Effects of vitamin E depletion/repletion on biomarkers of oxidative stress in healthy aging

Annals of the New York Academy of Sciences

Volumn 1031, Issue , 2004, Pages 361-364

  Winklhofer Roob, Brigitte M ^a   Meinitzer, Andreas ^a,b   Maritschnegg, Michaela ^a   Roob, Johannes M ^b   Khoschsorur, Gholamali ^b   Ribalta, Josep ^c   Sundl, Isabella ^a   Wuga, Sandra ^a   Wonisch, Willibald ^b   Tiran, Beate ^b   Rock, Edmond ^d  

^a UNIVERSITY OF GRAZ   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^d CEMAGREF   (France)

Author keywords

8 hydroxydeoxyguanosine; 8 isoprostanes; Aging; Dietary restriction; Glutathione peroxidase; LDL oxidation; Lycopene; Malondialdehyde; Nonsmokers; Oxidative stress; Peroxides; Supplementation; Vitamin C; Vitamin E; carotene

Indexed keywords

ALPHA TOCOPHEROL; BIOLOGICAL MARKER; DNA; LOW DENSITY LIPOPROTEIN;

ADULT; AGED; AGING; ANTIOXIDANT ACTIVITY; BLOOD SAMPLING; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPLETION; DIET RESTRICTION; DNA MODIFICATION; ENZYME ACTIVITY; ERYTHROCYTE; EX VIVO STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; LIPID PEROXIDATION; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PROTECTION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 20144375578     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1331.045     Document Type: Conference Paper

References (9)

1. AEBISCHER, C.P., J. SCHIERLE & W. SCHÜEP. 1999. Simultaneous determination of retinol, tocopherols, carotene, lycopene, and xanthophylls in plasma by means of reversed-phase high-performance liquid chromatography. Method. Enzymol. 299: 348-362.
2. LYKKESFELDT, J., S. LOFT & H.E. POULSEN. 1995. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection - are they reliable markers of oxidative stress? Anal. Biochem. 299: 329-335.
3. KOSCHSORUR, G.A., B.M. WINKLHOFER-ROOB, H. RABL, et al. 2000. Evaluation of a sensitive HPLC method for the determination of malondialdehyde, and application of the method to different biological materials. Chromatographia 52: 181-184.
4. LENGGER, C., G. SCHÖCH & H. TOPP. 2000. A high-performance liquid chromatographic method for the determination of 8-oxo-7,8-dihydro- 2′-deoxyguanosine in urine from man and rat. Anal. Biochem. 287: 65-72.
5. ROBERTS, L.J. II & J.D. MORROW. 1994. Isoprostanes. Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury. Ann. N.Y. Acad. Sci. 15: 237-242.
6. TATZBER, F., S. GRIEBENOW, W. WONISCH & R. WINKLER. 2003. Dual method for the determination of peroxidase activity and total peroxide-iodide leads to a significant increase of peroxidase activity in human sera. Anal. Biochem. 316: 147-153.
7. PAGLIA, D.E. & W.N. VALENTINE. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70: 158-169.
8. BERGMANN, A.R., P. RAMOS, H. ESTERBAUER & B.M. WINKLHOFER-ROOB. 1997. RRR-α-tocopherol can be substituted for by trolox in determination of kinetic parameters of LDL oxidizability by copper. J. Lipid Res. 38: 2580-2588.
9. WAEG, G., G. DIMSITY & H. ESTERBAUER. 1996. Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins. Free Radic. Res. 25: 149-159.