메뉴 건너뛰기




Volumn 63, Issue 2, 2008, Pages 160-164

Functional outcomes for clinical trials in frail older persons: Time to be moving

(18)  Evans, William J a   Bhasin, Shalender b   Cress, Elaine c   Espeland, Mark A d   Ferrucci, Luigi e   Fried, Linda P f   Gill, Thomas M g   Pahor, Marco h   Studenski, Stephanie i   Guralnik, Jack j   Nayfield, Susan k   Romashkin, Sergei k   Eldadah, Basil A k   Suzman, Richard l   Haaga, John l   Perlstein, Robert m   Burke, Laurie m   Parks, Mary m  


Author keywords

[No Author keywords available]

Indexed keywords

AGING; CLINICAL PRACTICE; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; FRAIL ELDERLY; HEALTH CARE COST; HUMAN; LIFESTYLE; MEDICAL RESEARCH; MUSCLE ATROPHY; OSTEOPOROSIS; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; AGED; ARTICLE; CHRONIC DISEASE; DAILY LIFE ACTIVITY; DISABLED PERSON; DISEASE COURSE; GERIATRIC ASSESSMENT; GERIATRICS; HEALTH CARE PLANNING; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL;

EID: 42449130997     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/63.2.160     Document Type: Review
Times cited : (154)

References (46)
  • 1
    • 0028838732 scopus 로고
    • What is sarcopenia?
    • Nov;
    • Evans W. What is sarcopenia? J Gerontol. 1995 Nov;50 Spec No:5-8.
    • (1995) J Gerontol , Issue.50 SPEC , pp. 5-8
    • Evans, W.1
  • 3
    • 0036318659 scopus 로고    scopus 로고
    • Medical and long-term care costs when older persons become more dependent
    • Guralnik JM, Alecxih L, Branch LG, Wiener JM. Medical and long-term care costs when older persons become more dependent. Am J Public Health. 2002;92:1244-1245.
    • (2002) Am J Public Health , vol.92 , pp. 1244-1245
    • Guralnik, J.M.1    Alecxih, L.2    Branch, L.G.3    Wiener, J.M.4
  • 4
    • 2442699834 scopus 로고    scopus 로고
    • Frailty in older adults: Evidence for a phenotype
    • Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol Med Sci. 2001;56A:M146-M156.
    • (2001) J Gerontol Med Sci , vol.56 A
    • Fried, L.P.1    Tangen, C.M.2    Walston, J.3
  • 5
    • 33745158645 scopus 로고    scopus 로고
    • Frailty syndrome and skeletal muscle: Results from the Invecchiare in Chianti study
    • Cesari M, Leeuwenburgh C, Lauretani F, et al. Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr. 2006;83:1142-1148.
    • (2006) Am J Clin Nutr , vol.83 , pp. 1142-1148
    • Cesari, M.1    Leeuwenburgh, C.2    Lauretani, F.3
  • 6
    • 0037111615 scopus 로고    scopus 로고
    • Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study
    • Walston J, McBurnie MA, Newman A, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162:2333-2341.
    • (2002) Arch Intern Med , vol.162 , pp. 2333-2341
    • Walston, J.1    McBurnie, M.A.2    Newman, A.3
  • 7
    • 44349129520 scopus 로고    scopus 로고
    • Public Health Service Act of 1974, P.L. Subpart 5 - National Institute on Aging: Sec.443 (285e). 1974:93-296.
    • Public Health Service Act of 1974, P.L. Subpart 5 - National Institute on Aging: Sec.443 (285e). 1974:93-296.
  • 8
    • 0029013637 scopus 로고
    • A randomized trial of care in a hospital medical unit especially designed to improve the functional outcomes of acutely ill older patients
    • Landefeld CS, Palmer RM, Kresevic DM, Fortinsky RH, Kowal J. A randomized trial of care in a hospital medical unit especially designed to improve the functional outcomes of acutely ill older patients. N Engl J Med. 1995;332:1338-1344.
    • (1995) N Engl J Med , vol.332 , pp. 1338-1344
    • Landefeld, C.S.1    Palmer, R.M.2    Kresevic, D.M.3    Fortinsky, R.H.4    Kowal, J.5
  • 9
    • 0032031122 scopus 로고    scopus 로고
    • Comparison of the WOMAC (Western Ontario and McMaster Universities) osteoarthritis index and a self-report format of the self-administered Lequesne-Algofunctional index in patients with knee and hip osteoarthritis
    • Stucki G, Sangha O, Stucki S, et al. Comparison of the WOMAC (Western Ontario and McMaster Universities) osteoarthritis index and a self-report format of the self-administered Lequesne-Algofunctional index in patients with knee and hip osteoarthritis. Osteoarthritis Cartilage. 1998;6:79-86.
    • (1998) Osteoarthritis Cartilage , vol.6 , pp. 79-86
    • Stucki, G.1    Sangha, O.2    Stucki, S.3
  • 10
    • 0036711374 scopus 로고    scopus 로고
    • Reliability and sensitivity to change assessed for a summary measure of lower body function: Results from the Women's Health and Aging Study
    • Ostir GV, Volpato S, Fried LP, Chaves P, Guralnik JM. Reliability and sensitivity to change assessed for a summary measure of lower body function: results from the Women's Health and Aging Study. J Clin Epidemiol. 2002;55:916-921.
    • (2002) J Clin Epidemiol , vol.55 , pp. 916-921
    • Ostir, G.V.1    Volpato, S.2    Fried, L.P.3    Chaves, P.4    Guralnik, J.M.5
  • 11
    • 0028292936 scopus 로고
    • Short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission
    • Guralnik JM, Simonsick EM, Ferrucci L, Wallace RB. Short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol Med Sci. 1994;49A:M85-M94.
    • (1994) J Gerontol Med Sci , vol.49 A
    • Guralnik, J.M.1    Simonsick, E.M.2    Ferrucci, L.3    Wallace, R.B.4
  • 12
    • 0028898029 scopus 로고
    • Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
    • Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332:556-561.
    • (1995) N Engl J Med , vol.332 , pp. 556-561
    • Guralnik, J.M.1    Ferrucci, L.2    Simonsick, E.M.3    Salive, M.E.4    Wallace, R.B.5
  • 13
    • 0034098121 scopus 로고    scopus 로고
    • Lower extremity function and subsequent disability: Consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery
    • Guralnik JM, Ferrucci L, Pieper CF, et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol Med Sci. 2000;55A:M221-M231.
    • (2000) J Gerontol Med Sci , vol.55 A
    • Guralnik, J.M.1    Ferrucci, L.2    Pieper, C.F.3
  • 14
    • 33644750575 scopus 로고    scopus 로고
    • Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women
    • Rolland Y, Lauwers-Cances V, Cesari M, Vellas B, Pahor M, Grandjean H. Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women. Eur J Epidemiol. 2006;21:113-122.
    • (2006) Eur J Epidemiol , vol.21 , pp. 113-122
    • Rolland, Y.1    Lauwers-Cances, V.2    Cesari, M.3    Vellas, B.4    Pahor, M.5    Grandjean, H.6
  • 15
    • 16644389842 scopus 로고    scopus 로고
    • Incidence of loss of ability to walk 400 meters in a functionally limited older population
    • Chang M, Cohen-Mansfield J, Ferrucci L, et al. Incidence of loss of ability to walk 400 meters in a functionally limited older population. J Am Geriatr Soc. 2004;52:2094-2098.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 2094-2098
    • Chang, M.1    Cohen-Mansfield, J.2    Ferrucci, L.3
  • 17
    • 2342488634 scopus 로고    scopus 로고
    • Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    • Penninx BW, Pahor M, Cesari M, et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc. 2004;52:719-724.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 719-724
    • Penninx, B.W.1    Pahor, M.2    Cesari, M.3
  • 18
    • 33745005054 scopus 로고    scopus 로고
    • Meaningful change and responsiveness in common physical performance measures in older adults
    • Perera S, Mody SH, Woodman RC, Studenski SA. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc. 2006;54:743-749.
    • (2006) J Am Geriatr Soc , vol.54 , pp. 743-749
    • Perera, S.1    Mody, S.H.2    Woodman, R.C.3    Studenski, S.A.4
  • 19
    • 33749449793 scopus 로고    scopus 로고
    • Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: The LADIS study
    • Gouw AA, Van der Flier WM, van Straaten EC, et al. Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS study. J Neurol. 2006;253:1189-1196.
    • (2006) J Neurol , vol.253 , pp. 1189-1196
    • Gouw, A.A.1    Van der Flier, W.M.2    van Straaten, E.C.3
  • 20
    • 0034724426 scopus 로고    scopus 로고
    • White matter abnormalities in mobility-impaired older persons
    • Guttmann CR, Benson R, Warfield SK, et al. White matter abnormalities in mobility-impaired older persons. Neurology. 2000;54:1277-1283.
    • (2000) Neurology , vol.54 , pp. 1277-1283
    • Guttmann, C.R.1    Benson, R.2    Warfield, S.K.3
  • 21
    • 1642316427 scopus 로고    scopus 로고
    • Inflammatory markers and physical performance in older persons: The InCHIANTI study
    • Cesari M, Penninx BW, Pahor M, et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol Biol Sci Med Sci. 2004;59A:242-248.
    • (2004) J Gerontol Biol Sci Med Sci , vol.59 A , pp. 242-248
    • Cesari, M.1    Penninx, B.W.2    Pahor, M.3
  • 22
    • 30944459212 scopus 로고    scopus 로고
    • D-dimer and inflammatory markers as predictors of functional decline in men and women with and without peripheral arterial disease
    • McDermott MM, Ferrucci L, Liu K, et al. D-dimer and inflammatory markers as predictors of functional decline in men and women with and without peripheral arterial disease. J Am Geriatr Soc. 2005;53:1688-1696.
    • (2005) J Am Geriatr Soc , vol.53 , pp. 1688-1696
    • McDermott, M.M.1    Ferrucci, L.2    Liu, K.3
  • 23
    • 0033850684 scopus 로고    scopus 로고
    • Characteristics of nondisabled older persons who perform poorly in objective tests of lower extremity function
    • Ferrucci L, Penninx BW, Leveille SG, et al. Characteristics of nondisabled older persons who perform poorly in objective tests of lower extremity function. J Am Geriatr Soc. 2000;48:1102-1110.
    • (2000) J Am Geriatr Soc , vol.48 , pp. 1102-1110
    • Ferrucci, L.1    Penninx, B.W.2    Leveille, S.G.3
  • 24
    • 33749240144 scopus 로고    scopus 로고
    • Body mass index, free insulin-like growth factor I, and physical function among older adults: Results from the ilSIRENTE study
    • Onder G, Liperoti R, Russo A, et al. Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study. Am J Physiol Endocrinol Metab. 2006;291:E829-E834.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Onder, G.1    Liperoti, R.2    Russo, A.3
  • 25
    • 23244464042 scopus 로고    scopus 로고
    • Lower limb function as predictor of falls and loss of mobility with social repercussions one year after discharge among elderly inpatients
    • Quadri P, Tettamanti M, Bernasconi S, Trento F, Loew F. Lower limb function as predictor of falls and loss of mobility with social repercussions one year after discharge among elderly inpatients. Aging Clin Exp Res. 2005;17:82-89.
    • (2005) Aging Clin Exp Res , vol.17 , pp. 82-89
    • Quadri, P.1    Tettamanti, M.2    Bernasconi, S.3    Trento, F.4    Loew, F.5
  • 27
    • 33745650685 scopus 로고    scopus 로고
    • Lifetime occupation and physical function: A prospective cohort study on persons aged 80 years and older living in a community
    • Russo A, Onder G, Cesari M, et al. Lifetime occupation and physical function: a prospective cohort study on persons aged 80 years and older living in a community. Occup Environ Med. 2006;63:438-442.
    • (2006) Occup Environ Med , vol.63 , pp. 438-442
    • Russo, A.1    Onder, G.2    Cesari, M.3
  • 28
    • 0037347297 scopus 로고    scopus 로고
    • Physical performance measures in the clinical setting
    • Studenski S, Perera S, Wallace D, et al. Physical performance measures in the clinical setting. J Am Geriatr Soc. 2003;51:314-322.
    • (2003) J Am Geriatr Soc , vol.51 , pp. 314-322
    • Studenski, S.1    Perera, S.2    Wallace, D.3
  • 29
    • 27544456849 scopus 로고    scopus 로고
    • Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women
    • Gerdhem P, Ringsberg KA, Obrant KJ, Akesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int. 2005;16:1425-1431.
    • (2005) Osteoporos Int , vol.16 , pp. 1425-1431
    • Gerdhem, P.1    Ringsberg, K.A.2    Obrant, K.J.3    Akesson, K.4
  • 30
    • 27744564977 scopus 로고    scopus 로고
    • Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older
    • Montero-Odasso M, Schapira M, Soriano ER, et al. Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older. J Gerontol Biol Sci Med Sci. 2005;60A:1304-1309.
    • (2005) J Gerontol Biol Sci Med Sci , vol.60 A , pp. 1304-1309
    • Montero-Odasso, M.1    Schapira, M.2    Soriano, E.R.3
  • 31
    • 18944394857 scopus 로고    scopus 로고
    • Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults
    • Rosano C, Kuller LH, Chung H, Arnold AM, Longstreth WT Jr, Newman AB. Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults. J Am Geriatr Soc. 2005;53:649-654.
    • (2005) J Am Geriatr Soc , vol.53 , pp. 649-654
    • Rosano, C.1    Kuller, L.H.2    Chung, H.3    Arnold, A.M.4    Longstreth Jr, W.T.5    Newman, A.B.6
  • 32
    • 20144364111 scopus 로고    scopus 로고
    • Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test
    • Wise RA, Brown CD. Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test. COPD. 2005;2:125-129.
    • (2005) COPD , vol.2 , pp. 125-129
    • Wise, R.A.1    Brown, C.D.2
  • 33
    • 0027443521 scopus 로고
    • Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction
    • Bittner V, Weiner DH, Yusuf S, et al. Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. JAMA. 1993;270:1702-1707.
    • (1993) JAMA , vol.270 , pp. 1702-1707
    • Bittner, V.1    Weiner, D.H.2    Yusuf, S.3
  • 35
    • 33746329320 scopus 로고    scopus 로고
    • Reliability, validity, and responsiveness of a 2-min walk test to assess exercise capacity of COPD patients
    • Leung AS, Chan KK, Sykes K, Chan KS. Reliability, validity, and responsiveness of a 2-min walk test to assess exercise capacity of COPD patients. Chest. 2006;130:119-125.
    • (2006) Chest , vol.130 , pp. 119-125
    • Leung, A.S.1    Chan, K.K.2    Sykes, K.3    Chan, K.S.4
  • 36
    • 33846386753 scopus 로고    scopus 로고
    • Six-minute walk distance as parameter of functional outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    • Reesink HJ, van der Plas MN, Verhey NE, van Steenwijk RP, Kloek JJ, Bresser P. Six-minute walk distance as parameter of functional outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. J Thorac Cardiovasc Surg. 2007;133:510-516.
    • (2007) J Thorac Cardiovasc Surg , vol.133 , pp. 510-516
    • Reesink, H.J.1    van der Plas, M.N.2    Verhey, N.E.3    van Steenwijk, R.P.4    Kloek, J.J.5    Bresser, P.6
  • 37
    • 0034791944 scopus 로고    scopus 로고
    • Measuring higher level physical function in well-functioning older adults: Expanding familiar approaches in the Health ABC study
    • Simonsick EM, Newman AB, Nevitt MC, et al. Measuring higher level physical function in well-functioning older adults: expanding familiar approaches in the Health ABC study. J Gerontol Med Sci. 2001;56A:M644-M649.
    • (2001) J Gerontol Med Sci , vol.56 A
    • Simonsick, E.M.1    Newman, A.B.2    Nevitt, M.C.3
  • 38
    • 33646197938 scopus 로고    scopus 로고
    • Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability
    • Newman AB, Simonsick EM, Naydeck BL, et al. Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. JAMA. 2006;295:2018-2026.
    • (2006) JAMA , vol.295 , pp. 2018-2026
    • Newman, A.B.1    Simonsick, E.M.2    Naydeck, B.L.3
  • 40
    • 0036122380 scopus 로고    scopus 로고
    • The relationship between leg power and physical performance in mobility-limited older people
    • Bean JF, Kiely DK, Herman S, et al. The relationship between leg power and physical performance in mobility-limited older people. J Am Geriatr Soc. 2002;50:461-467.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 461-467
    • Bean, J.F.1    Kiely, D.K.2    Herman, S.3
  • 41
    • 4244185542 scopus 로고    scopus 로고
    • Exercise strategies should be designed to increase muscle power
    • Evans WJ. Exercise strategies should be designed to increase muscle power. J Gerontol Med Sci. 2000;55A:M309-M310.
    • (2000) J Gerontol Med Sci , vol.55 A
    • Evans, W.J.1
  • 42
    • 0034801881 scopus 로고    scopus 로고
    • Muscle power of the ankle flexors predicts functional performance in community-dwelling older women
    • Suzuki T, Bean JF, Fielding RA. Muscle power of the ankle flexors predicts functional performance in community-dwelling older women. J Am Geriatr Soc. 2001;49:1161-1167.
    • (2001) J Am Geriatr Soc , vol.49 , pp. 1161-1167
    • Suzuki, T.1    Bean, J.F.2    Fielding, R.A.3
  • 43
    • 18244382783 scopus 로고    scopus 로고
    • Randomized controlled drug trials on very elderly subjects: Descriptive and methodological analysis of trials published between 1990 and 2002 and comparison with trials on adults
    • Le Quintrec JL, Bussy C, Golmard JL, Herve C, Baulon A, Piette F. Randomized controlled drug trials on very elderly subjects: descriptive and methodological analysis of trials published between 1990 and 2002 and comparison with trials on adults. J Gerontol Biol Sci Med Sci. 2005;60A:340-344.
    • (2005) J Gerontol Biol Sci Med Sci , vol.60 A , pp. 340-344
    • Le Quintrec, J.L.1    Bussy, C.2    Golmard, J.L.3    Herve, C.4    Baulon, A.5    Piette, F.6
  • 44
    • 20044388344 scopus 로고    scopus 로고
    • Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    • Bhasin S, Woodhouse L, Casaburi R, et al. Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab. 2005;90:678-688.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 678-688
    • Bhasin, S.1    Woodhouse, L.2    Casaburi, R.3
  • 45
    • 14744299711 scopus 로고    scopus 로고
    • Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes
    • Allore HG, Tinetti ME, Gill TM, Peduzzi PN. Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes. Clin Trials. 2005;2:13-21.
    • (2005) Clin Trials , vol.2 , pp. 13-21
    • Allore, H.G.1    Tinetti, M.E.2    Gill, T.M.3    Peduzzi, P.N.4
  • 46
    • 1842784019 scopus 로고    scopus 로고
    • Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: A consensus report
    • Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr, Walston JD. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc. 2004;52:625-634.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 625-634
    • Ferrucci, L.1    Guralnik, J.M.2    Studenski, S.3    Fried, L.P.4    Cutler Jr, G.B.5    Walston, J.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.