Contrast-assisted destruction-replenishment ultrasound for the assessment of tumor microvasculature in a rat model

Technology in Cancer Research and Treatment

Volumn 1, Issue 6, 2002, Pages 459-470

  Pollard, Rachel E ^a   Sadlowski, Amy R ^b   Bloch, Susannah H ^b   Murray, Lesley ^c   Wisner, Erik R ^d   Griffey, Stephen ^a   Ferrara, Katherine W ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c SUGEN INC   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; PERFLUTREN; SU 11657; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B SCAN; BREAST ADENOCARCINOMA; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; MEASUREMENT; MICROVASCULARIZATION; NONHUMAN; RAT; TUMOR BLOOD FLOW; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME;

EID: 0038674306     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.1177/153303460200100606     Document Type: Article

References (26)

1. Weidner, N., Tumour Vascularity and Proliferation: Clear Evidence of a Close Relationship. J. Pathol. 189, 297-9 (1999).
2. Rosen, L. S., Clinical Experience With Angiogenesis Signaling Inhibitors: Focus on Vascular Endothelial Growth Factor (VEGF) Blockers. Cancer Control 9, 36-44 (2002).
3. Mendel, D., et al., In Vivo Anti-tumor Activity of SU11248, A Novel Tyrosine Kinase Inhibitor Targeting VEGF and PDGF Receptors: Determination of a Pharmacokinetic/Pharmacodynamic Relationship. Clinical Cancer Research, in press (2002).
4. Vajkoczy, P., et al., Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy. Neoplasia 1, 31-41 (1999).
5. Burns, P., S. Wilson, and D. Hope Simpson, Pulse Inversion Imaging of Liver Blood Flow: Improved Method for Characterizing Focal Masses with Microbubble Contrast. Investigative Radiology 35, 58-71 (2000).
6. Ragavendra, N., et al., Harmonic Imaging of Porcine Intraovarian Arteries Using Sonographic Contrast Medium: Initial Findings. Ultrasound Obstet Gynecol 9, 266-70 (1997).
7. Chomas, J. E., et al., Contrast-assisted Ultrasound Evaluation of Tumor Microcirculation. Radiology, in press.
8. Freireich, E. J., et al., Quantitative Comparison of Toxicity of Anticancer Agents in Mouse, Rat, Hamster, Dog, Monkey, and Man. Cancer Chemother Rep 50, 219-44 (1966).
9. Chomas, J. E., The Optimization of Ultrasonic Contrast Agent Destruction for the Assessment of Blood Perfusion. Ph.D. Dissertation, University of Virginia, 2002.
10. Simpson, N. E. and J. L. Evelhoch, Deuterium NMR Tissue Perfusion Measurements Using the Tracer Uptake Approach: II. Comparison with Microspheres in Tumors. Magn. Reson. Med. 42, 240-7 (1999).
11. Netti, P. A., et al., Effect of Transvascular Fluid Exchange on Pressure-flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity. Microvasc. Res. 52, 27-46 (1996).
12. Chomas, J. E., et al., Mechanisms of Contrast Agent Destruction. IEEE Trans. Ultrason Med. Biol. Control 48, 232-48 (2001).
13. Sboros, V., et al., Contrast Agent Stability: A Continuous B-mode Imaging Approach. Ultrasound Med. Biol. 27, 1367-77 (2001).
14. Tiemann, K., et al., The Impact of Emission Power on the Destruction of Echo Contrast Agents and on the Origin of Tissue Harmonic Signals Using Power Pulse-inversion Imaging. Ultrasound Med. Biol. 27, 1525-33 (2001).
15. Wei, K., et al., Quantification of Myocardial Blood Flow with Ultrasound-induced Destruction of Microbubbles Administered as a Constant Venous Infusion. Circulation 97, 473-83 (1998).
16. Rocchi, G., et al., Usefulness of Power Doppler Contrast Echocardiography to Identify Reperfusion After Acute Myocardial Infarction. Am. J. Cardiol. 87, 278-82 (2001).
17. Porter, T. R., et al., Noninvasive Identification of Acute Myocardial Ischemia and Reperfusion with Contrast Ultrasound Using Intravenous Perfluoropropane-exposed Sonicated Dextrose Albumin. J. Am. Coll. Cardiol. 26, 33-40 (1995).
18. Hancock, J., et al., Evaluation of Myocardial, Hepatic, and Renal Perfusion in a Variety of Clinical Conditions Using an Intravenous Ultrasound Contrast Agent (Optison) and Second Harmonic Imaging. Heart 81, 636-41 (1999).
19. Wei, K., et al., Quantification of Renal Blood Flow with Contrast-enhanced Ultrasound. J. Am. Coll. Cardiol. 37, 1135-40 (2001).
20. Lindner, J. R., et al., Assessment of Resting Perfusion with Myocardial Contrast Echocardiography: Theoretical and Practical Considerations. Am. Heart. J. 139, 231-40 (2000).
21. Forsberg, F., W. T. Shi, and B. B. Goldberg, Subharmonic Imaging of Contrast Agents. Ultrasonics 38, 93-8 (2000).
22. Blomley, M. J., et al., Contrast Bolus Dynamic Computed Tomography for the Measurement of Solid Organ Perfusion. Invest. Radiol. 28, S72-7; discussion S78 (1993).
23. Guthaner, D. F., M. Nassi, and B. Bradley, Validation of a CT Method for Flow Determination. Work in progress. Radiology 151, 429-32 (1984).
24. Dawson, P. and A. M. Peters, What is the Nephrogram? Br. J. Radiol. 67, 21-5 (1994).
25. Miles, K. A., Tumour Angiogenesis and its Relation to Contrast Enhancement on Computed Tomography: A Review. Eur. J. Radiol. 30, 198-205 (1999).
26. Harvey, C. J., et al., Functional CT Imaging of the Acute Hyperemic Response to Radiation Therapy of the Prostate Gland: Early Experience. J. Comput. Assist. Tomogr. 25, 43-9 (2001).