Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Hsieh, Ming Ju ^a   Lan, Kuang Ping ^b   Liu, Hao Yu ^a   Zhang, Xiao Zong ^c   Lin, Yaw Feng ^d   Chen, Tzy Yen ^a,e   Chiou, Hui Ling ^a,e  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b Kaomei College of Health Care and Management   (Taiwan)

^c CiShan Hospital   (Taiwan)

^d NATIONAL PINGTUNG UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

E2 envelope protein; GSK3 ; Hepatitis C virus; Insulin receptor substrate 1 (IRS 1); Insulin resistance; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOPROTEIN E2; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; SERINE; SUPPRESSOR OF CYTOKINE SIGNALING 3; THREONINE;

ARTICLE; CELL COMPOSITION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INSULIN RESISTANCE; LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; WESTERN BLOTTING;

CELL LINE; DIABETES MELLITUS, TYPE 2; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; HEPACIVIRUS; HEPATOCYTES; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; SIGNAL TRANSDUCTION; TRANSFECTION; VIRAL ENVELOPE PROTEINS;

EID: 84862506235     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-74     Document Type: Article

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