Peripubertal administration of icariin and icaritin advances pubertal development in female rats

Biomolecules and Therapeutics

Volumn 20, Issue 2, 2012, Pages 189-195

  Kang, Hyun Ku ^a   Lee, Sang Bum ^a   Kwon, Hyosuk ^a   Sung, Chung Ki ^b   Park, Young In ^a   Dong, Mi Sook ^a  

^a Korea University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Epimedii herba; Female pubertal development; Icariin; Icaritin

Indexed keywords

AROMATASE; BETA ACTIN; EPIMEDII HERBA EXTRACT; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYLESTRADIOL; ICARIIN; ICARITIN; PHYTOESTROGEN; PLANT EXTRACT; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; C3 GENE; CABP9K GENE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; EPIMEDII HERBA; EPIMEDIUM; ESTROGEN RECEPTOR ALPHA GENE; ESTROGEN RECEPTOR BETA GENE; ESTRUS CYCLE; FEMALE; GENE; GENE LOCATION; GENE OVEREXPRESSION; HYPOPHYSIS; IGFBP1 GENE; NEUROENDOCRINE SYSTEM; NONHUMAN; ORGAN SIZE; OVARY; PROGESTERONE RECEPTOR GENE; PUBERTY; RAT; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL MATURATION; UTERUS WEIGHT; WEANING;

EID: 84862650227     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.20.2.189     Document Type: Article

References (27)

1. Ashby, J., Tinwell, H., Stevens, J., Pastoor, T. and Breckenridge, C. B. (2002) The effects of atrazine on the sexual maturation of female rats. Regul. Toxicol. Pharmacol. 35, 468-473.
2. Cassidy, A. (2003) Potential risks and benefits of phytoestrogen-rich diets. Int. J. Vitam. Nutr. Res. 73, 120-126.
3. Champlin, A. K., Dorr, D. L. and Gates, A. H. (1973) Determining the stage of the estrous cycle in the mouse by the appearance of the vagina. Biol. Reprod. 8, 491-494.
4. Chen, X. J., Ji, H., Wang, Y. T. and Li, S. P. (2008) Simultaneous determination of seven flavonoids in Epimedium using pressurized liquid extraction and capillary electrochromatography. J. Sep. Sci. 31, 881-887.
5. Chiu, J. H., Chen, K. K., Chien, T. M., Chiou, W. F., Chen, C. C., Wang, J. Y., Lui, W. Y. and Wu, C. W. (2006) Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway. Int. J. Impot. Res. 18, 335-342.
6. Coughtrie, M. W., Burchell, B., Leakey, J. E. and Hume, R. (1988) The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes. Mol. Pharmacol. 34, 729-735.
7. Dong, M. S., Kwon, H., Lee, S. B., Kang, H. K., Kim, D. H., Sung, C. S. and Park, Y. I. (2012) Estrogenic/antiestrogenic activity of the Epimedium koreanum extract and its major components; in vitro and in vivo studies. Submitted to Journal of Food and Toxicology (1989) Neurobiology of reproduction in the female rat. A fifty-year perspective. Monographs in Endocrinology. 32, 1-133.
8. Everett, J.W. (1989) Neurobiology of reproduction in the female rat. A fifty-year perspective. Monographs in Endocrinology 32, 1-133.
9. Geis, R. B., Diel, P., Degen, G. H. and Vollmer, G. (2005) Effects of genistein on the expression of hepatic genes in two rat strains (Sprague-Dawley and Wistar). Toxicol. Lett. 157, 21-29.
10. Goldman, J. M., Laws, S. C., Balchak, S. K., Cooper, R. L. and Kavlock, R. J. (2000) Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid activity in the female rat. A focus on the EDSTAC recommendations. Crit. Rev. Toxicol. 30, 135-196.
11. Goldman, J. M., Murr, A. S. and Cooper, R. L. (2007) The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res. B. Dev. Reprod. Toxicol. 80, 84-97.
12. Islam, N. M., Yoo, H. H., Lee, M. W., Dong, M. S., Park, Y. I., Jeong, H. S. and Kim, D. H. (2008) Simultaneous quantitation of five flavonoid glycosides in Herba Epimedii by high-performance liquid chromatography-tandem mass spectrometry. Phytochem. Anal. 19, 71-77.
13. Jefferson, W. N., Doerge, D., Padilla-Banks, E., Woodling, K. A., Kissling, G. E. and Newbold, R. (2009) Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system. Environ. Health Perspect. 117, 1883-1889.
14. Kim, H. S., Shin, J. H., Moon, H. J., Kang, I. H., Kim, T. S., Kim, I. Y., Seok, J. H., Pyo, M. Y. and Han, S. Y. (2002) Comparative estrogenic effects of p-nonylphenol by 3-day uterotrophic assay and female pubertal onset assay. Reprod. Toxicol. 16, 259-268.
15. Kouki, T., Kishitake, M., Okamoto, M., Oosuka, I., Takebe, M. and Yamanouchi, K. (2003) Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis. Horm. Behav. 44, 140-145.
16. Liu, W. J., Xin, Z. C., Xin, H., Yuan, Y. M., Tian, L. and Guo, Y. L. (2005) Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J. Androl. 7, 381-388.
17. Liu, Y., Liu, Y., Dai, Y., Xun, L. and Hu, M. (2003) Enteric disposition and recycling of flavonoids and ginkgo flavonoids. J. Altern. Complement Med. 9, 631-640.
18. Ma, H., He, X., Yang, Y., Li, M., Hao, D. and Jia, Z. (2011) The genus Epimedium: an ethnopharmacological and phytochemical review. J. Ethnopharmacol. 134, 519-541.
19. Makarova, M. N., Pozharitskaya, O. N., Shikov, A. N., Tesakova, S. V., Makarov, V. G. and Tikhonov, V. P. (2007) Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats. J. Ethnopharmacol. 114, 412-416.
20. Patisaul, H. B. and Jefferson, W. (2010) The pros and cons of phytoestrogens. Front Neuroendocrinol. 31, 400-419.
21. Shen, P., Guo, B. L., Gong, Y., Hong, D. Y., Hong, Y. and Yong, E. L. (2007) Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry. 68, 1448-1458.
22. Strom, B. L., Schinnar, R., Ziegler, E. E., Barnhart, K. T., Sammel, M. D., Macones, G. A., Stallings, V. A., Drulis, J. M., Nelson, S. E. and Hanson, S. A. (2001) Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood. JAMA. 286, 807-814.
23. Wang, Z. Q. and Lou, Y. J. (2004) Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Eur. J. Pharmacol. 504, 147-153.
24. Whitten, P. L. and Naftolin, F (1992) Effects of a phytoestrogen diet on estrogen-dependent reproductive processes in immature female rats. Steroids. 57, 56-61.
25. Xu, W., Zhang, Y., Yang, M., Shen, Z., Zhang, X., Zhang, W. and Li, H. (2007) LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma. J. Pharm. Biomed. Anal. 45, 667-672.
26. Yap, S. P., Shen, P., Li, J., Lee, L. S. and Yong, E. L. (2007) Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J. Ethnopharmacol. 113, 218-224.
27. Zhang, G., Wang, X. L., Sheng, H., Xie, X. H., He, Y. X., Yao, X. S., Li, Z. R., Lee, K. M., He, W., Leung, K. S. and Qin, L. (2009) Constitutional flavonoids derived from Epimedium dose-dependently reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular targets. PLoS One. 4, e6419.