Micrometastases: Marker of metastatic potential or evidence of residual disease?

Gut

Volumn 40, Issue 4, 1997, Pages 512-515

  O'Sullivan, G C ^a   Collins, J K ^a   Kelly, J ^a   Morgan, J ^a   Madden, M ^a   Shanahan, F ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b University College Cork and INFANT Centre   (Ireland)

Author keywords

Cancer; Flow cytometry; Metastases; Residual disease

Indexed keywords

ARTICLE; BONE MARROW METASTASIS; DIGESTIVE SYSTEM CANCER; FLOW CYTOMETRY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0031011135     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.40.4.512     Document Type: Article

References (16)

1. Mansi JL, Berger U, Easton D, McDonnell T, Redding WH, Gazet JC, et al. Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases. BMJ 1987; 295: 1093-6.
2. Cote RJ, Rosen PP, Lesser ML, Old LJ, Osborne MP. Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micro metastases. J Clin Oncol 1991;9: 1749-56.
3. Cote RJ, Beattie EJ, Chaiwun B, ShiS-R, HarveyJ, Chen S-C, et al Detection of occult bone marrow micrometastases in patients with operable lung carcinoma. Ann Surg 1995; 222:415-25.
4. Pantel K, Izbicki J, Passlick B, Angstwurm M, Haüssinger K, Thetter O, et al. Frequency and prognostic significance of isolated turmour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases. Lancet 1996; 347: 649-53.
5. Lindemann F, Schlimok G, Dirschedl P, Witte J, Riethmüller G. Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet 1992; 340: 685-9.
6. O'Sullivan GC, Collins JK, O'Brien F, Crowley B, Murphy K, Lee G, Shanahan F. Micrometastases in bone marrow of patients undergoing "curative" surgery for gastrointestinal cancer. Gastroenterology 1995; 109: 1535-40.
7. Nossal GJV. Minimal residual disease as the target for immunotherapy of cancer. Lancet 1994; 343: 1172-4.
8. Sinicrope FA, Sugarman SM. Role of adjuvant therapy in surgically resected colorectal carcinoma. Gastroenterology 1995; 109:984-93.
9. Folkman J, Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1: 27-31.
10. Boyum A. Separation of leukocytes from blood and bone marrrow. Scand J Clin Lab Invest 1968; 21: 31-50.
11. Cordell JL, Falini B, Erber WN, Gosh AK, Abdulaziz Z, MacDonald S, et al. Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal antialkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984; 32: 219-29.
12. Schlimok G, Riethmüller G, Detection, characterization and tumorigenicity of disseminated tumor cells in human bone marrow. Semin Cancer Biol 1990; 1: 207-15.
13. Brugger W, Bross KJ, Glatt M, Weber F, Mertelsmann R, Kanz L. Mobilisation of tumor cells and hemapoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 1994; 83: 636-40.
14. Shpall EJ, Jones RB. Release of tumor cells from bone marrow. Blood 1994; 83: 623-5.
15. Eschwege P, Dumas F, Blanchet P, Le Marie V, Benoit G, Jardin A, et al. Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy. Lancet 1995; 346: 1528-30.
16. Rubio CA, Emas S, Nylander G. A critical reappraisal of Dukes' classification. Surg Gynecol Obstet 1977; 145: 682-4.