Susceptibility Variants for Waist Size in Relation to Abdominal, Visceral, and Hepatic Adiposity in Postmenopausal Women

Journal of the Academy of Nutrition and Dietetics

Volumn 112, Issue 7, 2012, Pages 1048-1055

  Lim, Unhee ^a   Ernst, Thomas ^c   Wilkens, Lynne R ^a   Albright, Cheryl L ^b   Lum Jones, Annette ^a   Seifried, Ann ^a   Buchthal, Steven D ^c   Novotny, Rachel ^a   Kolonel, Laurence N ^a   Chang, Linda ^a   Cheng, Iona ^c   Le Marchand, Loïc ^a  

^a UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^b University of Hawaii at Manoa School of Nursing and Dental Hygiene   (United States)

^c UNIVERSITY OF HAWAII   (United States)

Author keywords

Body composition; Liver fat; Single nucleotide polymorphisms; Subcutaneous adipose tissue; Visceral adipose tissue

Indexed keywords

FTO PROTEIN, HUMAN; LYPLAL1 PROTEIN, HUMAN; LYSOPHOSPHOLIPASE; PROTEIN; TFAP2B PROTEIN, HUMAN; TRANSCRIPTION FACTOR AP 2;

ABDOMINAL FAT; AGED; ARTICLE; ASIAN AMERICAN; BODY COMPOSITION; BODY MASS; CAUCASIAN; COHORT ANALYSIS; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETICS; HUMAN; INTRAABDOMINAL FAT; JAPAN; LIVER; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PHOTON ABSORPTIOMETRY; POSTMENOPAUSE; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES; WAIST CIRCUMFERENCE;

ABDOMINAL FAT; ABSORPTIOMETRY, PHOTON; ADIPOSITY; AGED; ASIAN AMERICANS; BODY COMPOSITION; BODY MASS INDEX; COHORT STUDIES; CROSS-SECTIONAL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOME-WIDE ASSOCIATION STUDY; HAWAII; HUMANS; INTRA-ABDOMINAL FAT; JAPAN; LIVER; LYSOPHOSPHOLIPASE; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; PROTEINS; TRANSCRIPTION FACTOR AP-2; WAIST CIRCUMFERENCE;

EID: 84862643690     PISSN: 22122672     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jand.2012.03.034     Document Type: Article

References (47)

1. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414(6865):782-787.
2. Lavie C.J., Milani R.V., Artham S.M., et al. The obesity paradox, weight loss, and coronary disease. Am J Med 2009, 122(12):1106-1114.
3. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective 2007, World Cancer Research Fund/American Insitute for Cancer Research, American Insitute for Cancer Research, Washington, DC.
4. Harriss D.J., Atkinson G., George K., et al. Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index. Colorectal Dis 2009, 11(6):547-563.
5. Stewart S.T., Cutler D.M., Rosen A.B. Forecasting the effects of obesity and smoking on US life expectancy. N Engl J Med 2009, 361(23):2252-2260.
6. Litwin S.E. Which measures of obesity best predict cardiovascular risk?. J Am Coll Cardiol 2008, 52(8):616-619.
7. Lee C.M., Huxley R.R., Wildman R.P., et al. Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: A meta-analysis. J Clin Epidemiol 2008, 61(7):646-653.
8. Nyamdorj R., Qiao Q., et al. BMI compared with central obesity indicators in relation to diabetes and hypertension in Asians. Obesity (Silver Spring) 2008, 16(7):1622-1635. Decoda Study Group.
9. Larsson S.C., Wolk A. Obesity and colon and rectal cancer risk: A meta-analysis of prospective studies. Am J Clin Nutr 2007, 86(3):556-565.
10. Lahmann P.H., Hoffmann K., Allen N., et al. Body size and breast cancer risk: Findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer 2004, 111(5):762-771.
11. Seidell J.C. Waist circumference and waist/hip ratio in relation to all-cause mortality, cancer and sleep apnea. Eur J Clin Nutr 2010, 64(1):35-41.
12. Carr D.B., Utzschneider K.M., Hull R.L., et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 2004, 53(8):2087-2094.
13. Goodpaster B.H., Krishnaswami S., Harris T.B., et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 2005, 165(7):777-783.
14. Kuk J.L., Church T.S., Blair S.N., et al. Does measurement site for visceral and abdominal subcutaneous adipose tissue alter associations with the metabolic syndrome?. Diabetes Care 2006, 29(3):679-684.
15. Wu C.H., Heshka S., Wang J., et al. Truncal fat in relation to total body fat: Influences of age, sex, ethnicity and fatness. Int J Obes (Lond) 2007, 31(9):1384-1391.
16. Bouchard C., Despres J.P., Mauriege P. Genetic and nongenetic determinants of regional fat distribution. Endocr Rev 1993, 14(1):72-93.
17. Bouchard C., Rice T., Lemieux S., et al. Major gene for abdominal visceral fat area in the Quebec Family Study. Int J Obes Relat Metab Disord 1996, 20(5):420-427.
18. Lindgren C.M., Heid I.M., Randall J.C., et al. Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet 2009, 5(6):e1000508.
19. Heard-Costa N.L., Zillikens M.C., Monda K.L., et al. NRXN3 is a novel locus for waist circumference: A genome-wide association study from the CHARGE Consortium. PLoS Genet 2009, 5(6):e1000539.
20. Lim U., Ernst T., Buchthal S.D., et al. Asian women have greater abdominal and visceral adiposity than Caucasian women with similar body mass index [published online ahead of print May 2011] Nutr Diabetes, Accessed February 25, 2012. http://www.nature.com/nutd/journal/v1/n5/index_by_arttype.html.
21. Kolonel L.N., Henderson B.E., Hankin J.H., et al. A multiethnic cohort in Hawaii and Los Angeles: Baseline characteristics. Am J Epidemiol 2000, 151(4):346-357.
22. Kolonel L.N., Altshuler D., Henderson B.E. The Multiethnic Cohort study: Exploring genes, lifestyle and cancer risk. Nat Rev Cancer 2004, 4(7):519-527.
23. Glickman S.G., Marn C.S., Supiano M.A., et al. Validity and reliability of dual-energy x-ray absorptiometry for the assessment of abdominal adiposity. J Appl Physiol 2004, 97(5):509-514.
24. Guiu B., Loffroy R., Petit J.M., et al. Mapping of liver fat with triple-echo gradient echo imaging: Validation against 3.0-T proton MR spectroscopy. Eur Radiol 2009, 19(7):1786-1793.
25. Matise T.C., Ambite J.L., Buyske S., et al. The Next PAGE in understanding complex traits: Design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol 2011, 174(7):849-859.
26. Szczepaniak L.S., Nurenberg P., Leonard D., et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005, 288(2):E462-E468.
27. Borra R.J., Salo S., Dean K., et al. Nonalcoholic fatty liver disease: Rapid evaluation of liver fat content with in-phase and out-of-phase MR imaging. Radiology 2009, 250(1):130-136.
28. Frayling T.M., Timpson N.J., Weedon M.N., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316(5826):889-894.
29. Scuteri A., Sanna S., Chen W.M., et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007, 3(7):e115.
30. Willer C.J., Speliotes E.K., Loos R.J., et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009, 41(1):25-34.
31. Thorleifsson G., Walters G.B., Gudbjartsson D.F., et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009, 41(1):18-24.
32. Speliotes E.K., Willer C.J., Berndt S.I., et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010, 42(11):937-948.
33. Heid I.M., Jackson A.U., Randall J.C., et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010, 42(11):949-960.
34. Haupt A., Thamer C., Machann J., et al. Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss. Obesity (Silver Spring) 2008, 16(8):1969-1972.
35. Peeters A., Beckers S., Verrijken A., et al. Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 2008, 93(4):481-484.
36. Wing M.R., Ziegler J., Langefeld C.D., et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet 2009, 125(5-6):615-626.
37. Hotta K., Nakamura M., Nakamura T., et al. Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. J Hum Genet 2010, 55(11):738-742.
38. Wauters M., Mertens I., Chagnon M., et al. Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women. Int J Obes Relat Metab Disord 2001, 25(5):714-720.
39. Kloting N., Schleinitz D., Ruschke K., et al. Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia 2008, 51(4):641-647.
40. Lee G.H., Proenca R., Montez J.M., et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996, 379(6566):632-635.
41. Chua S.C., Chung W.K., Wu-Peng X.S., et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996, 271(5251):994-996.
42. Takaya K., Ogawa Y., Hiraoka J., et al. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat Genet 1996, 14(2):130-131.
43. Montague C.T., Prins J.B., Sanders L., et al. Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution. Diabetes 1997, 46(3):342-347.
44. Van Harmelen V., Reynisdottir S., Eriksson P., et al. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998, 47(6):913-917.
45. Schwenzer N.F., Machann J., Schraml C., et al. Quantitative analysis of adipose tissue in single transverse slices for estimation of volumes of relevant fat tissue compartments: A study in a large cohort of subjects at risk for type 2 diabetes by MRI with comparison to anthropometric data. Invest Radiol 2010, 45(12):788-794.
46. Shen W., Punyanitya M., Wang Z., et al. Visceral adipose tissue: Relations between single-slice areas and total volume. Am J Clin Nutr 2004, 80(2):271-278.
47. Demerath E.W., Reed D., Rogers N., et al. Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. Am J Clin Nutr 2008, 88(5):1263-1271.