Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway

International Journal of Impotence Research

Volumn 18, Issue 4, 2006, Pages 335-342

  Chiu, J H ^a,b,c   Chen, K K ^a,b   Chien, T M ^a   Chiou, W F ^d   Chen, C C ^d   Wang, J Y ^a   Lui, W Y ^b   Wu, C W ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHENG HSIN REHABILITATION MEDICAL CENTER   (Taiwan)

^d NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

cGMP; Epimedium brevicornum; Erectile dysfunction; Organ bath; PDE 5

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; EPIMEDIUM BREVICORNUM MAXIM EXTRACT; GUANYLATE CYCLASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PHOSPHODIESTERASE V INHIBITOR; PLANT EXTRACT; SILDENAFIL; TADALAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; DRUG POTENTIATION; EPIMEDIUM; EPIMEDIUM BREVICORNUM; ERECTILE DYSFUNCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TREATMENT OUTCOME;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; ARGININE; CYCLIC GMP; DRUG SYNERGISM; ENZYME INHIBITORS; EPIMEDIUM; MALE; MUSCLE RELAXATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE; PENILE ERECTION; PENIS; PHENYLEPHRINE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PLANT EXTRACTS; RABBITS; SIGNAL TRANSDUCTION;

EID: 33745728801     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901437     Document Type: Article

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