The adaptor protein FHL2 enhances the cellular innate immune response to influenza A virus infection

Cellular Microbiology

Volumn 14, Issue 7, 2012, Pages 1135-1147

  Nordhoff, Carolin ^a   Hillesheim, Andrea ^a   Walter, Beate M ^a   Haasbach, Emanuel ^b   Planz, Oliver ^b   Ehrhardt, Christina ^a   Ludwig, Stephan ^a   Wixler, Viktor ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Interfaculty Institute for Cell Biology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BETA INTERFERON; FHL2 PROTEIN; INTERFERON REGULATORY FACTOR 3; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR IMMUNITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLUENZA A; INFLUENZA VIRUS A; INNATE IMMUNITY; KNOCKOUT GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS REPLICATION; WILD TYPE;

ANIMALS; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERFERON REGULATORY FACTOR-3; LIM-HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; TRANSCRIPTION FACTORS;

INFLUENZA A VIRUS;

EID: 84862563633     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2012.01787.x     Document Type: Article

References (28)

1. Akira, S., Uematsu, S., and Takeuchi, O. (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
2. Bai, S., Kitaura, H., Zhao, H., Chen, J., Muller, J.M., Schule, R., etal. (2005) FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest 115: 2742-2751.
3. Chen, D., Xu, W., Bales, E., Colmenares, C., Conacci-Sorrell, M., Ishii, S., etal. (2003) SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res 63: 6626-6634.
4. Cheung, T.K., and Poon, L.L. (2007) Biology of influenza a virus. Ann N Y Acad Sci 1102: 1-25.
5. Dudek, S.E., Luig, C., Pauli, E.K., Schubert, U., and Ludwig, S. (2010) The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state. J Virol 84: 9439-9451.
6. Ehrhardt, C., Kardinal, C., Wurzer, W.J., Wolff, T., von Eichel-Streiber, C., Pleschka, S., etal. (2004) Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3. FEBS Lett 567: 230-238.
7. Ehrhardt, C., Seyer, R., Hrincius, E.R., Eierhoff, T., Wolff, T., and Ludwig, S. (2010) Interplay between influenza A virus and the innate immune signaling. Microbes Infect 12: 81-87.
8. Emeny, J.M., and Morgan, M.J. (1979) Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production. J Gen Virol 43: 247-252.
9. Hale, B.G., Albrecht, R.A., and Garcia-Sastre, A. (2010) Innate immune evasion strategies of influenza viruses. Future Microbiol 5: 23-41.
10. Hervy, M., Hoffman, L., and Beckerle, M.C. (2006) From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol 18: 524-532.
11. Hornung, V., Ellegast, J., Kim, S., Brzozka, K., Jung, A., Kato, H., etal. (2006) 5′-Triphosphate RNA is the ligand for RIG-I. Science 314: 994-997.
12. Johannessen, M., Moller, S., Hansen, T., Moens, U., and Van Ghelue, M. (2006) The multifunctional roles of the four-and-a-half-LIM only protein FHL2. Cell Mol Life Sci 63: 268-284.
13. Kawai, T., and Akira, S. (2006) Innate immune recognition of viral infection. Nat Immunol 7: 131-137.
14. Konig, K., Diehl, L., Rommerscheidt-Fuss, U., Golletz, C., Quast, T., Kahl, P., etal. (2010) Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration. J Immunol 185: 1466-1475.
15. Labalette, C., Renard, C.A., Neuveut, C., Buendia, M.A., and Wei, Y. (2004) Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin. Mol Cell Biol 24: 10689-10702.
16. Ludwig, S., Pleschka, S., Planz, O., and Wolff, T. (2006) Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells. Cell Microbiol 8: 375-386.
17. Martin, B., Schneider, R., Janetzky, S., Waibler, Z., Pandur, P., Kuhl, M., etal. (2002) The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts. J Cell Biol 159: 113-122.
18. Martin, B.T., Kleiber, K., Wixler, V., Raab, M., Zimmer, B., Kaufmann, M., and Strebhardt, K. (2007) FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells. Cell Cycle 6: 1779-1788.
19. Mazur, I., Wurzer, W.J., Ehrhardt, C., Pleschka, S., Puthavathana, P., Silberzahn, T., etal. (2007) Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity. Cell Microbiol 9: 1683-1694.
20. Mogensen, T.H. (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22: 240-273. Table of Contents.
21. Morlon, A., and Sassone-Corsi, P. (2003) The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1. Proc Natl Acad Sci USA 100: 3977-3982.
22. Muller, J.M., Metzger, E., Greschik, H., Bosserhoff, A.K., Mercep, L., Buettner, R., and Schule, R. (2002) The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J 21: 736-748.
23. Park, J., Will, C., Martin, B., Gullotti, L., Friedrichs, N., Buettner, R., etal. (2008) Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins. FASEB J 22: 2508-2520.
24. Randall, R.E., and Goodbourn, S. (2008) Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89: 1-47.
25. Schmolke, M., and Garcia-Sastre, A. (2010) Evasion of innate and adaptive immune responses by influenza A virus. Cell Microbiol 12: 873-880.
26. Spiering, D., Schmolke, M., Ohnesorge, N., Schmidt, M., Goebeler, M., Wegener, J., etal. (2009) MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover. J Biol Chem 284: 24972-24980.
27. Wixler, V., Hirner, S., Muller, J.M., Gullotti, L., Will, C., Kirfel, J., etal. (2007) Deficiency in the LIM-only protein Fhl2 impairs skin wound healing. J Cell Biol 177: 163-172.
28. Wiznerowicz, M., and Trono, D. (2003) Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol 77: 8957-8961.