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Volumn 49, Issue SUPPL. 1, 2012, Pages

Management Strategies for Relapsed/Refractory Multiple Myeloma: Current Clinical Perspectives

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BORTEZOMIB; CARMUSTINE; CISPLATIN; CLODRONIC ACID; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; ENOXAPARIN; ETOPOSIDE; LENALIDOMIDE; MELPHALAN; METHYLPREDNISOLONE; PAMIDRONIC ACID; PARACETAMOL; PLACEBO; PREDNISONE; THALIDOMIDE; VINCRISTINE; WARFARIN; ZOLEDRONIC ACID;

EID: 84862665352     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2012.05.003     Document Type: Article
Times cited : (33)

References (154)
  • 1
    • 0025064260 scopus 로고
    • VAD-based regimens as primary treatment for multiple myeloma
    • Alexanian R., Barlogie B., Tucker S. VAD-based regimens as primary treatment for multiple myeloma. Am J Hematol 1990, 33:86-89.
    • (1990) Am J Hematol , vol.33 , pp. 86-89
    • Alexanian, R.1    Barlogie, B.2    Tucker, S.3
  • 5
    • 8944220233 scopus 로고    scopus 로고
    • A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Français du Myélome
    • Attal M., Harousseau J.L., Stoppa A.M., et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Français du Myélome. N Engl J Med 1996, 335:91-97.
    • (1996) N Engl J Med , vol.335 , pp. 91-97
    • Attal, M.1    Harousseau, J.L.2    Stoppa, A.M.3
  • 6
    • 3042775299 scopus 로고    scopus 로고
    • Clinical course of patients with relapsed multiple myeloma
    • Kumar S.K., Therneau T.M., Gertz M.A., et al. Clinical course of patients with relapsed multiple myeloma. Mayo Clin Proc 2004, 79:867-874.
    • (2004) Mayo Clin Proc , vol.79 , pp. 867-874
    • Kumar, S.K.1    Therneau, T.M.2    Gertz, M.A.3
  • 7
    • 78650087357 scopus 로고    scopus 로고
    • Emerging therapies for the treatment of relapsed or refractory multiple myeloma
    • Dimopoulos M.A., San-Miguel J.F., Anderson K.C. Emerging therapies for the treatment of relapsed or refractory multiple myeloma. Eur J Haematol 2011, 86:1-15.
    • (2011) Eur J Haematol , vol.86 , pp. 1-15
    • Dimopoulos, M.A.1    San-Miguel, J.F.2    Anderson, K.C.3
  • 8
    • 77950563131 scopus 로고    scopus 로고
    • Korean Multiple Myeloma Working Party (KMMWP). Clinical efficacy of a bortezomib, cyclophosphamide, thalidomide, and dexamethasone (Vel-CTD) regimen in patients with relapsed or refractory multiple myeloma: a phase II study
    • Kim Y.K., Sohn S.K., Lee J.H., et al. Korean Multiple Myeloma Working Party (KMMWP). Clinical efficacy of a bortezomib, cyclophosphamide, thalidomide, and dexamethasone (Vel-CTD) regimen in patients with relapsed or refractory multiple myeloma: a phase II study. Ann Hematol 2010, 89:475-482.
    • (2010) Ann Hematol , vol.89 , pp. 475-482
    • Kim, Y.K.1    Sohn, S.K.2    Lee, J.H.3
  • 9
    • 73349122918 scopus 로고    scopus 로고
    • Relapse/refractory myeloma patient: potential treatment guidelines
    • San Miguel J.F. Relapse/refractory myeloma patient: potential treatment guidelines. J Clin Oncol 2009, 27:5676-5677.
    • (2009) J Clin Oncol , vol.27 , pp. 5676-5677
    • San Miguel, J.F.1
  • 10
    • 84856725064 scopus 로고    scopus 로고
    • Treatment strategies in relapsed and refractory multiple myeloma: a focus on drug sequencing and 'retreatment' approaches in the era of novel agents
    • Mohty B., El-Cheikh J., Yakoub-Agha I., Avet-Loiseau H., Moreau P., Mohty M. Treatment strategies in relapsed and refractory multiple myeloma: a focus on drug sequencing and 'retreatment' approaches in the era of novel agents. Leukemia 2012, 26:73-85.
    • (2012) Leukemia , vol.26 , pp. 73-85
    • Mohty, B.1    El-Cheikh, J.2    Yakoub-Agha, I.3    Avet-Loiseau, H.4    Moreau, P.5    Mohty, M.6
  • 11
    • 84862692502 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology. Multiple myeloma. Version 1.
    • National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology. Multiple myeloma. Version 1.2012.
    • (2012)
  • 12
    • 77954339963 scopus 로고    scopus 로고
    • Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • ESMO Guidelines Working Group
    • Harousseau J.L., Dreyling M. Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010, 21(Suppl 5):v155-v157. ESMO Guidelines Working Group.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Harousseau, J.L.1    Dreyling, M.2
  • 13
    • 0023552805 scopus 로고
    • High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma
    • Barlogie B., Alexanian R., Dicke K.A., et al. High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma. Blood 1987, 70:869-872.
    • (1987) Blood , vol.70 , pp. 869-872
    • Barlogie, B.1    Alexanian, R.2    Dicke, K.A.3
  • 14
    • 0022510876 scopus 로고
    • High-dose melphalan with autologous bone marrow transplantation for multiple myeloma
    • Barlogie B., Hall R., Zander A., Dicke K., Alexanian R. High-dose melphalan with autologous bone marrow transplantation for multiple myeloma. Blood 1986, 67:1298-1301.
    • (1986) Blood , vol.67 , pp. 1298-1301
    • Barlogie, B.1    Hall, R.2    Zander, A.3    Dicke, K.4    Alexanian, R.5
  • 15
    • 0022655622 scopus 로고
    • High-dose glucocorticoid treatment of resistant myeloma
    • Alexanian R., Barlogie B., Dixon D. High-dose glucocorticoid treatment of resistant myeloma. Ann Intern Med 1986, 105:8-11.
    • (1986) Ann Intern Med , vol.105 , pp. 8-11
    • Alexanian, R.1    Barlogie, B.2    Dixon, D.3
  • 16
    • 0029582856 scopus 로고
    • A phase II study of high-dose methylprednisolone in refractory or relapsed multiple myeloma
    • Gertz M.A., Garton J.P., Greipp P.R., Witzig T.E., Kyle R.A. A phase II study of high-dose methylprednisolone in refractory or relapsed multiple myeloma. Leukemia 1995, 9:2115-2118.
    • (1995) Leukemia , vol.9 , pp. 2115-2118
    • Gertz, M.A.1    Garton, J.P.2    Greipp, P.R.3    Witzig, T.E.4    Kyle, R.A.5
  • 17
    • 0021322023 scopus 로고
    • Effective treatment of advanced multiple myeloma refractory to alkylating agents
    • Barlogie B., Smith L., Alexanian R. Effective treatment of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 1984, 310:1353-1356.
    • (1984) N Engl J Med , vol.310 , pp. 1353-1356
    • Barlogie, B.1    Smith, L.2    Alexanian, R.3
  • 18
    • 0029559531 scopus 로고
    • Phase III study comparing vincristine, doxorubicin (Adriamycin), and dexamethasone (VAD) chemotherapy with VAD plus recombinant interferon alfa-2 in refractory or relapsed multiple myeloma. An Eastern Cooperative Oncology Group study
    • Gertz M.A., Kalish L.A., Kyle R.A., Hahn R.G., Tormey D.C., Oken M.M. Phase III study comparing vincristine, doxorubicin (Adriamycin), and dexamethasone (VAD) chemotherapy with VAD plus recombinant interferon alfa-2 in refractory or relapsed multiple myeloma. An Eastern Cooperative Oncology Group study. Am J Clin Oncol 1995, 18:475-480.
    • (1995) Am J Clin Oncol , vol.18 , pp. 475-480
    • Gertz, M.A.1    Kalish, L.A.2    Kyle, R.A.3    Hahn, R.G.4    Tormey, D.C.5    Oken, M.M.6
  • 20
    • 0029056875 scopus 로고
    • A randomized study of MOD versus VAD in the treatment of relapsed and resistant multiple myeloma
    • Phillips J.K., Sherlaw-Johnson C., Pearce R., et al. A randomized study of MOD versus VAD in the treatment of relapsed and resistant multiple myeloma. Leuk Lymphoma 1995, 17:465-472.
    • (1995) Leuk Lymphoma , vol.17 , pp. 465-472
    • Phillips, J.K.1    Sherlaw-Johnson, C.2    Pearce, R.3
  • 21
    • 0022922110 scopus 로고
    • Improved survival duration with combination chemotherapy induction for multiple myeloma: a Southwest Oncology Group study
    • Durie B.G., Dixon D.O., Carter S., et al. Improved survival duration with combination chemotherapy induction for multiple myeloma: a Southwest Oncology Group study. J Clin Oncol 1986, 4:1227-1237.
    • (1986) J Clin Oncol , vol.4 , pp. 1227-1237
    • Durie, B.G.1    Dixon, D.O.2    Carter, S.3
  • 22
    • 0033997659 scopus 로고    scopus 로고
    • Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol
    • Giles F.J., Wickham N.R., Rapoport B.L., et al. Cyclophosphamide, etoposide, vincristine, adriamycin, and dexamethasone (CEVAD) regimen in refractory multiple myeloma: an International Oncology Study Group (IOSG) phase II protocol. Am J Hematol 2000, 63:125-130.
    • (2000) Am J Hematol , vol.63 , pp. 125-130
    • Giles, F.J.1    Wickham, N.R.2    Rapoport, B.L.3
  • 23
    • 0028872645 scopus 로고
    • VAD chemotherapy as remission induction for multiple myeloma
    • Anderson H., Scarffe J.H., Ranson M., et al. VAD chemotherapy as remission induction for multiple myeloma. Br J Cancer 1995, 71:326-330.
    • (1995) Br J Cancer , vol.71 , pp. 326-330
    • Anderson, H.1    Scarffe, J.H.2    Ranson, M.3
  • 24
    • 34249746735 scopus 로고    scopus 로고
    • Dexamethasone, cyclophosphamide, etoposide and cisplatin (DCEP) for relapsed or refractory multiple myeloma patients
    • Dadacaridou M., Papanicolaou X., Maltesas D., et al. Dexamethasone, cyclophosphamide, etoposide and cisplatin (DCEP) for relapsed or refractory multiple myeloma patients. J Buon 2007, 12:41-44.
    • (2007) J Buon , vol.12 , pp. 41-44
    • Dadacaridou, M.1    Papanicolaou, X.2    Maltesas, D.3
  • 25
    • 0041629471 scopus 로고    scopus 로고
    • DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma
    • Lee C.K., Barlogie B., Munshi N., et al. DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma. J Clin Oncol 2003, 21:2732-2739.
    • (2003) J Clin Oncol , vol.21 , pp. 2732-2739
    • Lee, C.K.1    Barlogie, B.2    Munshi, N.3
  • 26
    • 0003247367 scopus 로고    scopus 로고
    • Dexamethasone, cyclophosphamide, etoposide and cisplatinum (DCEP), an effective regimen for relapse after high-dose chemotherapy and autologous transplantation (AT)
    • abstract 586a
    • Munshi N., Desikan K., Jagannath S., et al. Dexamethasone, cyclophosphamide, etoposide and cisplatinum (DCEP), an effective regimen for relapse after high-dose chemotherapy and autologous transplantation (AT). Blood 1996, 88. abstract 586a.
    • (1996) Blood , vol.88
    • Munshi, N.1    Desikan, K.2    Jagannath, S.3
  • 27
    • 33646401089 scopus 로고    scopus 로고
    • Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma
    • Garban F., Attal M., Michallet M., et al. Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma. Blood 2006, 107:3474-3480.
    • (2006) Blood , vol.107 , pp. 3474-3480
    • Garban, F.1    Attal, M.2    Michallet, M.3
  • 28
    • 0029039069 scopus 로고
    • Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma
    • Gahrton G., Tura S., Ljungman P., et al. Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma. J Clin Oncol 1995, 13:1312-1322.
    • (1995) J Clin Oncol , vol.13 , pp. 1312-1322
    • Gahrton, G.1    Tura, S.2    Ljungman, P.3
  • 29
    • 4644249497 scopus 로고    scopus 로고
    • Relapse to prior autograft and chronic graft-versus-host disease are the strongest prognostic factors for outcome of melphalan/fludarabine-based dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma
    • Kröger N., Perez-Simon J.A., Myint H., et al. Relapse to prior autograft and chronic graft-versus-host disease are the strongest prognostic factors for outcome of melphalan/fludarabine-based dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma. Biol Blood Marrow Transplant 2004, 10:698-708.
    • (2004) Biol Blood Marrow Transplant , vol.10 , pp. 698-708
    • Kröger, N.1    Perez-Simon, J.A.2    Myint, H.3
  • 30
    • 79952277849 scopus 로고    scopus 로고
    • Toxicity of a second autologous peripheral blood stem cell transplant in patients with relapsed or recurrent multiple myeloma
    • Burzynski J.A., Toro J.J., Patel R.C., et al. Toxicity of a second autologous peripheral blood stem cell transplant in patients with relapsed or recurrent multiple myeloma. Leuk Lymphoma 2009, 50:1442-1447.
    • (2009) Leuk Lymphoma , vol.50 , pp. 1442-1447
    • Burzynski, J.A.1    Toro, J.J.2    Patel, R.C.3
  • 31
    • 33646880695 scopus 로고    scopus 로고
    • Prolonged overall survival with second on-demand autologous transplant in multiple myeloma
    • Elice F., Raimondi R., Tosetto A., et al. Prolonged overall survival with second on-demand autologous transplant in multiple myeloma. Am J Hematol 2006, 81:426-431.
    • (2006) Am J Hematol , vol.81 , pp. 426-431
    • Elice, F.1    Raimondi, R.2    Tosetto, A.3
  • 32
    • 3943073152 scopus 로고    scopus 로고
    • Second autologous transplantation for multiple myeloma patients relapsing after the first autograft-a pilot study for the evaluation of experimental maintenance therapies. Report of the prospective non-randomized pilot study of the
    • Czech Myeloma Group
    • Krivanová A., Hájek R., Krejcí M., et al. Second autologous transplantation for multiple myeloma patients relapsing after the first autograft-a pilot study for the evaluation of experimental maintenance therapies. Report of the prospective non-randomized pilot study of the. Onkologie 2004, 27:275-279. Czech Myeloma Group.
    • (2004) Onkologie , vol.27 , pp. 275-279
    • Krivanová, A.1    Hájek, R.2    Krejcí, M.3
  • 33
    • 62549086569 scopus 로고    scopus 로고
    • Second auto-SCT is safe and effective salvage therapy for relapsed multiple myeloma
    • Olin R.L., Vogl D.T., Porter D.L., et al. Second auto-SCT is safe and effective salvage therapy for relapsed multiple myeloma. Bone Marrow Transplant 2009, 43:417-422.
    • (2009) Bone Marrow Transplant , vol.43 , pp. 417-422
    • Olin, R.L.1    Vogl, D.T.2    Porter, D.L.3
  • 34
    • 33644510445 scopus 로고    scopus 로고
    • Second autologous or allogeneic transplantation after the failure of first autograft in patients with multiple myeloma
    • Qazilbash M.H., Saliba R., De Lima M., et al. Second autologous or allogeneic transplantation after the failure of first autograft in patients with multiple myeloma. Cancer 2006, 106:1084-1089.
    • (2006) Cancer , vol.106 , pp. 1084-1089
    • Qazilbash, M.H.1    Saliba, R.2    De Lima, M.3
  • 36
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S., Mehta J., Desikan R., et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999, 341:1565-1571.
    • (1999) N Engl J Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 37
    • 0035880229 scopus 로고    scopus 로고
    • Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients
    • Barlogie B., Desikan R., Eddlemon P., et al. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. Blood 2001, 98:492-494.
    • (2001) Blood , vol.98 , pp. 492-494
    • Barlogie, B.1    Desikan, R.2    Eddlemon, P.3
  • 38
    • 0036212935 scopus 로고    scopus 로고
    • Salvage therapy with thalidomide in patients with advanced relapsed/refractory multiple myeloma
    • Tosi P., Zamagni E., Cellini C., et al. Salvage therapy with thalidomide in patients with advanced relapsed/refractory multiple myeloma. Haematologica 2002, 87:408-414.
    • (2002) Haematologica , vol.87 , pp. 408-414
    • Tosi, P.1    Zamagni, E.2    Cellini, C.3
  • 39
    • 0036380265 scopus 로고    scopus 로고
    • Thalidomide in patients with advanced multiple myeloma: a study of 83 patients-report of the Intergroupe Françophone du Myelome (IFM)
    • Yakoub-Agha I., Attal M., Dumontet C., et al. Thalidomide in patients with advanced multiple myeloma: a study of 83 patients-report of the Intergroupe Françophone du Myelome (IFM). Hematol J 2002, 3:185-192.
    • (2002) Hematol J , vol.3 , pp. 185-192
    • Yakoub-Agha, I.1    Attal, M.2    Dumontet, C.3
  • 40
    • 0034116457 scopus 로고    scopus 로고
    • Frequent good partial remissions from thalidomide including best response ever in patients with advanced refractory and relapsed myeloma
    • Juliusson G., Celsing F., Turesson I., Lenhoff S., Adriansson M., Malm C. Frequent good partial remissions from thalidomide including best response ever in patients with advanced refractory and relapsed myeloma. Br J Haematol 2000, 109:89-96.
    • (2000) Br J Haematol , vol.109 , pp. 89-96
    • Juliusson, G.1    Celsing, F.2    Turesson, I.3    Lenhoff, S.4    Adriansson, M.5    Malm, C.6
  • 41
    • 3042735765 scopus 로고    scopus 로고
    • Thalidomide for patients with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity
    • Richardson P., Schlossman R., Jagannath S., et al. Thalidomide for patients with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity. Mayo Clin Proc 2004, 79:875-882.
    • (2004) Mayo Clin Proc , vol.79 , pp. 875-882
    • Richardson, P.1    Schlossman, R.2    Jagannath, S.3
  • 42
    • 0035007047 scopus 로고    scopus 로고
    • Thalidomide treatment of resistant or relapsed multiple myeloma patients
    • Polish Multiple Myeloma Study Group
    • Hus M., Dmoszynska A., Soroka-Wojtaszko M., et al. Thalidomide treatment of resistant or relapsed multiple myeloma patients. Haematologica 2001, 86:404-408. Polish Multiple Myeloma Study Group.
    • (2001) Haematologica , vol.86 , pp. 404-408
    • Hus, M.1    Dmoszynska, A.2    Soroka-Wojtaszko, M.3
  • 43
    • 11844263905 scopus 로고    scopus 로고
    • Analysis of efficacy and toxicity of thalidomide in 122 patients with multiple myeloma: response of soft-tissue plasmacytomas
    • Wu K.L., Helgason H.H., van der Holt B., et al. Analysis of efficacy and toxicity of thalidomide in 122 patients with multiple myeloma: response of soft-tissue plasmacytomas. Leukemia 2005, 19:143-145.
    • (2005) Leukemia , vol.19 , pp. 143-145
    • Wu, K.L.1    Helgason, H.H.2    van der Holt, B.3
  • 44
    • 0038305911 scopus 로고    scopus 로고
    • Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age
    • Mileshkin L., Biagi J.J., Mitchell P., et al. Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age. Blood 2003, 102:69-77.
    • (2003) Blood , vol.102 , pp. 69-77
    • Mileshkin, L.1    Biagi, J.J.2    Mitchell, P.3
  • 45
    • 11144354538 scopus 로고    scopus 로고
    • Early response predicts thalidomide efficiency in patients with advanced multiple myeloma
    • Waage A., Gimsing P., Juliusson G., et al. Early response predicts thalidomide efficiency in patients with advanced multiple myeloma. Br J Haematol 2004, 125:149-155.
    • (2004) Br J Haematol , vol.125 , pp. 149-155
    • Waage, A.1    Gimsing, P.2    Juliusson, G.3
  • 46
    • 33644898842 scopus 로고    scopus 로고
    • A systematic review of phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma
    • Glasmacher A., Hahn C., Hoffmann F., et al. A systematic review of phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma. Br J Haematol 2006, 132:584-593.
    • (2006) Br J Haematol , vol.132 , pp. 584-593
    • Glasmacher, A.1    Hahn, C.2    Hoffmann, F.3
  • 47
    • 84856949009 scopus 로고    scopus 로고
    • Low-dose v. high-dose thalidomide for advanced multiple myeloma: a prospective trial from the Intergroupe Francophone du Myelome
    • Yakoub-Agha I., Mary J.Y., Hulin C., et al. Low-dose v. high-dose thalidomide for advanced multiple myeloma: a prospective trial from the Intergroupe Francophone du Myelome. Eur J Haematol 2012, 88:249-259.
    • (2012) Eur J Haematol , vol.88 , pp. 249-259
    • Yakoub-Agha, I.1    Mary, J.Y.2    Hulin, C.3
  • 48
    • 84860547342 scopus 로고    scopus 로고
    • Thalidomide versus dexamethasone for the treatment of relapsed and/or refractory multiple myeloma: results from OPTIMUM, a randomized trial
    • Kropff M., Giongco-Baylon H., Hillengass J., et al. Thalidomide versus dexamethasone for the treatment of relapsed and/or refractory multiple myeloma: results from OPTIMUM, a randomized trial. Haematologica 2012, 97:784-791.
    • (2012) Haematologica , vol.97 , pp. 784-791
    • Kropff, M.1    Giongco-Baylon, H.2    Hillengass, J.3
  • 49
    • 1942522741 scopus 로고    scopus 로고
    • The oral combination of thalidomide, cyclophosphamide and dexamethasone (ThaCyDex) is effective in relapsed/refractory multiple myeloma
    • García-Sanz R., González-Porras J.R., Hernández J.M., et al. The oral combination of thalidomide, cyclophosphamide and dexamethasone (ThaCyDex) is effective in relapsed/refractory multiple myeloma. Leukemia 2004, 18:856-863.
    • (2004) Leukemia , vol.18 , pp. 856-863
    • García-Sanz, R.1    González-Porras, J.R.2    Hernández, J.M.3
  • 50
    • 21344459018 scopus 로고    scopus 로고
    • Low-dose thalidomide in combination with oral weekly cyclophosphamide and pulsed dexamethasone is a well tolerated and effective regimen in patients with relapsed and refractory multiple myeloma
    • Kyriakou C., Thomson K., D'Sa S., et al. Low-dose thalidomide in combination with oral weekly cyclophosphamide and pulsed dexamethasone is a well tolerated and effective regimen in patients with relapsed and refractory multiple myeloma. Br J Haematol 2005, 129:763-770.
    • (2005) Br J Haematol , vol.129 , pp. 763-770
    • Kyriakou, C.1    Thomson, K.2    D'Sa, S.3
  • 51
    • 34247180141 scopus 로고    scopus 로고
    • Pulsed cyclophosphamide, thalidomide and dexamethasone regimen for previously treated patients with multiple myeloma: long term follow up and disease control after subsequent treatments
    • Roussou M., Anagnostopoulos A., Kastritis E., et al. Pulsed cyclophosphamide, thalidomide and dexamethasone regimen for previously treated patients with multiple myeloma: long term follow up and disease control after subsequent treatments. Leuk Lymphoma 2007, 48:754-758.
    • (2007) Leuk Lymphoma , vol.48 , pp. 754-758
    • Roussou, M.1    Anagnostopoulos, A.2    Kastritis, E.3
  • 52
    • 54049155831 scopus 로고    scopus 로고
    • Clarithromycin with low dose dexamethasone and thalidomide is effective therapy in relapsed/refractory myeloma
    • Morris T.C., Kettle P.J., Drake M., et al. Clarithromycin with low dose dexamethasone and thalidomide is effective therapy in relapsed/refractory myeloma. Br J Haematol 2008, 143:349-354.
    • (2008) Br J Haematol , vol.143 , pp. 349-354
    • Morris, T.C.1    Kettle, P.J.2    Drake, M.3
  • 54
    • 33644834155 scopus 로고    scopus 로고
    • Intravenous melphalan, thalidomide and prednisone in refractory and relapsed multiple myeloma
    • Palumbo A., Avonto I., Bruno B., et al. Intravenous melphalan, thalidomide and prednisone in refractory and relapsed multiple myeloma. Eur J Haematol 2006, 76:273-277.
    • (2006) Eur J Haematol , vol.76 , pp. 273-277
    • Palumbo, A.1    Avonto, I.2    Bruno, B.3
  • 55
    • 0035018156 scopus 로고    scopus 로고
    • Low-dose thalidomide plus dexamethasone is an effective salvage therapy for advanced myeloma
    • Palumbo A., Giaccone L., Bertola A., et al. Low-dose thalidomide plus dexamethasone is an effective salvage therapy for advanced myeloma. Haematologica 2001, 86:399-403.
    • (2001) Haematologica , vol.86 , pp. 399-403
    • Palumbo, A.1    Giaccone, L.2    Bertola, A.3
  • 56
    • 4544386351 scopus 로고    scopus 로고
    • Efficacy of low-dose thalidomide and dexamethasone as first salvage regimen in multiple myeloma
    • Palumbo A., Bertola A., Falco P., et al. Efficacy of low-dose thalidomide and dexamethasone as first salvage regimen in multiple myeloma. Hematol J 2004, 5:318-324.
    • (2004) Hematol J , vol.5 , pp. 318-324
    • Palumbo, A.1    Bertola, A.2    Falco, P.3
  • 57
    • 0347383742 scopus 로고    scopus 로고
    • Thalidomide with or without dexamethasone for refractory or relapsing multiple myeloma
    • Alexanian R., Weber D., Anagnostopoulos A., Delasalle K., Wang M., Rankin K. Thalidomide with or without dexamethasone for refractory or relapsing multiple myeloma. Semin Hematol 2003, 40(4 suppl 4):3-7.
    • (2003) Semin Hematol , vol.40 , Issue.4 SUPPL. 4 , pp. 3-7
    • Alexanian, R.1    Weber, D.2    Anagnostopoulos, A.3    Delasalle, K.4    Wang, M.5    Rankin, K.6
  • 58
    • 0034899464 scopus 로고    scopus 로고
    • Thalidomide and dexamethasone combination for refractory multiple myeloma
    • Dimopoulos M.A., Zervas K., Kouvatseas G., et al. Thalidomide and dexamethasone combination for refractory multiple myeloma. Ann Oncol 2001, 12:991-995.
    • (2001) Ann Oncol , vol.12 , pp. 991-995
    • Dimopoulos, M.A.1    Zervas, K.2    Kouvatseas, G.3
  • 59
    • 0042161862 scopus 로고    scopus 로고
    • Hyperfractionated cyclophosphamide in combination with pulsed dexamethasone and thalidomide (HyperCDT) in primary refractory or relapsed multiple myeloma
    • Kropff M.H., Lang N., Bisping G., et al. Hyperfractionated cyclophosphamide in combination with pulsed dexamethasone and thalidomide (HyperCDT) in primary refractory or relapsed multiple myeloma. Br J Haematol 2003, 122:607-616.
    • (2003) Br J Haematol , vol.122 , pp. 607-616
    • Kropff, M.H.1    Lang, N.2    Bisping, G.3
  • 60
    • 11144356289 scopus 로고    scopus 로고
    • Pulsed cyclophosphamide, thalidomide and dexamethasone: an oral regimen for previously treated patients with multiple myeloma
    • Dimopoulos M.A., Hamilos G., Zomas A., et al. Pulsed cyclophosphamide, thalidomide and dexamethasone: an oral regimen for previously treated patients with multiple myeloma. Hematol J 2004, 5:112-117.
    • (2004) Hematol J , vol.5 , pp. 112-117
    • Dimopoulos, M.A.1    Hamilos, G.2    Zomas, A.3
  • 61
    • 33745749976 scopus 로고    scopus 로고
    • Combination chemotherapy with cyclophosphamide, thalidomide and dexamethasone for patients with refractory, newly diagnosed or relapsed myeloma
    • Sidra G., Williams C.D., Russell N.H., Zaman S., Myers B., Byrne J.L. Combination chemotherapy with cyclophosphamide, thalidomide and dexamethasone for patients with refractory, newly diagnosed or relapsed myeloma. Haematologica 2006, 91:862-863.
    • (2006) Haematologica , vol.91 , pp. 862-863
    • Sidra, G.1    Williams, C.D.2    Russell, N.H.3    Zaman, S.4    Myers, B.5    Byrne, J.L.6
  • 62
    • 23244458669 scopus 로고    scopus 로고
    • Combined thalidomide and cyclophosphamide treatment for refractory or relapsed multiple myeloma patients: a prospective phase II study
    • Hovenga S., Daenen S.M., de Wolf J.T., et al. Combined thalidomide and cyclophosphamide treatment for refractory or relapsed multiple myeloma patients: a prospective phase II study. Ann Hematol 2005, 84:311-316.
    • (2005) Ann Hematol , vol.84 , pp. 311-316
    • Hovenga, S.1    Daenen, S.M.2    de Wolf, J.T.3
  • 64
    • 0036909461 scopus 로고    scopus 로고
    • Use of melphalan, thalidomide, and dexamethasone in treatment of refractory and relapsed multiple myeloma
    • Srkalovic G., Elson P., Trebisky B., Karam M.A., Hussein M.A. Use of melphalan, thalidomide, and dexamethasone in treatment of refractory and relapsed multiple myeloma. Med Oncol 2002, 19:219-226.
    • (2002) Med Oncol , vol.19 , pp. 219-226
    • Srkalovic, G.1    Elson, P.2    Trebisky, B.3    Karam, M.A.4    Hussein, M.A.5
  • 65
    • 32544447241 scopus 로고    scopus 로고
    • Low-dose thalidomide with pegylated liposomal doxorubicin and high-dose dexamethasone for relapsed/refractory multiple myeloma: a prospective, multicenter, phase II study
    • Offidani M., Corvatta L., Marconi M., et al. Low-dose thalidomide with pegylated liposomal doxorubicin and high-dose dexamethasone for relapsed/refractory multiple myeloma: a prospective, multicenter, phase II study. Haematologica 2006, 91:133-136.
    • (2006) Haematologica , vol.91 , pp. 133-136
    • Offidani, M.1    Corvatta, L.2    Marconi, M.3
  • 66
    • 33745628076 scopus 로고    scopus 로고
    • Phase 2 study of pegylated liposomal doxorubicin, vincristine, decreased-frequency dexamethasone, and thalidomide in newly diagnosed and relapsed-refractory multiple myeloma
    • Hussein M.A., Baz R., Srkalovic G., et al. Phase 2 study of pegylated liposomal doxorubicin, vincristine, decreased-frequency dexamethasone, and thalidomide in newly diagnosed and relapsed-refractory multiple myeloma. Mayo Clin Proc 2006, 81:889-895.
    • (2006) Mayo Clin Proc , vol.81 , pp. 889-895
    • Hussein, M.A.1    Baz, R.2    Srkalovic, G.3
  • 67
    • 0035895104 scopus 로고    scopus 로고
    • Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy
    • Moehler T.M., Neben K., Benner A., et al. Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy. Blood 2001, 98:3846-3848.
    • (2001) Blood , vol.98 , pp. 3846-3848
    • Moehler, T.M.1    Neben, K.2    Benner, A.3
  • 68
    • 0033532557 scopus 로고    scopus 로고
    • Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production
    • Muller G.W., Chen R., Huang S.Y., et al. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett 1999, 9:1625-1630.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 1625-1630
    • Muller, G.W.1    Chen, R.2    Huang, S.Y.3
  • 69
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson P.G., Schlossman R.L., Weller E., et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002, 100:3063-3067.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3
  • 70
    • 68249135722 scopus 로고    scopus 로고
    • Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma
    • Richardson P., Jagannath S., Hussein M., et al. Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma. Blood 2009, 114:772-778.
    • (2009) Blood , vol.114 , pp. 772-778
    • Richardson, P.1    Jagannath, S.2    Hussein, M.3
  • 71
    • 0003234481 scopus 로고    scopus 로고
    • Results of phase I study of CC-5013 for the treatment of multiple myeloma patients who relapse after high dose chemotherapy (HDCT)
    • abstract 3226
    • Zangari M.T.G., Zeldis J., Eddlemon P., Saghafifar F., Barlogie B. Results of phase I study of CC-5013 for the treatment of multiple myeloma patients who relapse after high dose chemotherapy (HDCT). Blood 2001, abstract 3226.
    • (2001) Blood
    • Zangari, M.T.G.1    Zeldis, J.2    Eddlemon, P.3    Saghafifar, F.4    Barlogie, B.5
  • 72
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber D.M., Chen C., Niesvizky R., et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 2007, 357:2133-2142.
    • (2007) N Engl J Med , vol.357 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 73
    • 36349023319 scopus 로고    scopus 로고
    • Multiple Myeloma 9010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
    • Dimopoulos M., Spencer A., Attal M., et al. Multiple Myeloma 9010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med 2007, 357:2123-2132.
    • (2007) N Engl J Med , vol.357 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 74
    • 33845350847 scopus 로고    scopus 로고
    • Lenalidomide and pegylated liposomal doxorubicin-based chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy
    • Baz R., Walker E., Karam M.A., et al. Lenalidomide and pegylated liposomal doxorubicin-based chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy. Ann Oncol 2006, 17:1766-1771.
    • (2006) Ann Oncol , vol.17 , pp. 1766-1771
    • Baz, R.1    Walker, E.2    Karam, M.A.3
  • 75
    • 66149109580 scopus 로고    scopus 로고
    • Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom)
    • Knop S., Gerecke C., Liebisch P., et al. Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom). Blood 2009, 113:4137-4143.
    • (2009) Blood , vol.113 , pp. 4137-4143
    • Knop, S.1    Gerecke, C.2    Liebisch, P.3
  • 76
    • 78650097573 scopus 로고    scopus 로고
    • Phase I-II trial of oral cyclophosphamide, prednisone and lenalidomide (revlimid(R)) (CPR) for the treatment of patients with relapsed and refractory multiple myeloma
    • abstract 1874
    • Reece D.E., Masih-Kahn M., Khan A., et al. Phase I-II trial of oral cyclophosphamide, prednisone and lenalidomide (revlimid(R)) (CPR) for the treatment of patients with relapsed and refractory multiple myeloma. Blood 2009, 114. abstract 1874.
    • (2009) Blood , vol.114
    • Reece, D.E.1    Masih-Kahn, M.2    Khan, A.3
  • 77
    • 71949101004 scopus 로고    scopus 로고
    • CRD: a phase 1 dose escalation study to determine the maximum tolerated dose of cyclophosphamide in combination with lenalidomide and dexamethasone in relapsed/refractory myeloma
    • abstract 3707
    • Schey S., Morgan G., Ramasamy K., et al. CRD: a phase 1 dose escalation study to determine the maximum tolerated dose of cyclophosphamide in combination with lenalidomide and dexamethasone in relapsed/refractory myeloma. Blood 2008, 112. abstract 3707.
    • (2008) Blood , vol.112
    • Schey, S.1    Morgan, G.2    Ramasamy, K.3
  • 78
    • 70450230539 scopus 로고    scopus 로고
    • Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    • Dimopoulos M.A., Chen C., Spencer A., et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia 2009, 23:2147-2152.
    • (2009) Leukemia , vol.23 , pp. 2147-2152
    • Dimopoulos, M.A.1    Chen, C.2    Spencer, A.3
  • 79
    • 84862639087 scopus 로고    scopus 로고
    • Efficacy of lenalidomide plus dexamethasone in patients older than 75 years with relapsed multiple myeloma
    • [Epub ahead of print]
    • Touzeau C., Blin N., Clavert A., et al. Efficacy of lenalidomide plus dexamethasone in patients older than 75 years with relapsed multiple myeloma. Leuk Lymphoma 2012 Jan 31, [Epub ahead of print].
    • (2012) Leuk Lymphoma
    • Touzeau, C.1    Blin, N.2    Clavert, A.3
  • 80
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    • Eastern Cooperative Oncology Group
    • Rajkumar S.V., Jacobus S., Callander N.S., et al. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial. Lancet Oncol 2010, 11:29-37. Eastern Cooperative Oncology Group.
    • (2010) Lancet Oncol , vol.11 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3
  • 81
    • 72649087729 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid) combined with continuous oral cyclophosphamide (endoxan) and prednisone (REP) is effective in lenalidomide/dexamethasone-refractory myeloma
    • van de Donk N.W., Wittebol S., Minnema M.C., Lokhorst H.M. Lenalidomide (Revlimid) combined with continuous oral cyclophosphamide (endoxan) and prednisone (REP) is effective in lenalidomide/dexamethasone-refractory myeloma. Br J Haematol 2010, 148:335-337.
    • (2010) Br J Haematol , vol.148 , pp. 335-337
    • van de Donk, N.W.1    Wittebol, S.2    Minnema, M.C.3    Lokhorst, H.M.4
  • 82
    • 34047233904 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid), in combination with cyclophosphamide and dexamethasone (RCD), is an effective and tolerated regimen for myeloma patients
    • Morgan G.J., Schey S.A., Wu P., et al. Lenalidomide (Revlimid), in combination with cyclophosphamide and dexamethasone (RCD), is an effective and tolerated regimen for myeloma patients. Br J Haematol 2007, 137:268-269.
    • (2007) Br J Haematol , vol.137 , pp. 268-269
    • Morgan, G.J.1    Schey, S.A.2    Wu, P.3
  • 83
    • 0037111832 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski R.Z., Stinchcombe T.E., Mitchell B.S., et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002, 20:4420-4427.
    • (2002) J Clin Oncol , vol.20 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 84
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson P.G., Barlogie B., Berenson J., et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003, 348:2609-2617.
    • (2003) N Engl J Med , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 85
    • 5644250621 scopus 로고    scopus 로고
    • A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
    • Jagannath S., Barlogie B., Berenson J., et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 2004, 127:165-172.
    • (2004) Br J Haematol , vol.127 , pp. 165-172
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.3
  • 86
    • 20444433230 scopus 로고    scopus 로고
    • ; Assessment of Proteasome Inhibition for Extending Remossions (APEX) Investigators. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • Richardson P.G., Sonneveld P., Schuster M.W., et al. ; Assessment of Proteasome Inhibition for Extending Remossions (APEX) Investigators. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005, 352:2487-2498.
    • (2005) N Engl J Med , vol.352 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 87
    • 35148825003 scopus 로고    scopus 로고
    • Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial
    • Richardson P.G., Sonneveld P., Schuster M., et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial. Blood 2007, 110:3557-3560.
    • (2007) Blood , vol.110 , pp. 3557-3560
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.3
  • 88
    • 34548539381 scopus 로고    scopus 로고
    • Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression
    • Orlowski R.Z., Nagler A., Sonneveld P., et al. Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J Clin Oncol 2007, 25:3892-3901.
    • (2007) J Clin Oncol , vol.25 , pp. 3892-3901
    • Orlowski, R.Z.1    Nagler, A.2    Sonneveld, P.3
  • 89
    • 34447114537 scopus 로고    scopus 로고
    • Bortezomib in combination with intermediate-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myeloma
    • Deutsche Studiengruppe Multiples Myelom
    • Kropff M., Bisping G., Schuck E., et al. Bortezomib in combination with intermediate-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myeloma. Br J Haematol 2007, 138:330-337. Deutsche Studiengruppe Multiples Myelom.
    • (2007) Br J Haematol , vol.138 , pp. 330-337
    • Kropff, M.1    Bisping, G.2    Schuck, E.3
  • 90
    • 44849092180 scopus 로고    scopus 로고
    • Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma
    • Palumbo A., Gay F., Bringhen S., et al. Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma. Ann Oncol 2008, 19:1160-1165.
    • (2008) Ann Oncol , vol.19 , pp. 1160-1165
    • Palumbo, A.1    Gay, F.2    Bringhen, S.3
  • 91
    • 77649092410 scopus 로고    scopus 로고
    • Phase II trial of combination therapy with bortezomib, pegylated liposomal doxorubicin, and dexamethasone in patients with newly diagnosed myeloma
    • Jakubowiak A.J., Kendall T., Al-Zoubi A., et al. Phase II trial of combination therapy with bortezomib, pegylated liposomal doxorubicin, and dexamethasone in patients with newly diagnosed myeloma. J Clin Oncol 2009, 27:5015-5022.
    • (2009) J Clin Oncol , vol.27 , pp. 5015-5022
    • Jakubowiak, A.J.1    Kendall, T.2    Al-Zoubi, A.3
  • 92
    • 33644916110 scopus 로고    scopus 로고
    • Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
    • Berenson J.R., Yang H.H., Sadler K., et al. Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. J Clin Oncol 2006, 24:937-944.
    • (2006) J Clin Oncol , vol.24 , pp. 937-944
    • Berenson, J.R.1    Yang, H.H.2    Sadler, K.3
  • 93
    • 54249122860 scopus 로고    scopus 로고
    • Phase I-II trial of bortezomib plus oral cyclophosphamide and prednisone in relapsed and refractory multiple myeloma
    • Reece D.E., Rodriguez G.P., Chen C., et al. Phase I-II trial of bortezomib plus oral cyclophosphamide and prednisone in relapsed and refractory multiple myeloma. J Clin Oncol 2008, 26:4777-4783.
    • (2008) J Clin Oncol , vol.26 , pp. 4777-4783
    • Reece, D.E.1    Rodriguez, G.P.2    Chen, C.3
  • 94
    • 60649085451 scopus 로고    scopus 로고
    • Bortezomib, low-dose intravenous melphalan, and dexamethasone for patients with relapsed multiple myeloma
    • Popat R., Oakervee H., Williams C., et al. Bortezomib, low-dose intravenous melphalan, and dexamethasone for patients with relapsed multiple myeloma. Br J Haematol 2009, 144:887-894.
    • (2009) Br J Haematol , vol.144 , pp. 887-894
    • Popat, R.1    Oakervee, H.2    Williams, C.3
  • 95
    • 14744278225 scopus 로고    scopus 로고
    • Bortezomib in combination with dexamethasone for relapsed multiple myeloma
    • Kropff M.H., Bisping G., Wenning D., et al. Bortezomib in combination with dexamethasone for relapsed multiple myeloma. Leuk Res 2005, 29:587-590.
    • (2005) Leuk Res , vol.29 , pp. 587-590
    • Kropff, M.H.1    Bisping, G.2    Wenning, D.3
  • 96
    • 33745801771 scopus 로고    scopus 로고
    • Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone
    • SUMMIT/CREST Investigators
    • Jagannath S., Richardson P.G., Barlogie B., et al. Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone. Haematologica 2006, 91:929-934. SUMMIT/CREST Investigators.
    • (2006) Haematologica , vol.91 , pp. 929-934
    • Jagannath, S.1    Richardson, P.G.2    Barlogie, B.3
  • 97
    • 58149086029 scopus 로고    scopus 로고
    • High response rate to bortezomib with or without dexamethasone in patients with relapsed or refractory multiple myeloma: results of a global phase 3b expanded access program
    • Mikhael J.R., Belch A.R., Prince H.M., et al. High response rate to bortezomib with or without dexamethasone in patients with relapsed or refractory multiple myeloma: results of a global phase 3b expanded access program. Br J Haematol 2009, 144:169-175.
    • (2009) Br J Haematol , vol.144 , pp. 169-175
    • Mikhael, J.R.1    Belch, A.R.2    Prince, H.M.3
  • 98
    • 34848815741 scopus 로고    scopus 로고
    • The combination of cyclophosphamide, velcade and dexamethasone induces high response rates with comparable toxicity to velcade alone and velcade plus dexamethasone
    • Davies F.E., Wu P., Jenner M., Srikanth M., Saso R., Morgan G.J. The combination of cyclophosphamide, velcade and dexamethasone induces high response rates with comparable toxicity to velcade alone and velcade plus dexamethasone. Haematologica 2007, 92:1149-1150.
    • (2007) Haematologica , vol.92 , pp. 1149-1150
    • Davies, F.E.1    Wu, P.2    Jenner, M.3    Srikanth, M.4    Saso, R.5    Morgan, G.J.6
  • 99
    • 44249092118 scopus 로고    scopus 로고
    • The addition of liposomal doxorubicin to bortezomib, thalidomide and dexamethasone significantly improves clinical outcome of advanced multiple myeloma
    • Ciolli S., Leoni F., Casini C., Breschi C., Santini V., Bosi A. The addition of liposomal doxorubicin to bortezomib, thalidomide and dexamethasone significantly improves clinical outcome of advanced multiple myeloma. Br J Haematol 2008, 141:814-819.
    • (2008) Br J Haematol , vol.141 , pp. 814-819
    • Ciolli, S.1    Leoni, F.2    Casini, C.3    Breschi, C.4    Santini, V.5    Bosi, A.6
  • 100
    • 57849161431 scopus 로고    scopus 로고
    • The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis
    • Terpos E., Kastritis E., Roussou M., et al. The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis. Leukemia 2008, 22:2247-2256.
    • (2008) Leukemia , vol.22 , pp. 2247-2256
    • Terpos, E.1    Kastritis, E.2    Roussou, M.3
  • 101
    • 33947575994 scopus 로고    scopus 로고
    • Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma
    • Italian Multiple Myeloma Network; Gruppo Italiano Malattie Ematologicche dell'Adulto
    • Palumbo A., Ambrosini M.T., Benevolo G., et al. Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma. Blood 2007, 109:2767-2772. Italian Multiple Myeloma Network; Gruppo Italiano Malattie Ematologicche dell'Adulto.
    • (2007) Blood , vol.109 , pp. 2767-2772
    • Palumbo, A.1    Ambrosini, M.T.2    Benevolo, G.3
  • 102
    • 47549115250 scopus 로고    scopus 로고
    • VTD combination therapy with bortezomib-thalidomide-dexamethasone is highly effective in advanced and refractory multiple myeloma
    • Pineda-Roman M., Zangari M., van Rhee F., et al. VTD combination therapy with bortezomib-thalidomide-dexamethasone is highly effective in advanced and refractory multiple myeloma. Leukemia 2008, 22:1419-1427.
    • (2008) Leukemia , vol.22 , pp. 1419-1427
    • Pineda-Roman, M.1    Zangari, M.2    van Rhee, F.3
  • 103
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson P.G., Weller E., Jagannath S., et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 2009, 27:5713-5719.
    • (2009) J Clin Oncol , vol.27 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 104
    • 77951141778 scopus 로고    scopus 로고
    • A prospective randomized phase i/ii study of lenalidomide, melphalan, prednisone and thalidomide (RMPT) for relapsed/refractory multiple myeloma patients
    • abstract 2864
    • Cavallo F., Larocca A., Petrucci M.T., Federico V., Falcone A.P., Sanpaolo G., et al. A prospective randomized phase i/ii study of lenalidomide, melphalan, prednisone and thalidomide (RMPT) for relapsed/refractory multiple myeloma patients. Blood 2009, 114. abstract 2864.
    • (2009) Blood , vol.114
    • Cavallo, F.1    Larocca, A.2    Petrucci, M.T.3    Federico, V.4    Falcone, A.P.5    Sanpaolo, G.6
  • 105
    • 70349296572 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (MM): encouraging response rates and tolerability with correlation of outcome and adverse cytogenetics in a phase II study
    • abstract 1742
    • Richardson P., Jagannath S., Jakubowiak A., et al. Lenalidomide, bortezomib, and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (MM): encouraging response rates and tolerability with correlation of outcome and adverse cytogenetics in a phase II study. Blood 2008, 112. abstract 1742.
    • (2008) Blood , vol.112
    • Richardson, P.1    Jagannath, S.2    Jakubowiak, A.3
  • 106
    • 77952108875 scopus 로고    scopus 로고
    • The addition of bortezomib to the combination of lenalidomide and dexamethasone increases bone formation in relapsed/refractory myeloma: a prospective study in 91 patients
    • abstract 1815
    • Terpos E., Christoulas D., Kastritis E., et al. The addition of bortezomib to the combination of lenalidomide and dexamethasone increases bone formation in relapsed/refractory myeloma: a prospective study in 91 patients. Blood 2009, 114. abstract 1815.
    • (2009) Blood , vol.114
    • Terpos, E.1    Christoulas, D.2    Kastritis, E.3
  • 108
    • 51649117633 scopus 로고    scopus 로고
    • A systematic review of phase II trials of thalidomide/dexamethasone combination therapy in patients with relapsed or refractory multiple myeloma
    • von Lilienfeld-Toal M., Hahn-Ast C., Furkert K., et al. A systematic review of phase II trials of thalidomide/dexamethasone combination therapy in patients with relapsed or refractory multiple myeloma. Eur J Haematol 2008, 81:247-252.
    • (2008) Eur J Haematol , vol.81 , pp. 247-252
    • von Lilienfeld-Toal, M.1    Hahn-Ast, C.2    Furkert, K.3
  • 109
    • 70349972023 scopus 로고    scopus 로고
    • Neurological adverse effects caused by cytotoxic and targeted therapies
    • Schiff D., Wen P.Y., van den Bent M.J. Neurological adverse effects caused by cytotoxic and targeted therapies. Nat Rev Clin Oncol 2009, 6:596-603.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 596-603
    • Schiff, D.1    Wen, P.Y.2    van den Bent, M.J.3
  • 110
    • 33751160358 scopus 로고    scopus 로고
    • Optimizing the management of treatment-related peripheral neuropathy in patients with multiple myeloma
    • Reddy G.K., Mughal T.I., Lonial S. Optimizing the management of treatment-related peripheral neuropathy in patients with multiple myeloma. Support Cancer Ther 2006, 4:19-22.
    • (2006) Support Cancer Ther , vol.4 , pp. 19-22
    • Reddy, G.K.1    Mughal, T.I.2    Lonial, S.3
  • 111
    • 77952817334 scopus 로고    scopus 로고
    • Management of treatment-related adverse events in patients with multiple myeloma
    • Mateos M.V. Management of treatment-related adverse events in patients with multiple myeloma. Cancer Treat Rev 2010, 36(Suppl 2):S24-S32.
    • (2010) Cancer Treat Rev , vol.36 , Issue.SUPPL. 2
    • Mateos, M.V.1
  • 112
    • 41949131848 scopus 로고    scopus 로고
    • Prospective evaluation of coagulopathy in multiple myeloma patients before, during and after various chemotherapeutic regimens
    • van Marion A.M., Auwerda J.J., Lisman T., et al. Prospective evaluation of coagulopathy in multiple myeloma patients before, during and after various chemotherapeutic regimens. Leuk Res 2008, 32:1078-1084.
    • (2008) Leuk Res , vol.32 , pp. 1078-1084
    • van Marion, A.M.1    Auwerda, J.J.2    Lisman, T.3
  • 113
    • 39149109289 scopus 로고    scopus 로고
    • Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma
    • International Myeloma Working Group
    • Palumbo A., Rajkumar S.V., Dimopoulos M.A., et al. Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia 2008, 22:414-423. International Myeloma Working Group.
    • (2008) Leukemia , vol.22 , pp. 414-423
    • Palumbo, A.1    Rajkumar, S.V.2    Dimopoulos, M.A.3
  • 114
    • 19944368366 scopus 로고    scopus 로고
    • Prevention of venous thromboembolism with low molecular-weight heparin in patients with multiple myeloma treated with thalidomide and chemotherapy
    • Minnema M.C., Breitkreutz I., Auwerda J.J., et al. Prevention of venous thromboembolism with low molecular-weight heparin in patients with multiple myeloma treated with thalidomide and chemotherapy. Leukemia 2004, 18:2044-2046.
    • (2004) Leukemia , vol.18 , pp. 2044-2046
    • Minnema, M.C.1    Breitkreutz, I.2    Auwerda, J.J.3
  • 115
    • 4544332965 scopus 로고    scopus 로고
    • Deep vein thrombosis in patients with multiple myeloma treated with thalidomide and chemotherapy: effects of prophylactic and therapeutic anticoagulation
    • Zangari M., Barlogie B., Anaissie E., et al. Deep vein thrombosis in patients with multiple myeloma treated with thalidomide and chemotherapy: effects of prophylactic and therapeutic anticoagulation. Br J Haematol 2004, 126:715-721.
    • (2004) Br J Haematol , vol.126 , pp. 715-721
    • Zangari, M.1    Barlogie, B.2    Anaissie, E.3
  • 116
    • 37149054965 scopus 로고    scopus 로고
    • Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma
    • Niesvizky R., Martinez-Baños D., Jalbrzikowski J., et al. Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma. Leuk Lymphoma 2007, 48:2330-2337.
    • (2007) Leuk Lymphoma , vol.48 , pp. 2330-2337
    • Niesvizky, R.1    Martinez-Baños, D.2    Jalbrzikowski, J.3
  • 117
    • 43249097561 scopus 로고    scopus 로고
    • Thalidomide for treatment of multiple myeloma: 10 years later
    • Palumbo A., Facon T., Sonneveld P., et al. Thalidomide for treatment of multiple myeloma: 10 years later. Blood 2008, 111:3968-3977.
    • (2008) Blood , vol.111 , pp. 3968-3977
    • Palumbo, A.1    Facon, T.2    Sonneveld, P.3
  • 118
    • 84862656206 scopus 로고    scopus 로고
    • Revlimid (lenalidomide), Celgene CorporationCelgene Corporation, [prescribing information], Assessed on Janaury 15, 2012
    • Summit N.J. Revlimid (lenalidomide), Celgene CorporationCelgene Corporation, [prescribing information], Assessed on Janaury 15, 2012. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021880s023lbl.pdf.
    • Summit, N.J.1
  • 119
    • 84859196307 scopus 로고    scopus 로고
    • IMWG consensus on maintenance therapy in multiple myeloma
    • Ludwig H., Durie B.G.M., McCarthy P., et al. IMWG consensus on maintenance therapy in multiple myeloma. Blood 2012, 119:3003-3015.
    • (2012) Blood , vol.119 , pp. 3003-3015
    • Ludwig, H.1    Durie, B.G.M.2    McCarthy, P.3
  • 120
    • 84855295447 scopus 로고    scopus 로고
    • Lenalidomide and dexamethasone (LEN plus DEX) treatment in relapsed/refractory multiple myeloma (RRMM) patients (pts) and risk of second primary malignancies (SPM): Analysis of MM-009/010
    • abstract 8009
    • Dimopoulos M.A., Orlowski R.Z., Niesvizky R., et al. Lenalidomide and dexamethasone (LEN plus DEX) treatment in relapsed/refractory multiple myeloma (RRMM) patients (pts) and risk of second primary malignancies (SPM): Analysis of MM-009/010. J Clin Oncol 2011, 29(suppl). abstract 8009.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL..
    • Dimopoulos, M.A.1    Orlowski, R.Z.2    Niesvizky, R.3
  • 121
    • 33846997484 scopus 로고    scopus 로고
    • Optimizing the efficacy and safety of bortezomib in relapsed multiple myeloma
    • discussion 8; suppl 13
    • Richardson P., Jagannath S., Colson K. Optimizing the efficacy and safety of bortezomib in relapsed multiple myeloma. Clin Adv Hematol Oncol 2006, 4:1. discussion 8; suppl 13.
    • (2006) Clin Adv Hematol Oncol , vol.4 , pp. 1
    • Richardson, P.1    Jagannath, S.2    Colson, K.3
  • 122
    • 77956928323 scopus 로고    scopus 로고
    • Multiple myeloma: management of adverse events
    • Gay F., Palumbo A. Multiple myeloma: management of adverse events. Med Oncol 2010, 27:646-653.
    • (2010) Med Oncol , vol.27 , pp. 646-653
    • Gay, F.1    Palumbo, A.2
  • 123
    • 76749127007 scopus 로고    scopus 로고
    • Bortezomib-induced peripheral neuropathy in multiple myeloma: a comparison between previously treated and untreated patients
    • Corso A., Mangiacavalli S., Varettoni M., Pascutto C., Zappasodi P., Lazzarino M. Bortezomib-induced peripheral neuropathy in multiple myeloma: a comparison between previously treated and untreated patients. Leuk Res 2010, 34:471-474.
    • (2010) Leuk Res , vol.34 , pp. 471-474
    • Corso, A.1    Mangiacavalli, S.2    Varettoni, M.3    Pascutto, C.4    Zappasodi, P.5    Lazzarino, M.6
  • 124
    • 70249146895 scopus 로고    scopus 로고
    • Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy
    • Richardson P.G., Xie W., Mitsiades C., et al. Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy. J Clin Oncol 2009, 27:3518-3525.
    • (2009) J Clin Oncol , vol.27 , pp. 3518-3525
    • Richardson, P.G.1    Xie, W.2    Mitsiades, C.3
  • 125
    • 78649681350 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
    • Bringhen S., Larocca A., Rossi D., et al. Efficacy and safety of once-weekly bortezomib in multiple myeloma patients. Blood 2010, 116:4745-4753.
    • (2010) Blood , vol.116 , pp. 4745-4753
    • Bringhen, S.1    Larocca, A.2    Rossi, D.3
  • 126
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study
    • Moreau P., Pylypenko H., Grosicki S., et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 2011, 12:431-440.
    • (2011) Lancet Oncol , vol.12 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3
  • 127
    • 54249089458 scopus 로고    scopus 로고
    • Analysis of herpes zoster events among bortezomib-treated patients in the phase III APEX study
    • Chanan-Khan A., Sonneveld P., Schuster M.W., et al. Analysis of herpes zoster events among bortezomib-treated patients in the phase III APEX study. J Clin Oncol 2008, 26:4784-4790.
    • (2008) J Clin Oncol , vol.26 , pp. 4784-4790
    • Chanan-Khan, A.1    Sonneveld, P.2    Schuster, M.W.3
  • 128
    • 84862656209 scopus 로고    scopus 로고
    • (eds). SEER Cancer Statistics Review 1975-2007. National Cancer Institute. Bethesda, MD, . Based on November 2009 SEER data submission posted to the SEER Website, 2010. Accessed on March 19
    • Altekruse S, Kosary C, Krapcho M, et al (eds). SEER Cancer Statistics Review 1975-2007. National Cancer Institute. Bethesda, MD, . Based on November 2009 SEER data submission posted to the SEER Website, 2010. Accessed on March 19, 2012. http://seer.cancer.gov/csr/1975-2007/.
    • (2012)
    • Altekruse, S.1    Kosary, C.2    Krapcho, M.3
  • 129
    • 80055066620 scopus 로고    scopus 로고
    • Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN)
    • Palumbo A., Bringhen S., Ludwig H., et al. Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN). Blood 2011, 118:4519-4529.
    • (2011) Blood , vol.118 , pp. 4519-4529
    • Palumbo, A.1    Bringhen, S.2    Ludwig, H.3
  • 130
    • 0025581591 scopus 로고
    • Cancer pain relief and palliative care. Report of a WHO Expert Committee
    • Cancer pain relief and palliative care. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser 1990, 804:1-75.
    • (1990) World Health Organ Tech Rep Ser , vol.804 , pp. 1-75
  • 132
    • 6844252283 scopus 로고    scopus 로고
    • Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events
    • Myeloma Aredia Study Group
    • Berenson J.R., Lichtenstein A., Porter L., et al. Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. J Clin Oncol 1998, 16:593-602. Myeloma Aredia Study Group.
    • (1998) J Clin Oncol , vol.16 , pp. 593-602
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 133
    • 9044219839 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma
    • Myeloma Aredia Study Group
    • Berenson J.R., Lichtenstein A., Porter L., et al. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. N Engl J Med 1996, 334:488-493. Myeloma Aredia Study Group.
    • (1996) N Engl J Med , vol.334 , pp. 488-493
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 134
    • 78650174738 scopus 로고    scopus 로고
    • First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial
    • National Cancer Research Institute Haematological Oncology Clinical Study Group
    • Morgan G.J., Davies F.E., Gregory W.M., et al. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet 2010, 376:1989-1999. National Cancer Research Institute Haematological Oncology Clinical Study Group.
    • (2010) Lancet , vol.376 , pp. 1989-1999
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3
  • 135
    • 79960891058 scopus 로고    scopus 로고
    • Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial
    • National Cancer Research Institute Haematological Oncology Clinical Study Group
    • Morgan G.J., Child J.A., Gregory W.M., et al. Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial. Lancet Oncol 2011, 12:743-752. National Cancer Research Institute Haematological Oncology Clinical Study Group.
    • (2011) Lancet Oncol , vol.12 , pp. 743-752
    • Morgan, G.J.1    Child, J.A.2    Gregory, W.M.3
  • 136
    • 69449108135 scopus 로고    scopus 로고
    • The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network
    • European Myeloma Network
    • Terpos E., Sezer O., Croucher P.I., et al. The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009, 20:1303-1317. European Myeloma Network.
    • (2009) Ann Oncol , vol.20 , pp. 1303-1317
    • Terpos, E.1    Sezer, O.2    Croucher, P.I.3
  • 137
    • 67650882219 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw complicating bisphosphonate treatment for bone disease in multiple myeloma: an overview with recommendations for prevention and treatment
    • Dickinson M., Prince H.M., Kirsa S., et al. Osteonecrosis of the jaw complicating bisphosphonate treatment for bone disease in multiple myeloma: an overview with recommendations for prevention and treatment. Intern Med J 2009, 39:304-316.
    • (2009) Intern Med J , vol.39 , pp. 304-316
    • Dickinson, M.1    Prince, H.M.2    Kirsa, S.3
  • 138
  • 139
    • 13744250353 scopus 로고    scopus 로고
    • Clinical practice. Hypercalcemia associated with cancer
    • Stewart A.F. Clinical practice. Hypercalcemia associated with cancer. N Engl J Med 2005, 352:373-379.
    • (2005) N Engl J Med , vol.352 , pp. 373-379
    • Stewart, A.F.1
  • 140
    • 37849003198 scopus 로고    scopus 로고
    • Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update
    • American Society of Clinical Oncology; American Society of Hematology
    • Rizzo J.D., Somerfield M.R., Hagerty K.L., et al. Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update. J Clin Oncol 2008, 26:132-149. American Society of Clinical Oncology; American Society of Hematology.
    • (2008) J Clin Oncol , vol.26 , pp. 132-149
    • Rizzo, J.D.1    Somerfield, M.R.2    Hagerty, K.L.3
  • 141
    • 80053982198 scopus 로고    scopus 로고
    • Management of relapsed and relapsed/refractory multiple myeloma
    • Laubach J.P., Mitsiades C.S., Mahindra A., et al. Management of relapsed and relapsed/refractory multiple myeloma. J Natl Compr Canc Netw 2011, 9:1209-1216.
    • (2011) J Natl Compr Canc Netw , vol.9 , pp. 1209-1216
    • Laubach, J.P.1    Mitsiades, C.S.2    Mahindra, A.3
  • 142
    • 54249092519 scopus 로고    scopus 로고
    • Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myelome
    • Intergroupe Françophone du Myélome
    • Decaux O., Lodé L., Magrangeas F., et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myelome. J Clin Oncol 2008, 26:4798-4805. Intergroupe Françophone du Myélome.
    • (2008) J Clin Oncol , vol.26 , pp. 4798-4805
    • Decaux, O.1    Lodé, L.2    Magrangeas, F.3
  • 143
    • 33845518467 scopus 로고    scopus 로고
    • Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
    • Jagannath S., Richardson P.G., Sonneveld P., et al. Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials. Leukemia 2007, 21:151-157.
    • (2007) Leukemia , vol.21 , pp. 151-157
    • Jagannath, S.1    Richardson, P.G.2    Sonneveld, P.3
  • 144
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • VISTA Trial Investigators
    • San Miguel J.F., Schlag R., Khuageva N.K., et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 2008, 359:906-917. VISTA Trial Investigators.
    • (2008) N Engl J Med , vol.359 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 145
    • 78049501226 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone induction improves outcome in patients with t(4;14) myeloma but not outcome of patients with del(17p)
    • Avet-Loiseau H., Leleu X., Roussel M., et al. Bortezomib plus dexamethasone induction improves outcome in patients with t(4;14) myeloma but not outcome of patients with del(17p). J Clin Oncol 2010, 28:4630-4634.
    • (2010) J Clin Oncol , vol.28 , pp. 4630-4634
    • Avet-Loiseau, H.1    Leleu, X.2    Roussel, M.3
  • 146
    • 84856278440 scopus 로고    scopus 로고
    • Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p
    • Neben K., Lokhorst H.M., Jauch A., et al. Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p. Blood 2012, 119:940-948.
    • (2012) Blood , vol.119 , pp. 940-948
    • Neben, K.1    Lokhorst, H.M.2    Jauch, A.3
  • 147
    • 0028135393 scopus 로고
    • Renal function in newly diagnosed multiple myeloma-a demographic study of 1353 patients
    • The Nordic Myeloma Study Group
    • Knudsen L.M., Hippe E., Hjorth M., Holmberg E., Westin J. Renal function in newly diagnosed multiple myeloma-a demographic study of 1353 patients. Eur J Haematol 1994, 53:207-212. The Nordic Myeloma Study Group.
    • (1994) Eur J Haematol , vol.53 , pp. 207-212
    • Knudsen, L.M.1    Hippe, E.2    Hjorth, M.3    Holmberg, E.4    Westin, J.5
  • 148
    • 20044381304 scopus 로고    scopus 로고
    • Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function
    • SUMMITT/CREST Investigators
    • Jagannath S., Barlogie B., Berenson J.R., et al. Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function. Cancer 2005, 103:1195-1200. SUMMITT/CREST Investigators.
    • (2005) Cancer , vol.103 , pp. 1195-1200
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.R.3
  • 149
    • 42349108452 scopus 로고    scopus 로고
    • Efficacy and safety of bortezomib in patients with renal impairment: results from the APEX phase 3 study
    • San-Miguel J.F., Richardson P.G., Sonneveld P., et al. Efficacy and safety of bortezomib in patients with renal impairment: results from the APEX phase 3 study. Leukemia 2008, 22:842-849.
    • (2008) Leukemia , vol.22 , pp. 842-849
    • San-Miguel, J.F.1    Richardson, P.G.2    Sonneveld, P.3
  • 150
    • 3242755855 scopus 로고    scopus 로고
    • Thalidomide alone or in combination with dexamethasone in patients with advanced, relapsed or refractory multiple myeloma and renal failure
    • Tosi P., Zamagni E., Cellini C., et al. Thalidomide alone or in combination with dexamethasone in patients with advanced, relapsed or refractory multiple myeloma and renal failure. Eur J Haematol 2004, 73:98-103.
    • (2004) Eur J Haematol , vol.73 , pp. 98-103
    • Tosi, P.1    Zamagni, E.2    Cellini, C.3
  • 151
    • 84862692504 scopus 로고    scopus 로고
    • Thalomid (thalidomide), [prescribing information], Celgene Corporation, Summit, NJ, Assessed on Janaury 15, 2012
    • 2006, Thalomid (thalidomide), [prescribing information], Celgene Corporation, Summit, NJ, Assessed on Janaury 15, 2012. http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021430lbl.pdf.
    • (2006)
  • 152
    • 84862692505 scopus 로고    scopus 로고
    • Velcade (bortezomib), [prescribing information], Millennium Pharmaceuticals, Inc., Cambridge, MA, Assessed on Janaury 15, 2012
    • 2011, Velcade (bortezomib), [prescribing information], Millennium Pharmaceuticals, Inc., Cambridge, MA, Assessed on Janaury 15, 2012. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021602s029s030lbl.pdf%20Assessed%20on%20Janaury%2015,%202012.
    • (2011)
  • 153
    • 33746010219 scopus 로고    scopus 로고
    • Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib
    • Richardson P.G., Briemberg H., Jagannath S., et al. Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. J Clin Oncol 2006, 24:3113-3120.
    • (2006) J Clin Oncol , vol.24 , pp. 3113-3120
    • Richardson, P.G.1    Briemberg, H.2    Jagannath, S.3
  • 154
    • 75649085683 scopus 로고    scopus 로고
    • Current multiple myeloma treatment strategies with novel agents: a European perspective
    • Ludwig H., Beksac M., Bladé J., et al. Current multiple myeloma treatment strategies with novel agents: a European perspective. Oncologist 2010, 15:6-25.
    • (2010) Oncologist , vol.15 , pp. 6-25
    • Ludwig, H.1    Beksac, M.2    Bladé, J.3


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