Disseminated tumor cells in pancreatic cancer-an independent prognosticator of disease progression and survival

International Journal of Cancer

Volumn 131, Issue 4, 2012, Pages

  Effenberger, Katharina E ^a   Schroeder, Cornelia ^a   Eulenburg, Christine ^a   Reeh, Matthias ^a   Tachezy, Michael ^a   Riethdorf, Sabine ^a   Vashist, Yogesh K ^a   Izbicki, Jakob R ^a   Pantel, Klaus ^a   Bockhorn, Maximilian ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

bone marrow; disseminated tumor cells; micrometastasis; pancreatic cancer; prognostic factor

Indexed keywords

CYTOKERATIN;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; CANCER GROWTH; CANCER PATIENT; CANCER SURGERY; CANCER SURVIVAL; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HEALTH STATUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; RISK FACTOR;

AGED; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; PANCREATIC NEOPLASMS; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 84862551626     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26439     Document Type: Article

References (32)

1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M,. Cancer statistics, 2001. CA Cancer J Clin 2001; 51: 15-36. (Pubitemid 32166444)
2. Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA,. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 2006; 20: 1218-49. (Pubitemid 43727584)
3. Bardeesy N, DePinho RA,. Pancreatic cancer biology and genetics. Nat Rev Cancer 2002; 2: 897-909. (Pubitemid 37328891)
4. Braun S, Vogl FD, Naume B, Janni W, Osborne MP, Coombes RC, Schlimok G, Diel IJ, Gerber B, Gebauer G, Pierga JY, Marth C, et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 2005; 353: 793-802. (Pubitemid 41215488)
5. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW, Hayes DF,. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004; 351: 781-91. (Pubitemid 39095313)
6. de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, Doyle GV, Terstappen LW, Pienta KJ, Raghavan D,. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res 2008; 14: 6302-9.
7. Kollermann J, Weikert S, Schostak M, Kempkensteffen C, Kleinschmidt K, Rau T, Pantel K,. Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment. J Clin Oncol 2008; 26: 4928-33.
8. Pantel K, Izbicki J, Passlick B, Angstwurm M, Haussinger K, Thetter O, Riethmuller G,. Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases. Lancet 1996; 347: 649-53. (Pubitemid 26076131)
9. Sugio K, Kase S, Sakada T, Yamazaki K, Yamaguchi M, Ondo K, Yano T,. Micrometastasis in the bone marrow of patients with lung cancer associated with a reduced expression of E-cadherin and beta-catenin: risk assessment by immunohistochemistry. Surgery 2002; 131: S226-31. (Pubitemid 34118645)
10. Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, Doyle GV, Tissing H, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 3213-21.
11. Lindemann F, Schlimok G, Dirschedl P, Witte J, Riethmuller G,. Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet 1992; 340: 685-9.
12. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massague J,. Tumor self-seeding by circulating cancer cells. Cell 2009; 139: 1315-26.
13. Fehm T, Braun S, Muller V, Janni W, Gebauer G, Marth C, Schindlbeck C, Wallwiener D, Borgen E, Naume B, Pantel K, Solomayer E,. A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer 2006; 107: 885-92. (Pubitemid 44291136)
14. Pantel K, Brakenhoff RH, Brandt B,. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 2008; 8: 329-40. (Pubitemid 351596394)
15. Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane EB,. Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability. Biochemistry 2004; 43: 1283-95. (Pubitemid 38176526)
16. Effenberger KE, Borgen E, Eulenburg CZ, Bartkowiak K, Grosser A, Synnestvedt M, Kaaresen R, Brandt B, Nesland JM, Pantel K, Naume B,. Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern. Breast Cancer Res Treat 2011; 125: 729-38.
17. Roder JD, Thorban S, Pantel K, Siewert JR,. Micrometastases in bone marrow: prognostic indicators for pancreatic cancer. World J Surg 1999; 23: 888-91. (Pubitemid 29398468)
18. Thorban S, Roder JD, Pantel K, Siewert JR,. Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma. Am J Surg 1996; 172: 297-8. (Pubitemid 26327921)
19. Braun S, Pantel K, Muller P, Janni W, Hepp F, Kentenich CR, Gastroph S, Wischnik A, Dimpfl T, Kindermann G, Riethmuller G, Schlimok G,. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med 2000; 342: 525-33. (Pubitemid 30117892)
20. Borgen E, Naume B, Nesland JM, Kvalheim G, Beiske K, Fodstad O, Diel IJ, Solomayer EF, Theocharous P, Coombes RC, Smith BM, Wunder E, et al. Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cells. Cytotherapy 1999; 1: 377-88.
21. Soeth E, Grigoleit U, Moellmann B, Roder C, Schniewind B, Kremer B, Kalthoff H, Vogel I,. Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival. J Cancer Res Clin Oncol 2005; 131: 669-76. (Pubitemid 41502210)
22. Z'Graggen K, Centeno BA, Fernandez-del Castillo C, Jimenez RE, Werner J, Warshaw AL,. Biological implications of tumor cells in blood and bone marrow of pancreatic cancer patients. Surgery 2001; 129: 537-46. (Pubitemid 32374984)
23. Hoffmann K, Kerner C, Wilfert W, Mueller M, Thiery J, Hauss J, Witzigmann H,. Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients. World J Gastroenterol 2007; 13: 257-63. (Pubitemid 46231329)
24. van Heek NT, Tascilar M, van Beekveld JL, Drillenburg P, Offerhaus GJ, Gouma DJ,. Micrometastases in bone marrow of patients with suspected pancreatic and ampullary cancer. Eur J Surg Oncol 2001; 27: 740-5. (Pubitemid 33085543)
25. Vogel I, Kruger U, Marxsen J, Soeth E, Kalthoff H, Henne-Bruns D, Kremer B, Juhl H,. Disseminated tumor cells in pancreatic cancer patients detected by immunocytology: a new prognostic factor. Clin Cancer Res 1999; 5: 593-9. (Pubitemid 29131969)
26. Thorban S, Roder JD, Pantel K, Siewert JR,. Epithelial tumour cells in bone marrow of patients with pancreatic carcinoma detected by immunocytochemical staining. Eur J Cancer 1996; 32A: 363-5.
27. Thorban S, Roder JD, Siewert JR,. Detection of micrometastasis in bone marrow of pancreatic cancer patients. Ann Oncol 1999; 10 (Suppl 4): 111-3.
28. Chiang AC, Massague J,. Molecular basis of metastasis. N Engl J Med 2008; 359: 2814-23.
29. O'Sullivan GC, Collins JK, Kelly J, Morgan J, Madden M, Shanahan F,. Micrometastases: marker of metastatic potential or evidence of residual disease? Gut 1997; 40: 512-5. (Pubitemid 27204932)
30. Bartkowiak K, Wieczorek M, Buck F, Harder S, Moldenhauer J, Effenberger KE, Pantel K, Peter-Katalinic J, Brandt BH,. Two-dimensional differential gel electrophoresis of a cell line derived from a breast cancer micrometastasis revealed a stem/progenitor cell protein profile. J Proteome Res 2009; 8: 2004-14.
31. Gnant M, Mlineritsch B, Schippinger W, Luschin-Ebengreuth G, Postlberger S, Menzel C, Jakesz R, Seifert M, Hubalek M, Bjelic-Radisic V, Samonigg H, Tausch C, et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med 2009; 360: 679-91.
32. Fizazi K, Lipton A, Mariette X, Body JJ, Rahim Y, Gralow JR, Gao G, Wu L, Sohn W, Jun S,. Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol 2009; 27: 1564-71.