The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Kayali, Ayse G ^a   Lopez, Ana D ^a   Hao, Ergeng ^a   Hinton, Andrew ^a   Hayek, Alberto ^a   King, Charles C ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GLUCAGON; INSULIN; NEUROGENIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVITY; GESTATIONAL AGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENCE; IMMUNOFLUORESCENCE MICROSCOPY; MOUSE; NONHUMAN; PANCREAS CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADULT; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; C-PEPTIDE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMOKINE CXCL12; ENDOCRINE CELLS; EPITHELIAL CELLS; FETUS; FLUORESCENT ANTIBODY TECHNIQUE; HETEROCYCLIC COMPOUNDS; HUMANS; ISLETS OF LANGERHANS; MICE; MICE, NUDE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84862639471     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038721     Document Type: Article

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