Design and synthesis of 3,5-disubstituted boron-containing 1,2,4-oxadiazoles as potential combretastatin A-4 (CA-4) analogs

Tetrahedron Letters

Volumn 53, Issue 31, 2012, Pages 3947-3950

  Das, Bhaskar C ^a   Tang, Xiang Ying ^b   Rogler, Patrick ^b   Evans, Todd ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

3,5 Disubstituted 1,2,4 oxadiazole; Bioisosteres; Boron containing CA4 compound; Combretastatin A 4; Tubulin; Vascular disrupting agent

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; ALKENE; ANTIMITOTIC AGENT; BASE; CARBOXYLIC ACID; COMBRETASTATIN A4; DRUG ANALOG; PHENYL GROUP; REAGENT;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

EID: 84862674896     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2012.02.110     Document Type: Article

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