Transcriptional targets in adipocyte biology

Expert Opinion on Therapeutic Targets

Volumn 13, Issue 8, 2009, Pages 975-986

  Rosen, Evan ^a   Eguchi, Jun ^a   Xu, Zhao ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Adipocytes; Adipogenesis; Adipokines; Lipogenesis; Lipolysis

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; FORKHEAD TRANSCRIPTION FACTOR; KRUPPEL LIKE FACTOR 5; LEPTIN; LIVER X RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOL BINDING PROTEIN 4; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR GATA 2; UNCOUPLING PROTEIN 1;

ADIPOCYTE; ADIPOGENESIS; BROWN ADIPOSE TISSUE; CYTOKINE RELEASE; CYTOLOGY; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; LIPOGENESIS; LIPOLYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; POLYMERASE CHAIN REACTION; REVIEW; TRANSCRIPTION REGULATION;

ADIPOCYTES; ANIMALS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; HUMANS; OBESITY; TRANSCRIPTION, GENETIC;

EID: 69149095335     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220903039706     Document Type: Review

References (106)

1. James WP. WHO recognition of the global obesity epidemic. Int J Obes (Lond) 2008;32(Suppl 7):S120-6
2. Benson L, Baer HJ, Kaelber DC. Trends in the diagnosis of overweight and obesity in children and adolescents: 1999-2007. Pediatrics 2009;123:e153-8
3. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432 (Pubitemid 24365442)
4. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008;93(11 Suppl 1):S64-73
5. Farooqi IS, O'Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009;89:980-4S
6. Catalan V, Gomez-Ambrosi J, Rodriguez A, et al. Adipokines in the treatment of diabetes mellitus and obesity. Expert Opin Pharmacother 2009;10:239-254
7. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006;444:847-853 (Pubitemid 46024991)
8. Cao H, Gerhold K, Mayers JR, et al. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008;134:933-944
9. Rizos CV, Liberopoulos EN, Mikhailidis DP, Elisaf MS. Pleiotropic effects of thiazolidinediones. Expert Opin Pharmacother 2008;9:1087-1108
10. Lefterova MI, Zhang Y, Steger DJ, et al. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 2008;22:2941-2952
11. Nielsen R, Pedersen TA, Hagenbeek D, et al. Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev 2008;22:2953-2967
12. Rizos CV, Elisaf MS, Mikhailidis DP, Liberopoulos EN. How safe is the use of thiazolidinediones in clinical practice? Expert Opin Drug Saf 2009;8:15-32
13. Garg A, Agarwal AK. Lipodystrophies: disorders of adipose tissue biology. Biochim Biophys Acta 2009 [Epub ahead of print]
14. Farmer SR. Molecular determinants of brown adipocyte formation and function. Genes Dev 2008;22:1269-1275
15. Farmer SR. Transcriptional control of adipocyte formation. Cell Metab 2006;4:263-273
16. Rosen ED, Macdougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 2006;7:885-896
17. Jimenez MA, Akerblad P, Sigvardsson M, Rosen ED. Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. Mol Cell Biol 2007;27:743-757
18. Rosen ED, Hsu CH, Wang X, et al. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 2002;16:22-26 (Pubitemid 34049634)
19. Barak Y, Nelson MC, Ong ES, et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999;4:585-595 (Pubitemid 29531138)
20. Kubota N, Terauchi Y, Miki H, et al. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999;4:597-609 (Pubitemid 29531139)
21. Rosen ED, Sarraf P, Troy AE, et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999;4:611-617 (Pubitemid 29531140)
22. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994;79:1147-1156
23. Cheung KJ, Tzameli I, Pissios P, et al. Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab 2007;5:115-128 (Pubitemid 46187493)
24. Tzameli I, Fang H, Ollero M, et al. Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem 2004;279:36093-36102 (Pubitemid 39100617)
25. Kim JB, Wright HM, Wright M, Spiegelman BM. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA 1998;95:4333-4337 (Pubitemid 28207912)
26. Barroso I, Gurnell M, Crowley VE, et al. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999;402:880-883 (Pubitemid 30017170)
27. Ren D, Collingwood TN, Rebar EJ, et al. PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev 2002;16:27-32 (Pubitemid 34049635)
28. Mueller E, Drori S, Aiyer A, et al. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem 2002;277:41925-41930 (Pubitemid 35257505)
29. Medina-Gomez G, Virtue S, Lelliott C, et al. The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferatoractivated receptor-gamma2 isoform. Diabetes 2005;54:1706-1716 (Pubitemid 40770761)
30. Zhang J, Fu M, Cui T, et al. Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci USA 2004;101:10703-10708 (Pubitemid 38955806)
31. Darlington GJ, Ross SE, Macdougald OA. The role of C/EBP genes in adipocyte differentiation. J Biol Chem 1998;273:30057-30060
32. Wu Z, Rosen ED, Brun R, et al. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 1999;3:151-158 (Pubitemid 29292616)
33. Kawamura Y, Tanaka Y, Kawamori R, Maeda S. Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. Mol Endocrinol 2006;20:844-856
34. Banerjee SS, Feinberg MW, Watanabe M, et al. The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptorgamma expression and adipogenesis. J Biol Chem 2003;278:2581-2584 (Pubitemid 36801336)
35. Sue N, Jack BH, Eaton SA, et al. Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol 2008;28:3967-3978 (Pubitemid 351812983)
36. Oishi Y, Manabe I, Tobe K, et al. Kruppellike transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 2005;1:27-39 (Pubitemid 43960584)
37. Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metab 2008;7:339-347
38. Li D, Yea S, Li S, et al. Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J Biol Chem 2005;280:26941-26952 (Pubitemid 41040730)
39. Mori T, Sakaue H, Iguchi H, et al. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem 2005;280:12867-12875 (Pubitemid 40491108)
40. Gray S, Feinberg MW, Hull S, et al. The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem 2002;277:34322-34328 (Pubitemid 35056255)
41. Akerblad P, Lind U, Liberg D, et al. Early B-cell factor (O/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation. Mol Cell Biol 2002;22:8015-8025 (Pubitemid 35217309)
42. Tong Q, Dalgin G, Xu H, et al. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 2000;290:134-138 (Pubitemid 30752086)
43. Tong Q, Tsai J, Tan G, et al. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Biol 2005;25:706-715 (Pubitemid 40096591)
44. Nakae J, Kitamura T, Kitamura Y, et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell 2003;4:119-129 (Pubitemid 36105338)
45. Nakae J, Cao Y, Oki M, et al. Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes 2008;57:563-576
46. Wolfrum C, Shih DQ, Kuwajima S, et al. Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest 2003;112:345-356 (Pubitemid 38063763)
47. Davis KE, Moldes M, Farmer SR. The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation. J Biol Chem 2004;279:42453-42461 (Pubitemid 39372128)
48. Gerin I, Bommer GT, Lidell ME, et al. On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake. J Biol Chem 2009;284:10755-10763
49. Cederberg A, Gronning LM, Ahren B, et al. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 2001;106:563-573 (Pubitemid 32879318)
50. Letexier D, Pinteur C, Large V, et al. Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue. J Lipid Res 2003;44:2127-2134 (Pubitemid 37509628)
51. Coleman RA, Lee DP. Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 2004;43:134-176 (Pubitemid 37492937)
52. Kim JB, Sarraf P, Wright M, et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest 1998;101:1-9 (Pubitemid 28058896)
53. Shimano H, Shimomura I, Hammer RE, et al. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J Clin Invest 1997;100:2115-2124 (Pubitemid 27459368)
54. Shimomura I, Hammer RE, Richardson JA, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 1998;12:3182-3194 (Pubitemid 28496263)
55. Juvet LK, Andresen SM, Schuster GU, et al. On the role of liver X receptors in lipid accumulation in adipocytes. Mol Endocrinol 2003;17:172-182 (Pubitemid 36187394)
56. Gerin I, Dolinsky VW, Shackman JG, et al. LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem 2005;280:23024-23031 (Pubitemid 40861694)
57. He Z, Jiang T, Wang Z, et al. Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue. Am J Physiol Endocrinol Metab 2004;287:E424-30 (Pubitemid 39095875)
58. Wang S, Soni KG, Semache M, et al. Lipolysis and the integrated physiology of lipid energy metabolism. Mol Genet Metab 2008;95:117-126
59. Zimmermann R, Lass A, Haemmerle G, Zechner R. Fate of fat: the role of adipose triglyceride lipase in lipolysis. Biochim Biophys Acta 2008
60. Guan HP, Li Y, Jensen MV, et al. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med 2002;8:1122-1128
61. Tan GD, Debard C, Tiraby C, et al. A 'futile cycle' induced by thiazolidinediones in human adipose tissue? Nat Med 2003;9:811-812
62. Tan GD, Debard C, Tiraby C, et al. Peroxisome proliferator-activated receptor delta: a conserved director of lipid homeostasis through regulation of the oxidative capacity of muscle. PPAR Res 2008;2008:172676
63. Wang YX, Lee CH, Tiep S, et al. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003;113:159-170 (Pubitemid 36514968)
64. Barak Y, Liao D, He W, et al. Effects of peroxisome proliferator- activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci USA 2002;99:303-308 (Pubitemid 34060358)
65. Im SS, Kwon SK, Kim TH, et al. Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes. IUBMB Life 2007;59:134-145
66. Dowell P, Cooke DW. Olf-1/early B cell factor is a regulator of glut4 gene expression in 3T3-L1 adipocytes. J Biol Chem 2002;277:1712-1718 (Pubitemid 34968741)
67. Eguchi J, Yan QW, Schones DE, et al. Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metab 2008;7:86-94
68. Wertheim N, Cai Z, Mcgraw TE. The transcription factor CCAAT/enhancerbinding protein alpha is required for the intracellular retention of GLUT4. J Biol Chem 2004;279:41468-41476 (Pubitemid 39313587)
69. Araki E, Haag BL 3rd, Matsuda K, et al. Characterization and regulation of the mouse insulin receptor substrate gene promoter. Mol Endocrinol 1995;9:1367-1379
70. Abizaid A, Horvath TL. Brain circuits regulating energy homeostasis. Regul Pept 2008;149:3-10
71. He Y, Chen H, Quon MJ, Reitman M. The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha. J Biol Chem 1995;270:28887-28891
72. Buyse M, Viengchareun S, Bado A, Lombes M. Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes. FASEB J 2001;15:1357-1366 (Pubitemid 32531813)
73. Mason MM, He Y, Chen H, et al. Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor. Endocrinology 1998;139:1013-1022
74. Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 1996;97:2152-2157
75. Torpy DJ, Bornstein SR, Cizza G, Chrousos GP. The effects of glucocorticoids on leptin levels in humans may be restricted to acute pharmacologic dosing. J Clin Endocrinol Metab 1998;83:1821-1822 (Pubitemid 28501067)
76. Bertile F, Raclot T. Differences in mRNA expression of adipocyte-derived factors in response to fasting, refeeding and leptin. Biochim Biophys Acta 2004;1683:101-109 (Pubitemid 38844664)
77. Fasshauer M, Klein J, Neumann S, et al. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett 2001;507:142-146 (Pubitemid 33001531)
78. Fasshauer M, Klein J, Neumann S, et al. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2002;290:1084-1089 (Pubitemid 34687474)
79. Fasshauer M, Kralisch S, Klier M, et al. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2003;301:1045-1050 (Pubitemid 36279218)
80. Gustafson B, Jack MM, Cushman SW, Smith U. Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes. Biochem Biophys Res Commun 2003;308:933-939 (Pubitemid 36976549)
81. Park SK, Oh SY, Lee MY, et al. CCAAT/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue. Diabetes 2004;53:2757-2766
82. Kim HB, Kong M, Kim TM, et al. NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes. Diabetes 2006;55:1342-1352 (Pubitemid 44195373)
83. Seo JB, Moon HM, Noh MJ, et al. Adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element-binding protein 1c regulates mouse adiponectin expression. J Biol Chem 2004;279:22108-22117
84. Doran AC, Meller N, Cutchins A, et al. The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin. Circ Res 2008;103:624-634
85. Iwaki M, Matsuda M, Maeda N, et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 2003;52:1655-1663 (Pubitemid 36792453)
86. Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356-362 (Pubitemid 41065039)
87. Graham TE, Yang Q, Bluher M, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006;354:2552-2563 (Pubitemid 43882351)
88. von Eynatten M, Humpert PM. Retinol-binding protein-4 in experimental and clinical metabolic disease. Expert Rev Mol Diagn 2008;8:289-299 (Pubitemid 351724708)
89. Graham TE, Wason CJ, Bluher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia 2007;50:814-823 (Pubitemid 46355817)
90. Mercader J, Granados N, Bonet ML, Palou A. All-trans retinoic acid decreases murine adipose retinol binding protein 4 production. Cell Physiol Biochem 2008;22:363-372
91. Wu H, Wei L, Bao Y, et al. Fenofibrate reduces serum retinol binding protein 4 by suppressing its expression in adipose tissue. Am J Physiol Endocrinol Metab 2008;296:pE628-34
92. Kajimura S, Seale P, Tomaru T, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 2008;22:1397-1409 (Pubitemid 351717529)
93. Seale P, Kajimura S, Yang W, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007;6:38-54 (Pubitemid 47008902)
94. Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008;454:961-967
95. Hansen JB, Jorgensen C, Petersen RK, et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci USA 2004;101:4112-4117 (Pubitemid 38405892)
96. Puigserver P. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes (Lond) 2005;29(Suppl 1):5-9 (Pubitemid 40343163)
97. Hayes SA, Miller JM, Hoshizaki DK. Serpent, a GATA-like transcription factor gene, induces fat-cell development in Drosophila melanogaster. Development 2001;128:1193-1200
98. Leonardsson G, Steel JH, Christian M, et al. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci USA 2004;101:8437-8442 (Pubitemid 38736593)
99. Puri V, Virbasius JV, Guilherme A, Czech MP. RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27. Acta Physiol (Oxf) 2008;192:103-115
100. Waki H, Park KW, Mitro N, et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 2007;5:357-370 (Pubitemid 46667757)
101. Graves RA, Tontonoz P, Platt KA, et al. Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression. J Cell Biochem 1992;49:219-224
102. Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell 2007;128:669-681
103. Yu H, Zhu S, Zhou B, et al. Inferring causal relationships among different histone modifications and gene expression. Genome Res 2008;18:1314-1324
104. Melillo RM, Pierantoni GM, Scala S, et al. Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation. Mol Cell Biol 2001;21:2485-2495 (Pubitemid 32222101)
105. Xu Z, Yu S, Hsu CH, et al. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci USA 2008;105:2421-2426
106. Matys V, Kel-Margoulis OV, Fricke E, et al. TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res 2006;34(Database issue):D108-10