Disruption of the pelota gene causes early embryonic lethality and defects in cell cycle progression

Molecular and Cellular Biology

Volumn 23, Issue 4, 2003, Pages 1470-1476

  Adham, Ibrahim M ^a,b   Sallam, Mahmoud A ^a   Steding, Gerd ^a   Korabiowska, Monika ^a   Brinck, Ulrich ^a   Hoyer Fender, Sigrid ^a   Oh, Changkyu ^a   Engel, Wolfgang ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Institut fur Humangenetik   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; DNA CONTENT; DROSOPHILA MELANOGASTER; EMBRYO; GENE; GENE DISRUPTION; GENE MUTATION; GENOTYPE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PELO GENE; PELOTA GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANIMALS; BLASTOCYST; CELL CYCLE; FETAL DEATH; GENETIC ENGINEERING; MICE; MICE, MUTANT STRAINS; MITOSIS; MUTATION; STEM CELLS;

ANIMALIA; DROSOPHILA MELANOGASTER; EUKARYOTA; MELANOGASTER; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037315673     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.4.1470-1476.2003     Document Type: Article

References (33)

1. Auer, G. U., T. O. Caspersson, and A. S. Wallgren. 1980. DNA content and survival in mammary carcinoma. Anal. Quant. Cytol. 2:161-165.
2. Basu, J., B. C. Williams, Z. Li, E. V. Williams, and M. L. Goldberg. 1998. Depletion of a Drosophila homolog of yeast Sup35p disrupts spindle assembly, chromosome segregation, and cytokinesis during male meiosis. Cell Motil. Cytoskeleton 39:286-302.
3. Benachenhou, N., S. Guiral, I. Gorska-Flipot, D. Labuda, and D. Sinnett. 1999. Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and hMSH3 in sporadic breast cancer. Br. J. Cancer 79:1012-1017.
4. Brown, E. J., and D. Baltimore. 2000. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14:397-402.
5. Bunz, F., A. Dutriaux, C. Lengauer, T. Waldman, S. Zhou, J. P. Brown, J. M. Sedivy, K. W. Kinzler, and B. Vogelstein. 1998. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497-1501.
6. Carr-Schmid, A., C. Pfund, E. A. Craig, and T. G. Kinzy. 2002. Novel G-protein complex whose requirement is linked to the translational status of the cell. Mol. Cell. Biol. 22:2564-2574.
7. Castrillon, D. H., P. Gönczy, S. Alexander, R. Rawson, C. G. Eberhart, S. Viswanathan, S. DiNardo, and S. A. Wasserman. 1993. Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutant generated by single E-element mutagenesis. Genetics 135:489-505.
8. Davis, L., and J. Engebrecht. 1998. Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes. Genetics 149:45-56.
9. Dobles, M., V. Liberal, M. L. Scott, R. Benezra, and P. K. Sorger. 2000. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101:635-645.
10. Eberhart, C. G., and S. A. Wasserman. 1995. The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis. Development 121:3477-3486.
11. Frolova, L., X. Le Goff, H. H. Rasmussen, S. Cheperegin, G. Drugeon, M. Kress, I. Arman, A. L. Haenni, J. E. Celis, M. Philipp, J. Justesen, L. Kisselev. 1994. A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor. Nature 372:701-703.
12. Hartwell, L. H., and T. A. Weinert. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science 246:629-635.
13. He, X., T. E. Patterson, and S. Sazer. 1997. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc. Natl. Acad. Sci. USA 94:7965-7970.
14. Hoyt, M. A., I. Totis, and B. T. Roberts. 1991. S. Cerevisiae gene required for cell cycle arrest in response to loss of microtubule function. Cell 66:507-517.
15. Kalitsis, P., E. Earle, K. J. Fowler, and K. H. Choo. 2000. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev. 14:2277-2282.
16. Kinzler, K. W., and B. Vogelstein. 1997. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386:761-763.
17. Kuriyama, R., P. Savereide, P. Lefebvre, and S. Dasgupta. 1990. The predicted amino acid sequence of a centrosphere protein in dividing sea urchin eggs is similar to elongation factor (EF-1α). J. Cell Sci. 95:231-236.
18. Lengauer, C., K. Kinzler, and B. Vogelstein. 1997. Genetic instability in colorectal cancers. Nature 386:623-627.
19. Murty, V. V., V. E. Reuter, G. J. Bosl, and R. S. Chaganti. 1996. Deletion mapping identifies loss of heterozygosity at 5q15.1-15.2,5q11 and 5q34-35 in human male germ cell tumors. Oncogene 12:2719-2723.
20. Nagy, A., and J. Rossant. 1993. Production of completely ES cell-derived fetuses, p. 147-179. In A. L. Joyner (ed.), Gene targeting: a practical approach. IRL Press, Oxford, England.
21. Ohta, K., M. Toriyama; M. Miyazaki, M. Murofushi, S. Hosoda, S. Endo, and H. Sakai. 1990. The mitotic apparatus-associated 51-kDa protein from sea urchin eggs is a GTP-binding protein and is immunologically related to yeast polypeptide elongation factor 1α. J. Biol. Chem. 265:3240-3247.
22. Ragan, M. A., J. M. Logsdon, C. W. Sensen, R. L. Charlebois, and W. F. Doolittle. 1996. An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes. FEMS Microbiol. Lett. 144:151-155.
23. Rugh, R. 1990. The mouse, p. 44-101. Oxford University Press, London. England.
24. Shamsadin, R., I. M. Adham, G. von Beust, and W. Engel. 2000. Molecular cloning, expression and chromosomal localization of the human pelota gene PELO. Cytogenet. Cell Genet. 90:75-78.
25. Shamsadin, R., I. M. Adham, and W. Engel. 2002. Mouse pelota gene (Pelo): cDNA cloning, genomic structure, and chromosomal localization. Cytogenet. Genome Res. 97:95-99.
26. Shiina, N., Y. Gotoh, N. Kubomura, A. Iwamatsu, and E. Nishida. 1994. Microtubule severing by elongation factor 1α. Science 266:282-285.
27. Snow, M. 1977. Gastrulation in the mouse: growth and regionalization of the epiblast. J. Embryol. Exp. Morphol. 42:293-303.
28. -/- mice. Genes Dev. 14:1439-1447.
29. Tybulewicz, V. L., C. E. Crawford, P. T. Bronson, and R. C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl protooncogene. Cell 65:1153-1163.
30. Waldman, T., C. Lenghauer, K. W. Kinzler, and B. Vogelstein. 1996. Uncoupling of the S phase and mitosis induced by anticancer agents in cell lacking p21. Nature 381:713-716.
31. Walworth, N., S. Davey, and D. Beach. 1993. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363:368-371.
32. Wurst, W., and A. L. Joyner. 1993. Production of targeted embryonic stem cell clones, p. 33-61. In A. L. Joyner (ed.), Gene targeting: a practical approach. IRL Press, Oxford, England.
33. Xu, X., Z. Weaver, S. P. Linke, C. Li, J. Gotay, X.-W. Wang, C. C. Harris, T. Ried, and C.-X. Deng. 1999. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetics instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3:389-395.