메뉴 건너뛰기




Volumn 7, Issue 6, 2012, Pages

Transcriptional profiling of serogroup B Neisseria meningitidis growing in human blood: An approach to vaccine antigen discovery

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; COMPLEMENT FACTOR H BINDING PROTEIN VACCINE; GLUTAMIC ACID; MENINGOCOCCUS VACCINE; NEISSERIAL SURFACE PROTEIN A VACCINE; PROTEINASE; PURINE; PYRIMIDINE; UNCLASSIFIED DRUG;

EID: 84862663950     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039718     Document Type: Article
Times cited : (24)

References (51)
  • 1
    • 34250795027 scopus 로고    scopus 로고
    • Epidemic meningitis, meningococcaemia, and Neisseria meningitidis
    • Stephens DS, Greenwood B, Brandtzaeg P, (2007) Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 369: 2196-2210.
    • (2007) Lancet , vol.369 , pp. 2196-2210
    • Stephens, D.S.1    Greenwood, B.2    Brandtzaeg, P.3
  • 2
    • 63049088278 scopus 로고    scopus 로고
    • Pathogenic neisseriae: surface modulation, pathogenesis and infection control
    • Virji M, (2009) Pathogenic neisseriae: surface modulation, pathogenesis and infection control. Nat Rev Microbiol 7: 274-286.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 274-286
    • Virji, M.1
  • 3
    • 33847250370 scopus 로고    scopus 로고
    • Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18
    • Bentley SD, Vernikos GS, Snyder LA, Churcher C, Arrowsmith C, et al. (2007) Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18. PLoS Genet 3: e23.
    • (2007) PLoS Genet , vol.3
    • Bentley, S.D.1    Vernikos, G.S.2    Snyder, L.A.3    Churcher, C.4    Arrowsmith, C.5
  • 4
    • 0034732226 scopus 로고    scopus 로고
    • Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
    • Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, et al. (2000) Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature 404: 502-506.
    • (2000) Nature , vol.404 , pp. 502-506
    • Parkhill, J.1    Achtman, M.2    James, K.D.3    Bentley, S.D.4    Churcher, C.5
  • 5
    • 37349066291 scopus 로고    scopus 로고
    • Characterization of ST-4821 complex, a unique Neisseria meningitidis clone
    • Peng J, Yang L, Yang F, Yang J, Yan Y, et al. (2008) Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. Genomics 91: 78-87.
    • (2008) Genomics , vol.91 , pp. 78-87
    • Peng, J.1    Yang, L.2    Yang, F.3    Yang, J.4    Yan, Y.5
  • 6
    • 0034629478 scopus 로고    scopus 로고
    • Complete genome sequence of Neisseria meningitidis serogroup B strain MC58
    • Tettelin H, Saunders NJ, Heidelberg J, Jeffries AC, Nelson KE, et al. (2000) Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 287: 1809-1815.
    • (2000) Science , vol.287 , pp. 1809-1815
    • Tettelin, H.1    Saunders, N.J.2    Heidelberg, J.3    Jeffries, A.C.4    Nelson, K.E.5
  • 7
    • 0033678157 scopus 로고    scopus 로고
    • Functional genomics of Neisseria meningitidis pathogenesis
    • Sun YH, Bakshi S, Chalmers R, Tang CM, (2000) Functional genomics of Neisseria meningitidis pathogenesis. Nat Med 6: 1269-1273.
    • (2000) Nat Med , vol.6 , pp. 1269-1273
    • Sun, Y.H.1    Bakshi, S.2    Chalmers, R.3    Tang, C.M.4
  • 8
    • 0014531759 scopus 로고
    • Human immunity to the meningococcus. I. The role of humoral antibodies
    • Goldschneider I, Gotschlich EC, Artenstein MS, (1969) Human immunity to the meningococcus. I. The role of humoral antibodies. J Exp Med 129: 1307-1326.
    • (1969) J Exp Med , vol.129 , pp. 1307-1326
    • Goldschneider, I.1    Gotschlich, E.C.2    Artenstein, M.S.3
  • 9
    • 0032825280 scopus 로고    scopus 로고
    • Assessment of immune response to meningococcal disease: comparison of a whole-blood assay and the serum bactericidal assay
    • Ison CA, Anwar N, Cole MJ, Galassini R, Heyderman RS, et al. (1999) Assessment of immune response to meningococcal disease: comparison of a whole-blood assay and the serum bactericidal assay. Microb Pathog 27: 207-214.
    • (1999) Microb Pathog , vol.27 , pp. 207-214
    • Ison, C.A.1    Anwar, N.2    Cole, M.J.3    Galassini, R.4    Heyderman, R.S.5
  • 10
    • 67249157162 scopus 로고    scopus 로고
    • Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity
    • Plested JS, Welsch JA, Granoff DM, (2009) Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity. Clin Vaccine Immunol 16: 785-791.
    • (2009) Clin Vaccine Immunol , vol.16 , pp. 785-791
    • Plested, J.S.1    Welsch, J.A.2    Granoff, D.M.3
  • 11
    • 0037472386 scopus 로고    scopus 로고
    • Transcriptome-based antigen identification for Neisseria meningitidis
    • Kurz S, Hubner C, Aepinus C, Theiss S, Guckenberger M, et al. (2003) Transcriptome-based antigen identification for Neisseria meningitidis. Vaccine 21: 768-775.
    • (2003) Vaccine , vol.21 , pp. 768-775
    • Kurz, S.1    Hubner, C.2    Aepinus, C.3    Theiss, S.4    Guckenberger, M.5
  • 12
    • 79958032046 scopus 로고    scopus 로고
    • Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival
    • Echenique-Rivera H, Muzzi A, Del Tordello E, Seib KL, Francois P, et al. (2011) Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival. PLoS Pathog 7: e1002027.
    • (2011) PLoS Pathog , vol.7
    • Echenique-Rivera, H.1    Muzzi, A.2    Del Tordello, E.3    Seib, K.L.4    Francois, P.5
  • 13
    • 3142783512 scopus 로고    scopus 로고
    • Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease
    • Ovstebo R, Brandtzaeg P, Brusletto B, Haug KB, Lande K, et al. (2004) Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease. J Clin Microbiol 42: 2980-2987.
    • (2004) J Clin Microbiol , vol.42 , pp. 2980-2987
    • Ovstebo, R.1    Brandtzaeg, P.2    Brusletto, B.3    Haug, K.B.4    Lande, K.5
  • 14
    • 0002433046 scopus 로고
    • A study of the virulence of Meningococci form man and of human susceptibility to meningococcic infection
    • Heist GD, Solis-Cohen S, Solis-Cohen M, (1922) A study of the virulence of Meningococci form man and of human susceptibility to meningococcic infection. J Immunol 7: 1-33.
    • (1922) J Immunol , vol.7 , pp. 1-33
    • Heist, G.D.1    Solis-Cohen, S.2    Solis-Cohen, M.3
  • 15
    • 44349122321 scopus 로고    scopus 로고
    • The T7-primer is a source of experimental bias and introduces variability between microarray platforms
    • Kerkhoven RM, Sie D, Nieuwland M, Heimerikx M, De Ronde J, et al. (2008) The T7-primer is a source of experimental bias and introduces variability between microarray platforms. PLoS One 3: e1980.
    • (2008) PLoS One , vol.3
    • Kerkhoven, R.M.1    Sie, D.2    Nieuwland, M.3    Heimerikx, M.4    de Ronde, J.5
  • 16
    • 1642451816 scopus 로고    scopus 로고
    • The gross structure of the respiratory complex I: a Lego System
    • Friedrich T, Bottcher B, (2004) The gross structure of the respiratory complex I: a Lego System. Biochim Biophys Acta 1608: 1-9.
    • (2004) Biochim Biophys Acta , vol.1608 , pp. 1-9
    • Friedrich, T.1    Bottcher, B.2
  • 17
    • 0031597437 scopus 로고    scopus 로고
    • The (alpha2->8)-linked polysialic acid capsule and lipooligosaccharide structure both contribute to the ability of serogroup B Neisseria meningitidis to resist the bactericidal activity of normal human serum
    • Kahler CM, Martin LE, Shih GC, Rahman MM, Carlson RW, et al. (1998) The (alpha2->8)-linked polysialic acid capsule and lipooligosaccharide structure both contribute to the ability of serogroup B Neisseria meningitidis to resist the bactericidal activity of normal human serum. Infect Immun 66: 5939-5947.
    • (1998) Infect Immun , vol.66 , pp. 5939-5947
    • Kahler, C.M.1    Martin, L.E.2    Shih, G.C.3    Rahman, M.M.4    Carlson, R.W.5
  • 18
    • 45149091798 scopus 로고    scopus 로고
    • A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies
    • Uria MJ, Zhang Q, Li Y, Chan A, Exley RM, et al. (2008) A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies. J Exp Med 205: 1423-1434.
    • (2008) J Exp Med , vol.205 , pp. 1423-1434
    • Uria, M.J.1    Zhang, Q.2    Li, Y.3    Chan, A.4    Exley, R.M.5
  • 19
    • 0033062972 scopus 로고    scopus 로고
    • Mechanisms of neisserial serum resistance
    • Vogel U, Frosch M, (1999) Mechanisms of neisserial serum resistance. Mol Microbiol 32: 1133-1139.
    • (1999) Mol Microbiol , vol.32 , pp. 1133-1139
    • Vogel, U.1    Frosch, M.2
  • 20
    • 77957652922 scopus 로고    scopus 로고
    • The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement
    • Lewis LA, Ngampasutadol J, Wallace R, Reid JE, Vogel U, et al. (2010) The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement. PLoS Pathog 6: e1001027.
    • (2010) PLoS Pathog , vol.6
    • Lewis, L.A.1    Ngampasutadol, J.2    Wallace, R.3    Reid, J.E.4    Vogel, U.5
  • 21
    • 67249113222 scopus 로고    scopus 로고
    • Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates
    • Schneider MC, Prosser BE, Caesar JJ, Kugelberg E, Li S, et al. (2009) Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. Nature 458: 890-893.
    • (2009) Nature , vol.458 , pp. 890-893
    • Schneider, M.C.1    Prosser, B.E.2    Caesar, J.J.3    Kugelberg, E.4    Li, S.5
  • 22
    • 27444447753 scopus 로고    scopus 로고
    • Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages
    • Leuzzi R, Serino L, Scarselli M, Savino S, Fontana MR, et al. (2005) Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages. Mol Microbiol 58: 669-681.
    • (2005) Mol Microbiol , vol.58 , pp. 669-681
    • Leuzzi, R.1    Serino, L.2    Scarselli, M.3    Savino, S.4    Fontana, M.R.5
  • 23
    • 0032849337 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae bacterioferritin: structural heterogeneity, involvement in iron storage and protection against oxidative stress
    • Chen CY, Morse SA, (1999) Neisseria gonorrhoeae bacterioferritin: structural heterogeneity, involvement in iron storage and protection against oxidative stress. Microbiology 145 (Pt 10): 2967-2975.
    • (1999) Microbiology , vol.145 , Issue.Pt 10 , pp. 2967-2975
    • Chen, C.Y.1    Morse, S.A.2
  • 25
    • 33644757638 scopus 로고    scopus 로고
    • Identification of a meningococcal L-glutamate ABC transporter operon essential for growth in low-sodium environments
    • Monaco C, Tala A, Spinosa MR, Progida C, De Nitto E, et al. (2006) Identification of a meningococcal L-glutamate ABC transporter operon essential for growth in low-sodium environments. Infect Immun 74: 1725-1740.
    • (2006) Infect Immun , vol.74 , pp. 1725-1740
    • Monaco, C.1    Tala, A.2    Spinosa, M.R.3    Progida, C.4    de Nitto, E.5
  • 26
    • 58549112573 scopus 로고    scopus 로고
    • A Neisseria meningitidis NMB1966 mutant is impaired for invasion of respiratory epithelial cells, survival in human blood and for virulence in vivo
    • Li MS, Chow NY, Sinha S, Halliwell D, Finney M, et al. (2009) A Neisseria meningitidis NMB1966 mutant is impaired for invasion of respiratory epithelial cells, survival in human blood and for virulence in vivo. Med Microbiol Immunol 198: 57-67.
    • (2009) Med Microbiol Immunol , vol.198 , pp. 57-67
    • Li, M.S.1    Chow, N.Y.2    Sinha, S.3    Halliwell, D.4    Finney, M.5
  • 27
    • 80051934372 scopus 로고    scopus 로고
    • Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst
    • Tala A, Monaco C, Nagorska K, Exley RM, Corbett A, et al. (2011) Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst. Mol Microbiol 81: 1330-1342.
    • (2011) Mol Microbiol , vol.81 , pp. 1330-1342
    • Tala, A.1    Monaco, C.2    Nagorska, K.3    Exley, R.M.4    Corbett, A.5
  • 28
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3    Mukherjee, S.4    Ebert, B.L.5
  • 29
    • 12144289598 scopus 로고    scopus 로고
    • Regulation and differential expression of gdhA encoding NADP-specific glutamate dehydrogenase in Neisseria meningitidis clinical isolates
    • Pagliarulo C, Salvatore P, De Vitis LR, Colicchio R, Monaco C, et al. (2004) Regulation and differential expression of gdhA encoding NADP-specific glutamate dehydrogenase in Neisseria meningitidis clinical isolates. Mol Microbiol 51: 1757-1772.
    • (2004) Mol Microbiol , vol.51 , pp. 1757-1772
    • Pagliarulo, C.1    Salvatore, P.2    de Vitis, L.R.3    Colicchio, R.4    Monaco, C.5
  • 30
    • 40349098615 scopus 로고    scopus 로고
    • Nucleotide biosynthesis is critical for growth of bacteria in human blood
    • Samant S, Lee H, Ghassemi M, Chen J, Cook JL, et al. (2008) Nucleotide biosynthesis is critical for growth of bacteria in human blood. PLoS Pathog 4: e37.
    • (2008) PLoS Pathog , vol.4
    • Samant, S.1    Lee, H.2    Ghassemi, M.3    Chen, J.4    Cook, J.L.5
  • 31
    • 0035783169 scopus 로고    scopus 로고
    • Review: mechanisms of disaggregation and refolding of stable protein aggregates by molecular chaperones
    • Ben-Zvi AP, Goloubinoff P, (2001) Review: mechanisms of disaggregation and refolding of stable protein aggregates by molecular chaperones. J Struct Biol 135: 84-93.
    • (2001) J Struct Biol , vol.135 , pp. 84-93
    • Ben-Zvi, A.P.1    Goloubinoff, P.2
  • 32
    • 8544233512 scopus 로고    scopus 로고
    • Characterization of a novel Neisseria meningitidis Fur and iron-regulated operon required for protection from oxidative stress: utility of DNA microarray in the assignment of the biological role of hypothetical genes
    • Grifantini R, Frigimelica E, Delany I, Bartolini E, Giovinazzi S, et al. (2004) Characterization of a novel Neisseria meningitidis Fur and iron-regulated operon required for protection from oxidative stress: utility of DNA microarray in the assignment of the biological role of hypothetical genes. Mol Microbiol 54: 962-979.
    • (2004) Mol Microbiol , vol.54 , pp. 962-979
    • Grifantini, R.1    Frigimelica, E.2    Delany, I.3    Bartolini, E.4    Giovinazzi, S.5
  • 34
    • 80052313162 scopus 로고    scopus 로고
    • The Neisseria meningitidis Macrophage Infectivity Potentiator Protein Induces Cross-Strain Serum Bactericidal Activity and Is a Potential Serogroup B Vaccine Candidate
    • Hung MC, Salim O, Williams JN, Heckels JE, Christodoulides M, (2011) The Neisseria meningitidis Macrophage Infectivity Potentiator Protein Induces Cross-Strain Serum Bactericidal Activity and Is a Potential Serogroup B Vaccine Candidate. Infect Immun 79: 3784-3791.
    • (2011) Infect Immun , vol.79 , pp. 3784-3791
    • Hung, M.C.1    Salim, O.2    Williams, J.N.3    Heckels, J.E.4    Christodoulides, M.5
  • 35
    • 77957355947 scopus 로고    scopus 로고
    • A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA
    • Keiser PB, Gibbs BT, Coster TS, Moran EE, Stoddard MB, et al. (2010) A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA. Vaccine 28: 6970-6976.
    • (2010) Vaccine , vol.28 , pp. 6970-6976
    • Keiser, P.B.1    Gibbs, B.T.2    Coster, T.S.3    Moran, E.E.4    Stoddard, M.B.5
  • 36
    • 0033756918 scopus 로고    scopus 로고
    • Endocrine and metabolic responses in children with meningoccocal sepsis: striking differences between survivors and nonsurvivors
    • Joosten KF, de Kleijn ED, Westerterp M, de Hoog M, Eijck FC, et al. (2000) Endocrine and metabolic responses in children with meningoccocal sepsis: striking differences between survivors and nonsurvivors. J Clin Endocrinol Metab 85: 3746-3753.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3746-3753
    • Joosten, K.F.1    de Kleijn, E.D.2    Westerterp, M.3    de Hoog, M.4    Eijck, F.C.5
  • 37
    • 77954199597 scopus 로고    scopus 로고
    • PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
    • Yu NY, Wagner JR, Laird MR, Melli G, Rey S, et al. (2010) PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes. Bioinformatics 26: 1608-1615.
    • (2010) Bioinformatics , vol.26 , pp. 1608-1615
    • Yu, N.Y.1    Wagner, J.R.2    Laird, M.R.3    Melli, G.4    Rey, S.5
  • 38
    • 70350712113 scopus 로고    scopus 로고
    • Examination of post-transcriptional regulations in prokaryotes by integrative biology
    • Picard F, Dressaire C, Girbal L, Cocaign-Bousquet M, (2009) Examination of post-transcriptional regulations in prokaryotes by integrative biology. C R Biol 332: 958-973.
    • (2009) C R Biol , vol.332 , pp. 958-973
    • Picard, F.1    Dressaire, C.2    Girbal, L.3    Cocaign-Bousquet, M.4
  • 39
    • 0036714329 scopus 로고    scopus 로고
    • Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays
    • Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, et al. (2002) Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat Biotechnol 20: 914-921.
    • (2002) Nat Biotechnol , vol.20 , pp. 914-921
    • Grifantini, R.1    Bartolini, E.2    Muzzi, A.3    Draghi, M.4    Frigimelica, E.5
  • 40
    • 33646417659 scopus 로고    scopus 로고
    • Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection
    • Bartolini E, Frigimelica E, Giovinazzi S, Galli G, Shaik Y, et al. (2006) Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection. Mol Microbiol 60: 963-972.
    • (2006) Mol Microbiol , vol.60 , pp. 963-972
    • Bartolini, E.1    Frigimelica, E.2    Giovinazzi, S.3    Galli, G.4    Shaik, Y.5
  • 41
    • 0032954440 scopus 로고    scopus 로고
    • Structural and evolutionary inference from molecular variation in Neisseria porins
    • Derrick JP, Urwin R, Suker J, Feavers IM, Maiden MC, (1999) Structural and evolutionary inference from molecular variation in Neisseria porins. Infect Immun 67: 2406-2413.
    • (1999) Infect Immun , vol.67 , pp. 2406-2413
    • Derrick, J.P.1    Urwin, R.2    Suker, J.3    Feavers, I.M.4    Maiden, M.C.5
  • 42
    • 0029894768 scopus 로고    scopus 로고
    • The maintenance of strain structure in populations of recombining infectious agents
    • Gupta S, Maiden MC, Feavers IM, Nee S, May RM, et al. (1996) The maintenance of strain structure in populations of recombining infectious agents. Nat Med 2: 437-442.
    • (1996) Nat Med , vol.2 , pp. 437-442
    • Gupta, S.1    Maiden, M.C.2    Feavers, I.M.3    Nee, S.4    May, R.M.5
  • 43
    • 67650723102 scopus 로고    scopus 로고
    • Meningococcal biofilm growth on an abiotic surface - a model for epithelial colonization?
    • O'Dwyer CA, Li MS, Langford PR, Kroll JS, (2009) Meningococcal biofilm growth on an abiotic surface - a model for epithelial colonization? Microbiology 155: 1940-1952.
    • (2009) Microbiology , vol.155 , pp. 1940-1952
    • O'Dwyer, C.A.1    Li, M.S.2    Langford, P.R.3    Kroll, J.S.4
  • 44
    • 24944588868 scopus 로고    scopus 로고
    • Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species
    • Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, et al. (2005) Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. Microbiology 151: 2907-2922.
    • (2005) Microbiology , vol.151 , pp. 2907-2922
    • Stabler, R.A.1    Marsden, G.L.2    Witney, A.A.3    Li, Y.4    Bentley, S.D.5
  • 45
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3
    • Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
    • (2004) Stat Appl Genet Mol Biol , vol.3
    • Smyth, G.K.1
  • 46
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc, Ser B 57: 289-300.
    • (1995) J Roy Stat Soc, Ser B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 47
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 48
    • 0027968068 scopus 로고
    • CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ, (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 50
    • 79952711441 scopus 로고    scopus 로고
    • Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination
    • Budroni S, Siena E, Hotopp JC, Seib KL, Serruto D, et al. (2011) Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination. Proc Natl Acad Sci U S A 108: 4494-4499.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4494-4499
    • Budroni, S.1    Siena, E.2    Hotopp, J.C.3    Seib, K.L.4    Serruto, D.5
  • 51
    • 77957850942 scopus 로고    scopus 로고
    • Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence
    • Joseph B, Schneiker-Bekel S, Schramm-Gluck A, Blom J, Claus H, et al. (2010) Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence. J Bacteriol 192: 5363-5377.
    • (2010) J Bacteriol , vol.192 , pp. 5363-5377
    • Joseph, B.1    Schneiker-Bekel, S.2    Schramm-Gluck, A.3    Blom, J.4    Claus, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.