995; 50 Spec No: 130-136.
    • (1995) J Gerontol A Biol Sci Med Sci , vol.50 , pp. 130-136
    • McCully, K.K.1    Posner, J.D.2
  • 66
    • 0027357969 scopus 로고
    • Changes in skeletal muscle with aging: effects of exercise training
    • Rogers MA, Evans WJ. Changes in skeletal muscle with aging: effects of exercise training. Exerc Sport Sci Rev 1993; 21: 65-102.
    • (1993) Exerc Sport Sci Rev , vol.21 , pp. 65-102
    • Rogers, M.A.1    Evans, W.J.2
  • 67
    • 77956228506 scopus 로고    scopus 로고
    • Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men
    • Ochi M, Kohara K, Tabara Y etal. Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men. Atherosclerosis 2010; 212: 327-332.
    • (2010) Atherosclerosis , vol.212 , pp. 327-332
    • Ochi, M.1    Kohara, K.2    Tabara, Y.3
  • 68
    • 33745953370 scopus 로고    scopus 로고
    • Effect of inflammation on the aging microcirculation: impact on skeletal muscle blood flow control
    • Payne GW. Effect of inflammation on the aging microcirculation: impact on skeletal muscle blood flow control. Microcirculation 2006; 13: 343-352.
    • (2006) Microcirculation , vol.13 , pp. 343-352
    • Payne, G.W.1
  • 70
    • 70350289385 scopus 로고    scopus 로고
    • Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle
    • Buford TW, Cooke MB, Willoughby DS. Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle. Eur J Appl Physiol 2009; 107: 463-471.
    • (2009) Eur J Appl Physiol , vol.107 , pp. 463-471
    • Buford, T.W.1    Cooke, M.B.2    Willoughby, D.S.3
  • 71
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
    • Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A 2009; 106: 20405-20410.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 72
    • 73249122843 scopus 로고    scopus 로고
    • Disproportionate changes in skeletal muscle strength and size with resistance training and ageing
    • Degens H, Erskine RM, Morse CI. Disproportionate changes in skeletal muscle strength and size with resistance training and ageing. J Musculoskelet Neuronal Interact 2009; 9: 123-129.
    • (2009) J Musculoskelet Neuronal Interact , vol.9 , pp. 123-129
    • Degens, H.1    Erskine, R.M.2    Morse, C.I.3
  • 73
    • 8844232689 scopus 로고    scopus 로고
    • In vivo human muscle structure and function: adaptations to resistance training in old age
    • Reeves ND, Narici MV, Maganaris CN. In vivo human muscle structure and function: adaptations to resistance training in old age. Exp Physiol 2004; 89: 675-689.
    • (2004) Exp Physiol , vol.89 , pp. 675-689
    • Reeves, N.D.1    Narici, M.V.2    Maganaris, C.N.3
  • 74
    • 50649088962 scopus 로고    scopus 로고
    • Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients
    • Suetta C, Andersen JL, Dalgas U etal. Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients. J Appl Physiol 2008; 105: 180-186.
    • (2008) J Appl Physiol , vol.105 , pp. 180-186
    • Suetta, C.1    Andersen, J.L.2    Dalgas, U.3
  • 75
    • 0034122574 scopus 로고    scopus 로고
    • Reexamining the sarcopenia hypothesis. Muscle mass versus muscle strength. Health, Aging, and Body Composition Study Research Group
    • Visser M, Newman AB, Nevitt MC etal. Reexamining the sarcopenia hypothesis. Muscle mass versus muscle strength. Health, Aging, and Body Composition Study Research Group. Ann N Y Acad Sci 2000; 904: 456-461.
    • (2000) Ann N Y Acad Sci , vol.904 , pp. 456-461
    • Visser, M.1    Newman, A.B.2    Nevitt, M.C.3
  • 76
    • 34347394201 scopus 로고    scopus 로고
    • Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity
    • D'Antona G, Pellegrino MA, Carlizzi CN, Bottinelli R. Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity. Eur J Appl Physiol 2007; 100: 603-611.
    • (2007) Eur J Appl Physiol , vol.100 , pp. 603-611
    • D'Antona, G.1    Pellegrino, M.A.2    Carlizzi, C.N.3    Bottinelli, R.4
  • 77
    • 58149389257 scopus 로고    scopus 로고
    • Muscle mitochondrial changes with aging and exercise
    • Lanza IR, Nair KS. Muscle mitochondrial changes with aging and exercise. Am J Clin Nutr 2009; 89: 467S-471S.
    • (2009) Am J Clin Nutr , vol.89
    • Lanza, I.R.1    Nair, K.S.2
  • 78
    • 61449143815 scopus 로고    scopus 로고
    • Exercise is medicine and physicians need to prescribe it!
    • Sallis RE. Exercise is medicine and physicians need to prescribe it! Br J Sports Med 2009; 43: 3-4.
    • (2009) Br J Sports Med , vol.43 , pp. 3-4
    • Sallis, R.E.1
  • 79
    • 70350751292 scopus 로고    scopus 로고
    • Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events
    • Pietrangelo T, Mancinelli R, Toniolo L etal. Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events. Int J Mol Med 2009; 24: 503-512.
    • (2009) Int J Mol Med , vol.24 , pp. 503-512
    • Pietrangelo, T.1    Mancinelli, R.2    Toniolo, L.3
  • 80
    • 77951922812 scopus 로고    scopus 로고
    • Oxidative stress, molecular inflammation and sarcopenia
    • Meng SJ, Yu LJ. Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci 2010; 11: 1509-1526.
    • (2010) Int J Mol Sci , vol.11 , pp. 1509-1526
    • Meng, S.J.1    Yu, L.J.2
  • 81
    • 0033778580 scopus 로고    scopus 로고
    • Strength training in the elderly: effects on risk factors for age-related diseases
    • Hurley BF, Roth SM. Strength training in the elderly: effects on risk factors for age-related diseases. Sports Med 2000; 30: 249-268.
    • (2000) Sports Med , vol.30 , pp. 249-268
    • Hurley, B.F.1    Roth, S.M.2
  • 82
    • 8644290928 scopus 로고    scopus 로고
    • Interventions for sarcopenia and muscle weakness in older people
    • Borst SE. Interventions for sarcopenia and muscle weakness in older people. Age Ageing 2004; 33: 548-555.
    • (2004) Age Ageing , vol.33 , pp. 548-555
    • Borst, S.E.1
  • 83
    • 34548269021 scopus 로고    scopus 로고
    • Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association
    • Nelson ME, Rejeski WJ, Blair SN etal. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007; 39: 1435-1445.
    • (2007) Med Sci Sports Exerc , vol.39 , pp. 1435-1445
    • Nelson, M.E.1    Rejeski, W.J.2    Blair, S.N.3
  • 84
    • 0032849080 scopus 로고    scopus 로고
    • Once-weekly resistance exercise improves muscle strength and neuromuscular performance in older adults
    • Taaffe DR, Duret C, Wheeler S, Marcus R. Once-weekly resistance exercise improves muscle strength and neuromuscular performance in older adults. J Am Geriatr Soc 1999; 47: 1208-1214.
    • (1999) J Am Geriatr Soc , vol.47 , pp. 1208-1214
    • Taaffe, D.R.1    Duret, C.2    Wheeler, S.3    Marcus, R.4
  • 85
    • 49949106422 scopus 로고    scopus 로고
    • The functional effects of physical exercise training in frail older people: a systematic review
    • Chin APMJ, van Uffelen JG, Riphagen I, van Mechelen W. The functional effects of physical exercise training in frail older people: a systematic review. Sports Med 2008; 38: 781-793.
    • (2008) Sports Med , vol.38 , pp. 781-793
    • Chin, A.P.M.J.1    van Uffelen, J.G.2    Riphagen, I.3    van Mechelen, W.4
  • 86
    • 70449625402 scopus 로고    scopus 로고
    • Aerobic exercise training improves whole muscle and single myofiber size and function in older women
    • Harber MP, Konopka AR, Douglass MD etal. Aerobic exercise training improves whole muscle and single myofiber size and function in older women. Am J Physiol Regul Integr Comp Physiol 2009; 297: R1452-R1459.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Harber, M.P.1    Konopka, A.R.2    Douglass, M.D.3
  • 87
    • 2542418311 scopus 로고    scopus 로고
    • Effects of resistance training on older adults
    • Hunter GR, McCarthy JP, Bamman MM. Effects of resistance training on older adults. Sports Med 2004; 34: 329-348.
    • (2004) Sports Med , vol.34 , pp. 329-348
    • Hunter, G.R.1    McCarthy, J.P.2    Bamman, M.M.3
  • 88
    • 70349257686 scopus 로고    scopus 로고
    • Impact of short-term aerobic interval training on maximal exercise in sedentary aged subjects
    • Lepretre PM, Vogel T, Brechat PH etal. Impact of short-term aerobic interval training on maximal exercise in sedentary aged subjects. Int J Clin Pract 2009; 63: 1472-1478.
    • (2009) Int J Clin Pract , vol.63 , pp. 1472-1478
    • Lepretre, P.M.1    Vogel, T.2    Brechat, P.H.3
  • 90
    • 77951965337 scopus 로고    scopus 로고
    • Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men
    • Fry CS, Glynn EL, Drummond MJ etal. Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. J Appl Physiol 2010; 108: 1199-1209.
    • (2010) J Appl Physiol , vol.108 , pp. 1199-1209
    • Fry, C.S.1    Glynn, E.L.2    Drummond, M.J.3


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