Involvement of 5-HT2A receptors in genetic mechanisms of autoregulation of brain 5-HT system

Molecular Biology

Volumn 46, Issue 3, 2012, Pages 375-380

  Naumenko, V S ^a   Tsybko, A S ^a   Bazovkina, D V ^a   Popova, N K ^a  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

Author keywords

5 HT and 5 HIAA levels; 5 HT transporter; 5 HT2A receptor; chronic DOI treatment; mice; tryptophan hydroxylase 2 activity; tryptophan hydroxylase 2 gene expression

Indexed keywords

MUS;

EID: 84862306017     PISSN: 00268933     EISSN: 16083245     Source Type: Journal    
DOI: 10.1134/S0026893312020100     Document Type: Article

References (28)

1. Jouvet M. 1969. Biogenic amines and the states of sleep. Science. 163, 32-41.
2. Popova N. K., Konusova A. V. 1985. Brain and peripheral effects of serotonin on thermoregulation. Biogenic Amines. 3, 125-134.
3. Jacobs B. L., Fornal C. A. 1995. Serotonin and behavior: A general hypothesis. In: Psychopharmacology: The Fourth Generation of Progress. Eds Bloom F. E., Kupfer D. J. N. Y.: Raven Press, pp. 461-469.
4. Kulikov A. V., Kozlachkova E., Popova N. K. 1989. Genetic control of catalepsy in mice. Genetika. 25, 1402-1408.
5. Berman M. E., Tracy J. I., Coccaro E. F. 1997. The serotonin hypothesis of aggression revisited. Clin. Psychol. Rev. 17, 651-665.
6. Amstislavskaya T. G., Popova N. K. 2006. Serotonergic receptor subtypes in male mouse and rat sexual arosal. In: Advances in Psychology Research. Ed. Columbus A. NY: Nova Science Publ., pp. 139-160.
7. Barnes N. M., Sharp T. 1999. A review of central 5-HT receptors and their function. Neuropharmacol. 38, 1083-1152.
8. Saudou F., Hen R. 1994. 5-Hydroxytryptamine receptor subtypes: Molecular and functional diversity. Adv. Pharmacol. 30, 327-380.
9. Popova N. K., Naumenko V. S., Cybko A. S., Bazovkina D. V. 2010. Receptor-genes cross-talk: effect of chronic 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system and on behavior. Neuroscience. 169, 229-235.
10. Stein D. J., Hemmings S., Moolman-Smook H., Audenaert K. 2007. 5-HT2A: Its role in frontally mediated executive function and related psychopathology. CNS Spectr. 12, 512-516.
11. 2A receptor gene polymorphism in humans. Ann. N. Y. Acad. Sci. 1086, 134-143.
12. Rasmussen H., Erritzoe D., Andersen R., et al. 2010. Decreased frontal serotonin 2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia. Arch. Gen. Psychiatry. 67, 9-16.
13. Rocchi A., Micheli D., Ceravolo R., Manca M. L., Tognoni G., Siciliano G., Murri L. 2003. Serotoninergic polymorphisms (5-HTTLPR and 5-HT2A): Association studies with psychosis in Alzheimer disease. Genet. Test. 7, 309-314.
14. Kuoppamaki M., Palvimaki E. P., Hietala J., Syvalahti E. 1995. Differential regulation of rat 5-HT2A and 5-HT2C receptors after chronic treatment with clozapine, chlorpromazine and three putative atypical antipsychotic drugs. Neuropsychopharmacology. 13, 139-150.
15. Darmani N. A., Martin B. R., Glennon R. A. 1992. Behavioral evidence for differential adaptation of the serotonergic system after acute and chronic treatment with (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin. J. Pharmacol. Exp. Ther. 262, 692-698.
16. Anji A., Kumari M., Sullivan Hanley N. R., Bryan G. L., Hensler J. G. 2000. Regulation of 5-HT(2A) receptor mRNA levels and binding sites in rat frontal cortex by the agonist DOI and the antagonist mianserin. Neuropharmacology. 39, 1996-2005.
17. Ross J. D., Herin D. V., Frankel P. S., Thomas M. L., Cunningham K. A. 2006. Chronic treatment with a serotonin(2) receptor (5-HT(2)R) agonist modulates the behavioral and cellular response to (+)-3, 4-methylenedioxymethamphetamine [(+)-MDMA]. Drug. Alcohol. Depend. 81, 117-127.
18. Naumenko V. S., Bazovkina D. V., Kondaurova E. M., Zubkov E. A., Kulikov A. V. 2010. The role of 5-HT2A receptor and 5-HT2A/5-HT1A receptor interaction in the suppression of catalepsy. Genes Brain. Behav. 9, 519-524.
19. Green A. R., Heal D. J. 1985. The effects of drugs on serotonin-mediated behavioural models. In: Neuropharmacology of Serotonin. Ed. Green A. R. Oxford: Oxford Univ. Press, pp. 326-365.
20. Fantegrossi W. E., Simoneau J., Cohen M. S., Zimmerman S. M., Henson C. M., Rice K. C., Woods J. H. 2010. Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2, 5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice. J. Pharmacol. Exp. Ther. 335, 728-734.
21. Klein A. B., Santini M. A., Aznar S., Knudsen G. M., Rios M. 2010. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. 169, 1007-1016.
22. Kulikov A. V., Naumenko V. S. 2007. Problems of mRNA quantification in the brain using RT-PCR. In: New Messenger RNA Research Communications. Ed. Kwang L. B. NY: Nova Science Publ., pp. 53-68.
23. Kulikov A. V., Naumenko V. S., Voronova I. P., Tikhonova M. A., Popova N. K. 2005. Quantitative RT-PCR assay of 5-HT1A and 5-HT2A serotonin receptor mRNAs using genomic DNA as an external standard. J. Neurosci. Methods. 141, 97-101.
24. Naumenko V. S., Kulikov A. V. 2006. Quantitative assay of 5-HT1A receptor gene expression in the brain. Mol. Biol. (Moscow). 40, 30-36.
25. Naumenko V. S., Osipova D. V., Kostina E. V., Kulikov A. V. 2008. Utilization of a two-standard system in real-time PCR for quantification of gene expression in the brain. J. Neurosci. Methods. 170, 197-203.
26. Smith R. L., Barrett R. J., Sanders-Bush E. 1999. Mechanism of tolerance development to 2, 5-dimethoxy-4-iodoamphetamine in rats: Down-regulation of the 5-HT2A, but not 5-HT2C, receptor. Psychopharmacology (Berlin). 144, 248-254.
27. Popova N. K., Kulikov A. V. 2010. Targeting tryptophan hydroxylase 2 in affective disorder. Expert. Opin. Ther. Targets. 14, 1259-1271.
28. Serretti A., Artioli P., De Ronchi D. 2004. The 5-HT2C receptor as a target for mood disorders. Expert. Opin. Ther. Targets. 8, 15-23.