The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women

Gene

Volumn 504, Issue 1, 2012, Pages 75-83

  Oishi, Yoshie ^a   Watanabe, Yoko ^a   Shinoda, Shoko ^a   Naka, Mamiko ^b   Ozawa, Yoshiteru ^c   Matsuyama, Takeshi ^c   Morozumi, Kyoei ^c   Fuke, Yoko ^a  

^a TOKYO METROPOLITAN UNIVERSITY   (Japan)

^b Ihc Marunouchi Integrated Health Clinic for Women   (Japan)

^c Fussa Hospital   (Japan)

Author keywords

Bone mineral density; Immune cytokine; Osteoporosis; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); INTERLEUKIN 17F; INTERLEUKIN 6; OSTEOPROTEGERIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BONE DENSITY; FEMALE; FEMUR NECK; GENE FREQUENCY; GENE TARGETING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; JAPANESE; LUMBAR SPINE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; COHORT STUDIES; FEMALE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-6; MIDDLE AGED; OSTEOPOROSIS; POLYMORPHISM, GENETIC; PROGNOSIS; YOUNG ADULT;

EID: 84862337570     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.04.054     Document Type: Article

References (50)

1. Albagha O.M.E., et al. Association of oestrogen receptor alpha gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone. J. Med. Genet. 2005, 42:240-246.
2. Arron J.R., Choi Y. Bone versus immune system. Nature 2000, 408:535-536.
3. Bachrach L.K. Acquisition of optimal bone mass in childhood and adolescence. Trends Endocrinol. Metab. 2001, 12:22-28.
4. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
5. Carrié Fässler A.L., Bonjour J.P. Osteoporosis as a pediatric problem. Pediatr. Clin. North Am. 1995, 42:811-824.
6. Czerny B., et al. The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women. Eur. J. Obstet. Gynecol. Reprod. Biol. 2010, 149:82-85.
7. Dempster D.W., et al. Normal human osteoclasts formed from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts. J. Cell. Biochem. 2005, 95:139-148.
8. Diamantopoulos A.P., et al. Incidence rates of fragility hip fracture in middle-aged and elderly men and women in southern Norway. Age Ageing 2012, 41:86-92.
9. Ferrari S.L., Garnero P., Emond S., Montgomery H., Humphries S.E., Greenspan S.L. A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women. Arthritis Rheum. 2001, 44:196-201.
10. Ilich J.Z., Badenhop N.E., Matkovic V. Primary prevention of osteoporosis: pediatric approach to disease of the elderly. Womens Health Issues 1996, 6:194-203.
11. Jacques P.F., et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996, 93:7-9.
12. Ji G.-R., Yao M., Sun C.-Y., Zhang L., Han Z. Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis. J. Int. Med. Res. 2009, 37:1725-1732.
13. Jørgensen H.L., et al. Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif. Tissue Int. 2002, 71:386-392.
14. Jørgensen H.L., Kusk P., Madsen B., Fenger M., Lauritzen J.B. Serum osteoprotegerin (OPG) and the A163G polymorphism in the OPG promoter region are related to peripheral measures of bone mass and fracture odds ratios. J. Bone Miner. Metab. 2004, 22:132-138.
15. Kawaguchi M., et al. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J. Allergy Clin. Immunol. 2006, 117:795-801.
16. Kawaguchi M., et al. IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway. Am. J. Physiol. Lung Cell Mol. Physiol. 2009, 296:L804-L810.
17. Kido S., Kuriwaka-Kido R., Imamura T., Ito Y., Inoue D., Matsumoto T. Mechanical stress induces interleukin-11 expression to stimulate osteoblast differentiation. Bone 2009, 45:1125-1132.
18. Kim O.J., et al. Association between tumor necrosis factor-alpha (-308G→A and -238G→A) polymorphisms and homocysteine levels in patients with ischemic strokes and silent brain infarctions. Cerebrovasc. Dis. 2010, 30:483-490.
19. Kleinbaum D.G., Kupper L.L., Muller K.E. Applied regeneration analysis and other multivariate methods 1998, 299-301. PWS-Kent, Boston. second ed.
20. Langdahl B.L., Carstens M., Stenkjaer L., Eriksen E.F. Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures. J. Bone Miner. Res. 2002, 17:1245-1255.
21. Lario S., Iñigo P., Campistol J.M., Poch E., Rivera F., Oppenheimer F. Restriction enzyme-based method for transforming growth factor-beta (1) genotyping: nonisotopic detection of polymorphisms in codons 10 and 25 and the 5'-flanking region. Clin. Chem. 1999, 45:1290-1292.
22. Li M., Lau E.M.C., Woo J. Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women. Bone 2004, 35:1369-1374.
23. Liao W.-C., et al. Serum interleukin-6 level but not genotype predicts survival after resection in stages II and III gastric carcinoma. Clin. Cancer Res. 2008, 14:428-434.
24. Magaziner J., Simonsick E.M., Kashner T.M., Hebel J.R., Kenzora J.E. Survival experience of aged hip fracture patients. Am. J. Public Health 1989, 79:274-278.
25. Miyao M., et al. Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif. Tissue Int. 2000, 66:190-194.
26. Miyaura C., et al. Endogenous bone-resorbing factors in estrogen deficiency: cooperative effects of IL-1 and IL-6. J. Bone Miner. Res. 1995, 10:1365-1373.
27. Moffett S.P., et al. Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women. J. Clin. Endocrinol. Metab. 2005, 90:3491-3497.
28. Morrison N.A., et al. Prediction of bone density from vitamin D receptor alleles. Nature 1994, 367:284-287.
29. Mudd S.H., et al. The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am. J. Hum. Genet. 1985, 37:1-31.
30. Mundy G.R. Bone remodeling and mechanisms of bone loss in osteoporosis. Osteoporosis: Diagnosis and Management 1998, 17-34. Martindunitz, London. P.J. Meumier (Ed.).
31. Oishi Y., Shinoda S., Watanabe Y., Naka M., Fuke Y. A pilot study of genetic polymorphisms commonly associated with osteoporosis and bone mineral density in young Japanese women. Jpn. J. Prev. Med. 2012, 7:11-15.
32. Orimo H., et al. Diagnostic criteria for primary osteoporosis. J. Bone Miner. Metab. 1998, 16:139-150.
33. Orimo H., et al. Diagnostic criteria for primary osteoporosis: year 2000 revision. J. Bone Miner. Metab. 2001, 19:331-337.
34. Ota N., et al. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. J. Hum. Genet. 2001, 46:267-272.
35. Oursler M.J., et al. Modulation of transforming growth factor-beta production in normal human osteoblast-like cells by 17 beta-estradiol and parathyroid hormone. Endocrinology 1991, 129:3313-3320.
36. Poli V., et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 1994, 13:1189-1196.
37. Riancho J.A., et al. Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication. Eur. J. Endocrinol. 2011, 164:123-131.
38. Roberts A.B., Sporn M.B. The transforming growth factor-βs. Peptide Growth Factors and Their Receptors, Part I 1990, 419-472. Springer-Verlag, Berlin. M.B. Sporn, A.B. Roberts (Eds.).
39. Saito M., Marumo K. Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos. Int. 2010, 21:195-214.
40. Sato K., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 2006, 203:2673-2682.
41. Seiderer J., et al. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm. Bowel Dis. 2008, 14:437-445.
42. Simonet W.S., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997, 89:309-319.
43. Soufi M., et al. Osteoprotegerin gene polymorphisms in men with coronary artery disease. J. Clin. Endocrinol. Metab. 2004, 89:3764-3768.
44. Suresh S. A new paradigm in autoimmunity-role in periodontal disease. Indian J. Dent. Adv. 2011, 03:583-586.
45. Takayanagi H. Mechanistic insight into osteoclast differentiation in osteoimmunology. J. Mol. Med. 2005, 83:170-179.
46. Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol. 2007, 7:292-304.
47. van Meurs J.B.J., et al. Homocysteine levels and the risk of osteoporotic fracture. N. Engl. J. Med. 2004, 350:2033-2041.
48. Yamada Y. Association of a Leu (10)->Pro polymorphism of the transforming growth factor-beta1 with genetic susceptibility to osteoporosis and spinal osteoarthritis. Mech. Ageing Dev. 2000, 116:113-123.
49. Yamada Y., Ando F., Niino N., Shimokata H. Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men. J. Clin. Endocrinol. Metab. 2003, 88:3372-3378.
50. Zajícková K., Zemanová A., Hill M., Zofková I. Is A163G polymorphism in the osteoprotegerin gene associated with heel velocity of sound in postmenopausal women?. Physiol. Res. 2008, 57(Suppl. 1):S153-S157.