Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation

Experimental Hematology

Volumn 40, Issue 7, 2012, Pages 564-574

  Iancu Rubin, Camelia ^a   Gajzer, David ^a   Mosoyan, Goar ^a   Feller, Faye ^b   Mascarenhas, John ^a   Hoffman, Ronald ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; HISTONE; PANOBINOSTAT; TUBULIN;

ACETYLATION; ARTICLE; CD34 SELECTION; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TARGETING; EX VIVO STUDY; GENE EXPRESSION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MICROTUBULE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; THROMBOCYTOSIS;

ACETYLATION; BLOOD PLATELETS; CELL PROLIFERATION; CELLS, CULTURED; HEMATOLOGIC NEOPLASMS; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; INDOLES; MEGAKARYOCYTES; MYELOPROLIFERATIVE DISORDERS; PROTEIN PROCESSING, POST-TRANSLATIONAL; THROMBOCYTOPENIA; THROMBOPOIESIS; TUBULIN;

EID: 84862511317     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2012.02.004     Document Type: Article

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