Mouse model of touch-evoked itch (alloknesis)

Journal of Investigative Dermatology

Volumn 132, Issue 7, 2012, Pages 1886-1891

  Akiyama, Tasuku ^a   Carstens, Mirela Iodi ^a   Ikoma, Akihiko ^b   Cevikbas, Ferda ^b   Steinhoff, Martin ^b   Carstens, Earl ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLTYROSYLPROLYLGLYCYLLYSYLPHENYLALANINAMIDE; BAM8 22; CHLOROQUINE; DERMATOLOGICAL AGENT; G PROTEIN COUPLED RECEPTOR; HISTAMINE; MRGPRC11 AGONIST; NALTREXONE; PROTEASE ACTIVATED RECEPTOR 2 AGONIST; PROTEASE ACTIVATED RECEPTOR 4 AGONIST; PROTEIN MRGRPC11; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 4; SEROTONIN; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINAMIDE; TERFENADINE; UNCLASSIFIED DRUG;

ALLOKNESIS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRY SKIN; EVOKED RESPONSE; HINDLIMB; MECHANICAL STIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PRURITUS; SCRATCHING; SKIN WATER LOSS; TIME; TOUCH;

EID: 84862327521     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.52     Document Type: Article

References (32)

1. Akiyama T, Carstens MI, Carstens E (2009a) Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch. J Neurophysiol 102:2176-83
2. Akiyama T, Carstens MI, Carstens E (2010a) Differential itch- and pain-related behavioral responses and micro-opoid modulation in mice. Acta Derm Venereol 90:575-81
3. Akiyama T, Carstens MI, Carstens E (2010b) Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch. Pain 151:378-83
4. Akiyama T, Carstens MI, Carstens E (2010c) Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice. J Neurophysiol 104:2442-50
5. Akiyama T, Carstens MI, Carstens E (2010d) Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model. Neurosci Lett 484:62-5
6. Akiyama T, Iodi Carstens M, Carstens E (2011) Enhanced responses of lumbar superficial dorsal horn neurons to intradermal PAR-2 agonist but not histamine in a mouse hindpaw dry skin itch model. J Neurophysiol 105:2811-7
7. Akiyama T, Merrill AW, Carstens MI et al. (2009b) Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. J Neurosci 29:6691-9
8. Akiyama T, Merrill AW, Zanotto K et al. (2009c) Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice. J Pharmacol Exper Ther 329:945-51
9. Brull SJ, Atanassoff PG, Silverman DG et al. (1999) Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosens Mot Res 16:299-303 (Pubitemid 30006505)
10. Carstens E, Kuraishi Y (2004) Animal models of itch: scratching away at the problem. In: Yosipovitch G, Greaves MW, Fleischer AB, McGlone F. Monticello (eds) Itch: Basic Mechanisms and Therapy. Marcel Dekker: NY, pp. 35-50
11. Davidson S, Giesler GJ (2010) The multiple pathways for itch and their interactions with pain. Trends Neurosci 33:550-8
12. Davidson S, Zhang X, Yoon CH et al. (2007) The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 27:10007-14 (Pubitemid 47404005)
13. Heyer G, Dotzer M, Diepgen TL et al. (1997) Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis. Pain 73:239-43 (Pubitemid 27491686)
14. Hosogi M, Schmelz M, Miyachi Y et al. (2006) Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch. Pain 126:16-23 (Pubitemid 44751949)
15. Ikoma A, Fartasch M, Heyer G et al. (2004a) Painful stimuli evoke itch in patients with chronic pruritus - central sensitization for itch. Neurology 62:212-7 (Pubitemid 38167127)
16. Ikoma A, Handwerker H, Miyachi Y et al. (2004b) Neuronal sensitization for itch in patients with chronic pruritus. Exper Dermatol 13:589
17. Ikoma A, Steinhoff M, Stander S et al. (2006) The neurobiology of itch. Nat Rev Neurosci 7:535-47 (Pubitemid 43995431)
18. Johanek LM, Meyer RA, Friedman RM et al. (2008) A role for polymodal C-fiber afferents in nonhistaminergic itch. J Neurosci 28:7659-69
19. Johanek LM, Meyer RA, Hartke T et al. (2007) Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci 27:7490-7 (Pubitemid 47066576)
20. LaMotte RH (1992) Subpopulations of nocifensor neurons contributing to pain and allodynia, itch and alloknesis. Am Pain Soc J 1:115-26
21. Liu Q, Tang Z, Surdenikova L et al. (2009) Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 139:1353-65
22. Liu Q, Weng HJ, Patel KN et al. (2011) The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal 4:ra45
23. Miyamoto T, Nojima H, Shinkado T et al. (2002) Itch-associated response induced by experimental dry skin in mice. Jpn J Pharmacol 88:285-92 (Pubitemid 34302979)
24. Namer B, Carr R, Johanek LM et al. (2008) Separate peripheral pathways for pruritus in man. J Neurophysiol 100:2062-9
25. Nojima H, Carstens MI, Carstens E (2003) c-fos Expression in superficial dorsal horn of cervical spinal cord associated with spontaneous scratching in rats with dry skin. Neurosci Lett 347:62-4 (Pubitemid 36831107)
26. Schmelz M, Schmidt R, Bickel A et al. (1997) Specific C-receptors for itch in human skin. J Neurosci 17:8003-8 (Pubitemid 27426235)
27. Sikand P, Dong X, Lamotte RH (2011) BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci 31:7563-7
28. Simone DA, Alreja M, LaMotte RH (1991) Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine. Somatosens Mot Res 8:271-9
29. Steinhoff M, Neisius U, Ikoma A et al. (2003) Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23:6176-80 (Pubitemid 36875617)
30. Wahlgren CF, Hagermark O, Bergstrom R (1991) Patients' perception of itch induced by histamine, compound 48/80 and wool fibres in atopic dermatitis. Acta Derm Venereol 71:488-94
31. Weisshaar E, Dunker N, Rohl FW et al. (2004) Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients. Exp Dermatol 13:298-304 (Pubitemid 38714429)
32. Wilson SR, Gerhold KA, Bifolck-Fisher A et al. (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci 14:595-602