Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes

Diabetologia

Volumn 55, Issue 5, 2012, Pages 1435-1445

  Vind, B F ^a   Birk, J B ^c   Vienberg, S G ^b   Andersen, B ^b   Beck Nielsen, H ^a   Wojtaszewski, J F P ^c   Hojlund K ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b HAGEDORN RESEARCH INSTITUTE   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

AKT; Glycogen synthase; Hyperglycaemia; Insulin signalling; Type 2 diabetes

Indexed keywords

GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; PROTEIN KINASE B; SERINE; THREONINE;

ADULT; ARTICLE; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLYCOGEN MUSCLE LEVEL; GLYCOGEN SYNTHESIS; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN METABOLISM; MALE; MUSCLE BIOPSY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLYCOGEN SYNTHASE; HUMANS; HYPERGLYCEMIA; INSULIN; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; THREONINE;

EID: 84862579826     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2482-8     Document Type: Article

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