Acetylcholinesterase inhibitors attenuate angiogenesis

Clinical Science

Volumn 123, Issue 4, 2012, Pages 241-249

  Miyazaki, Ryohei ^a   Ichiki, Toshihiro ^a   Hashimoto, Toru ^a   Ikeda, Jiro ^a   Kamiharaguchi, Aya ^a   Narabayashi, Eriko ^a   Matsuura, Hirohide ^a   Takeda, Kotaro ^a   Sunagawa, Kenji ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Acetylcholinesterase inhibitor; Angiogenesis; Hindlimb ischaemia; Interleukin 1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; BETHANECHOL; DONEPEZIL; INTERLEUKIN 1BETA; MESSENGER RNA; NICOTINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHYSOSTIGMINE; PROTEIN KINASE B; RECOMBINANT INTERLEUKIN 1BETA; VASCULOTROPIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHOLINESTERASE INHIBITOR; CHROMONE DERIVATIVE; INDAN DERIVATIVE; MORPHOLINE DERIVATIVE; PIPERIDINE DERIVATIVE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTERY LIGATION; ARTICLE; BLOOD FLOW; CAPILLARY DENSITY; CONTROLLED STUDY; DOWN REGULATION; DRUG ANTAGONISM; FEMORAL ARTERY; HINDLIMB; HINDLIMB ISCHEMIA; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIMB ISCHEMIA; MOUSE; MYOBLAST; NONHUMAN; OSMOTIC MINIPUMP; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; ISCHEMIA; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PHOSPHORYLATION; PHYSIOLOGY; VASCULARIZATION;

ACETYLCHOLINE; ANIMALS; CELLS, CULTURED; CHOLINESTERASE INHIBITORS; CHROMONES; HINDLIMB; INDANS; INTERLEUKIN-1BETA; ISCHEMIA; MICE; MICE, INBRED C57BL; MORPHOLINES; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84862337182     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20110633     Document Type: Article

References (27)

1. Winblad, B., Kilander, L., Eriksson, S., Minthon, L., Batsman, S., Wetterholm, A. L., Jansson-Blixt, C. and Haglund, A. (2006) Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study. Lancet 367, 1057-1065
2. Reale, M., Iarlori, C., Gambi, F., Lucci, I., Salvatore, M. and Gambi, D. (2005) Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1β and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Exp. Gerontol. 40, 165-171
3. Rosas-Ballina, M. and Tracey, K. J. (2009) Cholinergic control of inflammation. J. Intern. Med. 265, 663-679
4. Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J.W. and Tracey, K. J. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458-462
5. Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J. et al. (2004) Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 10, 1216-1221
6. de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M., van Westerloo, D. J., Bennink, R. J., Berthoud, H. R., Uematsu, S., Akira, S., van den Wijngaard, R. M. and Boeckxstaens, G. E. (2005) Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat. Immunol. 6, 844-851
7. Taqueti, V. R., Mitchell, R. N. and Lichtman, A. H. (2006) Protecting the pump: controlling myocardial inflammatory responses. Annu. Rev. Physiol. 68, 67-95
8. Hoefer, I. E., van Royen, N., Rectenwald, J. E., Bray, E. J., Abouhamze, Z., Moldawer, L. L., Voskuil, M., Piek, J. J., Buschmann, I. R. and Ozaki, C. K. (2002) Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. Circulation. 105, 1639-1641
9. Carmeliet, P. (2003) Angiogenesis in health and disease. Nat. Med. 9, 653-660
10. Tateno, K., Minamino, T., Toko, H., Akazawa, H., Shimizu, N., Takeda, S., Kunieda, T., Miyauchi, H., Oyama, T., Matsuura, K. et al. (2006) Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. Circ. Res. 98, 1194-1202
11. Bhat, R. V., Turner, S. L., Marks, M. J. and Collins, A. C. (1990) Selective changes in sensitivity to cholinergic agonists and receptor changes elicited by continuous physostigmine infusion. J. Pharmacol. Exp. Ther. 255, 187-196
12. Saxena, G., Singh, S. P., Agrawal, R. and Nath, C. (2008) Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. Eur. J. Pharmacol. 581, 283-289
13. Heeschen, C., Jang, J. J., Weis, M., Pathak, A., Kaji, S., Hu, R. S., Tsao, P. S., Johnson, F. L. and Cooke, J. P. (2001) Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat. Med. 7, 833-839
14. Choi, K. M., Zhu, J., Stoltz, G. J., Vernino, S., Camilleri, M., Szurszewski, J. H., Gibbons, S. J. and Farrugia, G. (2007) Determination of gastric emptying in nonobese diabetic mice. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G1039-G1045
15. Baschong, W., Suetterlin, R. and Laeng, R. H. (2001) Control of autofluorescence of archival formaldehyde-fixed, paraffin-embedded tissue in confocal laser scanning microscopy (CLSM). J. Histochem. Cytochem. 49, 1565-1572
16. Imayama, I., Ichiki, T., Inanaga, K., Ohtsubo, H., Fukuyama, K., Ono, H., Hashiguchi, Y. and Sunagawa, K. (2006) Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferatoractivated receptor γ. Cardiovasc. Res. 72, 184-190
17. Amano, K., Okigaki, M., Adachi, Y., Fujiyama, S., Mori, Y., Kosaki, A., Iwasaka, T. and Matsubara, H. (2004) Mechanism for IL-1β-mediated neovascularization unmasked by IL-1β knock-out mice. J. Mol. Cell. Cardiol. 36, 469-480
18. Turner, N. A., Mughal, R. S., Warburton, P., O'Regan, D. J., Ball, S. G. and Porter, K. E. (2007) Mechanism of TNF-α -induced IL-1α, IL-1β and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones. Cardiovasc. Res. 76, 81-90
19. Singh, S., Loke, Y. K. and Furberg, C. D. (2008) Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA, J. Am. Med. Assoc. 300, 1439-1450
20. Tashkin, D. P., Celli, B., Senn, S., Burkhart, D., Kesten, S., Menjoge, S. and Decramer, M. (2008) A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N. Engl. J. Med. 359, 1543-1554
21. Wessler, I., Kirkpatrick, C. J. and Racke, K. (1999) The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin. Exp. Pharmacol. Physiol. 26, 198-205
22. Hamann, M., Chamoin, M. C., Portalier, P., Bernheim, L., Baroffio, A., Widmer, H., Bader, C. R. and Ternaux, J. P. (1995) Synthesis and release of an acetylcholine-like compound by human myoblasts and myotubes. J. Physiol. 489, 791-803
23. Pavlov, V. A., Ochani, M., Gallowitsch-Puerta, M., Ochani, K., Huston, J. M., Czura, C. J., Al-Abed, Y. and Tracey, K. J. (2006) Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc. Natl. Acad. Sci. U.S.A. 103, 5219-5223
24. Deguchi, J. O., Yamazaki, H., Aikawa, E. and Aikawa, M. (2009) Chronic hypoxia activates the Akt and β-catenin pathways in human macrophages. Arterioscler., Thromb., Vasc. Biol. 29, 1664-1670
25. Kakinuma, Y., Furihata, M., Akiyama, T., Arikawa, M., Handa, T., Katare, R. G. and Sato, T. (2010) Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. J. Mol. Cell. Cardiol. 48, 680-693
26. Kim, J. A., March, K., Chae, H. D., Johnstone, B., Park, S. J., Cook, T., Merfeld-Clauss, S. and Broxmeyer, H. E. (2010) Muscle-derived Gr1dimCD11b+ cells enhance neovascularization in an ischemic hind limb mouse model. Blood 116, 1623-1626
27. Qi, X., Okamoto, Y., Murakawa, T., Wang, F., Oyama, O., Ohkawa, R., Yoshioka, K., Du, W., Sugimoto, N., Yatomi, Y. et al. (2010) Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. Eur. J. Pharmacol. 634, 121-131