Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival

PLoS Pathogens

Volumn 7, Issue 5, 2011, Pages

  Echenique Rivera, Hebert ^a   Muzzi, Alessandro ^a   Del Tordello, Elena ^a   Seib, Kate L ^a   Francois, Patrice ^b   Rappuoli, Rino ^a   Pizza, Mariagrazia ^a   Serruto, Davide ^a  

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CARRIER PROTEIN; FERRIC UPTAKE REGULATOR; LACTIC ACID; PERMEASE; TRANSCRIPTOME; TRANSFERRIN BINDING PROTEIN B; VIRULENCE FACTOR; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIAL RNA;

ARTICLE; BACTEREMIA; CONTROLLED STUDY; ENERGY METABOLISM; EX VIVO STUDY; GENE CONTROL; GENE EXPRESSION; GENETIC CODE; GENOME; HOST RESISTANCE; HUMAN; IRON TRANSPORT; MUTAGENESIS; NEISSERIA MENINGITIDIS; NONHUMAN; OPEN READING FRAME; PATHOGENESIS; PROTEIN ANALYSIS; UPREGULATION; VIRUS STRAIN; ADAPTATION; ADULT; BACTERIAL GENE; BACTERIAL GENOME; BIOLOGICAL MODEL; BLOOD; CLUSTER ANALYSIS; DOWN REGULATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; MALE; MENINGOCOCCOSIS; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY;

NEISSERIA MENINGITIDIS;

ADAPTATION, PHYSIOLOGICAL; ADULT; ANTIGENS, BACTERIAL; BACTEREMIA; BACTERIAL PROTEINS; CLUSTER ANALYSIS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENOME, BACTERIAL; HOST-PATHOGEN INTERACTIONS; HUMANS; MALE; MENINGOCOCCAL INFECTIONS; MODELS, BIOLOGICAL; NEISSERIA MENINGITIDIS, SEROGROUP B; RNA, BACTERIAL; SEQUENCE DELETION; TRANSCRIPTOME; UP-REGULATION; VIRULENCE FACTORS;

EID: 79958032046     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002027     Document Type: Article

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