Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: Their origin is 11-cis-RETINAL

Journal of Biological Chemistry

Volumn 287, Issue 26, 2012, Pages 22276-22286

  Boyer, Nicholas P ^a   Higbee, Daniel ^a   Currin, Mark B ^a   Blakeley, Lorie R ^a   Chen, Chunhe ^a   Ablonczy, Zsolt ^a   Crouch, Rosalie K ^a   Koutalos, Yiannis ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; CURRENT MODELS; FLUORESCENCE IMAGING; LIGHT EXPOSURE; OUTER SEGMENTS; PHOTOACTIVATION; RETINAL DISEASE; RETINAL PIGMENT EPITHELIUM; RHODOPSIN REGENERATION; ROD PHOTORECEPTORS; STARGARDT DISEASE; TANDEM MASS SPECTROMETRY; UV-VISIBLE ABSORPTION SPECTROSCOPY; WILD-TYPE STRAIN;

ANIMALS; FLUOROPHORES; MASS SPECTROMETRY;

OPHTHALMOLOGY;

11 CIS RETINAL; LIPOFUSCIN; N RETINYLIDENE N RETINYLETHANOLAMINE; RETINAL; RETINOID; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DARKNESS; FLUORESCENCE IMAGING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT DARK CYCLE; LIGHT EXPOSURE; MOUSE; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA ROD; STRAIN DIFFERENCE; TANDEM MASS SPECTROMETRY; TISSUE LEVEL; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLOR; LIGHT; LIPOFUSCIN; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; RETINA; RETINAL PIGMENT EPITHELIUM; RETINALDEHYDE; RETINOIDS; ROD CELL OUTER SEGMENT;

EID: 84862654645     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.329235     Document Type: Article

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