Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPlase) activity and is involved in persistence in macrophages

Molecular Microbiology

Volumn 58, Issue 3, 2005, Pages 669-681

  Leuzzi, Rosanna ^a   Serino, Laura ^a   Scarselli, Maria ^a   Savino, Silvana ^a   Fontana, Maria Rita ^a   Monaci, Elisabetta ^a   Taddei, Annarita ^b   Fischer, Gunter ^c   Rappuoli, Rino ^a   Pizza, Mariagrazia ^a  

^a CHIRON VACCINES   (Italy)

^b UNIVERSITY OF TUSCIA   (Italy)

^c MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN; MACROPHAGE INFLAMMATORY PROTEIN;

ARTICLE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; CELL SURVIVAL; ENZYME ACTIVITY; EVALUATION; GENE DELETION; MACROPHAGE; NEISSERIA GONORRHOEAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELLS, CULTURED; DIMERIZATION; GENE DELETION; GONORRHEA; HUMANS; IMMUNOPHILINS; LIPOPROTEINS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEISSERIA GONORRHOEAE; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE ALIGNMENT; SIROLIMUS;

BACTERIA (MICROORGANISMS); CHLAMYDIA; LEGIONELLA; NEISSERIA GONORRHOEAE; TRYPANOSOMA;

EID: 27444447753     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2005.04859.x     Document Type: Article

References (28)

1. Achtman, M., Neibert, M., Crowe, B.A., Strittmatter, W., Kusecek, B., Weyse, E., et al. (1988) Purification and characterization of eight class 5 outer membrane protein variants from a clone of Neisseria meningitidis serogroup A. J Exp Med 168: 507-525.
2. Cianciotto, N.P., and Fields, B.S. (1992) Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages. Proc Natl Acad Sci USA 89: 5188-5191.
3. Cianciotto, N.P., Eisenstein, B.I., Mody, C.H., Toews, G.B., and Engleberg, N.C. (1989) A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection. Infect Immun 57: 1255-1262.
4. Cianciotto, N.P., Eisenstein, B.I., Mody, C.H., and Engleberg, N.C. (1990) A mutation in the mip gene results in an attenuation of Legionella pneumophila virulence. J Infect Dis 162: 121-126.
5. Cianciotto, N.P., Stamos, J.K., and Kamp, D.W. (1995a) Infectivity of Legionella pneumophila mip mutant for alveolar epithelial cells. Curr Microbiol 30: 247-250.
6. Cianciotto, N.P., O'Connell, W., Dasch, G.A., and Mallavia, L.P. (1995b) Detection of mip-like sequences and Mip-related proteins within the family Rickettsiaceae. Curr Microbiol 30: 149-153.
7. Fischer, G., Bang, H., Ludwig, B., Mann, K., and Hacker, J. (1992) Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity. Mol Microbiol 6: 1375-1383.
8. Givan, A.L., White, H.D., Stern, U.E., Colby, E., Gosselin, E.J., Guyre, P.M., and Wira, C.R. (1997) Flow cytometric analysis of leukocytes in the human female reproductive tract: comparison of fallopian tube, uterus, cervix, and vagina. Am J Reprod Immunol 38: 350-359.
9. Hacker, J., and Fischer, G. (1993) Immunophilins: structure-function relationship and possible role in microbial pathogenicity. Mol Microbiol 10: 445-456.
10. Hamrick, T.S., Diaz, A.H., Havell, E.A., Horton, J.R., and Orndorff, P.E. (2003) Influence of extracellular bactericidal agents on bacteria within macrophages. Infect Immun 71: 1016-1019.
11. Knepper, B., Heuer, l., Meyer, T.F., and van Putten, J.P. (1997) Differential response of human monocytes to Neisseria gonorrhoeae variants expressing pili and opacity proteins. Infect Immun 65: 4122-4129.
12. Kohler, R., Fanghanel, J., Konig, B., Luneberg, E., Frosch, M., Rahfeld, J.U., et al. (2003) Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila. Infect Immun 71: 4389-4397.
13. Kraft, A.R., Templin, M.F., and Holtje, J.V. (1998) Membrane-bound lytic endotransglycosylase in Escherichia coli. J Bacteriol 180: 3441-3447.
14. Lundemose, A.G., Birkelund, S., Fey, S.J., Larsen, P.M., and Christiansen, G. (1991) Chlamydia trachomatis contains a protein similar to the Legionella pneumophila mip gene product. Mol Microbiol 5: 109-115.
15. Lundemose, A.G., Kay, J.E., and Pearce, J.H. (1993) Chlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection. Mol Microbiol 7: 777-783.
16. McGee, Z.A., Stephens, D.S., Hoffman, L.H., Schlech, W.F., 3rd, and Horn, R.G. (1983) Mechanisms of mucosal invasion by pathogenic Neisseria. Rev Infect Dis 5 (Suppl. 4): S708-S714.
17. Mo, Y.Y., Cianciotto, N.P., and Mallavia, L.P. (1995) Molecular cloning of a Coxiella burnetii gene encoding a macrophage infectivity potentiator (Mip) analogue. Microbiology 141: 2861-2871.
18. Moro, A., Ruiz-Cabello, F., Fernandez-Cano, A., Stock, R.P., and Gonzalez, A. (1995) Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection. EMBO J 14: 2483-2490.
19. Pereira, P.J., Vega, M.C., Gonzalez-Rey, E., Fernandez-Carazo, R., Macedo-Ribeiro, S., Gomis-Ruth, F.X., et al. (2002) Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix. EMBO Rep 3: 88-94.
20. Riboldi-Tunnicliffe, A., Konig, B., Jessen, S., Weiss, M.S., Rahfeld, J., Hacker, J., et al. (2001) Crystal structure of Mip, a prolylisomerase from Legionella pneumophila. Nat Struct Biol 8: 779-783.
21. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory.
22. Sampson, B.A., and Gotschlich, E.G. (1992) Neisseria meningitidis encodes an FK506-inhibitable rotamase. Proc Natl Acad Sci USA 89: 1164-1168.
23. Schmidt, B., Rahfeld, J., Schierhorn, A., Ludwig, B., Hacker, J., and Fischer, G. (1994) A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila. FEBS Lett 352: 185-190.
24. Schmidt, B., Konig, S., Svergun, D., Volkov, V., Fischer, G., and Koch, M.H. (1995) Small-angle X-ray solution scattering study on the dimerization of the FKBP25mem from Legionella pneumophila. FEBS Lett 372: 169-172.
25. Schreiber, S.L. (1991) Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251:283-287.
26. Virji, M., Heckels, J.E., and Watt, P.J. (1983) Monoclonal antibodies to gonococcal pili: studies on antigenic determinants on pili from variants of strain P9. J Gen Microbiol 129: 1965-1973.
27. Westrom, L., and Mardh, P.A. (1990). Acute pelvic inflammatory disease (PID). In Sexually Transmitted Diseases. Holmes, K.K., Mardh, P.A., Sparling, P.F., Weisner, P.J., Cates, W., Lemon, S.M., and Stamm, W.E. (eds). New York: McGraw-Hill, pp. 593-613.
28. Wintermeyer, E., Ludwig, B., Steinert, M., Schmidt, B., Fischer, G., and Hacker, J. (1995) Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cells. Infect Immun 63: 4576-4583.