Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo

Retrovirology

Volumn 7, Issue , 2010, Pages

  Zane, Linda ^a   Sibon, David ^a,b,g   Jeannin, Lionel ^a   Zandecki, Marc ^c   Delfau Larue, Marie Hélène ^d   Gessain, Antoine ^e   Gout, Olivier ^f   Pinatel, Christiane ^a   Lançon, Agnès ^a   Mortreux, Franck ^a   Wattel, Eric ^a,b  

^a UNIVERSITÉ DE LYON   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c ANGERS UNIVERSITY HOSPITAL   (France)

^d HENRI MONDOR HOSPITAL   (France)

^e INSTITUT PASTEUR   (France)

^f FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD   (France)

^g SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; TAX PROTEIN;

ARTICLE; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CYCLE; CELL DEATH; CELL EXPANSION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; LEUKEMOGENESIS; LYMPHOCYTE CLONE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; T CELL LEUKEMIA; VIRUS CARCINOGENESIS; VIRUS CELL INTERACTION; CELL PROLIFERATION; HOST PATHOGEN INTERACTION; PATHOGENICITY; REGULATOR GENE; VIROLOGY; VIRUS CELL TRANSFORMATION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; CELL PROLIFERATION; CELL TRANSFORMATION, VIRAL; GENE EXPRESSION; GENES, PX; HOST-PATHOGEN INTERACTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL;

EID: 77949469132     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-7-17     Document Type: Article

References (37)

1. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 1977, 50:481-492.
2. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de The G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985, 2:407-410. 10.1016/S0140-6736(85)92734-5, 2863442.
3. Mortreux F, Gabet AS, Wattel E. Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo. Leukemia 2003, 17:26-38. 10.1038/sj.leu.2402777, 12529656.
4. Mortreux F, Kazanji M, Gabet AS, de Thoisy B, Wattel E. Two-step nature of human T-cell leukemia virus type 1 replication in experimentally infected squirrel monkeys (Saimiri sciureus). J Virol 2001, 75:1083-1089. 10.1128/JVI.75.2.1083-1089.2001, 114008, 11134325.
5. Mortreux F, Leclercq I, Gabet AS, Leroy A, Westhof E, Gessain A, Wain-Hobson S, Wattel E. Somatic mutation in human T-cell leukemia virus type 1 provirus and flanking cellular sequences during clonal expansion in vivo. J Natl Cancer Inst 2001, 93:367-377. 10.1093/jnci/93.5.367, 11238698.
6. Pomier C, Alcaraz MT, Debacq C, Lancon A, Kerkhofs P, Willems L, Wattel E, Mortreux F. Early and transient reverse transcription during primary deltaretroviral infection of sheep. Retrovirology 2008, 5:16. 10.1186/1742-4690-5-16, 2270868, 18241341.
7. Moules V, Pomier C, Sibon D, Gabet AS, Reichert M, Kerkhofs P, Willems L, Mortreux F, Wattel E. Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy. Cancer Res 2005, 65:1234-1243. 10.1158/0008-5472.CAN-04-1834, 15735007.
8. Sibon D, Gabet AS, Zandecki M, Pinatel C, Thete J, Delfau-Larue MH, Rabaaoui S, Gessain A, Gout O, Jacobson S, Mortreux F, Wattel E. HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. J Clin Invest 2006, 116:974-983. 10.1172/JCI27198, 1421359, 16585963.
9. Zane L, Sibon D, Mortreux F, Wattel E. Clonal expansion of HTLV-1 infected cells depends on the CD4 versus CD8 phenotype. Front Biosci 2009, 14:3935-3941. 10.2741/3502, 19273324.
10. Callard R, Hodgkin P. Modeling T- and B-cell growth and differentiation. Immunol Rev 2007, 216:119-129.
11. Matsuoka M, Jeang KT. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 2007, 7:270-280. 10.1038/nrc2111, 17384582.
12. Saggioro D, Silic-Benussi M, Biasiotto R, D'Agostino DM, Ciminale V. Control of cell death pathways by HTLV-1 proteins. Front Biosci 2009, 14:3338-3351. 10.2741/3456, 19273278.
13. Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L. The HTLV-1 Tax interactome. Retrovirology 2008, 5:76. 10.1186/1742-4690-5-76, 2533353, 18702816.
14. Sieburg M, Tripp A, Ma JW, Feuer G. Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis. J Virol 2004, 78:10399-10409. 10.1128/JVI.78.19.10399-10409.2004, 516438, 15367606.
15. Haoudi A, Daniels RC, Wong E, Kupfer G, Semmes OJ. Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response. J Biol Chem 2003, 278:37736-37744. 10.1074/jbc.M301649200, 12842897.
16. Jeang KT, Widen SG, Semmes O, Wilson SH. HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene. Science 1990, 247:1082-1084. 10.1126/science.2309119, 2309119.
17. Neuveut C, Jeang KT. Cell cycle dysregulation by HTLV-I: role of the tax oncoprotein. Front Biosci 2002, 7:D157-163. 10.2741/neuveut, 11779707.
18. Neuveut C, Low KG, Maldarelli F, Schmitt I, Majone F, Grassmann R, Jeang KT. Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol Cell Biol 1998, 18:3620-3632. 108944, 9584203.
19. Liang MH, Geisbert T, Yao Y, Hinrichs SH, Giam CZ. Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis. J Virol 2002, 76:4022-4033. 10.1128/JVI.76.8.4022-4033.2002, 136099, 11907241.
20. Newbound GC, Andrews JM, O'Rourke JP, Brady JN, Lairmore MD. Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes. J Virol 1996, 70:2101-2106. 190046, 8642630.
21. Bangham CR, Meekings K, Toulza F, Nejmeddine M, Majorovits E, Asquith B, Taylor GP. The immune control of HTLV-1 infection: selection forces and dynamics. Front Biosci 2009, 14:2889-2903. 10.2741/3420, 19273242.
22. Cavrois M, Wain-Hobson S, Wattel E. Stochastic events in the amplification of HTLV-I integration sites by linker-mediated PCR. Res Virol 1995, 146:179-184. 10.1016/0923-2516(96)80578-4, 7481090.
23. Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E. Inactivation of hTERT transcription by Tax. Oncogene 2003, 22:3734-3741. 10.1038/sj.onc.1206468, 12802280.
24. Rabaaoui S, Zouhiri F, Lancon A, Leh H, d'Angelo J, Wattel E. Inhibitors of strand transfer that prevent integration and inhibit human T-cell leukemia virus type 1 early replication. Antimicrob Agents Chemother 2008, 52:3532-3541. 10.1128/AAC.01361-07, 2565912, 18316517.
25. Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res 2003, 63:8523-8530.
26. Saito M, Furukawa Y, Kubota R, Usuku K, Izumo S, Osame M, Yoshida M. Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence [see comments]. J Neurovirol 1996, 2:330-335. 10.3109/13550289609146897, 8912209.
27. Yamano Y, Nagai M, Brennan M, Mora CA, Soldan SS, Tomaru U, Takenouchi N, Izumo S, Osame M, Jacobson S. Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP). Blood 2002, 99:88-94. 10.1182/blood.V99.1.88, 11756157.
28. Theodorou I, Bigorgne C, Delfau MH, Lahet C, Cochet G, Vidaud M, Raphael M, Gaulard P, Farcet JP. VJ rearrangements of the TCR gamma locus in peripheral T-cell lymphomas: analysis by polymerase chain reaction and denaturing gradient gel electrophoresis. J Pathol 1996, 178:303-310. 10.1002/(SICI)1096-9896(199603)178:3<303::AID-PATH475>3.0.CO;2-I, 8778336.
29. Cavrois M, Gessain A, Gout O, Wain-Hobson S, Wattel E. Common human T cell leukemia virus type 1 (HTLV-1) integration sites in cerebrospinal fluid and blood lymphocytes of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis indicate that HTLV-1 crosses the blood-brain barrier via clonal HTLV-1-infected cells. J Infect Dis 2000, 182:1044-1050. 10.1086/315844, 10979898.
30. Cavrois M, Gessain A, Wain-Hobson S, Wattel E. Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM. Oncogene 1996, 12:2419-2423.
31. Cavrois M, Leclercq I, Gout O, Gessain A, Wain-Hobson S, Wattel E. Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy. Oncogene 1998, 17:77-82. 10.1038/sj.onc.1201906, 9671316.
32. Hanon E, Hall S, Taylor GP, Saito M, Davis R, Tanaka Y, Usuku K, Osame M, Weber JN, Bangham CR. Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood 2000, 95:1386-1392.
33. Furukawa Y, Kubota R, Tara M, Izumo S, Osame M. Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood 2001, 97:987-993. 10.1182/blood.V97.4.987, 11159527.
34. Tamiya S, Matsuoka M, Etoh K, Watanabe T, Kamihira S, Yamaguchi K, Takatsuki K. Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood 1996, 88:3065-3073.
35. Taniguchi Y, Nosaka K, Yasunaga J, Maeda M, Mueller N, Okayama A, Matsuoka M. Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology 2005, 2:64. 10.1186/1742-4690-2-64, 1289293, 16242045.
36. Doi K, Wu X, Taniguchi Y, Yasunaga J, Satou Y, Okayama A, Nosaka K, Matsuoka M. Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states. Blood 2005, 106:1048-1053. 10.1182/blood-2004-11-4350, 15840694.
37. Meekings KN, Leipzig J, Bushman FD, Taylor GP, Bangham CR. HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP. PLoS Pathog 2008, 4:e1000027. 10.1371/journal.ppat.1000027, 2265437, 18369476.