Drugs, nutrients, and hormones in mitochondrial function

Mitochondria in Health and Disease

Volumn , Issue , 2005, Pages 455-506

  Berdanier, Carolyn D ^a  

^a UNIVERSITY OF GEORGIA   (United States)

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EID: 84862667168     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (234)

1. TL Dawson, GJ Gores, AL Nieminen, B Herman, JJ Lemasters. Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes. Am J Physiol 264: C961-967; 1993.
2. RS Sohal. Mitochondria generate superoxide anion radicals and hydrogen peroxide. FASEB J 11:1269-1270; 1997.
3. M Glinn, L Ernster, CP Lee. Initiation of lipid peroxidation in submitochondrial particles: Effects of respiratory inhibitors. Arch Biochem Biophys 290:57-65; 1991.
4. B-O Lund, DM Miller, JS Woods. Studies on Hg(II) induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochem Pharmacol 45:2017-2024; 1993.
5. JH Karam, PA Lewitt, CW Young, RE Nowlain, BJ Frankel, H Fujiya, ZR Freedman, GM Gradsky. Insulinopenic diabetes after rodenticide (Vacor) ingestion. A unique model of acquired diabetes in man. Diabetes 29:971-978; 1980.
6. MD Espositi, A Ngo, MA Myers. Inhibition of mitochondrial complex I may account for IDDM induced by intoxication with rodenticide Vacor. Diabetes 45:1531-1534; 1996.
7. CB Wolheim. Beta-cell mitochondria in the regulation of insulin secretion: A new culprit in type 2 diabetes. Diabetologia43:265-277; 2000.
8. MD Esposti, A Ngo, GL McMullen, A Ghelle, A Sparla, B Benelli, M Ratta, AW Linnane. The specificity of mitochondrial complex I for ubiquinone. Biochem J 313:327-334; 1996.
9. AB Adolfe, ED Glasofer, WM Troetel, J Ziegenfuss, JE Stam-baugh, AJ Weiss, RW Manthei. Fate of streptozotocin (NSC-85998) in patients with advanced cancer. Cancer Chemother Rep 59: 547-551; 1975.
10. RN Arison, FL Feudale. Induction of renal tumors by streptozotocin in rat. Nature 214:1254-1255; 1967.
11. RN Arison, EL Ciaccio, MS Glitzer, JA Cassaro, MP Pruss. Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin. Diabetes 16:51-56; 1967.
12. G Brosky, J Logothetopolous. Streptozotocin diabetes in the mouse and guinea pig. Diabetes 18:606-611; 1969.
13. R Rasch. Tubular lesions in streptozotoci-diabetic rats. Diabe-tologia 27:32-37, 1984.
14. AA Like, AA Rossini. Streptozotocin-induced pancreatic insu-litis: New model of diabetes mellitus. Science 193:415-417; 1976.
15. S-G Paik, N Fleischer, S-I Shin. Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: Obligatory role of cell-mediated autoimmune processes. Proc Nat Acad Sci 77:6129-6133; 1980.
16. G Gold, M Manning, A Heldt, R Nowlain, JR Pettit, GA Grod-sky. Diabetes induced with multiple subdiabetogenic doses of streptozotocin. Lack of protection by exogenous superoxide dis-mutase. Diabetes 30:634-638; 1981.
17. N. Welsh, S Paabo, M Welsh. Decreased mitochondrial gene expression in isolated islets of rats injected neonatally with streptozotocin. Diabetologia 34:626-631; 1991.
18. X Huang, K-F Eriksson, A Vaag, M Lehtovirta, M Hansson, E Laurila, T Kanninen, BT Olesen, I Kurucz, L Koranyi, L Groop. Insulin regulated mitochondrial gene expression is associated with glucose flux in human skeletal muscle. Diabetes48:1508-1514; 1999.
19. DL Topping, ME Targ. Time course of changes in blood glucose and ketone bodies, plasma lipids and liver fatty acid composition in streptozotocin-diabetic male rats. Hormone Res6:129-137; 1975.
20. FH Fass, WL Carter. Altered fatty acid desaturation and microsomal fatty acid composition in the streptozotocin-treated diabetic rat. Lipids 15:953-961; 1980.
21. TA Brasitus, PK Dudeja. Corrrection of abnormal lipid fluidity and composition of rat ileal microvillus membranes in chronic streptozotocin-induced diabetes by insulin therapy. J Biol Chem 260:12405-12409; 1985.
22. DD Gallaher, AS Csallany, DW Shoeman, JM Olson. Diabetes increases excretion of urinary malonaldehyde conjugates in rats. Lipids 28:663-666; 1993.
23. L Boquist, I Ericsson. Inhibition by streptozotocin of the activity of succinyl-CoA synthetase in vitro and in vivo. FEBS196:341-343; 1986.
24. JS Dunn, J Kirkpatrick, NGB McLetchie, SV Telfer. Necrosis of the islets of Langerhans produced experimentally. J Path Bact 55:245-257; 1943.
25. S Lenzen, U Panten. Alloxan: History and mechanism of action. Diabetologia 31:337-342; 1988.
26. RE Heikkila. Free radical production by alloxan. Eur J Pharmacol 44:191-196; 1977.
27. WJ Malaisse. Alloxan toxicity to the pancreatic B-cell. A new hypothesis. Biochem Pharmacol 31:3527-3534; 1982.
28. JG Asuncion, ML Olmo, J Sastre, A Millan, A Pellin, FV Pal-lardo. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. J Clin Invest102:4-9; 1998.
29. JG Asuncion, ML Olmo, J Sastre, FV Pallardo, J Vina. Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver. Hepatology 29:985-987; 1999.
30. LF Pereira, MBM Oliveira, EGS Carnieri. Mitochondrial sensitivity to AZT. Cell Biochem Function 16:173-181; 1998.
31. RC Young, RF Ozols, CE Meyers. Adriamycin: A chemotherapeutic drug for malignancy treatment. N Eng J Med305:139-153; 1981.
32. K Nicolay, B De Kruijff. Effects of adriamycin on respiratory chain acitivités in mitochondria from rat liver, rat heart and bovine heart. Evidence for a preferential inhibition of complex III and IV. Biochemica Biophysica Acta 892:320-330; 1987.
33. K Nicolay, RJM Timmers, E Spoelstra, R Van Der Neut, JJ Fok, YM Huigen, AJ Verkleij, B De Kruijff. The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes. Biochemica Biophysica Acta 778:359-371; 1984.
34. E Goormaghtigh, P Huart, M Praet, R Brasseur, J-M Ruyss-chaert. Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity. Biophys Chem 35:247-257; 1990.
35. J Fischer, MA Johnson, RL Tackett. The effect of copper deficiency on adriamycin toxicity. Toxicol Lett 57:147-158; 1991.
36. L Moore, EJ Landon, DA Cooney. Inhibition of the cardiac mitochondrial calcium pump by adriamycin in vitro. Biochem Med 18:131-138; 1977.
37. PM Sokolove. Mitochondrial sulfhydryl group modification by adriamycin aglycones. FEB 234:199-202; 1988.
38. R Ogura, H Ueta, Y Hino, T Hidaka, M Sugiyama. Riboflavin deficiency caused by adriamycin. J Nutr Sci Vitaminol37:473-477; 1991.
39. G Wolf, RS Rivlin. Inhibition of thyroid hormone induction of mitochondrial a-glycerophosphate dehydrogenase in riboflavin deficiency. Endocrinol 86:1347-1353; 1970.
40. SS Chan, JN Fain. Uncoupling action of sulfonylureas on brown fat cells. Mol Pharmacol 6:513-523; 1970.
41. JM Lenhard, SA Kliewer, MA Paulik, KD Plunket, JM Lehmann, JE Weiel. Effects of troglitazone and metformin on glucose and lipid metabolism. Biochem Pharmacol 54:801-808; 1997.
42. MA Paulik, RG Buckholz, ME Lancaster, WS Dallas, EA Hull-Ryde, JE Weiel, JM Lenhard. Development of infrared imaging to measure thermogenesis in cell culture: Thermogenic effects of uncoupling protein-2, troglitazone and b-adrenergic agents. Pharmaceutical Res 15:944-949; 1998.
43. MA Tirmenstein, CX Hu, TL Gales, BE Maleeff, PK Narayanan, E Kurali, TK Hart, HC Thomas, LW Schwartz. Effects of troglitazone on HepG2 viability and mitochondrial function. Toxicol Sci 69:131-138; 2002.
44. MA Mehlman, RB Tobin, EM Sporn. Oxidative phosphorylation and respiration by rat liver mitochondria from aspirin treated rats. Biochem Pharmacol 21:3279-3285; 1972.
45. L Thomkins, KH Lee. The aspirin effect on respiration is due to its conversion to salicylic acid. J Pharm Sci 58:102-106; 1969.
46. JB Hoek. Mitochondrial energy metabolism in chronic alcoholism. Curr Topics Bioenergetics 17:197-241; 1994.
47. A Chedid, CL Mendenhall, T Tosch, T Chen, L Rabin, P Garcia-Pont, SJ Goldberg, T Kiernan, LB Seef, M Sorrell, C Tam-burro, RE Weesner, R Zetterman. Significance of megamitochondria in alcoholic liver disease. Gastroenterology90:1858-1864; 1986.
48. M Arai, MA Leo, M Nakano, ER Gordon, CS Lieber. Biochemical and morphological alterations of baboon hepatic mitochondria after chronic ethanol consumption. Hepatology 4:165-174; 1984.
49. S Wahid, JM Khanna, PJ Carmichael, Y Israel. Mitochondrial function following chronic ethanol treatment: Effect of diet. Res Comm Chem Path Pharmacol 30:477-491; 1980.
50. HA Krebs, RA Freedland, R Hems, M Stubbs. Inhibition of hepatic gluconeogenesis by ethanol. Biochem J 112:117-124; 1969.
51. CL Keen, T Tamura, B Lonnerdal, LS Hurley, CH Halsted. Changes in hepatic superoxide dismutase activity in alcoholic monkeys. Am J Clin Nutr 41:929-932; 1985.
52. A Endo. The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res 33:1569-1562; 1992.
53. DB Hunninghake, EA Stein, CA Dujovne, WS Harris, EB Feldman, VT Miller, JA Tobert, PM Laskarzewski, E Quiter, J Held, AM Taylor, S Hopper, SB Leonard, BK Brewer. The efficacy of intensive dietary therapy alone or combined with lovostatin in outpatients with hypercholesterolemia. N Eng J Med328:1213-1219; 1993.
54. G De Pinieux, P Chariot, M Ammi-Said, F Louarn, JL Lejone, A Astier, B Jacotot, R Gherardi. Lipid lowering drugs and mitochondrial function: Effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 42:333-337; 1996.
55. MJ Muller, HJ Seitz. Dose dependent stimulation of hepatic oxygen consumption and alanine conversion to CO2 and glucose by 3,5,3'-triiodo-L-thyronine (T3) in isolated perfused liver of hypothyroid rats. Life Sci 28:2243-2249; 1981.
56. CD Berdanier. Effects of thyroid hormone on the gluconeogenic capacity of lipemic BHE rats. Proc Sco Exp Biol Med172:187-193; 1983.
57. RB Tobin, CD Berdanier, RE Ecklund, V DeVore, C Caton. Mitochondrial shuttle activities in hyperthyroid and normal rats and guinea pigs. J Environ Pathol Toxicol 3:289-305, 1980.
58. CD Berdanier, D Shubeck. Effects of thyroid hormone on mitochondrial activity in lipemic BHE rats. Proc Soc Exp Biol Med166:348-354; 1981.
59. HG Klemperer. The uncoupling of oxidative phosphorylation in rat liver mitochondria. Biochem J 60:122-128; 1955.
60. RP Hafner, GC Brown, MD Brand. Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria. Bio-chem J 265:731-734; 1990.
61. P Venditti, S Di Meo, T De Leo. Effect of thyroid state on characteristics determining the susceptibility to oxidative stress of mitochondrial fractions from rat liver. Cell Physiol Biochem 6:283-295; 1996.
62. HJ Seitz, MJ Muller, S Soboll. Rapid thyroid-hormone effect on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell. Biochem J 227:149-153; 1985.
63. K Nishiki, M Erecinska, DF Wilson, S Copper. Evaluation of oxidative phosphorylation in hearts from euthyroid, hypothyroid and hyperthyroid rats. Am J Physiol 235:C212-C219; 1978.
64. RB Gregory, MN Berry. On the thyroid hormone-induced increase in respiratory capacity of isolated rat hepatocytes. Biochem Biophys Acta 1098:61-67; 1991.
65. S Luvisetto, I Schmehl, E Intravaia, E Conti, GF Azzone. Mechanism of loss of thermodynamic control in mitochondria due to hyperthyroidism and temperature. J Biol Chem267:15348-15355; 1992.
66. ME Harper, JS Ballantyne, M Leach, MD Brand. Effects of thyroid hormones on oxidative phosphorylation. Biochem Soc Trans 21:785-792; 1993.
67. WE Thomas, A Crespo-Armas, J Mowbray. The influence of nanomolar calcium ions and physiological levels of thyroid hormone on oxidative phosphorylation in rat liver mitochondria. A possible signal amplification mechanism. Biochem J247:315-320; 1987.
68. S Luvisetto, I Schmehl, E Conti, E Intravaia, GF Azzone. Activation of respiration and loss of thermodynamic control in hyperthyroidism. Is it due to increased slipping of mitochondrial pumps? FEBS 291:17-20; 1991.
69. ME Harper, MD Brand. Use of top-down elasticity analysis to identify sites of thyroid hormone-induced thermogenesis. Proc Soc Exp Biol Med 208:228-237; 1995.
70. J Bouhnik, J-P Clot, M Baudry, R Michel. Early effects of thyroidectomy and triiodothyronine administration on rat liver mitochondria. Mol Cell Endocrinol 15:1-12; 1979.
71. K Sterling. Thyroid hormone action at the cell level. N Eng J Med 300:117-123; 173-177; 1979.
72. S Sugiyama, T Kato, T Ozawa, K Yagi. Deterioration of mitochondrial function in heart muscles of rats with hypothyroidism. J Clin Biochem Nutr 11:199-204; 1991.
73. I Ezawa, M Yamamoto, S Kimura, E Ogata. Alterations of oxidative phosphorylation reactions in mitochondria isolated from hypothyroid rat liver. Eur J Biochem 141:9-13; 1984.
74. S Iossa, A Barletta, G Liverini. The effect of thyroid state and cold exposure on rat liver oxidative phosphorylation. Mol Cell Endocrinol 75:15-18; 1991.
75. FL Hoch, C Subramanian, GA Dhopeshwarkar, JF Mead. Thyroid control over biomembranes: Vi lipids in liver mitochondria and microsomes of hypothyroid rats. Lipids 16:328-335; 1981.
76. D Raederstorff, CA Meier, U Moser, P Walter. Hypothyroidism and thyroxin substitution affect the n-3 fatty acid composition of rat liver mitochondria. Lipids 26:781-787; 1991.
77. G Paradies, FM Ruggiero, P Dinoi. The influence of hypothyroidism on the transport of phosphate and on the lipid composition in rat liver mitochondria. Biochem Biophys Acta1070:180-189; 1991.
78. FL Hoch, JW Depierre, L Ernster. Thyroid control over biomembranes. Liver microsomal cytochrome b5 in hypothyroidism. Eur J Biochem 109:301-306; 1980.
79. KW Withers, AJ Hubert. The influence of dietary fatty acids and hypothyroidism on mitochondrial fatty acid composition. Nutr Res 7:1139-1159; 1987.
80. JA Stakkestad, J Bremer. The metabolism of fatty acids in hepatocytes isolated from triiodothyronine-treated rats. Bio-chem Biophys Acta 711:90-100; 1982.
81. FM Ruggiero, C Landriscina, GV Gnoni, E Quagiariello. Lipid composition of liver mitochondria and microsomes in hyperthyroid rats. Lipids 19:171-178; 1984.
82. CS Bangur, JL Howland, SS Kattare. Thyroid hormone treatment alters phospholipid composition and membrane fluidity of rat brain mitochondria. Biochem J 305:9-32; 1995.
83. Z Beleznai, E Amler, H Rauchova, Z Drahota, V Janecsik. Influence of thyroid status on the membranes of rat liver mitochondria. Unique localization of L-glycerol-3-phosphate dehydrogenase. FEB 243:247-250; 1989.
84. G Paradies, FM Ruggiero. Enhanced activity of the tricarbox-ylate carrier and modification of lipids in hepatic mitochondria from hyperthyroid rats. Arch Biochem Biophys 278:425-430; 1990.
85. JM Tibaldi, N Sahnoun, MI Surks. Response of hepatic mitochondrial a-glycerophosphate dehydrogenase and malic enzyme to constant infusions of L-triiodothyronine in rats bearing the Walker 256 carcinoma. Evidence for the divergent postreceptor regulation of the thyroid hormone response. J Clin Invest 74:705-714; 1984.
86. Y-P Lee, AE Takemori, H Lardy. Enhanced oxidation of a-glycerophosphate by mitochondria of thyroid-fed rats. J Biol Chem 234:3051-3055; 1959.
87. JH Oppenheimer, E Silva, HL Schwartz, MI Surks. Stimulation of hepatic mitochondrial a-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated. J Clin Invest 59:517-527; 1977.
88. C van Hardeveld, R Rusche, AAH Kassenaar. Sensitivity of mitochondrial a-glycerophosphate dehydrogenase to thyroid hormone in skeletal muscle of the rat. Horm Metab Res8:153-154; 1976.
89. B Bulos, B Saktor, IW Grossman, N Altman. Thyroid control over mitochondrial a-glycerophosphate dehydrogenase in rat liver as a function of age. J Gerontol 26:13-19; 1971.
90. S Muller, HJ Seitz. Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones. Proc Nat Acad Sci USA91:10581-10585; 1994.
91. W Hoppner, UB Rasmussen, G Abuerreish, H Wohlrab, HJ Seitz. Thyroid hormone effect on gene expression of the adenine nucleotide translocase in different rat tissues. Mol Endocrinol2:1127-1131; 1988.
92. MD Brand, D Steverding, B Kadenbach, PM Stevenson, RP Hafner. The mechanism of the increase in mitochondrial proton permeability induced by thyroid hormones. Eur J Biochem206:775-781; 1992.
93. SB Shears, JR Bronk. Ion transport in liver mitochondria from normal and thyroxine-treated rats. J Bioenergetics Biomembranes 12:379-393; 1980.
94. RF Castilho, AJ Kowaltowski, AE Vercesi. 3,5,3'-triiodothyro-nine induces mitochondrial permeability transition mediated by reactive oxygen species and membrane protein thiol oxidation. Arch Biochem Biophys 354:151-157; 1998.
95. G Paradies, FM Ruggiero. Stimulation of phosphate transport in rat-liver mitochondria by thyroid hormones. Biochim Bio-phys Acta 1019:133-136; 1990.
96. S Soboll, C Horst, H Hummerich, JP Schumacher, HJ Seitz. Mitochondrial metabolism in different thyroid states. Biochem J 281:171-173; 1992.
97. RS Tyzbir, AS Kunin, NM Sims, E Danforth. Influence of diet composition on serum triiodothyronine (T3) concentration, hepatic mitochondrial metabolism and shuttle system activity in rats. J Nutr 111:252-259; 1981.
98. OE Deaver, RC Wander, RH McCusker, CD Berdanier. Diet effects on mitochondrial phospholipid fatty acids and mitochondrial function in BHE rats. J Nutr 116:1148-1155; 1986.
99. RC Wander, CD Berdanier. Effects of dietary carbohydrate on mitochondrial composition and function in two strains of rats. J Nutr 115:190-199; 1985.
100. E Danforth, AG Burger. The impact of nutrition on thyroid hormone physiology and action. Annu Rev Nutr 9:210-227; 1989.
101. R Didier, C Remesy, C Demigne, P Fafournoux. Hepatic proliferation of mitochopndria in response to a high protein diet. Nutr Res 5:1093-1102; 1985.
102. J Ferreira, L Gil. Nutritional effects on mitochondrial bioenergetics. Alterations in oxidative phosphorylation by rat liver mitochondria. Biochem J 218:61-67; 1984.
103. JM Matz, JT Saari, AM Bode. Functional aspects of oxidative phosphorylation and electron transport in cardiac mitochondria of copper deficient rats. J Nutr Biochem 6:644-652; 1995.
104. REC Wildman, R Hopkins, ML Failla, DM Medeiros. Marginal copper-restricted diets produce altered cardiac ultrastructure in the rat. Proc Soc Exp Biol Med 210:43-49; 1995.
105. WT Johnson, SN Dufault, SM Neuman. Altered nucleotide content and changes in mitochondrial energy states associated with copper deficiency in rat platelets. J Nutr Biochem6:551-556; 1995.
106. Y Hoshi, O Hazeki, M Tamura. Oxygen dependence of redox state of copper in cytochrome oxidase in vitro. J Appl Physiol74:1622-1627; 1993.
107. M-JC Kim, CD Berdanier. Influence of menhaden oil on mitochondrial respiration in BHE rats. Proc Soc Exp Biol Med192:172-1176; 1989.
108. M-JC Kim, CD Berdanier. Nutrient-gene interactions determine mitochondrial function: Effect of dietary fat. FASEB J12:243-248; 1998.
109. K Wickwire, K Kras, C Gunnett, D Hartle, CD Berdanier. Menhaden oil feeding increases potential for renal free radical production in BHE/cdb rats. Proc Soc Exp Biol Med209:397-402; 1995.
110. CD Berdanier, B Johnson, DK Hartle, WA Crowell. Lifespan is shortened in BHE/cdb rats fed a diet containing 9% menhaden oil and 1% corn oil. J Nutr 122:1109-1131; 1992.
111. H Morii, Y Takeuchi, Y Watanabe. Selective inhibition of NADH-CoQ oxidoreductase (complex I) of rat brain mitochondria by arachidonic acid. Biochem Biophys Res Commun178:1120-1126; 1991.
112. H Rottenberg, S Steiner-Mordoch. Free fatty acids decouple oxidative phosphorylation by dissipating intramembranal protons without inhibiting ATP synthesis driven by the proton electrochemical gradient. FEBS 202:314-318; 1986.
113. H Rottenberg, K Hashimoto. Fatty acid uncoupling of oxidative phosphorylation in rat liver mitochondria. Biochemistry25:1747-1755; 1986.
114. TY Aw, DP Jones. Nutrient supply and mitochondrial function. Annu Rev Nutr 9:229-251; 1989.
115. KJA Davies, L Packer, GA Brooks. Biochemical adaptation of mitochondria, muscle and whole animal respiration to endurance training. Arch Biochem Biophys 209:539-554; 1981.
116. CA Tate, PE Wolkowicz, J McMillin-Wood. Exercise induced alterations of hepatic mitochondrial function. Biochem J208:695-701; 1982.
117. KR Short, JL Vittone, ML Bigelow, DN Proctor, RA Rizza, JM Coenen-Schimke, K Sreekumaran Nair. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52:1888-1896; 2003.
118. A Herrero, G Barja. ADP-regulation of mitochondrial free radical production is different with complex I or complex II-linked substrates: Implications for the exercise paradox and brain hypermetabolism. J Bioenergetics Biomembranes 29:241-249; 1997.
119. HE Poulson, S Loft, K Vistisen. Extreme exercise and oxidative DNA modification. J Sports Sci 14:343-346; 1996.
120. EA Siess, OH Wieland. Glucagon-induced stimulation of 2-oxoglutarate metabolism in mitochondria from rat liver. FEBS Lett 93:301-306; 1978.
121. CB Jensen, FD Sistare, HC Hamman, RC Haynes. Stimulation of mitochondrial functions by glucagon treatment. Evidence that effects are not artifacts of mitochondrial isolation. Bio-chem J 210:819-827; 1983.
122. MD Brand, L D’Alessandri, HMGPV Reis, RP Hafner. Stimulation of the electron transport chain in mitochondria isolated from rats treated with mannoheptulose or glucagon. Arch Bio-chem Biophys 283:278-284; 1990.
123. CD Berdanier, WF Flatt. DHEA and mitochondrial respiration. In: Dehydroepiandrosterone (M Kalimi and W Regelson, Eds.) Walter de Gruyter & Co, Berlin. 377-391; 2000.
124. EH Allen, AB Chisholm, MA Titheradge. Stimulation of hepatic oxidative phosphorylation following dexamethasone treatment of rats. Biochem Biophys Acta 725:71-76; 1983.
125. H Rottenberg. Uncoupling of oxidative phosphorylation in rat liver mitochondria by general anesthetics. Proc Nat Acad Sci USA 80:3313-3317; 1983.
126. RR Rajan, SS Katyare. Cooperativity in inhibition of coupled and uncoupled respiration in rat liver and brain mitochondria by imipramine. Indian J Biochem Biophys 22:71-77; 1985.
127. O Marcillat, Y Zhang, KJA Davies. Oxidative and nonoxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxirubicin. Biochem J259:181-189; 1989.
128. RB Tobin, B Friend, CD Berdanier, MA Mehlman, V DeVore. Metabolic responses of rats to chronic theophylline ingestion. J Toxicol Environ Health 2:361-369; 1976.
129. AJM Moreno, VMC Madeira. Mitochondrial bioenergetics as affected by DDT. Biochem Biophys Acta 1060:166-174; 1991.
130. KB Burrows, G Gudelsky, BK Yamamoto. Rapid and transient inhibition of mitochondrial function following methamphet-amine or 3,4-methylenedioxymethamphetamine administration. Eur J Pharmacol 9:11-18; 2000.
131. N-G Larsson, A Oldfors, E Holme, DA Clayton. Low levels of mitochondrial transcription factor A in mitochondrial depletion. Biochem Biophys Res Comm 200:1374-1381; 1994.
132. JA Enriquez, P Fernandez-Silva, J Montoya. Autonomous regulation in mammalian mitochondrial DNA transcription. Biol Chem 380:737-747; 1999.
133. H Tomura, H Endo, Y Kagawa, S Ohta. Novel regulatory enhancer in the nuclear gene of human mitochondrial ATP synthase ß-subunit. J Biol Chem 265:6525-6529; 1990.
134. JV Verbasius, RC Scarpulla. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors. A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc Natl Acad Sci USA 91:1309-1312; 1994.
135. MJ Evans, RC Scarpulla. NRF-1: A trans-activator of nuclear-encoded respiratory genes in animal cells. Genes Dev4:1023-1034; 1990.
136. CA Chau, MJ Evans, RC Scarpulla. Nuclear respiratory factor 1 activation sites in genes encoding the subunit of ATP synthase, eukaryotic initiation factor 2a and tyrosine aminotransferase: Specific interaction of purified NRF-1 with multiple target genes. J Biol Chem 267:6999-7002; 1992.
137. CA Virbasius, JV Virbasius, RC Scarpulla. NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA binding domain conserved in a family of developmental regulators. Genes Dev 7:2431-2436; 1993.
138. A Heddi, G Stepien, PJ Benke, DC Wallace. Coordinate induction of energy gene expression in tissues of mitochondrial disease patients. J Biol Chem 274:22968-22976; 1999.
139. J Marin-Garcia, R Ananthakrishnan, MJ Goldenthal. Mitochondrial gene expression in rat heart and liver during growth and development. Biochem Cell Biol 75:137-142; 1997.
140. LK Ostronoff, JM Izquierdo, JM Cuezva. Mt mRNA stability regulates the expression of the mitochondrial genome during liver development. Biochem Biophys Res Com 217:1094-1098; 1995.
141. LK Ostronoff, JM Izquierdo, JA Enriquez, J Montoya, JM Cuezva. Transient activation of mitochondrial translation regulates the expression of the mitochondrial genome during mammalian mitochondrial differentiation. Biochem J316:183-191; 1996.
142. JM Izquierdo, J Ricart, LK Ostronoff, G Egea, JM Cuezva. Changing patterns of transcriptional and post-transcriptional control of ß-F1 ATP synthase gene expression during mitochondrial biogenesis in liver. J Biol Chem 270:10342-10350; 1995.
143. AM Luis, JM Izquierdo, LK Ostronoff, M Salinas, JF Santaren, JM Cuezva. Translational regulation of mitochondrial differentiation in neonatal rat liver: Specific increase in the translational efficiency of the nuclear-encoded mitochondrial ß-F1-ATPase mRNA. J Biol Chem 268:1868-1875; 1993.
144. JM Izquierdo, JM Cuezva. Control of the translational efficiency of ß-F1-ATPase mRNA depends on the regulation of a protein that binds the 3' untranslated region of the mRNA. Mol Cell Biol 17:5255-5268; 1997.
145. FT Dionne, L Turcotte, M-C Thibault, MR Boulay, JS Skinner, C Bouchard. Mitochondrial DNA sequence polymorphism, VO2max and response to endurance training. Med Sci Sport Exercise 23:177-185; 1991.
146. M Tonkonogi, B Walsh, T Tiivel, V Saks, K Sahlin. Mitochondrial function in human skeletal muscle is not impaired by high intensity exercise. Pflugers Arch 437:562-568; 1999.
147. MB Brearley, S Zhou. Mitochondrial DNA and maximum oxygen consumption. Sport Sci 5:1-3; 2001.
148. AL Andreu, MG Hanna, H Reichmann, C Bruno, AS Penn, K Tanji, F Pallotti, S Iwata, E Bonilla, B Lach, J Morgan-Hughes, S DiMauro, S Shanske, CM Sue, T Pulkes, A Siddiqui, JB Clark, J Land, M Iwata, J Schaefer. Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA. N Eng J Med 341:1037-1044; 1999.
149. S Qingde, Y Xirang, Z Yong, J Jinlei, L Shusen. The effect of aging and aerobic exercise on mitochondrial DNA deletions in rat liver. Hong Kong KJ Sports Med Sports 14:1; 2002.
150. H-C Lee, P-H Yin, C-Y Lu, Y-H Wei. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J 348:425-432; 2000.
151. BT Rogea, JAL Calbetb, K Mollera, H Ulluma, HW Hendelc, J Gerstofta, BK Pedersena. Skeletal muscle mitochondrial function and exercise capacity in HIV-infected patients with lipodystrophy and elevated p-lactate levels. AIDS 16:973-982; 2002.
152. BY Hochachka. Endurance training induces muscle-specific changes in mitochondrial function in skinned muscle fibers. J Appl Physiol 92:2429-2438; 2002.
153. EE McKee, BL Grier, GS Thompson, ACF Leung, JD McCourt. Coupling of mitochondrial metabolism and protein synthesis in heart mitochondria. Am J Physiol 258:E503-E510; 1990.
154. T Gustafsson, J Bengtsson, U Widegren, N-G Larsson, E Jan-sson, CJ Sundberg. Increased protein levels of mitochondrial transcription factor A (Tfam) in response to exercise training. Scan Phys Abstr 262; 2000.
155. HL Garstka, M Facke, JR Escribano, RJ Wiesner. Stoichiometry of mitochondrial transcripts and regulation of gene expression by mitochondrial transcription factor A. BBRC200:619-626; 1994.
156. J Poulton, K Morten, C Freeman-Emmerson, C Potter, C Sewry, V Dubowitz, H Kidd, J Stephenson, W Whitehouse, FJ Hansen, M Paris, G Brown. Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. Hum Mol Genet3:1763-1773; 1994.
157. N-G Larsson, A Oldfors, E Holme, DA Clayton. Low levels of mitochondrial transcription factor A in mitochondrial depletion. Biochem Biophys Res Commun 200:1374-1378; 1994.
158. J Montoya, A Perez-Martos, HL Garstka, RJ Wiesner. Regulation of mitochondrial transcription by mitochondrial transcription factor A. Mol Cell Biochem 174:227-230; 1997.
159. ACF Leung, EE McKee. Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. Am J Physiol 258: E511-E518; 1990.
160. WL Wooten, J Cascarano. The effect of thyroid hormone on mitochondrial biogenesis and cellular hyperplasia. J Bioenergetics Biomembranes 12:1-12; 1980.
161. SL Sigurdson, J Hims Hagen. Role of hyperthyroidism in increased thermogenesis in the cold acclimated Syrian hamster. Can J Physiol Pharm 66:826-829; 1987.
162. KR Short, J Nygren, R Barazzoni, J Levine, KS Nair. T3 increases mitochondrial ATP production in oxidative muscle despite increased expression of UCP2 and 3. Am J Physiol Endocrinol Metab 280:E761-E769; 2001.
163. C Guerra, C Roncero, A Porras, M Fernandez, M Benito. Triiodothyronine induces the transcription of the uncoupling prot-tein genes and stabilizes its mRNA in fetal brown adipocyte primary cultures. J Biol Chem 271:2076-2081; 1996.
164. J Triandafillou, C Gwilliam, J Hims-Hagen. Role of thyroid hormone in cold induced changes in rat brown adipose tissue mitochondria. Can J Biochem 60:530-537; 1982.
165. S Soboll. Thyroid hormone action on mitochondrial energy transfer. Biochem Biophys Acta 1144:1-16; 1993.
166. P De Nayer. Thyroid hormone action at the cellular level. Hormone Res 26:48-57; 1987.
167. FRM van der Klis, WM Wiersinger, JJM de Vijlder. Studies on the mechanism of inhibition of nuclear triiodothyronine binding by fatty acids. FEB 246:6-12; 1989.
168. JM Izquierdo, E Jimenez, JM Cuezva. Hypothyroidism affects the expression of the B-F1-ATP synthase gene and limits mitochondrial proliferation in rat liver at all stages of development. Eur J Biochem 232:344-350; 1995.
169. K Sterling, PO Milch. Thyroid hormone binding by a component of mitochondrial membrane. Proc Nat Acad Sci USA72:3225-3229; 1975.
170. C Wrutniak, I Cassar-Malek, S Marchai, A Rascle, S Heusser, JM Keller, J Flechon, M Dauca, J Samarut, J Ghysdael. A 43-kDa protein related to c-Erb A a1 is located in the mitochondrial matrix of rat liver. J Biol Chem 270:16347-16354; 1995.
171. F Casas, P Rochard, A Rodier, I Cassar-Malek, S Marchal-Vic-torian, RJ Wiesner, G Cabello, C Wrutniak. A variant form of the nuclear triiodothyronine receptor c-ErbA alpha 1 plays a direct role in regulation of mitochondrial RNA synthesis. Mol Cell Biol 19:7913-7924; 1999.
172. P Rochard, I Cassar-Malek, S Marchal, C Wrutniakk, G Cabello. Changes in mitochondrial activity during avian myoblast differentiation: Influence of triiodothyronine or v-erb A expression. J Cell Physiol 168:239-247; 1996.
173. JA Enriquez, P Fernadez-Silva, N Garrido-Perez, MJ Lopez-Perez, A Perez-Martos, J Montoya. Direct regulation of mitochondrial RNA synthesis by thyroid hormone. Mol Cell Biol 19:657-670; 1999.
174. TM Pillar, HJ Seitz. Thyroid hormone and gene expression in the regulation of mitochondrial respiratory function. Eur J Endocrinol 136:231-239; 1997.
175. SC Meier-Heusler, X Zhu, C Juge-Aubry, A Pernin, AG Burger, S-Y Cheng, CA Meier. Modulation of thyroid hormone action by mutant thyroid hormone receptors, c-erb Aa2 and peroxisome proliferator-activated receptor: Evidence for different mechanisms of inhibition. Mol Cell Endocrinol 107:55-66; 1995.
176. HC Freake, KE Govoni, K Guda, C Huang, SA Zinn. Actions and interactions of thyroid hormone and zinc status in growing rats. J Nutr 131:1135-1141; 2001.
177. CV Demonacos, N Karayanni, E Hatzoglou, C Tsiriyiotis, DA Spandidos, CE Sekeris. Mitochondrial genes as sites of primary action of steroid hormones. Steroids 61:226-232; 1996.
178. F Djoudi, J Bastin, T Gilbert, A Rotig, P Rustin, C Merlet-Ben-ichou. Mitochondrial biogenesis and development of respiratory chain enzymes in kidney cells: Role of glucocorticoids. Am J Physiol 267:C245-C254; 1994.
179. M Raikhinstein, I Hanukoglu. Mitochondrial-genome-encoded RNAs: Differential regulation by corticotropin in bovine adrenocortical cells. Proc Nat Acad Sci USA 90:10509-10513; 1993.
180. JP Silva, M Kohler, C Graff, A Oldfors, MA Magnuson, P-O Berggren, N-G Larsson. Impaired insulin secretion and ß-cell loss in tissue specific knockout mice with mitochondrial diabetes. Nat Genet 26:336-340; 2000.
181. CB Wolheim. Beta cell mitochondria in the regulation of insulin secretion: A new culprit in type II diabetes. Diabetologia43:265-277; 2000.
182. T Hayakawa, M Noda, K Yasuda, H Taniguchi, I Miwa, H Sakura, Y Terauchi, J Hayashi, GW Sharp, Y Kanazawa, Y Akanuma, Y Yazaki, T Kadowaki. Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic betacell line betaHC9. J Biol Chem 273:20300-20307; 1998.
183. P Maechler, CB Wolheim. Mitochondrial function in normal and diabetic beta cells. Nature 414:807-812; 2001.
184. X Huang, K-F Eriksson, A Vaag, M Lehtovirta, M Hansson, E Laurila, T Kanninen, BT Oleson, I Kurucz, L Koranyi, L Groop. Insulin regulated mitochondrial gene expression is associated with glucose flux in human skeletal muscle. Diabetes48:1508-1514; 1999.
185. M Petkovich, NJ Brand, A Krust, P Chambon. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 220:444-450; 1987.
186. DJ Mangelsdorf, ES Ong, JA Dyke, RM Evans. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345:224-229; 1990.
187. P Kastner, A Krust, C Mendelsohn, JM Garnier, A Zelent, P LeRoy, A Staub, P Chambon. Murine isoforms of retinoic acid receptor y with specific patterns of expression, Proc Natl Acad Sci USA 87:2700-2704; 1990.
188. DJ Mandelsdorf, U Borgmeyer, RA Heyman, JY Zhou, ES Ong, AE Oro, A Kakizuka, RM Evans. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 6:329-344; 1992.
189. P LeRoy, H Nakshatri, P Chambon. Mouse retinoic acid receptor y2 isoform is transcribed from a promoter that contains a retinoic acid response element. Proc Natl Acad Sci USA, 88:10138-10142; 1991.
190. V Giguere, M Shago, R Zirngibl, P Tate, J Rossant, S Varmuza. Identification of a novel isoform of the retinoic acid receptor y expressed in the mouse embryo. Mol Cell Biol 10:2335-2340; 1990.
191. JM Lehmann, B Hoffman, M Pfahl. Genomic organization of the retinoic acid receptor gamma gene. Nucl Acids Res 19: 573-578; 1991.
192. P Chambon. The retinoid signaling pathway: Molecular and genetic analyses. Cell Biol 5:115-125; 1994.
193. K Takeyama, R Kojima, T Ohashi, T Sato, H Mano, S Masushige, S Kato. Retinoic acid differentially up-regulates the gene expression of retinoic acid receptor a and p isoforms in embryo and adult rats. Biochem Biophys Res Commun222:395-400; 1996.
194. R-U Haq, M Pfahl, F Chytil. Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats. Proc Natl Acad Sci USA 88:8272-8276; 1991.
195. D Lohnes, P Kastner, A Dierich, M Makr, M LeMeur, P Cham-bon. Function of retinoic acid receptor a in the mouse. Cell73:643-658; 1993.
196. P Kastner, JM Grondona, M Mark, A Gansmuller, M LeMeur, D Decimo, J-L Vonesch, P Dolle, P Chambon. Genetic analysis of RXR developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell78:987-1003; 1994.
197. C Mendelsohn, M Mark, P Dolle, A Dierich, MP Gaub, A Krust, C Lampron, P Chambon. Retinoic acid receptor p2 (RARp2) null mutant mice appear normal. Exp Biol 166:246-258; 1994.
198. JM Grondona, P Kastner, A Gansmuller, D Decimo, P Cham-bon, M Mark. Retinal dysplasia and degeneration in RAR2/RAR2 compound mutant mice. Development122:2173-2188; 1996.
199. W Krezel, N Ghyselinck, TA Samad, V Dupe, P Kastner, E Borrelli, P Chambon. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science 279:863-867; 1998.
200. P Kastner, M Mark, P Chambon. Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life?Cell 83:859-869; 1995.
201. HB Everts, DO Claassen, CL Hermoyian, CD Berdanier. Nutrient-gene interactions: Dietary vitamin A and mitochondrial gene expression. IUBMB Life 53:295-301; 2002.
202. SJ Ruff, DE Ong. Cellular retinoic acid binding protein is associated with mitochondria. FEBS Letters 487:282-286; 2000.
203. G Li, Y Liu, SS Tsang. Expression of a retinoic acid-inducible mitochondrial ND5 gene is regulated by cell density in bovine papillomavirus DNA-transformed mouse C127 cells but not in revertant cells. Int J Oncol 5:301-307; 1994.
204. IC Gaemers, AMM Van Pelt, APN, Themmen, DG De Rooij. Isolation and characterization of all-trans-retinoic acid-responsive genes in the rat testis. Mol Reprod Dev 50:1-6; 1998.
205. CD Berdanier, HB Everts, E Hermoyian, CE Mathews. Role of vitamin A in mitochondrial gene expression. Diab Res Clin Prac 54:511-527; 2001.
206. GK Whitfield, J-C Hsieh, PW Jurutka, SH Selznick, CA Haus-sler, PN MacDonald, MR Haussler. Genomic actions of 1,25-dihydroxyvitamin D3. J Nutr 125:1690S-1694S; 1995.
207. SY Chou, SS Hannah, KE Lowe, AW Norman, HL Henry. Tissue specific regulation by vitamin D status of nuclear and mitochondrial gene expression in kidney and intestine. Endocrinology 136:5520-5526; 1995.
208. P Cantatore, V Petruzzella, C Nicoletti, F Papadia, F Fracasso, P Rustin, MN Gadaleta. Alteration of mitochondrial DNA and RNA levels in human fibroblasts with impaired vitamin B12 coenzyme synthesis. FEBS Lett 432:173-178; 1998.
209. J Asin, A Perez-Martos, P Silva-Fernandez-Silva, J Montoya, AL Andreu. Iron II induces changes in the conformation of mammalian mitochondrial DNA resulting in a reduction of its transcriptional rate. FEBS Lett 480:161-164; 2000.
210. F Lucesoli, CG Fraga. Oxidative damage to lipids and DNA concurrent with decrease of antioxidants in rat testes after acute iron intoxication. Arch Biochem Biophys 316:567-571; 1995.
211. G Minotti. Sources and role of iron in lipid peroxidation. Chem Res Toxicol 6:134-146; 1992.
212. J Weaver, S Pollack. Two types of receptors for iron in mitochondria. Biochem J 271:463-466; 1990.
213. WT Willis, PR Dallman. Impaired control of respiration in iron deficient muscle mitochondria. Am J Physiol257:C1080-C1085; 1989.
214. Z Wu, P Puigserver, U Andersson, C Zhang, G Adelmant, V Mootha, A Troy, S Cinti, B Lowell, RC Scarpulla, BM Spiegel-man. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell98:115-124; 1999.
215. P Puigserver, Z Wu, CW Park, R Graves, M Wright, BM Spiegelman. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839; 1998.
216. JM Izquierdo, JM Cueza. Evidence of post-transcriptional regulation in mammalian mitochondrial biogenesis. Biochem Biophys Res Commun 196:55-60; 1993.
217. K Luciakova, R Li, BD Nelson. Differential regulation of the transcript levels of some nuclear-encoded and mitochondrial-encoded respiratory-chain components in response to growth activation. Eur J Biochem 207:253-257; 1992.
218. RJ Stevens, ML Nishio, DA Hood. Effect of hypothyroidism on the expression of cytochrome c and cytochrome c oxidase in heart and muscle during development. Mol Cell Biochem143:119-127; 1995.
219. BD Nelson, K Luciakova, R Li, S Betina. The role of thyroid hormone and promoter diversity in the regulation of nuclear encoded mitochondrial proteins. Biochim Biophys Acta1271:85-91; 1995.
220. K Luciakova, BD Nelson. Transcript levels for nuclear-encoded mammalian mitochondrial respiratory chain components are regulated by thyroid hormone in an uncoordinated fashion. Eur J Biochem 207:247-251; 1992.
221. JM Izquierdo, E Jimenez, JM Cuezva. Hypothyroidism affects the expression of the ß-F1-ATP synthase gene and limits mitochondrial proliferation in rat liver at all stages of development. Eur J Biochem 232:344-350; 1995.
222. JA Enriquez, P Fernadez-Silva, J Montoya. Autonomous regulation in mammalian mitochondrial DNA transcriptions. J Biol Chem 380:737-747; 1999.
223. Y Cai, BD Nelson, R Li, K Luciakova, JW DePierre. Thyromi-metic action of the peroxisome proliferators Clofibrate, perflu-orooctanoic acid and acetylsalicyclic acid includes changes in mRNA levels for certain genes involved in mitochondrial biogenesis. Arch Biochem Biophys 325:107-112; 1996.
224. DD Chang, DA Clayton. Precise assignment of the light-strand promoter of mouse mitochondrial DNA: A functional promoter consists of multiple upstream domains. Mol Cell Biol6:3253-3261; 1986.
225. DD Chang, DA Clayton. Precise assignment of the heavy-strand promoter of mouse mitochondrial DNA: Cognate start sites are not required for transcriptional initiation. Mol Cell Biol 6:3262-3267; 1986.
226. DF Bogenhagen, EF Applegate, BK Yoza. Identification of a promoter for transcription of the heavy strand mtDNA: In vitro transcription and deletion mutagenesis. Cell 36:1105-1113; 1984.
227. JFH Wong, DP Ma, RK Wilson, BA Roe. DNA sequence of the Xenopus Laevis mitochondrial heavy and light strand replication origins and flanking tRNA genes. Nucleic Acids Res11:4977-4995; 1983.
228. K Umesono, KK Murakami, CC Thompson, RM Evans. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65:1255-1266; 1991.
229. AM Naar, JM Boutin, SM Lipkin, VC Yu, JM Holloway, CK Glass, MG Rosenfeld. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell 65:1267-1279; 1991.
230. C Wrutniak, I Cassar-Malek, S Marchal, A Rascle, S Heusser, JM Keller, J Flechon, M Dauca, J Samarut, J Ghysdael. A 43-kDa protein related to c-Erb A a1 is located in the mitochondrial matrix of rat liver. J Biol Chem 270:16347-16354; 1995.
231. F Casas, L Domenjoud, P Rochard, R Hatier, L Daury, A Bianchi, P Kremarik-Bouillaud, P Becuwe, JM Keller, H Schohn, C Wrutniak-Cabello, G Cabello, M Dauca. A 45-kDa protein related to PPARy2 induced by peroxisome proliferators located in the mitochondrial matrix. FEBS Lett 478:4-8; 2000.
232. S Miranda, R Foncea, J Guerrero, F Leighton. Oxidative stress and upregulation of mitochondria;l biogenesis genes in mitochondrial DNA depleted HeLa cells. Biochem Biophys Res Commun 258:44-49; 1999.
233. HL Garstka, M Facke, JR Escribano, RJ Wiesner. Stoichiometry of mitochondrial transcripts and regulation of gene expression by mitochonrial transcription factor A. Biochem Biophys Res Commun 200:619-626; 1994.
234. F Casas, T Pineau, P Rochard, A Rodier, L Daury, M Dauca, G Cabello, C Wrutniak-Cabello. New molecular aspects of regulation of mitochondrial activity by fenofibrate and fasting. FEBS Lett 482:71-74; 2000.