Microparticle- and Nanoparticle-Based Contrast-Enhanced Ultrasound Imaging

Nanoplatform-Based Molecular Imaging

Volumn , Issue , 2011, Pages 233-262

  Deshpande, Nirupama ^a   Willmann, Jürgen K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Microparticle and nanoparticle based contrast enhanced ultrasound imaging; Pulse inversion imaging technology two successive ultrasonic pulses emitted, second phase pulse inverted with the first phase; Targeted nanoparticle use, for ultrasound imaging of inflammation and thrombus formation some published studies

Indexed keywords

EID: 84862487103     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470767047.ch11     Document Type: Chapter

References (82)

1. Hoskins, P. R.; Thrush, A.; Martin, K.; Whittingham, T. A. Diagnostic Ultrasound. Greenwich Medical Media Ltd, London, 2003.
2. Hauff, P.; Foster, S. Ultrasound Basics. Springer-Verlag: Berlin, 2008.
3. Dogra, V.; Rubens, D. J. Ultrasound Secrets. Hanley & Belfus Medical Publishers: Philadelphia, PA, 2003.
4. Aljarboua, Z. Ultrasound effect on biological tissue. Open Educational Resource. 2008.
5. Willmann, J. K.; van Bruggen, N.; et al. Molecular imaging in drug development. Nat. Rev. Drug Discov. 2008, 7(7), 591-607.
6. Rumack, C. M.; Wilson, S. R.; Charboneau, J. W.; Johnson, J. Diagnostic Ultrasound. Mosby: New York, 1998.
7. Leighton, G. The Acoustic Bubble. Academic Press, Inc: London, UK, 1997, 1-117.
8. Lindner, J. R. Molecular imaging with contrast ultrasound and targeted microbubbles. J. Nucl. Cardiol. 2004, 11(2), 215-221.
9. Soye, J. A.; Mullan, C. P.; et al. The use of contrast-enhanced ultrasound in the characterisation of focal liver lesions. Ulster Med. J. 2007, 76(1), 22-25.
10. Stanley, B. Safe use of ultrasound contrast agents. Ultrasound Med. Biol. 2007, 33(2), 171-172.
11. Klibanov, A. L. Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. Bioconjug. Chem. 2005, 16(1), 9-17.
12. Junru, Wu, W. L. N. Ultrasound, cavitation bubbles and their interaction with cells. Adv. Drug Deliv. Rev. 2008, 60, 1103-1116.
13. Klibanov, A. L.Molecular imaging with targeted ultrasound contrast microbubbles. Ernst Schering Res. Found. Workshop 2005, 49, 171-191.
14. Willmann, J. K.; Kimura, R. H.; Deshpande, N.; Lutz, A. M.; Rosenberg, J.; Cochran, J. R.; Gambhir, S. S. Novel integrin-binding ultrasound contrast agent for molecular ultrasound imaging of tumor angiogenesis. J. Nucl. Med. 2010, 51, 433-440.
15. Pysz, M. A.; Foygel, K.; Rosenberg, J.; Gambhir, S. S.; Schneider, M.; Willmann, J. K. Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55). Radiology 2010, 256(2), 519-527.
16. Pochon, S.; Tardy, I.; Bussat, P.; Bettinger, T.; Brochot, J.; von Wronski, M.; Passantino, L.; Schneider,M. BR55: a lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis. Invest Radiol. 2010, 45(2), 89-95.
17. Shah, P. M.; Gramiak, R.; et al. Determinants of atrial (S4) and ventricular (S3) gallop sounds in primary myocardial disease. N. Engl. J. Med. 1968, 278(14), 753-758.
18. Burns, M. Marketing challenges continue for ultrasound contrast media. Biotech Systems Inc. 2004, http://www.biotechsystems.com
19. Lanza, G. M.; Wickline, S. A. Targeted ultrasonic contrast agents for molecular imaging and therapy. Curr. Probl. Cardiol. 2003, 28(12), 625-653.
20. Lindner, J. R.; Song, J.; et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation 2000, 102(22), 2745-2750.
21. Fisher Science Education, Hanover Park, IL. www.fishersci.com
22. Oussoren, C.; Zuidema, J.; Crommelin, D. J.; Storm, G. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid dose. Biochm. Biophys. Acta. 1997, 1328, 261-272.
23. Klibanov, A. L. Targeted delivery of gas-filled microspheres, contrast agents for ultrasound imaging. Adv. Drug Deliv. Rev. 1999, 37, 139-157.
24. Klibanov, A. L.; Rasche, P. T.; et al. Detection of individual microbubbles of ultrasound contrast agents: imaging of free-floating and targeted bubbles. Invest. Radiol. 2004, 39(3), 187-195.
25. McCulloch, M.; Gresser, C.; et al. Ultrasound contrast physics: a series on contrast echocardiography, article 3. J. Am. Soc. Echocardiogr. 2000, 13(10), 959-967.
26. Leong-Poi, H.; Song, J.; et al. Influence of microbubble shell properties on ultrasound signal: implications for low-power perfusion imaging. J. Am. Soc. Echocardiogr. 2002, 15(10 Pt 2), 1269-1276.
27. Chomas, J. E.; Pollard, R. E.; et al. Contrast-enhanced US of microcirculation of superficially implanted tumors in rats. Radiology 2003, 229(2), 439-446.
28. Pollard, R. E.; Sadlowski, A. R.; et al. Contrast-assisted destruction-replenishment ultrasound for the assessment of tumor microvasculature in a rat model. Technol. Cancer Res. Treat. 2002, 1(6), 459-470.
29. Willmann, J. K.; Paulmurugan, R.; et al. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology 2008, 246(2), 508-518.
30. Walday, P.; Tolleshaug, H.; et al. Biodistributions of air-filled albumin microspheres in rats and pigs. Biochem. J. 1994, 299(Pt 2), 437-443.
31. Perkins, A. C.; Frier,M.; et al. Human biodistribution of an ultrasound contrast agent (Quantison) by radiolabelling and gamma scintigraphy. Br. J. Radiol. 1997, 70(834), 603-611.
32. Willmann, J. K.; Cheng, Z.; et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology 2008, 249(1), 212-219.
33. Weller, G. E.; Lu, E.; et al. Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1. Circulation 2003, 108(2), 218-224.
34. Korpanty, G.; Carbon, J. G.; et al. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin. Cancer Res. 2007, 13(1), 323-330.
35. Palmowski, M.; Huppert, J.; et al. Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects. Mol. Cancer Ther. 2008, 7(1), 101-109.
36. Gref, R.; Domb, P.; Quellec, P.; Blunk, T.; Muller, R. H.; Verbavatz, J. M.; Langer, R. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv. Drug Deliv. Rev. 1995, 16, 215-233.
37. Brigger, I.; Dubernet, C.; et al. Nanoparticles in cancer therapy and diagnosis. Adv. Drug. Deliv. Rev. 2002, 54(5), 631-651.
38. Lanza, G. M.; Wallace, K. D.; et al. High-frequency ultrasonic detection of thrombi with a targeted contrast system. Ultrasound Med. Biol. 1997, 23(6), 863-870.
39. Pana, D.;Wickline, S. A.; Caruthers, S. D. Nanomedicine: perspective and promises with liganddirected molecular imaging. Eur. J. Radiol. 2009, 70(2), 274-285.
40. Lanza, G. M.; Trousil, R. M.; Wallace, K. D.; Scott M. J.; Miller J. G.; Eisenberg P. R.; Gaffney P. J.;Wickline S. A. In vitro characterization of a novel, tissue-targeted ultrasonic contrast system with acoustic microscopy. J. Acoust. Soc. Am. 1998, 104, 3665-3672.
41. Kripfgans, O. D.; Fabiilli, M. L.; Cardon, P. L.; et al. On the acoustic vaporization of micrometersized droplets. J. Acoust. Soc. Am. 2004, 116(1), 272-281.
42. Amirriazi, S.; Eghtedari, M.; Jin, S.; et al. Increasing ultrasound sensitivity to perfluorocarbon emulsion droplets. World Molecular Imaging Congress: Montreal, Canada, 2009 (abstract).
43. Joseph, P. M.; Kundel, H. L.; Mukherji, B.; Sloviter, H. A.; Magnetic resonance imaging of fluorine in rats infused with artificial blood. Invest. Radiol. 1985, 20, 504-509.
44. Mukherji, H. A. S. a. B. Prolonged retention in the circulation of emulsified lipid-coated perfluorochemicals. Prog. Clin. Biol. Res. 1983, 122, 181-187.
45. Liu, J.; Levine, A. L.; Li, J.; et al. Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitro. Phys. Med. Biol. 2007, 52(16), 4739-4747.
46. Rapoport, N.; Gao, Z.; et al. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J. Natl. Cancer Inst. 2007, 99(14), 1095-1106.
47. Liu, J.; Mattoon, J. S.; Yamaguchi, M.; Lee, R. J.; Pan, X.; Rosol, T. J. Nanoparticles as image enhancing agents for ultrasonography. Phys. Med. Biol. 2006, 51(9), 2179-2189.
48. Maeda, H.; Wu, J.; et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Control. Release 2000, 65(1-2), 271-284.
49. Nolte, I.; Vince, G. H.; Maurer, M.; Herbold, C.; Goldbrunner, R.; Solymosi, L.; Stoll, G.; Bendszus, M. Iron particles enhance visualization of experimental gliomas with high resolution sonography. Am. J. Neuroradiol. 2005, 26, 1469-1474.
50. Linker, R. A.; Kroner, A.; et al. Iron particle-enhanced visualization of inflammatory central nervous system lesions by high resolution: preliminary data in an animal model. Am. J. Neuroradiol. 2006, 27(6), 1225-1229.
51. Torchilin, V. P. Liposomes as Carriers of Contrast Agents for In Vivo Diagnostics. Elsevier Science: New York, 1998.
52. MacDonald, R. Applications of Freezing and Thawing in Liposome Technology. CRC Press: Boca Raton, FL, 1993.
53. Demos, S.M.; Onyuksel, H.; et al. In vitro targeting of antibody-conjugated echogenic liposomes for site-specific ultrasonic image enhancement. J. Pharm. Sci. 1997, 86(2), 167-171.
54. Senior, J. H. Fate and behaviour of liposomes in vivo: a review of controlling factors. Crit. Rev. Ther. Drug Carrier Syst. 1987, 3, 123-193.
55. Oku, N.; Tokudome, Y.; et al. Evaluation of drug targeting strategies and liposomal trafficking. Curr. Pharm. Des. 2000, 6(16), 1669-1691.
56. Marik, J.; Tartis,M. S.; et al. Long-circulating liposomes radiolabeled with [18F]fluorodipalmitin ([18F]FDP). Nucl. Med. Biol. 2007, 34(2), 165-171.
57. Ellegala, D. B.; Leong-Poi, H.; et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 2003, 108(3), 336-341.
58. Weller, G. E.; Wong, M. K.; et al. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res. 2005, 65(2), 533-539.
59. Willmann, J. K.; Lutz, A. M.; et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology 2008, 248(3), 936-944.
60. Rychak, J. J.; Graba, J.; et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol. Imaging 2007, 6(5), 289-296.
61. Lyshchik, A.; Fleischer, A. C.; et al. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography. J. Ultrasound Med. 2007, 26(11), 1575-1586.
62. Deshpande, N.; Ren, Y.; Foygel, K.; Rosenberg, J.;Willmann, J. K. Tumor angiogenic marker expression levels during tumor growth: longitudinal assessment with molecular ultrasound imaging. Radiology (in press)
63. Lindner, J. R.; Song, J.; et al. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001, 104(17), 2107-2112.
64. Kaufmann, B. A.; Lewis,C.; Xie, A.; et al. Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography. Eur. Heart J. 2007, 28(16), 2011.
65. Villanueva, F. S.; Lu, E.; et al. Myocardial ischemic memory imaging with molecular echocardiography. Circulation 20(3), 345-352.
66. Bachmann, C.; Klibanov, A. L.; et al. Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasiage experimental Crohn's disease. Gastroenterology 2006, 130(1), 8-16.
67. Kaufmann, B. A.; Sanders, J. M.; et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasountion of vascular cell adhesion molecule-1. Circulation 2007, 116(3), 276-284.
68. Kondo, I.; Ohmori, K.; et al. Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acuteaft rejection in a rat cardiac transplantation model. Circulation 2004, 109(8), 1056-1061.
69. Unger, E. C.; McCreery, T. P.; et al. In vitro studies of a new thrombus-specific ultrasound contrast agent. Am. J. . 1998, 81(12A), 58G-61G.
70. Hauff, P.; Reinhardt, M.; et al. Molecular targeting of lymph nodes with L-selectin ligand-specific US contrast agenasibility study in mice and dogs. Radiology 2004, 231(3), 667-673.
71. Hamilton, A. J.; Huang, S. L.; et al. Intravascular ultrasound molecular imaging of atheroma components in vivo. J. l. Cardiol. 2004, 43(3), 453-460.
72. Lanza, G. M.; Abendschein, D. R.; et al. In vivo molecular imaging of stretch-induced tissue factor in carotid arterh ligand-targeted nanoparticles. J. Am. Soc. Echocardiogr. 2000, 13(6), 608-614.
73. Bloch, S. H.; Dayton, P. A.; et al. Targeted imaging using ultrasound contrast agents. Progess and opportunities foral and research applications. IEEE Eng. Med. Biol. Mag. 2004, 23(5), 18-29.
74. Kiessling, F.; Huppert, J.; et al. Functional and molecular ultrasound imaging: concepts and contrast agents. Curr. em. 2009, 16(5), 627-642.
75. Lindner, J. R.; Dayton, P. A.; Coggins,M. P.; Ley, K.; Song, J.; Ferrara, K.; Kaul, S. Noninvasive imaging of inflammy ultrasound detection of phagocytosed microbubbles. Circulation 2000, 102, 531-538.
76. Schumann, P. A.; Christiansen, J. P.; et al. Targeted-microbubble binding selectively to GPIIb IIIa receptors of plahrombi. Invest. Radiol. 2002, 37(11), 587-593.
77. Blomley,M. J.; Albrecht, T.; et al. Improved imaging of liver metastases with stimulated acoustic emission in the lae of enhancement with the US contrast agent SH U 508A: early experience. Radiology 1999, 210(2), 409-416.
78. Brice, J. "FDA eases black box restrictions for ultrasound contrast media." Diagnostic Imaging, 2008, http://www.diagmaging.com.
79. Kim, T. K.; M.; Jang, H.-J.; Wilson, S. R. Microbubble contrast agents for ultrasound imaging-safety and efficacy in al and vascular imaging. US Radiology 2008, 1(1), 54-57.
80. Deshpande, N.; Needles, A.; Willmann, J. K. Molecular ultrasound imaging: current status and future directions. Clin. 2010, 65, 567-581.
81. Pysz, M.; Gambhir, S. S.; Willmann, J. K. Molecular Imaging: current status and emerging strategies. Clin. Radiol. 20 500-515.
82. Deshpande, N.; Pysz, M.; Willmann, J. K. Molecular ultrasound assessment of tumor angiogenesis. Angiogenesis 2010 (Epd of print).