HTLV-1 positive and negative T cells cloned from infected individuals display telomerase and telomere genes deregulation that predominate in activated but untransformed CD4+ T cells

International Journal of Cancer

Volumn 131, Issue 4, 2012, Pages 821-833

  Zane, Linda ^a   Sibon, David ^a,b,i   Capraro, Valérie ^a,j   Galia, Perrine ^a   Karam, Maroun ^a   Delfau Larue, Marie Hélène ^c   Gilson, Eric ^d,e   Gessain, Antoine ^f   Gout, Olivier ^g   Hermine, Olivier ^h   Mortreux, Franck ^a   Wattel, Eric ^a,b  

^a UNIVERSITÉ DE LYON   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c HENRI MONDOR HOSPITAL   (France)

^d UNIVERSITÉ CÔTE D'AZUR   (France)

^e CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^f INSTITUT PASTEUR   (France)

^g FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD   (France)

^h HÔPITAL NECKER ENFANTS MALADES   (France)

ⁱ SAINT LOUIS HOSPITAL   (France)

^j UNIVERSITY OF LIÈGE   (Belgium)

more..

Author keywords

HTLV 1; leukemia; lymphocyte; lymphoma; telomerase; telomere; virus

Indexed keywords

TELOMERASE; TRANSCRIPTOME;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL CYCLE; CELL EXPANSION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA PKC GENE; ENZYME ACTIVITY; GENE SEQUENCE; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; IMMUNOSUPPRESSIVE TREATMENT; KU80 GENE; LYMPHOCYTE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; POT1 GENE; PRIORITY JOURNAL; SENESCENCE; TANK1 GENE; TELOMERE; TPP1 GENE; TRF1 GENE; TUMOR GROWTH; VIRUS GENE;

BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; DNA PRIMERS; HOMEOSTASIS; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LYMPHOCYTE ACTIVATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERASE; TELOMERE; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

EID: 84862519379     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26270     Document Type: Article

References (50)

1. Poiesz BJ, Ruscetti FW, Reitz MS, Kalyanaraman VS, Gallo RC,. Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukaemia. Nature 1981; 294: 268-71. (Pubitemid 12221494)
2. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de The G,. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985; 2: 407-10. (Pubitemid 15231248)
3. Mascarenhas RE, Brodskyn C, Barbosa G, Clarencio J, Andrade-Filho AS, Figueiroa F, Galvao-Castro B, Grassi F,. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clin Vaccine Immunol 2006; 13: 547-52. (Pubitemid 43736454)
4. Gabet AS, Mortreux F, Talarmin A, Plumelle Y, Leclercq I, Leroy A, Gessain A, Clity E, Joubert M, Wattel E,. High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis [In Process Citation]. Oncogene 2000; 19: 4954-60.
5. Mortreux F, Gabet AS, Wattel E,. Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo. Leukemia 2003; 17: 26-38. (Pubitemid 36175884)
6. Sibon D, Gabet AS, Zandecki M, Pinatel C, Thete J, Delfau-Larue MH, Rabaaoui S, Gessain A, Gout O, Jacobson S, Mortreux F, Wattel E,. HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. J Clin Invest 2006; 116: 974-83.
7. Zane L, Sibon D, Mortreux F, Wattel E,. Clonal expansion of HTLV-1 infected cells depends on the CD4 versus CD8 phenotype. Front Biosci 2009; 14: 3935-41.
8. Hayflick L,. The Limited in Vitro Lifetime of Human Diploid Cell Strains. Exp Cell Res 1965; 37: 614-36.
9. Hayflick L, Moorhead PS,. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
10. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE,. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-52. (Pubitemid 28063364)
11. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP,. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426: 194-8. (Pubitemid 37442589)
12. Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S,. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 1997; 16: 6018-33. (Pubitemid 27427297)
13. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J,. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 1995; 375: 503-6.
14. Stein GH, Drullinger LF, Soulard A, Dulic V,. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 1999; 19: 2109-17. (Pubitemid 29098269)
15. Erickson S, Sangfelt O, Heyman M, Castro J, Einhorn S, Grander D,. Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence. Oncogene 1998; 17: 595-602. (Pubitemid 28401028)
16. Jacobs JJ, de Lange T,. Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol 2004; 14: 2302-8. (Pubitemid 40033370)
17. Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA,. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000; 406: 641-5. (Pubitemid 30641052)
18. Rudolph KL, Millard M, Bosenberg MW, DePinho RA,. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 2001; 28: 155-9. (Pubitemid 32538061)
19. Broccoli D, Young JW, de Lange T,. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 1995; 92: 9082-6.
20. Buchkovich KJ, Greider CW,. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell 1996; 7: 1443-54. (Pubitemid 26304205)
21. Pan C, Xue BH, Ellis TM, Peace DJ, Diaz MO,. Changes in telomerase activity and telomere length during human T lymphocyte senescence. Exp Cell Res 1997; 231: 346-53. (Pubitemid 27187987)
22. Monteiro J, Batliwalla F, Ostrer H, Gregersen PK,. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol 1996; 156: 3587-90. (Pubitemid 26137643)
23. Chebel A, Bauwens S, Gerland LM, Belleville A, Urbanowicz I, de Climens AR, Tourneur Y, Chien WW, Catallo R, Salles G, Gilson E, Ffrench M,. Telomere uncapping during in vitro T-lymphocyte senescence. Aging Cell 2009; 8: 52-64.
24. Kubuki Y, Suzuki M, Sasaki H, Toyama T, Yamashita K, Maeda K, Ido A, Matsuoka H, Okayama A, Nakanishi T, Tsubouchi H,. Telomerase activity and telomere length as prognostic factors of adult T-cell leukemia. Leuk Lymphoma 2005; 46: 393-9. (Pubitemid 40220397)
25. Datta A, Bellon M, Sinha-Datta U, Bazarbachi A, Lepelletier Y, Canioni D, Waldmann TA, Hermine O, Nicot C,. Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. Blood 2006; 108: 1021-9. (Pubitemid 44154640)
26. Kchour G, Makhoul NJ, Mahmoudi M, Kooshyar MM, Shirdel A, Rastin M, Rafatpanah H, Tarhini M, Zalloua PA, Hermine O, Farid R, Bazarbachi A,. Zidovudine and interferon-alpha treatment induces a high response rate and reduces HTLV-1 proviral load and VEGF plasma levels in patients with adult T-cell leukemia from North East Iran. Leuk Lymphoma 2007; 48: 330-6. (Pubitemid 47007364)
27. Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E,. Inactivation of hTERT transcription by Tax. Oncogene 2003; 22: 3734-41. (Pubitemid 36760735)
28. Kuhlmann AS, Villaudy J, Gazzolo L, Castellazzi M, Mesnard JM, Duc Dodon M,. HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirol 2007; 4: 92.
29. Sinha-Datta U, Horikawa I, Michishita E, Datta A, Sigler-Nicot JC, Brown M, Kazanji M, Barrett JC, Nicot C,. Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood 2004; 104: 2523-31. (Pubitemid 39331856)
30. Escoffier E, Rezza A, Roborel de Climens A, Belleville A, Gazzolo L, Gilson E, Duc Dodon M,. A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1. TRF2 and. Pot1 in resting, activated. HTLV-1-transformed and. Tax-expressing human. T lymphocytes. Retrovirol 2005; 2: 77.
31. Hara T, Matsumura-Arioka Y, Ohtani K, Nakamura M,. Role of human T-cell leukemia virus type I Tax in expression of the human telomerase reverse transcriptase (hTERT) gene in human T-cells. Cancer Sci 2008; 99: 1155-63. (Pubitemid 351676627)
32. Terme JM, Mocquet V, Kuhlmann AS, Zane L, Mortreux F, Wattel E, Duc Dodon M, Jalinot P,. Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1. Leukemia 2009; 23: 2081-9.
33. Seikaly MG, Salhab N, Warady BA, Stablein D,. Use of rhGH in children with chronic kidney disease: lessons from NAPRTCS. Pediatr Nephrol 2007; 22: 1195-204.
34. Poncet D, Belleville A, t'kint de Roodenbeke C, Roborel de Climens A, Ben Simon E, Merle-Beral H, Callet-Bauchu E, Salles G, Sabatier L, Delic J, Gilson E,. Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Blood 2008; 111: 2388-91. (Pubitemid 351451451)
35. Bellon M, Datta A, Brown M, Pouliquen JF, Couppie P, Kazanji M, Nicot C,. Increased expression of telomere length regulating factors TRF1 TRF2 and TIN2 in patients with adult. T-cell leukemia. Int J Cancer 2006; 119: 2090-7. (Pubitemid 44423666)
36. Gisselsson D, Bjork J, Hoglund M, Mertens F, Dal Cin P, Akerman M, Mandahl N,. Abnormal nuclear shape in solid tumors reflects mitotic instability. Am J Pathol 2001; 158: 199-206. (Pubitemid 32096485)
37. Saito M, Furukawa Y, Kubota R, Usuku K, Izumo S, Osame M, Yoshida M,. Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence. J Neurovirol 1996; 2: 330-5. (Pubitemid 26372458)
38. Delfau-Larue MH, Laroche L, Wechsler J, Lepage E, Lahet C, Asso-Bonnet M, Bagot M, Farcet JP,. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood 2000; 96: 2987-92.
39. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8. (Pubitemid 34164012)
40. Pfaffl MW, Tichopad A, Prgomet C, Neuvians TP,. Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations. Biotechnol Lett 2004; 26: 509-15. (Pubitemid 38448421)
41. Wattel E, Mariotti M, Agis F, Gordien E, Le Coeur FF, Prin L, Rouger P, Chen IS, Wain-Hobson S, Lefrere JJ,. Quantification of HTLV-1 proviral copy number in peripheral blood of symptomless carriers from the French West Indies. J Acquir Immune Defic Syndr 1992; 5: 943-6.
42. Kosciolek BA, Rowley PT,. Human lymphocyte telomerase is genetically regulated. Genes. Chromosomes Cancer 1998; 21: 124-30. (Pubitemid 28081239)
43. Yamada O, Motoji T, Mizoguchi H,. Up-regulation of telomerase activity in human lymphocytes. Biochim Biophys Acta 1996; 1314: 260-6. (Pubitemid 26411451)
44. Zane L, Sibon D, Jeannin L, Zandecki M, Delfau-Larue MH, Gessain A, Gout O, Pinatel C, Lancon A, Mortreux F, Wattel E,. Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo. Retrovirology 2010; 7: 17.
45. Gisselsson D, Jonson T, Petersen A, Strombeck B, Dal Cin P, Hoglund M, Mitelman F, Mertens F, Mandahl N,. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci USA 2001; 98: 12683-8. (Pubitemid 33020006)
46. Itoyama T, Chaganti RS, Yamada Y, Tsukasaki K, Atogami S, Nakamura H, Tomonaga M, Ohshima K, Kikuchi M, Sadamori N,. Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area. Nagasaki. Blood 2001; 97: 3612-20.
47. Sieburg M, Tripp A, Ma JW, Feuer G,. Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis. J Virol 2004; 78: 10399-409. (Pubitemid 39258365)
48. Hatta Y, Koeffler HP,. Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL). Leukemia 2002; 16: 1069-85. (Pubitemid 34618845)
49. Montes M, Sanchez C, Verdonck K, Lake JE, Gonzalez E, Lopez G, Terashima A, Nolan T, Lewis DE, Gotuzzo E, White AC, Jr,. Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. PLoS Negl Trop Dis 3: e456, 2009.
50. Moules V, Pomier C, Sibon D, Gabet AS, Reichert M, Kerkhofs P, Willems L, Mortreux F, Wattel E,. Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy. Cancer Res 2005; 65: 1234-43. (Pubitemid 40270148)